‫‪laboratory sciences‬‬

‫‪morphological pattern of acute inflammation‬‬

‫إعداد الطالبة ‪ :‬عال باسم عبدالكاظم‬

‫كلية الطب ‪ /‬المرحلة الثانية‬
‫إشراف ‪ :‬د ‪ .‬دينا صالح‬

‫‪1‬‬
Acute inflammation is morphologically 
characterized by : 

–Dilatation of small blood vessels

–Slowing of blood flow
–Leukocyte infiltration
–Fluid accumulation in interstitial space

•Special morphologic patterns are seen

–Severity of reaction
–Specific cause of reaction
–Particular tissue/site involved

Morphologic Patterns of Acute

Inflammation include:

•SEROUS INFLAMMATION
• FIBRINOUS INFLAMMATION
• SUPPURATIVE INFLAMMATION
• ULCERATIVE INFLAMMATION

Serous Inflammation

Marked by :
Outpouring of thin fluid derived from
• Plasma
• Secretions of mesothelial cells
• Accumulation of fluid in these
cavities is called as EFFUSION
• Skin blister represent (serous pleural effusion)
accumulation of serous Fluid

2
Fibrinous Inflammation

Characterized by deposition of fibrin in the

extracellular spaces
Fibrinous exudate develops when
— Vascular leaks are large, or
— Local procoagulant stimulus

Fibrinous exudate is characteristic of:

— Inflammation in the lining of body cavities

Conversion to fibrous tissue (organization)
within pericardial sac leads to fibrous
thickening (Fibrinous pericarditis)

Fibrinous exudate-
Pericardium

Suppurative/purulent
Inflammation

Characterized by production of large

amounts of pus (purulent exudate), consist of

— PMN, liquefactive necrosis, edema fluid Pyogenic bacteria produce this
Abscess are localized collection of purulent inflammatory exudate
— Suppuration buried in an organ, tissue or confined space

• Central necrotic area

• Preserved PMN around this necrotic focus
• Vascular dilatation, parenchymal and fibroblastic proliferation occurs
peripherally

3
Ulcerative inflammation
A local defect or excavation, of the surface of an organ or tissue, produced
by the sloughing (shedding) of inflamed necrotic tissue Occur when tissue
necrosis and

inflammation exist on or near a surface

Encountered in

— Mouth, stomach, intestine, genital or urinary tract

— Skin & subcutaneous tissues

References

•Stedman's Medical Dictionary (Twenty-fifth ed.). Williams & Wilkins.

1990.
•Herrington, Simon (2014). Muir's Textbook of Pathology (15th ed.). CRC
Press. p. 59.
•Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). "Inflammation in wound
repair: molecular and cellular mechanisms". Journal of Investigative
Dermatology. 127 (3): 514–525.
•Sato, Y.; Ohshima, T.; Kondo, T. (1999). "Regulatory role of endogenous
interleukin-10 in cutaneous inflammatory response of murine wound
healing". Biochem Biophys Res Commun. 265 (1): 194–9.