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Aging Clinical and Experimental Research

The five-times-sit-to-stand test: validity,


reliability and detectable change in older females*
Allon Goldberg1,2, Martina Chavis1, Johnny Watkins1 and Tyler Wilson1
1Department of Health Care Sciences, Physical Therapy Program, Mobility Research Laboratory,
2Institute of Gerontology, Wayne State University, Detroit, MI, USA

ABSTRACT. Background and aims: The five-times- seconds to be considered real change beyond mea-
sit-to-stand test (FTSST) is a physical performance surement error.
test commonly-used in clinical geriatric studies. The re- (Aging Clin Exp Res 2012; 24: 339-344)
lationship between FTSST times and dynamic bal- ©2012, Editrice Kurtis
ance has not been widely investigated in older adults.
The main objective of this study was to evaluate the INTRODUCTION
validity of the FTSST as a measure of dynamic bal- More than 30% of older adults fall each year (1), in-
ance in older adults. A second objective was to quan- dicating an urgent need to uncover reliable and valid
tify relative and absolute reliability, as well as mini- clinical assessment tools to predict falls in older adults. Nu-
mum detectable change (MDC) of the FTSST in older merous clinical tests and measures are used to evaluate fall
adults. Methods: Twenty-nine females (mean age, risk in older adults. The five-times-sit-to-stand test (FTSST)
73.6 years) performed two trials of the FTSST, timed is a physical performance test commonly used in clinical
up and go (TUG), and functional reach (FR) tests. geriatric studies. Although sit-to-stand performance is
Validity of the FTSST as a measure of dynamic bal- associated with leg strength in older adults (2, 3), it is be-
ance was evaluated by quantifying strength of rela- coming increasingly apparent that it is associated with
tionships between the FTSST and two measures of dy- many other factors in addition to strength. These in-
namic balance, TUG and FR, using Pearson’s corre- clude a variety of physiological and psychological factors
lation coefficient. Measures of relative [intraclass cor- such as vision, proprioception, peripheral tactile sensitivity,
relation coefficient (ICC)] and absolute [standard error reaction time, postural sway, anxiety, and pain, all of
of measurement (SEM)] reliability, as well as the MDC which together with leg strength explained 34.9% of
at the 95% confidence level (MDC95) were computed the variance in FTSST time in older adults (2).
for the FTSST. Results: The Pearson’s correlation co- Older adults with balance dysfunction have significantly
efficient between FTSST and TUG (r=0.64, p<0.001) slower FTSST times (16.4 seconds) than older control
indicates that FTSST is a valid measure of dynamic adults (13.4 seconds) and FTSST times correlate with
balance and functional mobility in older adults. The scores on the Activities-specific Balance Confidence scale
ICC2,1 of 0.95 is indicative of excellent relative relia- (Spearman rho =–0.58; p<0.001) (4), a self-report balance
bility of the FTSST. SEM was 0.9 seconds and MDC95 confidence assessment tool (5). In older adults, FTSST
was 2.5 seconds for the FTSST. SEM (6.3% of mean times correlate with static balance assessed as postural
FTSST) and MDC (17.5% of mean FTSST) percent sway with eyes open on foam (r=0.26; p<0.01) (2), and
values were low. Conclusions: The FTSST is a valid with dynamic balance assessed as 360° turn (r=0.26;
measure of dynamic balance and functional mobility p<0.001) (6). Although strength of the relationship between
in older adults. The high ICC and low SEM and FTSST times and balance based on these studies is weak,
SEM% suggest excellent relative and absolute relia- these studies suggest that the FTSST exhibits some asso-
bility and reproducibility of the FTSST in older adults. ciation with static balance as well as with dynamic balance
Change in FTSST performance should exceed 2.5 capabilities in older adults. The relationship between FTSST

*Portions of the data in this manuscript were presented in podium format at the Combined Sections Meeting of the American Physical Ther-
apy Association in February 2012.
Key words: Dynamic balance, minimum detectable change, older adults, relative and absolute reliability, sit to stand.
Correspondence: Allon Goldberg, Department of Health Care Sciences, Physical Therapy Program, Mobility Research Laboratory, Wayne
State University, 259 Mack Ave., Detroit, MI, 48201, USA.
E-mail: agoldberg@wayne.edu
Received May 13, 2011; accepted in revised form November 3, 2011.

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Sit to stand in older adults

times and dynamic balance performance, however, has not state of health (excellent; very good; good; fair; poor), and
been widely investigated in older adults. Further studies are reported their level of physical activity or exercise on a
needed to evaluate and establish the validity of the FTSST weekly basis (more than 30 minutes 3 times per week; 5-
as a measure of dynamic balance capabilities in older 30 minutes 3 times per week; sedentary). They were
adults in order to facilitate its use as an outcome measure fully informed of the procedures employed in the study
in dynamic balance intervention studies. Therefore the and participated voluntarily. An informed consent docu-
main objective of this study was to evaluate the validity of ment approved by the Human Investigation Committee of
the FTSST as a measure of dynamic balance by quantifying Wayne State University was signed by each participant pri-
strength of relationships between the FTSST and two or to testing.
measures of balance which incorporate dynamic tasks, In order to estimate sample size for the study, we
the timed up and go (TUG) (7) and functional reach (FR) (8) conducted a power analysis based on a prior study show-
tests. The TUG is a measure of dynamic balance as it in- ing that FTSST times correlate with TUG in individuals
corporates control of the center of gravity during sit to stand with vestibular deficits (r=0.53; p<0.01) (11). To achieve
and during return to sitting. The TUG also incorporates 80% power for a Pearson’s correlation coefficient of
turning while taking steps; turning while stepping assesses r=0.50 and α=0.05, 28 individuals needed to be tested.
dynamic balance as it requires changes to the base of
support to accomplish the turning task (6). The FR is a test Assessments
of the margin of stability in which the individual maximal- Three testers were involved in data collection. The
ly reaches forward with an outstretched arm while bending same tester conducted two trials for each of the three vari-
at the waist and with the feet stationary. We hypothe- ables for a single participant. This ensured maximum
sized that the FTSST times would be associated with per- consistency of data collection for each variable for each
formance on the TUG and FR tests, but that the relation- participant. Prior to initiation of data collection, all testers
ship with TUG would be stronger than with FR. The second underwent a training session at which they were in-
objective of this study was to quantify relative and absolute structed by the senior author in the testing procedures
reliability, as well as minimum detectable change (MDC) of conducted in this study.
the FTSST in older adults. The MDC is the smallest dif-
ference between repeated trials of a variable of interest that Five-times-sit-to-stand
is not due to chance variation (9), and in clinical studies rep- Participants rose from a chair and returned to the
resents real change beyond that attributable to measurement seated position as quickly as possible for five repetitions.
error (10). Knowledge of real change values for the FTSST Participant’s arms were folded across their chests during
will enable clinicians and researchers to evaluate whether the test. In community-dwelling older adults test-retest re-
change in FTSST performance constitutes real change or liability of the FTSST is excellent [intraclass correlation co-
is due to measurement error. efficient (ICC)=0.89] (2). Two trials were performed with
approximately one-minute rest in between each trial as
METHODS needed. Mean of the two trials was computed for use in
Participants the analysis.
The study participants were a sample of convenience
and included 29 female older adults who were recruited at Timed up and go
an urban senior center. Participants were recruited by di- TUG is a measure of functional mobility (7) and balance
rect person-to-person solicitation at the center and (12-14), incorporating a series of dynamic activities. Par-
through flyers posted in the center. All testing took place ticipants stood up from a chair, walked 3 meters at their
at the center during a single testing session. Individuals usual safe walking speed, turned around and returned to
were included if they were female community-dwelling the seated position (7). A TUG cutoff score of 13.5 sec-
adults aged 60 years and older, able to walk at least 10 onds classifies fallers and non-fallers in older adults with
meters and stand at least 10 minutes without an assistive sensitivity of 80% (percent fallers) and specificity of 100%
device, and were alert and oriented. Exclusionary criteria (percent non-fallers), and with an overall correct faller pre-
were based on a detailed medical history and included diction rate of 90% (12). Interrater reliability of TUG is ex-
shortness of breath with minimal exertion, neurological cellent in community-dwelling older adults (ICC=0.98)
disease that may affect balance, diabetes with peripheral (12). Two trials were performed with approximately one
neuropathy, vestibular impairments, significant pain in the minute rest in between each trial as needed. Mean of the
lower extremities that might affect participation, active in- two trials was computed for use in the analysis.
fection or diagnosis of cancer, current injury, history of
fracture within the past year, recent dizziness or fainting Functional reach
episodes, uncorrected visual deficits, and amputation of an FR is a measure of balance and margin of stability (8).
extremity. Participants also provided a rating of their In standing, participants reached forward with the arm ex-

Aging Clin Exp Res, Vol. 24, No. 4 340


A. Goldberg, M. Chavis, J. Watkins et al.

tended while flexing the trunk, without rotating their Table 1 - Characteristics of 29 older adult females.
shoulders or stepping forward. FR was the maximum
Characteristic Mean (SD) or % Range
distance they were able to reach forward beyond arm
length while maintaining a fixed base of support, and was Anthropometric/demographic
measured with a yardstick affixed to the wall at the level Age (yr) 73.6 (7.4) 60-90
Height (cm) 162.7 (5.9) 149.9-172.7
of the acromion. Reliability of FR is excellent (ICC>0.92) Weight (Kg) 74.0 (14.5) 50.0-107.7
in community-dwelling older adults (13). Two trials were Body mass index (Kg/m2) 27.9 (5.2) 19.0-43.4
performed with approximately one-minute rest in be- Self-report state of health
tween each trial as needed. Mean of the two trials was Fair (%) 3.5 -
computed for use in the analysis. Good (%) 51.7 -
Very good (%) 37.9 -
Excellent (%) 6.9 -
Statistical analysis
Physical activity/exercise
Descriptive statistics including means, standard devia- Sedentary (%) 3.4 -
tions, ranges, and percentages were computed for par- 5-30 min 3 times/week (%) 41.4 -
ticipant characteristics. Means, standard error of the More than 30 min 3 times/week (%) 55.2 -
mean, 95% confidence intervals, and ranges were com- n
puted for FTSST, TUG and FR. The Kolmogorov-
Smirnov test was used to evaluate normality of the
FTSST, TUG and FR tests. The three tests all conformed RESULTS
to a normal distribution, allowing for the use of parametric Characteristics
statistical procedures. Strengths of relationships between The sample’s characteristics are presented in Table 1.
the FTSST and clinical balance measures (TUG and FR) A large proportion (55.2%) reported exercising or being
were computed using the Pearson correlation coeffi- physically active for more than 30 minutes 3 times per
cient. Difference between FTSST trials was assessed us- week. Forty-five percent of the sample reported their
ing a paired t-test. Test-retest reliability of the FTSST was health as very good or excellent.
computed using ICC2,1 (15), a measure of relative relia-
bility. The standard error of measurement (SEM) is a Assessments
measure of absolute reliability expressing measurement er- Means, standard error of means, 95% confidence in-
ror in the same units as the original measurement (16, tervals and ranges are presented for the FTSST, TUG and
17). The SEM of the FTSST was computed using the for- FR in Table 2.
mula SD×㲋(1- ICC2,1), (18), where SD was the standard
deviation of the FTSST trial with the highest standard de- Relationships among variables: validity of the FTSST
viation, and ICC2,1 the test-retest reliability coefficient. A FTSST times correlated significantly with TUG, such
Bland-Altman plot of each participant’s mean FTSST that better sit-to-stand performance is associated with
time plotted against their FTSST difference score (trial 1 better TUG score. The Pearson’s correlation coefficient
minus trial 2) depicts the spread of difference scores (r=0.64, p<0.001) revealed a moderate relationship be-
about the zero difference score. The Bland-Altman plot al- tween FTSST and TUG. There was a weaker relationship
so depicts the 95% limits of agreement (95% LOA) (19), between FTSST and FR (Pearson’s r= -0.36, p=0.06).
which represent an expected range of difference scores
across trials of the FTSST. The 95% LOA containing ze- Reliability and minimum detectable change of FTSST
ro indicates statistically the absence of systematic bias be- Mean FTSST times for each trial as well as reliability
tween repeated trials of a variable (10). The 95% LOA and minimum change values for FTSST times are pre-
was computed as –x ±1.96×SD, (19), where –x was the
mean of the difference scores between the first and sec-
ond trials of FTSST time, and SD the standard deviation
of the difference scores. The MDC at the 95% confidence Table 2 - Means, confidence intervals, and ranges for assessment
level (MDC 95 ) was computed for the FTSST as measures for 29 older adult females.
z×SEM×㲋2 (18). A value of 1.96 was used as the z- Mean±SEM 95% CI Range
score associated with the 95% confidence level and 㲋2 ac-
counted for added uncertainty in measurement associat- Assessments
ed with repeated trials of the FTSST. SEM and MDC95 FTSST (s) 14.3±0.7 12.9-15.8 8.00-21.3
were expressed as percentages (SEM% and MDC95%) of TUG (s) 10.4±0.6 9.2-11.6 6.8-22.1
FR (cm) 23.8±1.2 21.3-26.2 13.0-37.5
mean FTSST to enhance interpretation of the absolute
values of measurement error and minimum change (20). FTSST: five-times-sit-to-stand test; TUG: timed up and go; FR: functional
reach; SEM: standard error of the mean; CI: confidence interval.
Statistical significance was set at p≤0.05.

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Sit to stand in older adults

Table 3 - Reliability and minimum detectable change for five-times-sit-to-stand test for 29 older adult females.

Mean trial 1 (SD) Mean trial 2 (SD) ICC2,1 95% LOA SEM SEM% MDC95 MDC95%
[range] [range] [95% CI]

FTSST 14.3 (3.8) 14.3 (4.1) 0.95 –2.6 to +2.6 0.9 6.3 2.5 17.5
[7.5-20.7] [8.5-21.8] [0.89-0.97]
FTSST: five-times-sit-to-stand test; SD: standard deviation; ICC: intraclass correlation coefficient; CI: confidence interval; 95% LOA: 95% limits of agreement;
SEM: standard error of measurement; MDC95: minimum detectable change at the 95% confidence interval. FTSST means, 95% LOA, SEM, and MDC95 are
in seconds.

sented (Table 3). Mean FTSST times for each trial were ance during performance of the task. The complex nature
similar (p=0.94). The ICC2,1 of 0.95 is indicative of ex- of the FTSST task, particularly incorporating control of the
cellent test-retest reliability of the FTSST times. SEM center of mass bi-directionally over the base of support to
was computed as 0.9 seconds, while the SEM% was avoid losses of balance, renders it a useful measure of bal-
6.3%, a low measurement error percent value. Visual in- ance impairment and fall risk in older adults.
spection of the Bland-Altman plot indicates that the The ICC2,1, a measure of relative reliability, was ex-
FTSST difference scores are distributed above and below cellent, exceeding the value of 0.89 reported by others in
the zero difference score with no evidence of bias across community-dwelling older adults (2). It has been sug-
trials 1 and 2 of the FTSST. The expected range of dif- gested that for clinical measures, reliability coefficients
ference scores across the two trials of FTSST time was ex- should exceed 0.90 (18). Evaluation of absolute reliabili-
amined by computing the 95% LOA, which ranged from ty of the FTSST was conducted by computing the 95%
–2.6 seconds to +2.6 seconds (Table 3; Figure 1). As the LOA (19) as well as the SEM (16, 17). The 95% LOA
95% LOA contained zero, there was no statistical evi- was narrow and included zero, indicating excellent abso-
dence of systematic bias across trials 1 and 2 of the lute reliability of the FTSST with no statistical evidence of
FTSST. The MDC95 for FTSST time was 2.5 seconds, systematic bias across repeated trials. Measurement error
and the MDC95% was 17.5%, a low minimum change computed as the SEM was low in absolute terms as well
percent value. as when expressed as a percentage of mean FTSST.
The low SEM and low measurement error percent values
DISCUSSION (SEM%) suggest excellent absolute reliability of the FTSST
The relationship between sit-to-stand performance in older adults. Our comprehensive analyses of the rela-
assessed as the FTSST, and dynamic balance perfor- tive and absolute reliability of the FTSST indicating a
mance has not been widely investigated in older adults. high ICC and low SEM and SEM% values, suggests ex-
Previous studies show a weak relationship between
FTSST and dynamic balance assessed as 360° turn in old-
er adults (r=0.26; p<0.001) (6), but a stronger relationship
(r=0.53; p<0.01) between FTSST times and a measure 5
of dynamic balance, TUG, in individuals with vestibular 4
deficits (11). In this study we showed that the FTSST cor- 3
related moderately with TUG, indicating the FTSST is a 2
Difference (s)

valid measure of dynamic balance and functional mobili- 1


ty in older adults. These data add to the body of evidence 0
indicating that sit-to-stand performance is associated with -1
balance capabilities in older adults. As expected, the re- -2
lationship between FTSST and FR was weaker. -3
Sit to stand is a dynamic and complex mobility task un- -4
dertaken multiple times on a daily basis by older adults. -5
Deficits in sit-to-stand performance in older adults (21) and 0 5 10 15 20 25
after stroke (22) are associated with risk for falling. Al- Mean five-times-sit-to-stand (s)
ternately raising and lowering the trunk and body center
Fig. 1 - Bland-Altman plot for the five-times-sit-to-stand test.
of mass during the FTSST requires coordinated func- Means on the x-axis are the average of two trials for the five-times-
tioning from multiple lower extremity muscle groups in- sit-to-stand test; differences on the y-axis are five-times-sit-to-
cluding trunk musculature to effect the requisite move- stand test difference scores (trial 1 minus trial 2). The 95% lim-
its of agreement (LOA) are depicted (dashed lines). The 95%
ments. Coordinated trunk and lower extremity muscle LOA include zero, indicating no systematic bias in performance
functioning are also likely required to prevent losses of bal- between the two trials of the five-times-sit-to-stand test.

Aging Clin Exp Res, Vol. 24, No. 4 342


A. Goldberg, M. Chavis, J. Watkins et al.

cellent levels of reliability and reproducibility of this test in more individual-centered approach to change in per-
older adults. formance, the minimal clinically important difference, de-
The MDC95 as computed in this study indicates that for fined as the smallest clinical change that would be con-
a change (increase or decrease) in FTSST times to be con- sidered meaningful, worthwhile and beneficial by an in-
sidered real change beyond that of measurement error, it dividual (24, 25).
should exceed 2.5 seconds. The MDC95 interpretation is Future studies of measurement error and minimum
that the majority of individuals who have truly remained change in FTSST should blind testers as to the purpose of
stable in FTSST performance will display variation of the study, in order to reduce tester bias. Future studies
not more than 2.5 seconds on repeated assessments of should include males, as well as individuals who are more
the FTSST. If a change score exceeds 2.5 seconds, one sedentary and who have a greater disease burden than the
can be 95% confident that it is a real change; change less present cohort. Future studies should also include evalu-
than this value is considered to be attributable to mea- ation of FTSST rater reliability as well as minimal clinically
surement error. This value can guide clinicians in their in- important difference, which represents change that is
terpretation of FTSST change scores to evaluate the ef- important to the individual.
fectiveness of therapeutic interventions. Researchers can
use this minimum change score as a benchmark to eval- CONCLUSION
uate the success of interventions conducted during clini- These data highlight a moderate relationship between
cal trials. the FTSST and TUG, indicating that the FTSST is a
While knowledge of the absolute value of the MDC95 valid measure of dynamic balance and functional mobili-
is useful in clinical practice, expressing the MDC95 as a ty in older adults. The high ICC and low SEM and SEM%
percent of the mean FTSST enhances interpretability values suggest excellent relative and absolute reliability and
of the absolute MDC value (20). Expressing MDC inde- reproducibility of the FTSST in older adults. Change in
pendent of the units of measurement as a percentage of FTSST performance should exceed 2.5 seconds to be
the mean provides information as to the sensitivity of a considered real change beyond measurement error. The
measure to detect change, with lower MDC95% values threshold for real change in FTSST performance re-
suggesting greater sensitivity to detecting real change in ported here can be used in geriatric research trials and in
performance. The MDC95% of 17.5% computed in this clinical practice to evaluate the effectiveness of therapeutic
study may be considered a low minimum change percent interventions.
value, suggesting that the FTSST may be sensitive to de-
tecting real change in sit-to-stand performance in older ACKNOWLEDGEMENTS
adults. Low measurement error and minimum change per- Dr. Goldberg was supported by a Fellowship for Advanced Study in
Aging and Lifespan from the Institute of Gerontology and Office of the
cent values support the use of the FTSST as an out- Vice President for Research at Wayne State University. The financial
comes measure of physical performance in geriatric re- sponsors played no role in the design, execution, analysis, and inter-
search trials and in clinical practice. pretation of data, or in the decision to publish this manuscript.
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