UNIVERSITY OF ZIMBABWE 2016 May/June Examinations Science Faculty: Biochemistry Department... BC1M01/BC1DMO Paper code and Title:.. Duration: Examiner... Authorized Materials: Calculator, Graph Paper INSTRUCTIONS: 1. This paper contains 8 Questions 2. Answer 5 questions 3. Start each question on a new page 4. This question paper comprises 2 printed pages NB: DO NOT TURN OVER THE QUESTION PAPER OR COMMENCE WRITING UNTIL INSTRUCTED TO DO SO.(a) Write notes on the importance of inhibiting enzymes in medicine. [5 marks} (b) Aer the termination of the synthesis ofa protein chain, some of the chains subsequently undergo a variety of posttranslational modifications. Summarize FIVE of these modifications. [15 marks} (a) Describe the process of xenobiotic metabolism with reference to a named drug. [10 marks} (b) Describe FIVE mechanisms by which pathogens may protect themselves against the effects of therapeutic drugs. [10 marks} 3 (a) Discuss the role of low density lipoproteins in the metabolism of lipids. (10 marks} (©) Discuss the importance of the reaction that is shown below in the metabolism of cholesterol. [10 marks] 2NAor con Hy 006=C1 =F —Cik— HOH oH 4 (2) Briefly discuss any TWO of the following disorders of metabolism of amino acids: (i) phenylketonuria il) aleaptonuria (iii) albinism. {5 marks each] (b) Briefly describe the role of calcium ions in the contraction of a myofibril (4 marks} PLEASE Tl HE NEXT PAGEBC1MO01/BC1DMo1 PAGE TWO (©) People who have McArdle’s disease produce less ATP than healthy people. Use your knowledge of the sliding filament theory to suggest why the former are not able to maintain strong muscle contraction during exercise. [6 marks} s. (a) Using examples, explain how differences in patient genotype contribute to variability in drug response. (10 marks} (6) Describe the role of vitamin A in human health in the following: @ vision [6 marks} i) immune system [4 marks} 6. Discuss the role of nutrients including vitamins in iron metabolism and erythropoiesis. (20 marks} 7. Describe symptoms of skin diseases that are caused by herpesviruses in humans (20 marks} 8. (@) Given outline of energy mobilization during prolonged starvation. {5 marks} (b) Discuss the enterohepatic pathway for bile acids. (15 marks} END OF QUESTION PAPER