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UNIVERSITY OF ZIMBABWE
MIBChB I BIOCHEMISTRY BCIMOI
BDS I BIOCHEMISTRY BCIDM
SUPPLEMENTARY
BER 1999

any FIVE of the following EIGHT questions. The answer to each que’~tionis
20 marks. _____________

Describe how amino acids are classified according to their chemical properties.
(20 marks)

Describe a process for production of mouse monoclonal antibodies against a


bacterial antigen.

Give details of reactions ofthe urea cycle highlighting its role in nitrogen
metabolism, and the diseases that are associated with it.

Name the five main classes of steroid hormones. (5 marks)

Choose one example from one of these classes, and describe its biosynthesis from
cholesterol. The structure of the chosen hormone must be given. (15 marks)

Give an outline of the diseases associated with defects in purine or pyrimidine


metabolism.

Compare and contrast prokaryotic and eukaryotic ribosomes. (8 marks)

What do you understand by the Wobble hypothesis? (6 marks)

How do antibiotics counteract microbial infections without causing toxic side


effects in humans? (6 marks)

Describe the role ofdrug metabolism in resistance to antibacterial and


antiprotozoal agents. (10 marks)

With the aid of a well labelled diagram, i~rief]y describe the Arness Salmonella
test for mutagens. (10 marks)

Write a detailed account ofthe relationship between vitamins B6, B12, folic acid
and choline.
ENI) OF QUESTION PAPER
/j

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