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  • Biochem 2017 May Paper

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    Winnet Maruza
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    The document is a past exam paper for Biochemistry from the University of Zimbabwe. It contains 8 questions testing knowledge of various biochemical topics. The questions cover the enterohepatic cycle of bile acids, inborn errors of metabolism, vitamin B1 functions and deficiencies, protein synthesis initiation, the role of vitamins in iron metabolism and erythropoiesis, comments on personalized medicine, treatment measures for leukemias, causes of reduced T-cell production, a gene therapy protocol, mechanisms of Lesch-Nyhan syndrome and gout, and the biochemical mechanisms of cholera. Students are instructed to answer 5 of the 8 questions.

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    Biochem 2017 May paper

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    The document is a past exam paper for Biochemistry from the University of Zimbabwe. It contains 8 questions testing knowledge of various biochemical topics. The questions cover the enterohepatic cycle of bile acids, inborn errors of metabolism, vitamin B1 functions and deficiencies, protein synthesis initiation, the role of vitamins in iron metabolism and erythropoiesis, comments on personalized medicine, treatment measures for leukemias, causes of reduced T-cell production, a gene therapy protocol, mechanisms of Lesch-Nyhan syndrome and gout, and the biochemical mechanisms of cholera. Students are instructed to answer 5 of the 8 questions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    11 views2 pages

    Biochem 2017 May Paper

    Uploaded by

    Winnet Maruza
    The document is a past exam paper for Biochemistry from the University of Zimbabwe. It contains 8 questions testing knowledge of various biochemical topics. The questions cover the enterohepatic cycle of bile acids, inborn errors of metabolism, vitamin B1 functions and deficiencies, protein synthesis initiation, the role of vitamins in iron metabolism and erythropoiesis, comments on personalized medicine, treatment measures for leukemias, causes of reduced T-cell production, a gene therapy protocol, mechanisms of Lesch-Nyhan syndrome and gout, and the biochemical mechanisms of cholera. Students are instructed to answer 5 of the 8 questions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    - / rr~~~-~0

    ~~~~~~~
    -
    UNIVERSITY OF ZIMBABWE
    2 017 May/June Examinations
    •
    F Science
    acuity:.........................
    Biochemistry
    Department: ............................................................................................................................
    BC1M01/BC1DM01 : Biochemistry
    Paper code and Title: ........................................................................................................... .
    3 hours
    Duration: .................................................................................................................................
    Dr C. Chidewe
    Examiner: ................................................................................................................................
    0
    Authorized Materials: Calculator, Graph Paper

    INSTRUCTIONS:

    1. This paper contains 8 Questions


    2. Answer 5 questions
    3. Start each question on a new page
    4. This question paper comprises 2 printed pages

    NB: DO NOT TURN OVER THE QUESTION PAPER OR COMMENCE WRITING UNTIL
    INSTRUCTED TO DO SO.
    BC1M01/BC1DM01
    PAGE ONE

    1. Discuss the enterohepatic cycle of bile acids.


    [20 marks]
    2.
    (a) Discuss any ONE of the following:

    (i) phenylketonuria
    (ii) albinism
    (iii) maple syrup urine disease. (15 marks]
    (b) Explain the clinical significance of transaminases. (5 marks]

    3. Wri.t~ an account of thiamin (vitamin B1) including the functions, dietary sources,
    positive and negative interactions and diseases that arise due to deficiency of the
    vitamin. [20 marks]

    4. Starting with the preparatory phase, describe how initiation of protein synthesis takes
    place. Include the names of the components involved in this process. (20 marks]

    5. Describe the role of vitamins and nutrients in iron metabolism and erythropoesis.
    [20 marks)

    6.
    (a) "It is more important to know what sort of person has a disease than to know
    what sort of disease a person has." Comment. [5 marks]

    (b) Explain the measures to be taken prior to administration of antimetabolites


    such as 6-mercaptopurine (6-MP) in the treatment of leukemias. [5 marks]

    (c) Explain why the number of T-cells produced by people with a mutation in the
    ADA gene is drastically reduced. [5 marks]

    (d) Give an outline of a gene therapy protocol for the correction of the ADA gene.
    [5 marks]
    7.
    (a) Explain how the absence of activity of hypoxanthine guanine
    phosphoribosyl transferase (HGPRT) leads to Leasch-Nyhan syndrome and
    eventually gout. [5 marks]

    (b) Outline the biochemical mechanisms involved in cholera. [5 marks]

    PLEASE TURN TO THE NEXT PAGE

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