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Code No: 237AB / 227AB / 217AB / R9602
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
TU
B. Pharmacy IV Year I Semester Examinations, March-2021
BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 3hours Max.Marks:75
Answer any five questions
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All questions carry equal marks
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1.a) Define the following:
i) Biopharmaceutics
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ii) Pharmacokinetics
iii) Pharmacodynamics
iv) Drug disposition
v) Drug elimination.
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b) Discuss Biopharmaceutical Classification System by giving examples. [8+7]

2.a) Explain pH- partition hypothesis.

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b) Micronization of drugs leads to decrease in drug absorption, Justify.
c) Write the factors influencing absorption. [5+5+5]

3.a) Discuss the binding of drugs to various proteins by giving examples.

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b) Write about the kinetics of protein binding. [8+7]

4. Explain Phase II metabolism by giving examples. [15]

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5.a) Describe the concept of drug clearance by glomerular filtration and tubular secretion.
b) Write about the significance of drug excretion. [8+7]
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6.a) Discuss about bioequivalence study design.
b) Write a note on types of bioavailability studies. [7+8]
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7.a) Classify compartment modeling.
b) Write the reasons for drugs exhibiting nonlinear pharmacokinetics. [7+8]
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8.a) What is meant by standard error mean? Explain the utility of the concept of standard
error.
b) Write a note on t –test. [9+6]
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