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B PHARM/M PHARM
(SEM VI) THEORY EXAMINATION 2021-22
BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 3 Hours Total
Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

B PHARM/M PHARM
SECTION A (SEM VI) THEORY EXAMINATION 2021-22
1. Attempt all questions in brief. 10 x 2 = 20 BIOPHARMACEUTICS AND PHARMACOKINETICS
a. Why most of drugs are absorbed through passive absorption mechanism, explain? Time: 3 Hours Total
b What is nonlinear pharmacokinetics? Marks: 75
. Note: 1. Attempt all Sections. If require any missing data; then choose suitably.
c. Explain compartment modeling and its need
d Define maintenance dose,
. SECTION A
e. What is bioavailability explain? 1. Attempt all questions in brief. 10 x 2 = 20
f. Name various in vitro dissolution models. a. Why most of drugs are absorbed through passive absorption mechanism, explain?
g Differentiate between phase 1 and phase 2 metabolic reaction. b What is nonlinear pharmacokinetics?
. .
h Define apparent volume of distribution. c. Explain compartment modeling and its need
. d Define maintenance dose,
i. What are rate limiting steps during drug absorption? .
j. Exemplify non per oral extra vascular routes. e. What is bioavailability explain?
f. Name various in vitro dissolution models.
SECTION B g Differentiate between phase 1 and phase 2 metabolic reaction.
2. Attempt any two parts of the following: 2 x 10 = 20 .
a. Explain various physicochemical properties of drug affecting its absorption. h Define apparent volume of distribution.
.
b Determine various pharmacokinetic parameters for IV Infusion.
i. What are rate limiting steps during drug absorption?
.
c. Describe various methods for bioavailability determination. j. Exemplify non per oral extra vascular routes.

SECTION C SECTION B
3. Attempt any five parts of the following 7 x 5 = 35 2. Attempt any two parts of the following: 2 x 10 = 20
a. What is protein binding of drug, what is its clinical significance? a. Explain various physicochemical properties of drug affecting its absorption.
b Explain 2 conjugation reaction of drug metabolism with example. b Determine various pharmacokinetic parameters for IV Infusion.
. .
c. How will you increase bioavailability of poorly soluble drug? c. Describe various methods for bioavailability determination.
d Define various pharmacokinetics parameters.
. SECTION C
e. How you will calculate loading and maintenance dose? 3. Attempt any five parts of the following 7 x 5 = 35
f. What is Michaelis Menton method explain with example? a. What is protein binding of drug, what is its clinical significance?
g What is absorption window explain? b Explain 2 conjugation reaction of drug metabolism with example.
. .
c. How will you increase bioavailability of poorly soluble drug?

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d Define various pharmacokinetics parameters.
.
e. How you will calculate loading and maintenance dose?
f. What is Michaelis Menton method explain with example?
g What is absorption window explain?
.

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