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  • Mpharm 1 Sem Pharmacological and Toxicological Screening Methods 1 mpl103t 2019

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    This document outlines the sections and questions for a pharmacology and toxicology screening methods examination. Section A contains 10 short answer questions about topics like the definition of a test item in Good Laboratory Practice, chemicals used for cell fusion, the role of isoguvacine in GABA receptor binding assays, and behavioral tests for spatial learning. Section B contains 2 long answer questions about CPCSEA animal experimentation guidelines and in-vitro screening methods for anti-epileptics. Section C contains 5 long answer questions about topics such as GLP requirements, methods for screening sympathomimetic drugs, in-vivo screening of anti-emetics, in-vivo screening of anti-inflammatory agents, and

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    This document outlines the sections and questions for a pharmacology and toxicology screening methods examination. Section A contains 10 short answer questions about topics like the definition of a test item in Good Laboratory Practice, chemicals used for cell fusion, the role of isoguvacine in GABA receptor binding assays, and behavioral tests for spatial learning. Section B contains 2 long answer questions about CPCSEA animal experimentation guidelines and in-vitro screening methods for anti-epileptics. Section C contains 5 long answer questions about topics such as GLP requirements, methods for screening sympathomimetic drugs, in-vivo screening of anti-emetics, in-vivo screening of anti-inflammatory agents, and

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    Mpharm 1 Sem Pharmacological and Toxicological Screening Methods 1 mpl103t 2019

    Uploaded by

    anujsharma02011999
    This document outlines the sections and questions for a pharmacology and toxicology screening methods examination. Section A contains 10 short answer questions about topics like the definition of a test item in Good Laboratory Practice, chemicals used for cell fusion, the role of isoguvacine in GABA receptor binding assays, and behavioral tests for spatial learning. Section B contains 2 long answer questions about CPCSEA animal experimentation guidelines and in-vitro screening methods for anti-epileptics. Section C contains 5 long answer questions about topics such as GLP requirements, methods for screening sympathomimetic drugs, in-vivo screening of anti-emetics, in-vivo screening of anti-inflammatory agents, and

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    of 1

    Printed Pages: 01 Sub Code: MPL103T

    Paper Id: 298103 Roll No.

    M. PHARM.
    (SEM I) THEORY EXAMINATION 2018-19
    PHARMACOLOGICAL & TOXICOLOGICAL SCREENING METHODS-I
    Time: 3 Hours Total Marks: 75
    Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

    SECTION A

    1. Attempt all questions in brief. 10 x 2 = 20


    a. What do you mean by Test item in GLP?
    b. Which chemical is required for fusion of karyoplast with the enucleated cell?
    c. What is the role of Isoguvacine or muscimol in [ 3H]-GABA receptor binding assay for
    screening of GABAergic Compounds?
    d. Name the behavioral test used for assessing spatial learning.
    e. Which cell line is used for in-vitro NO release test (aphrodisiac activity)?
    f. Write down the principle of Konzett-Rossler method.
    g. Why aconitine used in preclinical screening of anti-arrhythmic agents? Write its
    mechanism of action.
    h. Enlist various models used for drug screening of non-insulin-dependent diabetes.
    i. Differentiate heterogeneous and homogenous immunoassay systems.
    j. What do you mean by micro-dosing studies?

    SECTION B

    2. Attempt any two parts of the following: 2 x 10 = 20


    a. Discuss CPCSEA guidelines to conduct experiments on animals.
    b. Explain any two in-vitro methods for the preclinical screening of anti-epileptics.
    c. Discuss possible animal alternative models for preclinical screening of
    immunomodulators.
    SECTION C
    3. Attempt any five parts of the following: 7 x 5 = 35
    a. What are the main requirements of GLP (Good Laboratory Practice)?
    b. Discuss different methods used for the screening of sympathomimetic drugs.
    c. Explain any two in-vivo methods for the preclinical screening of anti-emetics.
    d. Write a note on in-vivo methods for the screening of anti-inflammatory agents.
    e. Illustrate any two methods for the preclinical screening of antiatherosclerotic agents in
    detail.
    f. Name any five in-vivo models used for the screening of hepatoprotective agents.
    Explain any one in detail.
    g. Describe immunoassay for digoxin in detail.

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