Seat No.: _____ Enrolment No.

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GUJARAT TECHNOLOGICAL UNIVERSITY

PHARM.D YEAR-4/PHARM.D(PB) YEAR-1 EXAMINATION – SUMMER-2023

Subject Code: 848805/818905 Date: 28\06\2023

Subject Name: Biopharmaceutics & Pharmacokinetics
Time: 02:30 PM TO 05:30 PM Total Marks: 70
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss various factors affecting drug absorption through GIT. 06
(b) Explain passive diffusion in detail. 04
(c) Write a note on volume of distribution. 04
Q.2 (a) Explain briefly: 1) Cmax 2) Tmax and 3) AUC 06
(b) Discuss drug distribution barriers. 04
(c) Define: 1) Therapeutic window 2) Onset of action 3) Minimum effective 04
concentration 4) Maximum safe concentration
Q.3 (a) Explain one compartment open model for IV infusion. 06
(b) Discuss central compartment and peripheral compartment in two compartment 04
open model. Include various methods of assumptions.
(c) Explain two compartment open model for IV bolus administration. 04
Q.4 (a) Discuss the effect of size of drug dose and frequency of administration on 06
design of a dosage regimen.
(b) Explain loading dose and maintenance dose. 04
(c) Write on repetitive IV injections – one compartment open model. 04
Q.5 (a) Write a note on Michaelis Menten method of estimating parameters. 06
(b) Write a detailed note on factors causing non-linearity. 04
(c) Discuss BCS along with methods of enhancement of drug solubility. 04
Q. 6 (a) Write a note on physiological pharmacokinetic model. 06
(b) Discuss statistical moment theory. 04
(c) Explain the role of pH and pKa in drug absorption. 04
Q.7 (a) Explain in-vitro in-vivo correlations. 06
(b) Write a short note on therapeutic equivalents and define 1) Absolute 04
bioavailability and 2) Relative bioavailability.
(c) Give a brief explanation on bioavailability study protocol. 04

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