Seat No.: _____ Enrolment No.

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GUJARAT TECHNOLOGICAL UNIVERSITY

DIPLOMA PHARMACY YEAR-2 EXAMINATION – SUMMER - 2020

Subject Code:420003 Date: 28-10-2020

Subject Name: Pharmacology and Toxicology
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify antihypertensive agents. Give mechanism of action of antihypertensive 06

agents acting on rennin angiotensin system
(b) State similarities and dissimilarities between narcotic and non-narcotic 05
analgesics
(c) Write a note on i)Dale’s vasomotor reversal ii)Cholinesterase reactivators 05

Q.2 (a) Classify anti-parkinsonian drugs. Why is L-dopa given in combination with 06
carbidopa.
(b) Write a note on skeletal muscle relaxants. 05
(c) Explain the terms i)Pharmacokinetics ii)Therapeutic index 05
Q.3 (a) Detail different routes of drug administration stating their advantages and 06
disadvantages.
(b) Classify CNS stimulants. Give pharmacological actions of caffeine. 05
(c) Give mechanism of action of i)Sulphonamides ii)Tetracyclines 05
Q.4 (a) Classify different forms of epilepsy and give the first and second choice of anti- 06
epileptic agent used to treat it.
(b) Detail pharmacological actions of digitalis. 05
(c) Define receptor. Explain factors that modify drug action. 05
Q.5 (a) Classify penicillin’s and give its mechanism of action. 06
(b) Classify anti-arrthymic agents and explain mechanism of action of quinidine 05
(c) Give mechanism of action and therapeutic uses of i)Ranitidine 05
ii)Chlorpheniramine
Q. 6 (a) Explain mechanism of action and pharmacological actions of insulin. 06
(b) Classify anti TB drugs .Why is multiple drug regimen recommended to treat 05
TB.
(c) Classify emetics and anti-emetic agents 05
Q.7 (a) Classify parasympatholytics. Give pharmacological actions of atropine 06
(b) Write a note on anti-viral agents 05
(c) Give mechanism of action and therapeutic uses of i)Ketaconazole 05
ii)Metronidazole

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