Question Bank (Sessional I)

2 marks
1) Outline the synthesis of salbutamol.
2) What is protein binding? Write its significance.
3) Define the process of metabolism. Illustrate the factors affecting the metabolism of
drugs.
4) Define Medicinal chemistry and explain the SAR study.
5) Outline the synthesis of phenylephrine and mention its uses.
6) What are adrenergic neurotransmitters? Classify them with suitable examples.
7) What happens when catechol moiety is replaced by resorcinol structure in β Phenyl
ethyl amines of sympathomimetic agents? Sketch the resulting compounds with their
medicinal uses.
8) Draw the structure of Adrenaline with its IUPAC Name.
9) Sketch the structure of clonidine and its medicinal use.
10) Write the structure of terbutaline and isoproterenol and its uses.
11) Write a note on Chelation.

5 marks
1) Explain chelation and bioisosterism with examples.
2) Discuss in detail the phase I metabolism reaction.
3) Write a short note on the History and development of medicinal chemistry.
4) Explain how the following physicochemical properties affect drug action.
i)Hydrogen bonding ii) Geometrical isomerism
5) Mention the use and synthesis of salbutamol.
6) Write in detail about biosynthesis and catabolism of catecholamines.
7) Explain the factors affecting drug metabolism including stereochemical aspects.
8) Explain Hydrogen bonding with structural representations.
9) Discuss the structural activity relationship of β phenyl ethyl amines of direct-acting
sympathomimetics.

10 marks
1) Classify adrenergic receptors with their distribution. Classify sympathomimetic agents.
Explain the SAR of direct-acting sympathomimetic with therapeutic uses.
2) Explain the physicochemical properties that affect drug action.
3) Explain the following physiochemical properties related to the biological action.
a) Hydrogen bonding b) Optical and geometrical isomerism c) Protein binding
4) Explain drug metabolism and discuss in detail the phase I and phase II metabolism
reaction.