R09

Code No: R9602

JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JN
B. Pharmacy IV Year I Semester Examinations, September-2021
BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 3hours Max.Marks:75
TU
Answer any five questions
All questions carry equal marks
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1.a) What are the two rate-limiting steps in the oral absorption of a solid drug product?
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b) Discuss the effect of disintegrants and binders on the absorption of drugs from
GIT. [7+8]
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2. Discuss the different transport mechanism for the absorption of most drugs from
the gastrointestinal tract? [15]
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3. Discuss in detail about protein binding of drugs with suitable examples. [15]
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4. Write a note on:
a) Clinical significance of protein binding
b) In-Vitro Methods for determining protein binding constants. [7+8]
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5. Discuss in detail different oxidative reactions with suitable examples. [15]
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6.a) Why drug protein binding will effect only glomerular filtration compared to
tubular secretion?
b) Discuss the effect of alkalization or acidification of the urine on the renal
clearance of weak base with a pKa of 9.6.
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c) What is clearance? [6+6+3]

7. Discuss that bioavailability testing procedure and protocol as per CDSCO. [15]
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8. What is non-linear pharmacokinetics and discuss the reasons behind non-linearity
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and how it effects the clinical output of any drug? [15]
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