Professional Documents
Culture Documents
Yamadin®
Tablet
Description
The active ingredient of Yamadin tablet is Famotidine. Famotidine is a
novel, highly specific and potent competitive H2 receptor antagonist. It
has a rapid onset and prolonged duration of action. After oral
administration, the onset of the antisecretory effect occurs within one
hour and lasts for at least 12 hours by doses of 40 mg. Famotidine reduces
the acid and pepsin content, as well as the volume of basal, nocturnal and
stimulated gastric secretion. Food or antacid does not interfere its
absorption.
Indications
Yamadin is indicated in
♦ Short term treatment of active duodenal ulcer and benign gastric ulcer
♦ Maintenance therapy for prevention of relapses of duodenal ulceration
♦ Gastro-oesophageal reflux disease
♦ Zollinger Ellison Syndrome
Contraindication
There are no known contraindication to Yamadin. If any evidence of
hypersensitivity appear, the therapy should be discontinued and
consultation with physician is required.
425
463
T H E R A P E U T I C I N D E X
Precautions
Dosage reduction should be considered or interval between doses should
be prolonged if creatinine clearance falls to or below 30 ml/min.
Drug Interactions
Yamadin does not interact with the cytochrome P450 linked drug
metabolising enzyme system. So, no interactions have been found in man
with Warfarin, Theophylline, Phenytoin, Diazepam, Propranolol,
Aminopyrine or antipyrine.
Side Effects
Yamadin is generally well tolerated and side effects are uncommon.
Dizziness, headache, constipation and diarrhoea have been reported
rarely. Other side effects reported less frequently include dry mouth,
nausea and/or vomiting, rash, abdominal discomfort, anorexia and
fatigue.
Commercial Packs
Yamadin® 20 Tablet : Each round, film coated tablet contains 20 mg
Famotidine USP. Box containing 10 blister strips of 10 tablets.
426
464