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ADDITIONS AND CORRECTIONS / AJOUTS ET CORRECTIONS

Additions and corrections: Prion protein gene

sequence of Canada’s first non-imported case of
bovine spongiform encephalopathy (BSE)
Michael B. Coulthart, Rhonda Mogk, Jason M. Rancourt, Deborah L. Godal,
and Stefanie Czub

Ref.: Genome, 46: 1005–1009 (2003).

On page 1006 of the above-cited article, reference is made to a 2001 report by Horn et al. (Horn, G., Bobrow, M., Bruce, M.,
Goedert, M., McLean, A., and Webster, J. 2001. Review of the origin of BSE: report to United Kingdom Government.
http://147.46.94.112/BSE/bse0927.pdf), with the intention of directing the reader to the most recently published broad discus-
sion of various questions surrounding the origins of BSE, including but not limited to the occurrence of a spontaneous muta-
tion in cattle. Unfortunately, the single reference might suggest incorrectly that it was in this report that the hypothesis of the
origin of BSE via spontaneous mutation in cattle was first advanced. In fact, it was in the Report of the BSE Inquiry
(http://www.bseinquiry.gov.uk; see Vol. 2, paragraph 7.3) that the idea was first fully articulated. The reader is directed to the
Report to obtain a more complete background discussion on the novel-mutation hypothesis, in addition to detailed consider-
ation of alternative hypotheses.

Received 19 December 2003. Accepted 19 December 2003. Published on the Research Press Web site at http://genome.nrc.ca on
30 January 2004.
Corresponding Editor: P.B. Moens.
M.B. Coulthart, R. Mogk, J.M. Rancourt, and D.L. Godal. National Microbiology Laboratory, Health Canada, Canadian Science
Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.
S. Czub. National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Canadian Science Centre for Human and
Animal Health, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.
1
Corresponding author (e-mail: mike_coulthart@hc-sc.gc.ca).

Genome 47: 229 (2004) doi: 10.1139/G04-900 © 2004 NRC Canada

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