(19) pe A REE RAMI PHA 1¥ (12) SRA A ERG ee “* 7 (10) BRIRAAHS CN 105085209 (43) RRA AL 2 (21) BS 201510515294. 6 CO7K 14/77(2006. 01) (22) FHIEAL 2015.08. 20 CO) RBA hip ‘Mohit 200240 _Esfp rts BRAT 1X 45 118 800 5 CD BABA HEA ahi, (74) SARS Liat BCR 29m) 31236 AGRA WEP Beebo 61) Int. G1 0070 229/62(2008. 01) C070 227/04(2006..01) GOIN 33/543(2008. 01) CO7K 14/765(2008. 01) HER WRIA ATT 64) RRB HGR PRN CARR RI eT Te 6) 8B AR He RT — ee a OR BR ZR LB Be SE Hl Oy HK, BT ROPRMI AM KF HN COOCHCHS COOCH,CH; a TERESA BARRA — PR UL 20 A Be A) ‘rt BANE MEANY DEP BWR FAR ZA eT, He AS MG 2 5 Tob HE ER ZR HR aR HE TR TE GR LH do 838 — NR CCL eH hl) BASE EME ACA es DD PS A AK — AD RACER eR EN PTAA UT CAB CN Losnga294105085299 4 RW RK + 27 1 AAR ZU, JURA, MSTA LEAR HN coocn,cr, —COOCH,CH, : 2. AUR SCRIBE 1 SS YB FBR ZA RII et HORMEL SAL a HR SERIE PDL ERROR A BAAD AE AS ZI, Ep A ABI “FAIR ZB. WDA AD SEU Ah LEAR AEA BLA UR BGT" FR ALT 1S ET ZB, HE RABE FROZE DUR 3. 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HABLA SER 2 BN 6 FIA SAS — FR ZA HS, IEE BT, STS HE EM FER BL PR MEA HUG 1 HII BLE AR, AT pl AaSS TUE ¢ B2 RE EAA STEER TEL, THR BBR SS GR TPR eA HL SLT FU ID wg BAAR FOTIA 2a Jk D7 BEAT EBSA EA, PS BS Dil. 9. ARE BOMBER L FRY AB AS FAR ZUR Aad, HORM ET A Tk BE A AANA — ZA a. 10. FRET BOMBER | AR ABE — AR ZA aL, SORE CE TT 24105085299 4 RW RK + 2/24 SRA DRY ta Ae AONB ARAB AS FR ZL PO A TR EB: RUHR, WEE PROZAC AUCN 105085299 4 i mB 1/12 SARK ABO CREAR AH RT AT [ooo] AAAI BE Re — POE LR MH HH, LIE AE Dk AL BAS PR PEPUR SSB IE BREAK [ooo2] 3k — FARA S SE (LA) (48509 PARES) . 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Dn, ELAR BR RAE LAE DEP BEAT AL BEA ELEN SEE HE ATE 28, PEMD T9 FE EIR ACY DEP 5 PR SE A) 2a eh BR I FY SI FAA MLAS TE, LORE DEP ABBA AAR Ae BETS AL Aa FMF AT DEP, See SGP ul FS DEEP 5 clipe» HCA I AES SAL ED FR 296 A CHE As JLB ES TE, SUE Sc A, Ak IL BEF i BAS DEP, BU I LAS TAD A SE HB 2 SEE DEP 1 HB LAT. PAE, DEP ZEA 7K AS ESR EDT ABE RA RB BE HE, EAE EER AS PAE BET Mb BN HB SH 3 Hg RE He FE AS ES Se, Wet He 2 FE AEER EE “PCR PS He”. Cooos] FAN RE AAS FR ZY Bd FB eB yA A HE A WATE, ie AE BBS SE» MEL RARE A FPS PH Dy TSS AT AAC Ue Me A FE Re TERA: ASE IS 28 EMS a Fa ET ASHE CRA tH ASAT ES, PSS I A Be aM. PTE RCE eh, SORE RT, RL BSE TE TRAIN Aa SEG HSB SI (AY BE BIE Fy Tlexrosoasaig «Be [000s] 20 HEE 60 FARA ACI HIE 5 HT Cmmunoassay, 1A) Se SE-F SUR ASA AE FRYE. HY MPELE Ay RLUIPA RAS PE TP BT LAT RS A Sd TAA FE CH AE A PE RABE, AEE IE SS Sh A FH PT 8 See TB ER OR BIE FE Da TSR RT ITS BRAG RO AAI A» AAD YS AT HAE Td BR fg RUE A EA Lis Re. 1971 4E Engvail, Van Weerman “F4iGi8 7 Saw ‘oh SRA) IBFD UL Ad SHER BTA AS CIR SE MR OM 4 BTV (enzyme-linked immunosorbent assay, ELISA) © FRY. ELISA Aik LER My AE MI EBS © ELISA Dy id SEAL — SPA 2) AD YEG 0 AE A 2 WS OE Trike Hep, ARAN — WR SA RG HERI AAU IR — AeA ACI ee RB BE, WAR wind (HU SEUNG AAU RAR ELISA Dri PMR. ARE SN SAP PPE RY BE, PRL 68kKDa, AAAI EF eH 4 SE PAR, AE LAB A ERDF APRON 244) HERE. ERS RARE OE SRP, SSR AU Ay MOST AES, RAS BEE LOLSM BRP ADE DFE » A EBT PY HR EL A a HE [0007] EL HL GDR Aa EAE — En ACK eR FP TIA RH KN. MTA RZ AH AY, AE EE Bl PAIS AUG FEE Pe A OTST AR, BE 8 SF eR RE. AN, ABA FIR ZF Si IR i A AR SHE eA ASF I BE Gili, 3} TE SS YT, A YA HA EL Mo RAR Cocos) Ft xe AAR ARIE AS Ae UD RS AF IE DR SSE Ha A Aa TA: WAY ARE ABP i IE, FE HY AS OB ZG DR STI. [ooos] ARH LYALL PAA RSI ¢ [oor] Ay ih, AAA ET — BAB A ZAR, A Pt Sh ia [0011] H,N—7 —-COOCH,CH, Lb coocunen, ah Coo] ira Te YIU PR, Hi 90 ~ 92°C. Loos] LA TAL. AS Aa HRI Be — HPT SS FZ GLA HR IT TEED Coo1a] FSA IGT) a) A AES Rd WE SR AS Ze ER dT ABE FR ZG, RIES fa Loos] “Yi A «EAR DFTA LSE AUER, PAR HTL aC i] FS PY IW, HE HS FAR ZAG CBT DEP FSAI, TRAE RR PEE FAL, 5 AR A BE AIK Coors] (aS. FAs BT] 4A i 4 PTA SERA a He RHE A, SP BT LIL 6 Loon 7] (iat FITS ATL NLP ASH A By 8 A BS — RRP TE ZB 5CN 105085299 4 i mB 3/12 FE FP TIN AER, TE RI ES RE Coors] Firs iG SARE WAL RETIN, YM LR BEY AS UE HI AS RE EIA BRIN, BL aw SLE PME BIL MEA SY, PEA SURE sR AE JRL PR REE LE BURL TA OME SREB SUPE BE BOG RP TA, ZG AZ ay Coors) fides, PATA Vi Pak Tl Asta 4s FAT AS 4 WEA — FZ. PO ARE P15 ~ 7) (0.6 ~ 0.8). WGA ME A PEAT AS, BEAR ASF 4- SEBS — FIR, ZB WVBR AR Ee Hee 1: 2, ALI Te REM ad AS EAT, BR ZY PSA A SE AS BRAY 5 FALE (ELAS ELE 4— BSE 0 28 — FP RE ARE 7 FB EO ee EY EAC, BIT FEE PBL A DSU 4— TEE AS — FT AR LY 0. 6 FALE (ELAS RY A TSE ADAH GPEAR RID 0. 8 fie Coo20) fi ides, FSA YS BR i A FT DW FR NY REA Ey 86 ~ 90°C, FAFA JSG ALDINE Dg 8 ~ 10 A]stih Ga ISE SE Aa AUT Be BEAT, ALA at BRA tL WEL 8 ~ 10 ANTAL RBSE A. Cooar] ide, FATA Fait WP el (Ai i GA OBE Cooz2] AL BRS PAPAS SQ AAS FA AIS IL ZT A BR AR PHA rh BU Dts TL GAS, Bg eT AL» CE AG AT PA Be, tH AE ME AE [0023] AZ. BERR ATA Te AR TC ES, a, TR, DAS Ae BS CRUE. Coozs] fides, FATA AL A MRR PITA Ss PITA LAS RAS EY ZT CP EA VERA IE. (002s) fiat, PTR A2 APM TA HR ARAL HRY 10% HY Na,CO, FA, VERBOVAE ‘eth, JE pel Jy 7. 0-8. 0 = FAA HLS th LIC AK Zu TR TRE -20°C UR Tt 9B) BSR EE EAR RE ARE (J 9 4— GS AS FR ZI J AB PZ liad fas, ROR TAL Ad AEF ZL HTS FI 2CyoHl,sNO,, HPF HE 2267. 23 5 HERI 229 ~ 31°C. (ooze) iAH, PATS STL Rl BAY eR gS i AE PL, RRSP AR TIN APD LAS) TI AR, 3 A 2) Js PA TB Sith ALBERT AY Cooa7] FAFA AGN ARPT AL, RTE ECA EOS RE, HI ERI, BAT TMA, BiG LEIA BRE BAB EEL SP BCE ATE A CE AR SLR RAE ITAL LE, FALE AR ALES RL 28 Sl SF TAL, ZG ZA AE Cooze) fi itis FATA Art Dal AH Ae RR, BITS GEE LAR I AR RR PT SATB ERR A TR AIS FO SI (ooze) fi ide Hs, Arid dik DLA Ae A Ree, ara A Te Aa LH AT IAR ELIS 1: (550 ~ 580) : (20 ~ 22): (18 ~ 20). MULE MEA PRAT AS, HEMUARAS FB 4- AEA A — A A ZN GOL A PC AB AR LAE 1: 10: 10, (LIST IS MMOL ad A EAT. — BE SUPERSEDE UPL 4— TE 6 FEAR SLAY 20 EFDA LE, (AS REEL SURE 4 Fe SEIS — FAIR ZB AR SLA 22 FBF alt Sh I Pe iS A A, DA 6CN 105085299 4 i mB 12H TROBE EB 9 1 BF AE (ELAS RSL I AOR Lf TIT EA LA SRR URI AE A Sita BE A UI AE 25 FEA ALAS SU UE AR ALIS 28 fF 6 (oos0] fi ide, PTB LiL BR ii 09 2 DR, PTH Be ME RL RE 25 ~ 35°C, PPR EL FE)Ag 10 ~ 12 Avi 5 Sei ISE MEAS ANT SAT 5 ELS fs AP, ELAR ALVA 10 ~ 12 cts Mp RY Wee (oost] iia, TAS Ani alii Ae LAA AR [0032] BL. ATA ALANA, YO AIT IR BEA AA TA pH SRE [0033] B2. HF AL RAHI SLUR ATR AMOR, THR (0034) BS RSPR RAE HR A LT AU SP Ma (oo3s] BaP SAS wR Ari SE GT" aE AT EGER ec iT, FS AR, OA AB OS — FHP Z, AR-ESUR, B09 4- BEAR — PAR ZI ALTE A, BOR LA. BRAM AZ, FESR A FIL 2Cyl, NO, HF RE ~ 941. (0036) fiat, AP URL OH, TRO ARR TEI AGS ak, SISA pH A ALES SRS ICH YES a LSU GA (0037) fiat, APR 2, AT BLUE) 9 th ATARI IR TR Na,SO BK PR s PTR EIR FA Da AG» Coosa] — fiat, AME BS A RSS ITER TR Ae AHR HDE PS BL HIE Sh OR FLO A Wi PS RI EK (loose) ide, AB MHE Ba A, IPRA LIE HE AIT FA POC BRL AC PARAL 1:8 19 ZA LEA IT PAL. TLE AAO, ACA PAR A PAA PUR MYA, CRRA BEAL RH [0040] SEALS MAT Pista [0041] “Cars Ome Coes [0042] SARL. ANAL HE OY PH BS RZ Ba A FDA — A ZA [004s] SPY ART. AC Ag We AS PT AB FR ZO AT PTA UAL Ae AUT 8h BAS A RR Zt a a 12 ME NC TE IRR SB I GR (SE PPM BOA SS PS ACT AR Coosa] aS. TARR A LA PL ON es EA Coos] fi SiS. PTA AB AS Ae ZAC A it Dak BEA SBE H,CH,COOC—7 —N=N—BSA , J DEP-BSA 9? Bk 4 3 LOR AT foe H,cH,cooc— ] BR 4B AR HAT fo HjCH,COOC 47 —N=CH(CH,),CH=N, ov! DEPPOVA Te cxtcooc—! ‘ova, foots] SEH, BSA yA EEA, OVA AWWA. 7CN 105085299 4 i mB 5/12 [0047] ARRAN PRANAB RZ RANTS FIT, A FLAT I BE BNE DR FH PR RH TT ELV EE BE Si Aa AYRE RSE Ye AL, DG a BR AB I ZTE EE EE AGE. ST RET ITE IM, FH LIRA BR HE CBR — ESS DY ESURS BAD PBIB AAU (ABFA TBE A TA» SEAT PENG ET A 6, IL A a RA SAE A EP AE — A — ZB E SHES TDA TA SSCA AG AS — FP — Za i AS ZED SE REI TegG ACHE ASE Se HE TH SH 64) Je ME, DAT £8, AS ZA He FR MATES BE TTT TEAL TAA ERA ASE BEE AN 6S PE FAB FRA ZA. (loose) SINATRA EL, A AAT BBE CR (0049) 1, PAIR SEAL ERE = B24 — FPR ZV fA Hl A HE SA (AMIR APT LT B28 A ZH, AA LR a DW ABTS A BASES It AS OR ZS TA BR, YMC HE FRA CAAT. 88 8 DI 3A BR ADS — A — ZI AT DEP-OVA, 5 fil RE SEE SAS EES UA NBA SIE ST TT TRO (0050) 2, -P SURE MEME AR AA RS th eB 7 BAR RZ, A MATS 25 — FA PBR ZT 2 A a i A AR SBD RE SE, EAS BRB Coast] 3, SFL Ri A Ae AS BT AT Sit DLE i SL PEE SBA A MAS AURA FL i SAE, 7 FE TE PRE BB Coosa] aah ish Ba) ie SN VA BA PEL xe Ri ES IE PSA, AS 2 8 SRE EYAL AS eR 1 BD Coosa] FA 1 Ay QAR PAR ZU Tad AL Pb a [0054] MOAR ALI GE [0055] BR ZAP A (ose) FA 4 74 40 98 = FA = Z. ARF ik DEP-hapten, a (4 Bf 9 BSA AA TE 4 Sit DR DEP-BSA (389 G78 C0057] FA 5 7y 0 98 — FA = Z. AF dit k DEP-hapten, a (4 Bf 9 OVA AA TE 42 tit DR DEP-OVA FU Se 9b 36785 EA (oose] FH 6 Ay fHIHESE + BA-ELISA 32 35 BT Aa 12: BOM OS — FFT — ZW ET HER ATH Coos] Fiza AFL (ASME of AS A HIE AT ESI WR]. DS Se a AS Aa BP As BAS A GEE ENE AS BR) LAS LAE TIE SUPRA AR ESA EO AS RO A A BOR FEASTS AB SF) A ELT HAP HET WU 5 EI NRE 9 FEAR TAR EH Hote.CN 105085299 4 i mB 6/12 {o060] 3 — PR (ooe1] (1) DEP FSi Jat Fe As a (ooe2] HRA 1 AY A BAY LOOmL, = 7 DA JR EH, 1 CIEE AL 10g (0. 0474mo 1) 4— HE AE AB AE — FPR, BAL ME I A 16. 6mL (0. 2850m01) FE 7K Z. WE, LAE AE I A 1.65mi HE 1,80, (0. 0304mo1) #24b, 86°C Alii, ELEM RUEMTIE (TLC) REWER gE (bE i ee Sees a a A IPA, IE be sR ZA 5:1) ARERR EDSHE Oh Fa WiTEMe Cooes) AR ARH SS ASQ BEY ZANTE RGA kB A OE ASR A ko oH, BAPE AS ck UE J EB HTL HALA FT) 1026 Na,CO,FEAMGHR EK IRIE ES (pH 7. 0-8. 0) Se HARA ATL FEAR ZANE MS AG, 20°C UR Ta PETE EAR a A 4~ TE B28 — FB A — ZB DEP “F: DUP TEL (AS. 4 HAE AG AE — AR ZAHA FSU eC yall, NOg, SPF 2267. 73.6% shit 229-31°C, HUE 97% » [0064] (2) DEP “HiRISE Zee (oss) #89 (HY DEP “Sri WP Wel 4 4— WE 0 — FA PZ, SL A Db Hats EB MP BF TE KE, DEP “PS BR TL LP SUL Aras, HOP AE MIR IR(KBr) v /em 153 NO.) 1728. 04(C = 0), 1288, 11, 1131.01 (C-0-C), 2986. 02, 2875. 40 (-Cil,) , 1474, 52 (d-OCH.~) , 1612. 73, 1589. 33, 1446. 66(C = C), 3049. 64, 1726. 04, 837. 89 (CH, Ar)» SPOT 2H HAT A, 4 EE AB 2 — FF — ZA -NOLA AEA Cv goon) (BCA ZE 1536. 55cm "PATEL, AAA CV M0) AM UCAP SM AE 1352. T7em "WEE i Sh, SI RRAR ¥ . — IBRUSCIEE NI SEE BRAE 1728. Odom “4th, BA FA ES (HR OAH BE 1288. 11, 1131. Oem th FB VRC A ZE 1612. 73, 1589. 33, 1446. 66¢m "Wh. AACE, LE HE HP BE TL oe CAGE SEE BRE HE. (loose) seifitel 2. 49h as FR 4 [0067] (1) DEP “bist Fe As a (loose) HRS 1 HY A BAY LOOmL, = 1 DA Je EHR, 1 CIE AE A 10g (0. 0474mo 1) 4~ HE AE ABE FAR, BA EAE AC 13. TL (0. 2370mo1) FE 7K Z. BH, HAE IA 1. 5 5mL HE H,SO, (0. 0285m01) EAL, 90°CHEH ii, LAM HTIA (TLO) Bra URL Joe CLE i ei Vee SH a SP A, IE se RZ PEELE 8h Ja Bie + Coosa) AR ARH SS AS SQ MEY ZANTE RCA HA 9 TSR A ok oc BP EET Sk UE AASB AAA AAA 10% Na, COTA RULER BAIR (DH 70-8. 0) o Sather, ARAL FEL FEAR ZY SE PAG, 20°C UR Ta PETS BE EAR a A 4 TE 8 2 — FZ. DEP DUP TEL AS. 4 FAR AG AE — AR ZAHA FSU eC yoll,NOg, PFE 2267. 273.6% hit A 29-31'C, AONE 97% [0070] (2) DEP “AiR BE Zea Coors] 3849 AY DEP =¥: Sit bak Fi) fae 4— WR SHE ABS — FZ, SR HS LL GA SR Sb HG HEE AB OP BT SE. DEP Fb BRP 1 AS BD 2b aS HE BB eR (KBr) v /em ':1536, 55, 1352. 77 (-NO 2) 1728, 04(C = 0), 1288. 11, 1131. 01 (C-0-C), 9CN 105085299 4 i mB VK 2986. 02, 2875. 40 (-Cil,) , 1474, 52 (d-OCH,-) , 1612. 73, 1589. 33, 1446. 66(C = C), 3049. 64, 1726. 04, 837. 89(C-H, Ar)» SPU T2a RAT A, 4 WARE AB 28 — FQ — Z. MY NOLL AERA Cv goyon) (BCH HSE 1536. 55cm PAGEL, RAED CV oc) (EM WCE RCE 1352. 77cm "AEE ath, IFRRME v .— IORUSCHE I SE HSA 1728. Odom hb, AB AE FAC ES (ARR APH BLE: 1288. 11, L131. Oem ‘th BE vO AE 1612. 73, 1589. 33, 1446. 66cm "Ah. EAAACH, LR WE FE HP BLT LP oe ZEAE AE BRE SH HE (oo72] 3 i Py (0073) (1) DEP “Fit (oo74] HR SAT A A -BAIy LOOmL, = FDA JR BE HR, 1 HE IE AE A 10g (0. 0474mo 1) 4~ HE SE AB AE — FAR, BAG EME IM A 19. 2mL (0. 3318mo1) FE 7k Z. AE, HLL HE EL I A 2. O6mL HE H,S0, (0. 0379m01) HEAL, 90°CHEH Lie, LAHTI (TLO) Bra URL Juuk Cab HRs BHP P TA bY sD LIP AA, TE be eZ 1) BEPEEL IE 10h Fa Bese Coors) AR ART SS ASQ EY ZTE RCA BA Ok TSR Ak oc Bre Sick USA 7S BI AES PLAR I 10% NaCO,TA BEE BAIA IEE (OH 7, 0) 6 RUE. ARAL AR FEAR ZY MSE AL, 20°C UR Ta PETE EAR AR A 4 SB RB FEED DEP “= TURP TELA. A SEAGER ZAHA FSU eC iol, NOy, SPF 2267. 173. 6% she A 229-31'C, AONE 97% [0076] (2) DEP “AiR TBE Zea (oo77] $844 AY DEP =¥2 Sit Dat Te) fas 4— WE A SZ, J SLL GH FR Sb HG aE A I FB OP BTS KE, DEP “FSi BR PH A BD 2b aS A GE fF eR (KBr) 536. 55, 1352. 77 (-NO.) ,1728.04(C = 0), 1288. 11, 1131. 01(C-0-C) , 2986. 02, 2875. 40 (-Cil,) , 1474, 52 (d-OCHs-) , 1612. 73, 1589. 33, 1446. 66(C = C), 3049. 64, 1726. 04, 837. 89 (CH, Ar) o SP BT 2H HATH, 4— EE AB 2k — FF — ZA -NOLAY AIRED Cv goon) HBICAPSUZE 1536. 55cm VIEL, AAR CV M0) AM UCAPSMAE 1352. T7em "WEE Sh, SARAH v . — IBRUSCIME NSE BRAE 1728. Odom “Ah, B48 FA ES (HR APH BE 1288. 11, 1131. Oem th BE vO DE 1612. 73, 1589. 33, 1446. 66cm "Rh. AACA, WE HE OP BET ML oe CAGE ASE BRE HE [ors] Szififs 4, 4 — F — [0078] (1) DEP “Fi HS) 4 Coos] 1. 5g (0. 0056mo1) DEP “Pt Be PTA A (4~ HAAR ABR — FAR ZH) ABS 500ml, = 1 BAECS HIE FAS Aes Fd RCI AREAL A 280mL (3, 1495mo1) AL, APT DEE TRAE IG BMA 3. 4a BUPEBY (0. 0520m01) , BEFITS Ht UANA LOmL HE HCI (0. 1200mo1) » 3% LUBE 15min JG HEIN A 3. 4g SEPM (0. 0520mo 1) , 35°CHEHUR AZ 10h ¢ Coogi] SQ MEAA SCG A 340mL YO 7k MASSER AR FFL LM RUE AAA TAP ES HE. (HL 7.0-8. 5) sii'EL Lh JG PS ARS, HEAL AR ARC, GPA, AK Ia FFG 7k Na, SO, Ibi TR, SEHD 2 ABR RAS AE, 4 SP ES TAL ASE Gk ZI ERE CE 10 v/em!quis a Bt WBA. ZANE eH A V/V = 82 1)) JER ARI, PERE EK 4 BOE BE FRR — ZRH, BO DEP “FSG. SB AR ME FL C,H, NOs PFE 237. 25 57 3E 76. 2% shi RE 190 ~ 92°C, BEAE 98% . (oog2] (2) DEP “PAN 2e4iE (ooss] 3849 (1) DEP “Fi Jak 4 USE AB Ok — BR — ZO, J ME ARR HE Sb I iB eH PB PB A 9, DEP “PSL LO 0 NS FM 2 Pit as, SRP GIE SUF IR(KBr) ¥ /em':3466. 06, 3369, 16 (-NIl.) , 1720. 18(C = 0), 1257. 81, 1068. 87 (C-0-C) , 2980, 89, 2927. 48 (-Cl,) , 1449, 97 (d-OCH,~) , 1630. 07, 1564. 19, 1449. 97(C = C), 3227. 98, 1604. 33, 833. 75 (C+, Ar) o SPAT 2 AR AY A, 4— AE AB AS — FP ZA A NW BEE AED CV nc wi) BORER CV ou) PUMICE SP Sl TRAE 3466. 06 #03369. Lécm ‘PE, 1X CUES MAE BG WE ME Dh PFI vm SE, E1720. 18cm "le, AS — FH ANE EA 4 Sl SIRE 1257. 81, 1068. 87cm “BE FAI v ._ UUSCHPAAINZE 1630. 07, 1564. 19, 1449. 97cm ‘Bh. SAE, EIB BUE FE BAT BeBe ER, ZOU SE BE PANS AA Cooss] SLATE (1 3) (AMEE FUME ‘H-NMR (400MH2, CDCL,) + 8 7. 73d, LH, Arlt) 6. 73(4, 1H, Arlt) ,6. 67 (d, 1H, ArH) 4. 36 (q, 2H, OCHL) »4. 30 (q, 2H, OCH) 4. 26 (b, 2H, -NIL) » 1, 39.(t, 3H, OCH)» 1. 33 (t, 3H, OCH.) ppme MA CH RY BI) Si Bi tH AR PRE SL A BE BOE BA, 17 Sb es BSAC ARL ARG RL HN 220 SBT OE A EE ARORA ZANT (ooes] LAA ik, A Mb Tsai De BATALI Ane IE ME EH RY A EA FH AE, A SES WA PIERRE TGP WE DEP A APSR [0086] 5 = ~ i BLK [0087] (1) DEP “Fi HSA Coos] 1. 5g (0. 0056mo1) DEP “PUN PUA A (4~ HAAR AB A — FA ZH) AEBS 500ml, = 1 BAECS LIE FAS, BAL FL RCI AREA 288m (3. 2480mo1) AL, APPT DEAE TES BEIM, 3. 3g SEE (0. 0504mo1) , BEARISH VOM A LOmL He HCL (0. 1232mo1) . 3 5min AERAMA 3. 3g SUPER Bz, ' Ra A 33OmL 7K AAAS IR» PAL AM ASU BG PAE SE (pH si Lh Je aP SA ASS, EP ADC ah, PAL ZU AL TEAK Na,SO, IBA TR, AE HORSE 2 AB RAS KE, 4 SU YP ES AL ASE Gk ZH TERE CE TBA. ZANE eH AH V/V = 82 1)) Jer BER ZR A, OTR A = RS [0090] (oog1] #849 HY DEP -¥ Sit Jak A~ aU HE A OE — PZ, Bak HR A SiR BE Sb Te a eB BE se, DEP“: $7 UR (19 £0 Yb 3 8 PANS HE fa Re ER (KBr) v /em ':3466, 06, 3369. 16 (-Nil,) 1720. 18(C = 0), 1257. 81, 1068. 87 (C-0-C) , 2980. 89, 2927. 48 (-Cll,) + 1449. 97 (d-OCH.~) , 1630. 07, 1564. 19, 1449. 97(C = C), 3227. 98, 160: 833, 75(C-H, Ar) o SPATS ARAL AL, 4 USE AB A A ZB uCN 105085299 4 i mB 912 NBR CV a.) REAR Cv 4) HDCT Hi HH BRAE 3466, 06 40.3369. L6cm ‘PAE, 1X SMA BS WEE AE Dh PPR vB SH, E1720. 18cm "le, AB — FH 6 bg EA AG 3 HSA AE 1257. 81, 1068. 87cm “Bb ¢ FIN v .— OSCAR AATILAE 1630. 07, 1564. 19, 1449. 97cm ‘Bh. SAE, EIU FE FAT BRE rh ER, ZOU Ey BE PANS PAA 6 (ooo) 3 ie fa AL iM A) Be HE 24 HE AF HNMR (400M, CDCL,) + 8 7. 73d, LH, Art) 6. 73(4, IH, Arlt) ,6. 67 (d, 1H, Ari) 4. 36 (q, 2H, OCHL) »4. 30(q, 2H, OCH) 4. 26 (b, 2H, “NIL) » 1, 39.(t, 3H, OCH) 1. 33 (t, 3H, OCH.) ppme MA tH RY BY] Si Be th AR PR eS] BE BOE 5A. 17 Shes SEAR ABST HA 8 220 A SBT COE A EA ROAR ZANT (oogs] LAA ik, Ab sii De BATES Ane ME EH RY A EA FH AOE, AG HES WE PIERRE TGP WK DEP A TAHIR [oo94] Seif fel 6. 0 3 — FA ~ i AZ fi (o09s] (1) DEP “Fi Coos] #1. 5 (0. 0056mo1) DEP “PAL be PTE A (4~ FAA AB OR — FAR ZH) AEBS 500ml, = 1 BAECS LIE FAS AL FL RCI AREAL AA 280mL (3, 1495mo1) AL, APT DEE TRAE IG BMA 3. Te BUREBY (0. 0560m01) , EIT UUNA 9. SmL HE HCL (0. 112mo1) » 3% RUBE 15min JG HEAIMA 3. 7g SEEMED (0. 0560mo1) , 25°CHEHR MZ 12h + [0097] MEELIS A$ 370mL YO 7k MASSER AA FFL LM RUE ARE AE HE. (HL 7.08. 5) si Uh Ja SPS Met, BEL ARK IES, CP AIR ACHE Ie FLFE 2K Na2S04 IBA TR, AE HORS DALE AS ABR RAS RS, 4 SAU ES TAL ASE Gk ZH ERE CE TBAUN. ZRRAL TE e HAH V/V = 82 1)) Je BER ZR A, ABUT EK BEAD HE. ZR, RO DEP “PAU. BAK PR ZAP GY FIR eCLAHLSNOA 5 4}FHE 237. 25 + 3 Ri 190 ~ 92°C, BENE 98%. (oogs] (2) DEP “PALMAE (ooss] #8 74 HY DEP “tit Jak 4 UE AB OE = RZ fy HL ESE ARR AE Sb SE 18 BR Sb TG ais eB OY BE PB MEE, DEP “SR (19 20 Yb HS ALAS IE fod Re ER (KBr) v /em=1:3466, 06, 3369, 16 (-NH2) , 1720. 18(C = 0), 1257. 81, 1068. 87 (C-0-C) , 2980. 89, 2927. 48 (-CHI3) , 1449. 97 (d-OCH2-) , 1630. 07, 1564. 19, 1449. 97 (C = C), 3227. 98, 1604. 33, 833. 75 (CH, Ar) o> Wr $i A AL HL, A~ HE A a — AAR ZO 9 A BY NAAT BEY AB EB A AAR Cv as NH) ARE RRA AEH Cvs N-1D AOR USC AE 3} Bll EE JAZE 3466. 06 Al 3369. L6cm—1 PAPE, 33 PLE Se MAE Es HEIR EE Sb, Rv = o WB USC BF] SE HA SWR-ZE 1720, 18cm—1 At, 4 25: — FG (1 Si gs (1) AE AL A 1257. 81, 1068, 87em-1 Ab AMY vc = ¢ MICE HA DAZE 1630. 07, 1564. 19, 1449. 97cm-1 Bho AAO, EGR BUC FS OF i A TL ae AED ZEAE BE NS RHE (or0o] 34 1% PE A iB 9 BC HE 47 RK eH NMR 4OoMtz, CDC (d, 1H, Art) , 6. 73(d, 1H, ArH) ,6. 67 (d, 1H, ArH) .4. 36 (q, 2H, OCH2) , 4. 30(q, 2H, OCH2), 4, 26 (b, 2H, -NH2) » 1. 39(t, 3H, OCH2) , 1. 33 (t, 3H, OCH2) pmo AMP ALLEL AH AER EGA ABMS Te, 8 4. 17 Sb STARR AL, CHE HH D2 eA SF EAT 12owas a A Btn UR 4 BORE AB — AR — ZS ET Coron] LAA ih, Se ab tii De BAPE De ME Be (HY A EA hh aA aGE, BPE SESE EE IRE i a ATA TRe (o102] 3k (0103) KILO HAR — PA ZONE SUR BEE FE BG AB 2 — PZ Skea ey BE FAL» AD FEA AK IR HH BY IE, Al He A LA RS SORES. AEM AE be Ne BE — RZ, PRS Se eA TSS FL BABS FP ZA PF DB DB (o10s] RAL MERU TAA DEP 425 Nik DEP-BSA, FLA A EERE 24% 0. 0238g (0. LmM) DEP“ PUR ABBA 25m. HUAI, LATIN 0. T5mL HO WIE, HA EIA. 0. O25mL HE TCL , 48908 2 S50 SAG Yes AOE SBR HS YS A BEGET» AE °C ACHR Od» LM I ‘PLP ONSREHDL, FAL pH aK AUCH SQ ABR ISE Dy 2. 0-3. 0 TTINE FEE AY HR AL BB BRA BE CELINE Ti) BEIM GAY 1-35, RAG a EW BS EB A FAR SEE 30min, HN 2. Os BR BRAS RA I AE Fe] EB ALR PATINA 0. O8mMBSA HEB (O.O1M pil 9. 18 WING A282 WDE ) » EE 2 YeE RSS EL CS, ORR ie Eh SA SS GEMS, BT 0. 01M. pH7. 40 BRB ER AR HBL AB BT 3d, ENG 8h Berk 1K, ERD 4000r + min "2K 15min, HEFL EFF DEP KILI DEP-BSA. RHEE Sb — ATLA INE DEH AS SEG, REAR, -20° CHET THR ARIE -20°C RF. (o10s) sah isk a PREVA AGl DEP LHI DEP-OVA, FLA A ERE 24% 0. 0238 (0. ImM) DEP“ DURIRA BEBO 2omL HAE , 205001 ImLN, N~ — FEF Bee (DMP) RE, BEES) Jes TLE HA TL ABA] 0. OSmM OVA FEHBE (0. O1M. pel 7. 40 1B RGR? NORTE ACE) 1OmL. PBL Jet Bal 22382 AAP RNIN A 0. 036mL 2596 ROME, 4°C AGA RE RY 24h Ja AE BRL RDAGEVTR, AT 0. 01M pit 7, 40 BRRRARER MA HIE 4°COB HT 3d, RED 8h Birk 1k, BU 3826791 4000r emin LE Lomin, IL EAAWED DEP 2 BLN DEP-OVA. FABER REY) — BT TUBS IE TENET BSE IS» PUR PRR IPR, -20°CY Coros) — (AIRPDZEE AD RY IAL A> SG NGI Hh AST ME 9 Ja» MAP 4 or 5 AY DEP ALU IEA AOA LAR IPAS FA FY EAE HH, DEP “Ei RUNS AE CUE > 295m 5A HEA BSA HVPE USCwE REF 227 nm A 278m Ab, HEH 278m BE Hh Msc Aah RMI Ae AAG BRAS A OVA ARIAS RE HRMS, FP HAE 234nm Fil 279m Ate, He 27 Irn IR ba ae Ae AMC AL BR {IR (IGE DEP-BSA All DEP-OVA (YR Sh GHEE ASL} Hil A BSA Al OVA FAVRFTIEWE, ZEAE 336 #0 360mm Ab HBT HAT (PBSC. DEP-BSA Ail DEP-OVA “Ft DiC HEM CUE A ET LOS ATA, AR SEEN BAA TE HDR USC UE HE ESC. BRUSCHETTA GB ST, WE (26 9H] DEP-BSA AIL DEP-OVA (BIER » Covo7) iss 4 fi WRB AY VA FH] > Se, g2E an, Hah Wi Ae Se FE EA BT FR ie SB SPATE He eee ale (o10s) ts (0109) dR 2 Sir mea Ak, Am HWA Lies DEP-BSA #83145 FEC TE AMEN ISDA IG YA Ses AT PAS PB ARTE See, Ze 7 VC BE FAL BENGE DUET 5 SULLY, SLT BMAD Bl 120000. HO GL ARSE MIRE 13CN 105085299 4 i mB 1/12 BAB SORE FRE BAU 5 AWS {o110] i s Ary i (0111) Subsea F oe (0.05M pH 9. 60 Bi vA BL) ESA HE FEL CDEP-OVA) , 100 H L/ FL, IMA 96 TLE PEAR 1°C BL BERL BE oe HOI ED BRE, ARAL IN A 200 UL HERR HE (0. O1M. pHI7. 4OPBST) , HSS BE 2K Simin FAR A BA PAE a Jes SELIM ASS FAL 200 BL, 37°C 1 CS WL, HESS LR ERAS, DD BAGS DEP % SERED (Bio-pAb-DEP) AH EF LIE ARNE, ATLA URNA 50 w L Ae ALA 16H 50 WL DEP bRHERE A (ALA 5% — 7 SEA (DMSO) fy PBS (v/v) BREE AE ) , FLINA 100 WL PBS BEM, 37°C AFT 30 SH PILI ~ HUA Be LE, LIS TA i PBST i SAG BEAREL SUL CRP) Pricey RE REAR ATR CURP-SA) , HEAL A 100 BL, 37°C FFL Asi ABBE IRP-SA FR, CSS UL IR TLUK, ALI A TECH ME EM (400 wL 2. 5mg/ mL 3,37, 5, 57> VU FASE IRR RCIRCVOE BAS LOmL, TER ~ FERRARI DEH. 10 WL 30% HY 10,988 JU Wk 2, 98E ) 100 ve L/ FL, SEH ESE BME LSmin AE FLIMA 50 ow L AEH (2mol /L SMES) DAP GE, 8 LN Pe BCG MEAL CE 450nm A 630nm AEM ICEL COD {L) » Bh OD = ODjs0-OD aol E IRE EAL » SIE AR LANL KR a HF AB RO AR bs, MERE ARISE OS SELL Aa BRA a Re, PT BP 6 Ta. BE MULE (26) = (1-A/Ay) X 100, SEH A 9 BE AE AERSILAY OD AE, AIUD AT FEMA AE CENTLY OD (HL Cor12] EY ALA LSA IH AF 2A] 0. 05M pl 9. 60 WR AR AT EASA Ia fH DEP & AREAS HORE 2E 1. Omg/mL 2 i» WR QmL MAES NE 5 FH DMSO Pict 1. Omgy/mL, 490 -N— HE SEVIS EA EMG (BNHS) YER, lL HEI HALT HA NHS PEPE, (HE BNHS 3h DEP % a BEATA BEBE EGY 1 210, Sea PRECAST UTA Be EEE AGT SH, FAL PBS BE JET Sd, ER BeaK 3 Wo BSC PS Bs Bie BD I BID PA (Bio-pAb-DEP) , SLATE WL KEL Ba, T -20° CP MARE» (0113) TASES BA-ELISA S298 5} 6 Ar ZR AB AS — FP ZT bat ER BY = 22. S3LeCup*57. 96, HA RAC R = 0. 9832, FEAT Cio Ae A He BAT i AY IR AIS ON I 5026 ME AE BEA ATH HE 0. 43.1 g/L s1C RATT TI ROI BPR, ROH Ey 10% I AF BE HST 0.0079 Coo” Lay BEARER HEE 21 ng/L ~ 9.512 B B/| Cora] ob, SAME T 7 AY Shs Ri FR 4-6 Ft, DEP SBR RAM COMP) 63 — RPAH (PrP) . 46 FARR TBH (BP) . 464 FRRR—T AW (DIP) 40-8 — BRR (CAE) CUBH (DEP) 40-8 = RAR EEK (DINP) SERRA NI 3 RR LEAD Ay CH9ZE 526 DR), i- A-DENP AI 4-DEAP £1936 SQLS SUL: » 5 HFT VR a Hs T-3T FH DEP “Sit A et DL 4 DEP SLA RA BAS Fe EA, He ICE ATH SE EH REA Sit DEP Se BE AAT BE AY Rp FEE, HUTELBE BA-ELISA Jy i260. PE SUFE MP DEP LEA AT AT 5 (011s) 21 DEP 2a RURAL MN Se M ILE (or16]CN 105085299 4 i mB 12/12 Analogs Structure: TCio Gag) | Cross-reactivity (a) CRD att) CRU RD Der a oes a bor ene) 3796 504 bese oo 9028 i sen Dene Cr eerie 1060s aus Tics satel Cov. cH.cu.caycayen. cen, 18.704 237 bu 4 DENP = aes 2304 rae = aan 79 13m Cori7] PLEA ARE MEL ASHE AT TAS. a DEERAMP AE AS AR IAS PE AS ESE MET, AS IRR ANAT BALE BER HTT ES PR FL WK, IPA MAS SEIS FE 614 kk At Ww ‘COOCH,CH;, COOCH,CH, “TO CN 105085299 A 16CN 105085299 4 kk At Ww 2K gy age segs? su HN COOCH,CH, COOCH,CH,CN 105085299 4 we ot BAK 2.0 m E10 RE 0.5 0.0 200 250 350 400 300 EK am) a4 200 230 300 380 400CN 105085299 4 kk At Ww 4K 0.9832 es “ene 96 3 2 4 8 1 a DEP FRRERT AS 6