DATA SCIENCE, ARTIFICIAL

INTELLIGENCE & MACHINE LEARNING

FOR UNDERSTANDING THE CAUSE AND
BIOLOGY OF DISEASE

Marc A. Marti-Renom
ICREA & CRG-CNAG
Barcelona
Future of AI in medicine – current trajectory

E. Topol. Nature Medicine 25;44-56 (2019)

Future of AI in medicine – current trajectory

E. Topol. Nature Medicine 25;44-56 (2019)

Accurate Predictive Ability to
diagnosis power treat
Accurate Predictive Ability to
diagnosis power treat

Inferring
cause and effect
Predicting the future of cells and tissues, and
understanding how disease emerge in them
is a huge challenge of our time
U2OS cells expressing FP fused to LifeAct. Image by @NathanShaner (Scintillon Institute).
Diseases are driven by processes within our cells

~1016 cells in a Human

body

3.61 × 1011
Diseases are driven by processes within our cells

Machine learning and single cell biology leads to new maps

of cells and their functions: in health and disease
Li et al, Cell 2018
To transform medicine, medical AI will have to:
Map
Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7 Patient 8 Patient 9 Patient 10 Patient 11 Patient 12

Infer cause
and effect
Personalize
Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7 Patient 8 Patient 9 Patient 10 Patient 11 Patient 12

Empower novel therapies

 2019 2030
Omics + Modelling patients: Medical
Medical Records cause > effect counsel and treatment