KIDNEY 1 Lecture

Photos: Baxe and Tony

And Google
Dear Student,
Here are kidneys donated by your
generous colleagues, Baxe and Tony. They
saved your life from end-stage pathopathy.
Maybe, you should save others too.

http://www.facebook.com/group.php?gid=286413899935
http://hopetransplant.tripod.com/about.htm
Components of the normal Kidney
1. Blood Vessels
2. Glomeruli
3. Tubules
4. Interstitium

BGTIn
 Nephrotic Syndrome
(Acute Proliferative Glomerulonephritis)

• ACUTE PROLIFERATIVE GN
– Post-Streptococcal Infection
– Post-Infectious
Post-Streptococcal GN
 Juxy’s PostStrep HUMP

Only seen under ELECTRON MX

and by Juxy’s wonder eyes
Art Appreciation Section:
Explain to your seatmate what the hell this is
 RPGN
(Rapidly progressive glomerulonephritis)

BREAKS IN THE GBM

RPGN - Crescents
 RPGN - IF

A B
A. LINEAR – Anti-GBM Type 1
B. GRANULAR – Post- Infectious
* NONE – Pauci- immune
Membranous Glormerulopathy
 MOST COMMON CAUSE OF
NEPHROTIC SYNDROME IN ADULTS
Diffuse thickening of capillary wall
 ELECTRON MX:
Effacement of foot processes
Subepithelial electron-dense deposits
Basement membrane materials laid down between deposits
(SPIKES)
 SPIKES

MEMBRANOUS GLOMERULOPATHY
Membranous
Glomerulopathy

Electron
Mx
changes
Minimal Change Disease
 MOST COMMON CAUSE OF
NEPHROTIC SYNDROME IN CHILDREN
Uniform and diffuse
Effacement of podocytes
Or foot processes
Minimal Change Disease
 FSGS
(Focal Segmental Glomerulosclerosis)

PAS STAIN
A. LPO – Sclerosis in 1 of the 3 glomeruli (Blue arrow)
B. HPO – Hyaline insudation and lipid (small vacuoles) in sclerotic area

WORDS FOR DUMMIES:

insudation /in·su·da·tion/ (-soo-da´shun) the accumulation, as in the kidney,
of substances derived from the blood.
 FSGS Hallmark
• Degeneration and disruption of VISCERAL
EPITHELIAL CELLS
Membranoproliferative GN (MPGN)
Type 1 MPGN
- subendothelial
deposits

Type 2 MPGN
(Dense-Deposit
Disease)
ISOLATED URINARY ABNORMALITIES

I hate you
Whoever made
The champion
BERGER ad.
You made me believe.
ISOLATED URINARY ABNORMALITIES
IgA Nephropathy (BERGER DISEASE)
IgA deposits in Mesangium
BERGER DISEASE
Chronic glomerulonephritis (CGN)
chronic glomerulonephritis
Hyalinzation of glomerulus
DM: Nodular Glomerulosclerosis
FOR YOUR ADDED IMPT INFO FOR THIS TOPIC
PLS POST AT THE BATCH 2013 FB GROUP.

That’s if you think it is important and you’re not

Planning to sabotage the entire batch just cuz
You’re the only one WHO KNOWS! Britney!

Juxy’s Body Series:

Juxy’s Genital System
Juxy’s Boobies
Juxy’s Endocrine System