Professional Documents
Culture Documents
Emil-Alexandru Brujan
Cavitation in Non-Newtonian
Fluids
With Biomedical and Bioengineering
Applications
123
Emil-Alexandru Brujan
University Politechnica of Bucharest
Department of Hydraulics
Spl. Independentei 313, sector 6
060042 Bucharest
Romania
eabrujan@yahoo.com
v
vi Preface
1 Non-Newtonian Fluids . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1 Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1.1 Newtonian Fluids . . . . . . . . . . . . . . . . . . . . . . 1
1.1.2 Non-Newtonian Fluids . . . . . . . . . . . . . . . . . . . 4
1.2 Non-Newtonian Fluid Behaviour . . . . . . . . . . . . . . . . . . 7
1.2.1 Simple Flows . . . . . . . . . . . . . . . . . . . . . . . . 7
1.2.2 Intrinsic Viscosity and Solution Classification . . . . . . . 12
1.2.3 Dimensionless Numbers . . . . . . . . . . . . . . . . . . 13
1.2.4 Constitutive Equations . . . . . . . . . . . . . . . . . . . 15
1.3 Rheometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
1.3.1 Shear Rheometry . . . . . . . . . . . . . . . . . . . . . . 25
1.3.2 Extensional Rheometry . . . . . . . . . . . . . . . . . . . 29
1.3.3 Microrheology Measurement Techniques . . . . . . . . . . 32
1.4 Particular Non-Newtonian Fluids . . . . . . . . . . . . . . . . . . 34
1.4.1 Blood . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
1.4.2 Synovial Fluid . . . . . . . . . . . . . . . . . . . . . . . . 37
1.4.3 Saliva . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
1.4.4 Cell Constituents . . . . . . . . . . . . . . . . . . . . . . 41
1.4.5 Other Viscoelastic Biological Fluids . . . . . . . . . . . . 43
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
2 Nucleation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
2.1 Nucleation Models . . . . . . . . . . . . . . . . . . . . . . . . . 49
2.2 Nuclei Distribution . . . . . . . . . . . . . . . . . . . . . . . . . 53
2.2.1 Distribution of Cavitation Nuclei in Water . . . . . . . . . 53
2.2.2 Distribution of Cavitation Nuclei in Polymer Solutions . . 54
2.2.3 Cavitation Nuclei in Blood . . . . . . . . . . . . . . . . . 55
2.3 Tensile Strength . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
3 Bubble Dynamics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
3.1 Spherical Bubble Dynamics . . . . . . . . . . . . . . . . . . . . . 63
3.1.1 General Equations of Bubble Dynamics . . . . . . . . . . 63
ix
x Contents
A fluid can be defined as a material that deforms continually under the application of
an external force. In other words, a fluid can flow and has no rigid three-dimensional
structure. An ideal fluid may be defined as one in which there is no friction. Thus
the forces acting on any internal section of the fluid are purely pressure forces, even
during motion. In a real fluid, shearing (tangential) and extensional forces always
come into play whenever motion takes place, thus given rise to fluid friction, because
these forces oppose the movement of one particle relative to another. These friction
forces are due to a property of the fluid called viscosity. The friction forces in fluid
flow result from the cohesion and momentum interchange between the molecules
in the fluid. The viscosity of most of the fluids we encounter in every day life is
independent of the applied external force. There is, however, a large class of fluids
with a fundamental different behaviour. This happens, for example, whenever the
fluid contains polymer macromolecules, even if they are present in minute concen-
trations. Two properties are responsible for this behaviour. On one hand, polymers
change the viscosity of the suspension by changing their shape depending on the
type of flow. On the other hand, polymer have long relaxation times associated with
them, which are on same order as the time scale of the flow, and allow the polymers
to respond to the flow with a corresponding time delay. Other complex systems
consisting of several phases, such as suspensions or emulsions and most of the bio-
logical fluids, behave in a similar manner. In the following, we will focus on some
of the most important aspects of the flow of this class of fluids.
1.1 Definitions
of each other with a liquid film of thickness Y between them. The lower plate is at
rest, and the upper plate can be set in motion by a force F resulting in velocity U.
The movement of the upper plane first sets the immediately adjacent layer of liq-
uid molecules into motion; this layer transmits the action to the subsequent layers
underneath it because of the intermolecular forces between the liquid molecules. In
a steady state, the velocities of these layers range from U (the layer closest to the
moving plate) to 0 (the layer closest to the stationary plate).
The applied force acts on an area, A, of the liquid surface, inducing a shear stress
(F/A). The displacement of liquid at the top plate, x, relative to the thickness of
the film is called shear strain (x/L), and the shear strain per unit time is called the
shear rate (U/Y). If the distance Y is not too large or the velocity U too high, the
velocity gradient will be a straight line. It was shown that for a large class of fluids
AU
F ∼ . (1.1)
Y
It may be seen from similar triangles in Fig. 1.1 that U/Y can be replaced by the
velocity gradient du/dy. If a constant of proportionality η is now introduced, the
shearing stress between any two thin sheets of fluid may be expressed by
F U du
τ= =η =η . (1.2)
A Y dy
which is called the dynamic coefficient of viscosity. The term du/dy = γ̇ is called
the shear rate. The dimensions of dynamic viscosity are force per unit area divided
by velocity gradient or shear rate. In the metric system the dimensions of dynamic
viscosity is Pa·s. A widely used unit for viscosity in the metric system is the poise
(P). The poise = 0.1 Ns/m2 . The centipoise (cP) (= 0.01 P = mNs/m2 ) is frequently
a more convenient unit. It has a further advantage that the dynamic viscosity of water
at 20◦ C is 1 cP. Thus the value of the viscosity in centipoises is an indication of the
1.1 Definitions 3
viscosity of the fluid relative to that of water at 20◦ C. In many problems involving
viscosity there frequently appears the value of viscosity divided by density. This is
defined as kinematic viscosity, ν, so called because force is not involved, the only
dimensions being length and time, as in kinematics. Thus
η
v= . (1.4)
ρ
where T(x, t) denotes the symmetric Cauchy–Green stress tensor at position x and
time t, p(x, t) is the pressure in the fluid, τ is the extra stress tensor, λv is the volume
viscosity, and E is the rate of deformation tensor of the velocity field u(x, t):
1 ∂ui ∂uj
eij = + (1.7)
2 ∂xj ∂xi
or
1
E(x, t) = (∇u) + (∇u)T , (1.8)
2
where trE = eii = ∂ui /∂xi .
The extra stress tensor can be written as
The apparent viscosity η in the above equation is a function of the first, second
and third invariants of the rate of deformation tensor:
1
I1 = eii , I2 = (eii ejj − eij eij ), I3 = det(eij ). (1.10)
2
For incompressible fluids, the first invariant I1 becomes identically equal to zero.
The third invariant I3 vanishes for simple shear flows. The apparent viscosity then
is a function of the second invariant I2 alone, and Eq. (1.9) can be written in a
simplified form as
If the fluid does not undergo a volume change, i.e. it is incompressible, then the last
term on the right-hand side of Eq. (1.6) drops out and the volume viscosity has no
role to play.
There is a certain class of fluids, called non-Newtonian fluids, in which the viscosity
η varies with the shear rate. A particular feature of many non-Newtonian flu-
ids is the retention of a fading “memory” of their flow history which is termed
elasticity. Typical representatives of non-Newtonian fluids are liquids which are
formed either partly or wholly of macromolecules (polymers), or two phase
1.1 Definitions 5
and rheopectic fluid behaviour. In the case of thixotropic and rheopectic fluids, the
shear rate is a function of the magnitude and duration of shear, and the time lapse
between consecutive applications of shear stress.
Viscoelastic fluids have some additional features. When a viscoelastic fluid is
suddenly strained and then the strain is maintained constant afterward, the corre-
sponding stresses induced in the fluid decrease with time. This phenomenon is called
stress relaxation. If the fluid is suddenly stressed and then the stress is maintained
constant afterward, the fluid continues to deform, and the phenomenon is called
creep. If the fluid is subjected to a cycling loading, the stress–strain relationship in
the loading process is usually somewhat different from that in the unloading process,
and the phenomenon is called hysteresis.
There is a distinctive difference in flow behaviour between Newtonian and non-
Newtonian fluids to an extent that, at time, certain aspects of non-Newtonian flow
behaviour may seem abnormal or even paradoxical. For example, when a rod is
rotated in an elastic non-Newtonian fluid, the fluid climbs up the rod against the
force of gravity. This is because the rotational force acting in a horizontal plane
produces a normal force at right angles to that plane. The tendency of a fluid
to flow in a direction normal to the direction of shear stress is known as the
Weissenberg effect. Another effect caused by viscoelasticity is the die swell effect
of the fluid as it leaves a die exit. This expansion is an elastic response of the
fluid to energy stored when its shape changes while entering the die. This energy
is released as the fluid leaves the die and causes a swelling effect normal to the
direction of flow in the die. It has been also observed that, when a viscoelastic
fluid flows in a tube with a sudden contraction, bubbles with a certain diameter
come to a sudden stop right at the entrance of the contraction along the centerline
before finally passing through after a hold time. This behaviour has been termed the
Uebler effect.
1.2 Non-Newtonian Fluid Behaviour 7
We shall now examine some simple flow fields of fluids. Simple flow fields are
required to determine the material properties of the fluids and these are separated in
three groups: steady simple shear, small-amplitude oscillatory, and extensional flow.
ux = γ̇ y, uy = uz = 0, (1.12)
where (ux , uy , uz ) are the velocity components in the x, y, and z directions, and γ̇ =
dux /dy. For steady shear flow (sometimes called a viscometric flow) the shear rate
is independent of time; it is presumed that the shear rate has been constant for such
a long time that all the stresses in the fluid are time-independent. The extra stress
tensor in such a flow is thus defined by
⎛ ⎞
τxx τxy 0
τ = ⎝ τyx τyy 0 ⎠ , (1.13)
0 0 τzz
where τxy = τyx are called the shear stress components, and τxx , τyy , and τ zz are
called the normal stress components. The corresponding stress distribution for a
non-Newtonian fluid can be written in the form
where N1 and N2 are the first and second normal stress differences. For a Newtonian
fluid, η is a constant and N1 and N2 are zero. The variation of η with shear rate
and non-zero values of N1 and N2 are manifestations of non-Newtonian viscoelastic
behaviour. The second normal stress difference N2 , however, receives less atten-
tion due to difficulties in its measurement and for the smallness of its value. For
many non-Newtonian fluids, the value of N2 would be usually an order of magnitude
smaller than that of N2 .
The viscosity function η, the primary and secondary normal stress coefficients
ψ1 , and ψ2 , respectively, are the three parameters which completely determine the
state of stress in any steady simple shear flow. They are often referred to as the
viscometric functions. The normal stress coefficients are defined as follows:
and
and are also functions of the magnitude of the strain rate. The first and second nor-
mal stress coefficients do not change in sign when the direction of the strain rate
changes. The primary normal stress coefficient is used to characterize the elasticity
of a non-Newtonian fluid. A constant primary normal stress coefficient is obtained
when the primary normal stress varies quadratically with shear rate.
and
where γ 0 is the amplitude of the applied strain, γ̇0 is the shear rate amplitude, and
ω is the frequency. The resulting shear stress may be given in terms of amplitude,
τ0 , and phase shift, δ = π2 − φ, as follows:
and
These equations may be expanded and rewritten in terms of the in-phase and out-
of-phase parts of the shear stress and placed in terms of four viscoelastic material
functions as
τxy (t) = γ0 G sin(ωt) + G cos(ωt) , (1.23)
τxy (t) = γ0 ω η cos(ωt) + η sin(ωt) . (1.24)
The storage modulus, G , is defined as the stress in-phase with the strain in a sinu-
soidal shear deformation divided by the strain and is a measure of the elastic energy
stored in the system at a particular frequency. G represents the solid like response of
a material and, for a perfectly elastic solid, is equal to the constant shear modulus,
G, for a perfectly elastic solid with the loss modulus equal to zero. Similarly, the
loss modulus, G , is defined as the stress 90◦ out-of-phase with the strain divided by
the strain, and is a measure of the energy dissipated as a function of frequency. G
represents the viscous component or liquid-like response of a material to a defor-
mation. The dynamic viscosity, η , and dynamic rigidity, η , are related to G and
G by
G
η = , (1.25)
ω
G
η = . (1.26)
ω
The material functions G , G , η , and η are referred to as the linear viscoelastic
properties because they are determined from the shear stress which is linear in strain
for small deformations. It should be noted that as the frequency approaches zero,
η approaches η0 and 2G /ω2 approaches ψ1,0 (the zero-shear-rate value of ψ1 ).
Correspondingly, the loss modulus is asymptotic to η0 ω as ω → 0.
A method of comparing the storage and loss modulus is made by the calculation
of the loss tangent defined as
G
tan δ = , (1.27)
G
and represents the phase angle between stress and strain.
10 1 Non-Newtonian Fluids
For more detail on these and other linear viscoelastic properties, standard
references should be consulted (for example, Bird et al. 1987).
ε̇ ε̇
ux = ε̇x, uy = − y, uz = − z, (1.28)
2 2
where ε̇ = dux /dx is a constant strain rate, and the corresponding extra stress
tensor is
⎛ ⎞
τxx 0 0
τ=⎝ 0 τyy 0 ⎠ . (1.29)
0 0 τzz
Fig. 1.5 Extensional flow fields: (a) uniaxial, (b) biaxial, (c) planar
1.2 Non-Newtonian Fluid Behaviour 11
τij = 0, i = j, (1.31)
The intrinsic viscosity is another parameter that characterize the behaviour of non-
Newtonian fluids. The intrinsic viscosity, [η], of a polymer solution is defined as
the zero concentration limit of the reduced viscosity, ηred = ηsp /c, where c is the
polymer concentration and ηsp is the specific viscosity. The specific viscosity is
defined as the relative polymer contribution to viscosity ηsp = (η0 − ηs )/μs , where
η0 is the zero-shear viscosity and ηs is the solvent viscosity. The intrinsic viscosity
can thus be expressed as:
η0 − ηs
[η] = lim ηred = lim . (1.36)
c→0 c→0 cηs
Note that the intrinsic viscosity has dimensions of reciprocal concentration. The
intrinsic viscosity is determined graphically by plotting ηred versus c and extrapo-
lating to zero concentration. It is also found that extrapolation to zero concentration
of the inherent viscosity, ηinh = 1c ln(ηsp + 1), can also be used to determine the
intrinsic viscosity and the same result for [η] must be achieved.
The most common relation between specific viscosity and polymer concentration
is that of Huggins (1942),
ηsp
= [η] + k [η]2 c, (1.37)
c
where k is the Huggins slope constant. The alternative expression of Kraemer
(1938)
1.2 Non-Newtonian Fluid Behaviour 13
1 ηsp
ln = [η] − k [η]2 c, (1.38)
c c
where k is the Kraemer constant, may also be used. Huggins slope constant and
Kraemer constant are related by k + k = 0.5.
The intrinsic viscosity can be used to determine the viscosity molecular weight,
Mη , using the Mark-Houwink equation as follows (Bird et al. 1987)
where k and α are determined from a double logarithmic plot of intrinsic viscosity
and molecular weight. These parameters have been published for many systems by
Bandrup and Immergut (1975).
The polymer solutions are regarded as dilute when there is no interaction between
molecules. A standard method to evaluate whether a polymer solution is dilute is to
determine a dimensionless concentration of polymer solution which can be given
by either [η]c (Flory 1953) or cNA V/Mw (Doi and Edwards 1986), where c is the
polymer concentration, NA is the Avogadro’s number, V is the volume occupied by a
polymer molecule, and Mw is the average molecular weight. Flexible polymers tend
to occupy a spherical region in solution such that V = 4π R3h /3. In the case of rigid
molecules, the spherical region required such that the large aspect ratio molecule can
freely rotate without interaction with its neighbours is calculated from the molecule
length such that V = π L3 /6, where L is the length of the molecule. The length L can
be determined using relations
given by Broersma (1960) and
Young et al. (1978) for
rigid molecules, L = Rh 2δ − 0.19 − (8.24/δ) + 12/δ 2 , where δ = ln (L/r) is
the aspect ratio of a rod and r is the radius of the rigid rod. The polymer solution
is regarded as dilute when both dimensionless concentrations are less than unity.
When one of the dimensionless concentrations is larger than 1, the polymer solution
is considered semi-dilute.
LU ρLU
Re = = , (1.40)
ν η
where L is a linear dimension that may be any length that is significant in the flow
pattern and U is the flow velocity. For example, for a pipe completely filled, L
might be either the diameter or the radius, and the numerical value of Re will vary
accordingly.
which relates the relaxation time of the viscoelastic liquid to the flow deformation
time, either inverse extension rate 1/ε̇ or shear rate 1/γ̇ . When Wi is small, the
liquid relaxes before the flow deforms it significantly, and perturbations to equilib-
rium are small. As Wi approaches 1, the liquid does not have time to relax and is
deformed significantly.
τfluid
De = . (1.42)
τ flow
For small De values, the material responses like a fluid, while for large De values, we
have a solid-like response. In the limit, when De = 0 one has a Newtonian fluid, and
when De = ∞, an elastic solid. The usage of De and Wi can vary. Some references
use Wi exclusively to describe shear flows and use De for the general case, whereas
others use Wi for local flow time scales due to a local shear and De for global flow
time scales due to residence time in flow.
1.2 Non-Newtonian Fluid Behaviour 15
η = K γ̇ n , (1.44)
where K is referred to as the consistency index and n is the power law exponent. For
the special case of a Newtonian fluid (n = 1), the consistency index K is identically
equal to the viscosity of the fluid. When the magnitude of n < 1 the fluid is shear-
thinning, and when n > 1 the fluid is shear-thickening. The power-law model is the
most well-known and widely-used empiricism in engineering work, because a wide
variety of flow problems have been solved analytically for it. One can often get a
rough estimate of the effect of the non-Newtonian viscosity by making a calculation
based on the power-law model. One shortcoming of the power law model is that
it does not describe the low shear and high shear rate constant viscosity data of
16 1 Non-Newtonian Fluids
η0 − η∞
η = η∞ +
N , (1.45)
1 + (λc γ̇ )
where τ0 is the yield stress and ηp is the plateau viscosity, was employed in the study
of the rheological behaviour of glass-filled polymers (Poslinski et al. 1988).
where τ0 is the yield stress, captures both the yield stress and shear dependent vis-
cosity of a fluid. This model reduces to a Newtonian fluid when τ0 = 0. Equation
(1.47) indicates that a finite yield stress is required before flow can start. This yield
stress results in a plug flow and the velocity distribution shaped like a blunted
parabola that is so typical of blood flow in small diameter vessels. The Casson model
was originally developed to describe the flow of printing ink through capillaries and
was later applied to other fluids containing chain like particles. The Casson equa-
tion has also proven useful for the description of the flow of blood on both glass and
fibrin surfaces.
simulation of viscoelastic flows, where simple models have been essential in the
development of numerical strategies. Other important viscoelastic models that have
been used extensively are the dumbbell models and the KBKZ model.
∂τ
τ+λ = 2ηE, (1.48)
∂t
where λ is the relaxation time and η is the constant shear viscosity. For steady-state
motions this equation simplifies to the Newtonian fluid with viscosity η.
By replacing the time derivative with the convected time derivative, the upper
convected Maxwell model is obtained which is given as
∇
τ + λ τ = 2ηE, (1.49)
∇
where the upper convected derivative τ is defined by
∇ ∂τ
τ= + (u · ∇)τ − (∇u)T τ − τ (∇u) . (1.50)
∂t
For steady simple shear flow, the Maxwell relaxation time is
N1 ψ1
λ= = , (1.51)
2ηγ̇ 2 2η
while in small-amplitude oscillatory flow, the viscoelastic properties for this model
are given by
ληω2
G = , (1.52)
1 + λ2 ω 2
and
η
η = . (1.53)
1 + λ2 ω 2
At low frequency, G is predicted to vary quadratically with frequency while it
approaches a constant value at high frequencies.
The uniaxial extensional viscosity for the upper convected Maxwell model is
1
ηE = 3η . (1.54)
(1 + λε̇) (1 − 2λε̇)
18 1 Non-Newtonian Fluids
∇
Y · τ + λ τ = 2ηE. (1.55)
Two models that are widely used are the Giesekus model, which has
αλ
Y=I+ τ, (1.56)
η
and the Phan-Thien-Tanner model, for which
ελ
Y = exp tr(τ) I. (1.57)
η
Each of these models adds another dimensionless parameter, α or ε, that control the
nonlinearity.
A multi-mode Maxwell model may also be used to allow the material functions
to be predicted more accurately by adjusting the parameters in each mode. The
extra stress tensor is expressed, in this case, as a combination of several relaxation
times as
n
τ= τi , (1.58)
i=1
∇
τι + λi τi = 2ηi E. (1.59)
where λ1 and λ2 are the time constants (relaxation and retardation) and the viscosity
has also a constant value. We observe that, by setting λ2 = 0, the above equation
1.2 Non-Newtonian Fluid Behaviour 19
reduces to the upper convected Maxwell model. The Oldroyd-B model qualitatively
describes many features of the so-called Boger fluids (elastic fluids with almost
constant viscosity).
The material functions of this model are defined as
ψ1 = 2η (λ1 − λ2 ) , ψ2 = 0, (1.61)
(λ1 − λ2 )ηω2
G = , (1.62)
1 + λ21 ω2
and
1 + λ1 λ2 ω 2 η
η = . (1.63)
1 + λ21 ω2
As in the case of Maxwell model, the Oldryod-B model predicts that at low fre-
quencies the storage modulus varies quadratically with frequency while at high
frequencies a constant value is obtained.
The equation for the uniaxial extensional viscosity is given by
1 − λ2 ε̇ − 2λ1 λ2 ε̇2
ηE = 3η , (1.64)
1 − λ1 ε̇ − 2λ21 ε̇2
and, therefore, the extensional viscosity asymptotes to infinity when ε̇ = 1 (2λ1 ) .
In non-convected form, the Oldroyd-B model is referred to as the Jeffreys model
which is given by
∂τ ∂E
τ + λ1 = 2η E + λ2 . (1.65)
∂t ∂t
It is interesting to note that this equation was originally proposed for the study of
wave propagation in the earth’s mantle (Jeffreys 1929).
∇
τp + λH τp = nkB TλH E, (1.66)
20 1 Non-Newtonian Fluids
[η] ηs Mw
λ1 = , (1.68)
Rg T
m [η] ηs Mw 1
λD = , m= , (1.69)
Rg T m1 + m2
where the values of m1 and m2 depend on the details of the model, as listed by Ferry
(1980).
The extensional viscosity approaches a constant at relatively low extension rates
such that as ε̇ → ∞ the limiting extensional viscosity is
t
σp = μ t − t H (I1 , I2 ) B t, t dt , (1.71)
−∞
where σp is the polymer contribution to the extra stress tensor, μ t, t is the lin-
ear
viscoelastic
memory function, H(I1 , I2 ) is a non-linear damping function, and
B t, t is the Finger strain tensor given by
⎛ 2 ⎞
ς t, t 0 0
B t, t = ⎝ 0 ς 2m t, t 0 ⎠, (1.72)
0 0 ς −2(m+1) t, t
ς t, t = exp ε̇0 t − t , (1.73)
where m = –0.5 for uniaxial extension, m = 0 for planar extension, m = 1 for biaxial
extension, and ς is the extension ratio. The memory function is expressed as an
exponentially fading term while the strain function can be written as (Papanastasiou
et al. 1983)
a t − t
μ t, t = exp − , (1.74)
λ λ
α
H(I1 , I2 ) = , (1.75)
(α − 3) + βI1 + (1 − β) I2
where α and β are adjustable parameters determined from the shear and extensional
results, respectively. The set of parameters {λ, a} are the conventional relaxation
time and weight, which can be evaluated from simple rheological tests such as
stress relaxation or sinusoidal oscillations. Several other forms of the damping term
are known in literature such as those provided by Wagner (1976), Wagner and
Demarmels (1990):
1
H(I1 , I2 ) = √ , (1.76)
1 + α (I1 − 3)(I2 − 3)
H(I1 , I2 ) = exp −β αI1 + (1 − α)I2 − 3 . (1.77)
This constitutive equation has been found to accurately predict transient and shear
modes of simple shear, uniaxial extension and biaxial extension at low, moderate,
and high strains and rates of strain (Papanastasiou et al. 1983).
The rate of deformation and extra stress tensors have the following expressions:
⎛ ⎞ ⎛ ⎞ ⎛ ⎞
01 0 000 010
1 1 1 1
E= ∇u + ∇uT = ⎝ 0 0 0 ⎠ γ̇ + ⎝ 1 0 0 ⎠ γ̇ = ⎝ 1 0 0 ⎠ γ̇ , (2)
2 2 00 0 2 000 2 000
⎛ ⎞⎛ ⎞
∇ 010 010
du 1
E= − ∇u · E + E · ∇uT = − ⎝ 0 0 0 ⎠ ⎝ 1 0 0 ⎠ γ̇ 2
dt 2 000 000
⎛ ⎞⎛ ⎞ ⎛ ⎞ (3)
010 000 100
1
− ⎝ 1 0 0 ⎠ ⎝ 1 0 0 ⎠ γ̇ 2 = − ⎝ 0 0 0 ⎠ γ̇ 2 ,
2 000 000 000
⎛ ⎞
τxx τxy 0
τ = ⎝ τyx τyy 0 ⎠ , (4)
0 0 τzz
and
⎛ ⎞⎛ ⎞
010 τxx τxy 0
∇ dτ
τ= − ∇u · τ + τ · ∇uT = − ⎝ 0 0 0 ⎠ ⎝ τyx τyy 0 ⎠ γ̇
dt 000 0 0 τzz
⎛ ⎞⎛ ⎞ ⎛ ⎞ (5)
τxx τxy 0 000 2τxy τyy 0
− ⎝ τyx τyy 0 ⎠ ⎝ 1 0 0 ⎠ γ̇ = ⎝ τyy 0 0 ⎠ γ̇ .
0 0 τzz 000 0 0 0
Replacing these results into the equation of the rheological model, we can write
⎛ ⎞ ⎛ ⎞ ⎡ ⎛ ⎞ ⎛ ⎞⎤
τxx τxy 0 τxy τyy 0 010 100
1
⎝ τyx τyy 0 ⎠ − λ1 γ̇ ⎝ τyy 0 0 ⎠ = 2ηγ̇ ⎣ ⎝ 1 0 0 ⎠ − λ2 γ̇ ⎝ 0 0 0 ⎠⎦ , (6)
0 0 τzz 0 0 0 2 000 000
so that
and
ψ1 = 2η (λ1 − λ2 ) , ψ2 = 0. (9)
For an upper convective Maxwell fluid, λ2 = 0, and λ = ψ1 2η .
For a small amplitude oscillatory shearing flow
γ̇ (t) = γ0 ω cos (ωt) , τxy = γ0 G sin (ωt) + G cos (ωt) . (10)
We obtain
G − λ1 ωG = −λ2 ω2 η
, (12)
G + λ1 ωG = ωη
and
(λ1 − λ2 ) ηω2 1 + λ1 λ2 ω2 ηω
G =
, G = ,
1 + λ21 ω2 1 + λ21 ω2
(13)
1 + λ1 λ2 ω 2 η (λ1 − λ2 ) ηω
η = , η = .
1 + λ1 ω
2 2 1 + λ21 ω2
ληω2 ηω η ληω
G = , G = , η = , η = . (14)
1 + λω2 1 + λω2 1 + λω2 1 + λω2
1 1
ux = ε̇x, uy = − ε̇y, uz = − ε̇y. (15)
2 2
The rate of deformation tensor and the extra stress tensor become
⎛ ⎞ ⎛ ⎞ ⎛ ⎞
1 0 0 1 0 0 2 0 0
1⎝ 1 1
E= 0 −1 2 0 ⎠ ε̇ + ⎝ 0 −1 2 0 ⎠ ε̇ = ⎝ 0 −1 0 ⎠ ε̇,
2 0 0 −1 2 2 0 0 −1 2 2 0 0 −1
(16)
24 1 Non-Newtonian Fluids
⎛ ⎞⎛ ⎞
∇ 1 0 0 2 0 0
1
E = − ⎝ 0 −1 2 0 ⎠ ⎝ 0 −1 0 ⎠ ε̇2
2 0 0 −1 2 0 0 −1
⎛ ⎞⎛ ⎞ ⎛ ⎞ (17)
2 0 0 1 0 0 40 0
1⎝ 1
− 0 −1 0 ⎠ ⎝ 0 −1 2 0 ⎠ ε̇2 = − ⎝ 0 1 0 ⎠ ε̇2 ,
2 0 0 −1 0 0 −1 2 2 00 1
⎛ ⎞
τxx 0 0
τ = ⎝ 0 τyy 0 ⎠ , (18)
0 0 τzz
and
⎛ ⎞⎛ ⎞
1 0 0 τxx 0 0
∇
τ = − ⎝ 0 −1 2 0 ⎠ ⎝ 0 τyy 0 ⎠ ε̇
0 0 −1 2 0 0 τzz
⎛ ⎞⎛ ⎞ ⎛ ⎞ (19)
τxx 0 0 1 0 0 τxx 0 0
− ⎝ 0 τyy 0 ⎠ ⎝ 0 −1 2 0 ⎠ ε̇ = −2 ⎝ 0 − 2 τyy 0 ⎠ ε̇.
1
0 0 τzz 0 0 −1 2 0 0 − 12 τzz
Replacing these results into the equation of the rheological model, we can write in
the case of a steady uniaxial extensional flow
⎛ ⎞ ⎛ ⎞
τxx 0 0 τxx 0 0
⎝ 0 τyy 0 ⎠ − 2λ1 ε̇ ⎜ 1
⎝ 0 − τyy 0 ⎠
⎟
0 0 τzz 2
0 0 − 12 τzz (20)
⎡ ⎛ ⎞ ⎛ ⎞⎤
2 0 0 400
1 1
= 2ηε̇ ⎣ ⎝ 0 −1 0 ⎠ − λ2 ε̇ ⎝ 0 1 0 ⎠⎦ ,
2 0 0 −1 2 001
and
⎧
⎪
⎨τxx − 2λ1 ε̇τxx = 2ηε̇ − 4ηλ2 ε̇
2
1
ηE = 3η . (23)
(1 − 2λε̇) (1 + λε̇)
1.3 Rheometry
In the case of shear rheometry, the shear flow is generated between a moving and a
fixed rigid surface or by a pressure difference over a tube (Fig. 1.6). Classic exam-
ples of shear flow geometries belonging to the first group include cone and plate and
concentric cylinder. An example of shear flow geometry belonging to the second
group is capillary or Poiseuille flow.
Fig. 1.6 Shear rheometers. (a) Cone and plate, (b) Concentric cylinder, (c) Capillary rheometer
26 1 Non-Newtonian Fluids
γ̇ ∼
= , (1.78)
θ
3M
τxy = , (1.79)
2π R3
τxy 3M θ
μ (γ̇ ) = = , (1.80)
γ̇ 2π R3
where is the angular rotation rate of the plate, θ is the cone angle and R is the
radius of the cone and plate. The θ angle between the cone and the plate is assumed
to be small. Typically, θ is less than 4◦ . The small cone angle ensures that the shear
rate is constant throughout the shearing gap, this being of particular interest when
investigating time-dependent systems because all elements of the fluid sample expe-
rience the same shear history, but the small angle can lead to serious errors arising
from eccentricities and misalignment.
In the characterization of viscoelastic fluids, a force may result from the rotation
of the plate which acts to separate the plates. The total thrust, F, on the bottom plate
may then be used to determine the primary normal stress difference and typically
placed in terms of a primary normal stress coefficient as
2F
N1 = = ψ1 (γ̇ ) γ̇ 2 , (1.81)
π R2
and
2F θ 2
ψ1 (γ̇ ) = . (1.82)
π R2 2
All the above relationships are obtained under the assumption of negligible fluid
inertial and edge effects, including surface tension. For accurate measurements,
corrections for these possible errors are recommended in Carreau et al. (1997).
The cone and plate viscometer can be used for oscillatory shear measurements as
well. In this case, the fluid sample is deformed by an oscillatory driver and the ampli-
tude of the sinusoidal deformation is measured by a strain transducer. The force
1.3 Rheometry 27
deforming the fluid sample is measured by the small deformation of a relatively rigid
spring to which is attached a stress transducer. On account of the energy dissipated
by the fluid, a phase difference develops between the stress and the strain. The mate-
rial functions are determined from the amplitudes of stress and strain and the phase
angle between them.
The major advantage of this type of viscometer is the constant shear rate through-
out all the liquid. This is because, at a fixed radial position, the circumferential
viscosity varies linearly across the gap between the cone and the plate. A con-
sequence of this fact is that the cone and plate viscometer is well suited for
time-dependent measurements, such as dynamic measurements or transient mea-
surements that imply a step change in the rate of shear strain. On the other hand,
it should be noted that measurements can usually be made at relatively low shear
rates. With increasing shear rate, there is a tendency for the development of sec-
ondary flows in the fluid and the fluid will crawl out of the instrument under the
influence of centrifugal forces and elastic instabilities.
where Ro and Ri are the radii of the outer and inner cylinder, respectively. A narrow
gap approximation is typically involved to avoid a priori selection of a rheologi-
calmodel. It is recommended that the narrow gap approximation only be used for
Ri Ro ≥ 0.99 .
The main sources of error in the concentric cylinder rheometer arise from end
effects, wall slip, inertia and secondary flows, viscous heating effects and eccentric-
ities due to misalignment of the geometry. To minimize end effects the lower end of
the inner cylinder is a truncated cone. Secondary flows are of particular interest in
the controlled stress instruments which usually employ a rotating inner cylinder. In
this case, inertial forces cause an axisymmetric cellular secondary motion (Taylor
vortices). The dissipation of energy by these vortices leads to overestimation of the
torque. For a Newtonian fluid in a narrow gap, the stability criterion is (Macosko
1994)
The maximum value of the shear rate achievable with concentric cylinders
viscometers is, in most of the cases, not an instrument limitation but depends on the
viscosity of the fluid sample. For high viscosity fluids, viscous heating may become
a problem. For low viscosity fluids, the upper limit may be set by the occurrence of
secondary flows. Usually, the maximum value of the shear rate is about 102 s–1 . At
the other end of scale, it is possible to go down to shear rates as low as 10–2 s–1 ,
especially with high viscosity fluids.
τw
π R3
Q= 3 τ 2 γ̇ (τ ) dτ , (1.85)
τw
0
where τw = (R/2) (−p/L) is the shear stress at the wall of the tube, R is the tube
radius, L is the tube length, and p is the pressure drop over the length L. For a
Newtonian fluid, γ̇ (τ ) = τ/η, this equation yields
π R4 p
Q= − , (1.86)
8η L
from which η can be calculated using a value of Q obtained for a single value of
(−p/L). For flow of unknown form, Eq. (1.85) yields (see, for example, White
1995)
3n + 1 4Q
γ̇ (τw ) = , (1.87)
4n π R3
with
d log τw
n =
, (1.88)
d log π4QR3
method. Errors may occur due to wall slip, e.g. in the case of concentrated dis-
persions where the layer of particles may be more dilute near the wall than in
the bulk flow. The layer near the wall has a much lower viscosity, resulting in an
apparent slippage of the bulk fluid along the wall. In addition to these effects, vis-
cous dissipation heating, fluid compressibility, change of viscosity with pressure,
and flow instabilities can introduce errors into capillary viscometer measurements.
The temperature rise associated with viscous dissipation can be reduced by using a
smaller diameter capillary, since for shear-thinning fluids the rate of heat conduc-
tion to the wall increases more rapidly than viscous heat generation with decreasing
tube radius.
The intrinsic viscosity of polymer solutions is typically determined by measuring
the viscosity using capillary viscometers due to their ability to precisely detect small
differences in viscosity at low polymer concentration. Incorrect determination of the
viscosity and, therefore, intrinsic viscosity can arise if the polymer solution is shear
thinning and measurements must be made at low shear rates such that the viscosity
equates to the zero-shear viscosity.
FR TM
τc = = , (1.89)
A AL
where L is the length of the lever arm between the nozzle and transducer, R is the
nozzle radius, and A = π R2 is the area of the nozzle opening. Assuming a uniform
30 1 Non-Newtonian Fluids
jet entrance velocity, the apparent extensional rate, ε̇, in the flow field defined in
terms of the volumetric flow rate through a nozzle, Q, and the gap between the
nozzles, dn , is
Q
ε̇ = . (1.90)
Adn
τc
ηEa = . (1.91)
ε̇
One problem with the opposed-jet apparatus is that an upturn in the extensional vis-
cosity is measured at high rates of strain for Newtonian fluids of low viscosity which
Hermansky and Boger (1995) associated with fluid inertia. By introducing a correc-
tion coefficient, they indicated the following relationship between the measured and
corrected Trouton ratio
ηc ηa a(R) ρdn2
= E − ε̇, (1.92)
η η 4π LR2 η
where ηc is the corrected extensional viscosity and η is the shear viscosity. The
parameter a(R) was found to be constant for a particular jet. It should be noted here
that before the correction is applied to a viscoelastic fluid, it is recommended that
it be applied to a Newtonian fluid with a similar shear viscosity to the viscoelastic
fluid, in order to ensure accuracy. Corrections are not required for fluids with a shear
viscosity larger than about 50 mPa·s.
1.3 Rheometry 31
σ/Rm σ
ηEa = =− , (1.93)
ε̇ 2dRm /dt
where Rm is the midpoint radius of the filament. The instantaneous deformation
rate experienced by the fluid element at the axial midplane can be determined in a
filament rheometer in real-time using the high resolution laser micrometer which
measures Rm (t). Numerous experimental variants have been developed, and by pre-
cisely controlling the endplate displacement profile it is now possible to reliably
attain the desired kinematics. The results can be best represented on a “master
curve” showing the evolution of the imposed axial strain on the endplate ver-
sus the resulting radial strain at the midplane. The excellent review by McKinley
and Sridhar (2002) surveys some of the recent developments in filament stretching
extensional rheometry.
kB T
D= , (1.94)
6π aη
where kB is Boltzmann’s constant, a is the particle radius, and T is the absolute tem-
perature. In the above equation, it is assumed that particles are spherical and rigid
and no heterogeneities exist. The dynamics of particle motion are usually described
by the time-dependent mean-square displacement,
r2 (t). When particles diffuse
through a test fluid or are transported in a non-diffusive manner the mean-square dis-
placement becomes nonlinear with time and can be described with a time-dependent
power law,
r2 (t) ∝ tα . The slope of the log–log plot of the
r2 (t), denoted by
α (also referred to as the diffusive exponent), describes the mode of motion a par-
ticle is undergoing and is defined for physical processes between 0 ≤ α ≤ 2. The
time-dependent mean-square displacement can be used to obtain rheological prop-
erties of a complex fluid microenvironment. The Stokes–Einstein relation correlates
the particle radius, a, and the term
r2 (t) provide the creep compliance
π a
r2 (t)
D= . (1.95)
kB T
1.3 Rheometry 33
uniform force field over the entire field of view, and can orient objects regardless of
their geometry. They do have the disadvantage that it is difficult to make multiple
independent traps.
1.4.1 Blood
smaller than the red cells and do not contribute significantly to flow resistance.
They are preferentially distributed near microvessel walls, probably as a result of
hydrodynamic interaction with red cells (Tangelder et al. 1985). Under physiolog-
ical conditions white blood cells occupy 1/600 of total cell volume while platelets
occupy approximately 1/800 of total cell volume.
The viscosity of plasma has been shown to be invariant with γ̇ (Newtonian fluid)
and is dependent mainly on protein content and temperature. In normal conditions,
the viscosity of plasma is about 1.1 cP. Whole blood is a non-Newtonian fluid. At
small values of shear rate (γ̇ < 0.5 s–1 ), the apparent viscosity of whole blood shows
a zero-shear plateau followed, at higher shear rates, by a decrease of viscosity with
the shear rate. Blood is therefore a shear-thinning fluid. At very high values of shear
rate (γ̇ > 102 s–1 ), the apparent viscosity of blood is almost constant indicating an
infinite-shear plateau. At normal hematocrit content and at a temperature of 37◦ C,
the zero-shear viscosity of blood is as high as 120 cP (Chmiel and Walitza 1980)
while the infinite-shear viscosity is about 4 cP (MacKintosh and Walker 1973; Lowe
and Barbenel 1988). The rheology of blood is primarily determined by the behaviour
of the red blood cells at different shear rates. At sufficiently low shear rates the red
blood cells agglomerate into column-like structures called rouleaux and the con-
centration of fibrinogen and immunoglobulins in the plasma is known to have an
important role in this process (Baskurt and Meiselman 2003). At yet lower shear
rates these rouleaux may develop branches and at even lower shear rates complex
networks of red blood cells may be observed (Samsel and Perelson 1982; Baskurt
and Meiselman 2003). At rest, human blood cells form a gel all over the sample
and some researchers claim experimental evidence for the existence of a yield stress
(Thurston 1993; Picart et al. 1998). Red cell aggregation or rouleaux formation is
induced by many macromolecules, and particularly, fibrinogen and imunoglobulins
contained in plasma (Brooks et al. 1970). On the other hand, increase in shear breaks
down the bridging lattice and reduces the rouleaux length, with minimal aggregation
for shear rate above 102 s–1 . As aggregates are broken down with increasing shear,
the number of individual red cells increases. These align with the flow direction,
causing further reduction in viscosity for larger values of shear rates. Chien (1970)
has shown that for shear rate values up to 1 s–1 , aggregation dominates the viscous
behaviour, whereas in the range 1–100 s–1 , deformation of red blood cells is the
dominant factor. A comparison of this shear thinning characteristic of blood viscos-
ity in the presence and absence of aggregating agents suggests that about 75% of
the viscosity decrease is a result of the disruption of red cell aggregates, and 25% is
due to red cell deformation in response to increased shear stresses (Lipowski 2005).
At a given shear rate, blood viscosity rises exponentially with increasing red blood
cell concentration (hematocrit) to a degree dependent on prevailing γ̇ . Blood vis-
cosity is higher in men than in women because of the men’s higher hematocrit level.
Furthermore, blood viscosity decreases with increasing temperature (Eckmann et al.
2000).
The blood viscosity decreases with decreasing the diameter of the vessel. Fahreus
and Lindqvist (1931) were the first to indicate that the flow resistance of blood in
a cylindrical tube cannot be predicted on the basis of the viscosity of the blood as
36 1 Non-Newtonian Fluids
(1 − H)c − 1
η = 1 + (0.45 − 1) . (1.96)
(1 − 0.45)c − 1
Here, η0.45 the relative apparent blood viscosity for a fixed hematocrit of 45%, is
given by
The apparent blood viscosity exhibits a strong decrease with decreasing tube diam-
eter reaching a minimum at about 7 μm. At this value, the apparent viscosity of
blood with a hematocrit of 45% is only 25% higher than that of plasma. Only at
diameters below about 3.5 μm does the apparent viscosity increase above the level
seen in large vessels.
In the absence of shear, red blood cells only collide rarely so that aggregation
tends to be a slow process (Samsel and Perelson 1982). Aggregation and disaggre-
gation take place over differing non-zero time scales. Blood is therefore thixotropic
(Huang et al. 1975), in the sense that when a step increase in shear rate is applied to
blood the viscosity is a decreasing function of time. Blood thixotropy is exhibited
mostly at low shear rates (up to 10 s–1 ) (Huang et al. 1987) and has a fairly long time
scale. For example, initial resistance to flow start-up returns only slowly to normal
blood, with well over 1 min of standing required (Mewis 1979). This suggests that
thixotropy is of secondary importance in pulsatile blood flow, which has a time scale
of approximately 1 s.
Whole blood viscosity is an important physiological parameter (see, for a
detailed discussion, Baskurt 2003 and the references therein). For example, the
viscosity of whole blood was associated with coronary arterial diseases. Whole
blood viscosity is significantly higher in patients with peripheral arterial disease
than that in healthy controls. Other researchers investigated correlation between the
hemorheological parameters and stroke. They reported that stroke patients showed
two or more elevated rheological parameters, which included whole blood viscos-
ity, plasma viscosity, red blood cell and plate aggregation, red blood cell rigidity,
and hematocrit. It was also reported that both whole blood viscosity and plasma
viscosity are significantly higher in patients with essential hypertension than in
1.4 Particular Non-Newtonian Fluids 37
healthy people. In diabetics, whole blood viscosity, plasma viscosity, and hemat-
ocrit are elevated, whereas red blood cell deformability is decreased. There is also
a direct connection between whole blood viscosity and smoking, age, and gender. It
was found that smoking and aging might cause the elevated blood viscosity. In addi-
tion, it was reported that male blood possessed higher blood viscosity, red blood cell
aggregability, and red blood cell rigidity than premenopausal female blood, which
may be attributed to monthly blood-loss.
Blood is also a viscoelastic fluid. The deformations of the erythrocytes in flow
and the storage and release of elastic energy that this implies, as well as the dissi-
pation in blood due primarily to evolution of the erythrocyte networks (at low shear
rate) and internal friction (at higher shear rates) (Anand and Rajagopal 2004), give
rise to the viscoelastic character of blood (Chien et al. 1975). At normal hemat-
ocrit values, the viscous component, η , of the complex viscosity predominates over
the elastic component, η (Chmiel and Walitza 1980). This suggests that blood vis-
coelasticity also has a secondary impact on blood flow at physiological hematocrit
values. Thurston (1979) indicated that both components of the complex viscosity
have relatively constant values for shear rates below 1.5 s–1 . In this range, the elastic
and viscous components are approximately 3.9 mPa·s and 11.5 mPa·s, respectively.
As the shear rate is increased beyond this level, blood displays a nonlinear vis-
coelastic behaviour, i.e. η and η are dependent on shear rate. The value of η
starts dropping rapidly as the shear rate is increased beyond this level, diminishing
to 0.1 mPa·s by 16 s–1 . This sharp decrease is connected to the breakdown of the
blood microstructure formed by red blood cell aggregates.
The speed of sound in blood was investigated by Bakke et al. (1975), where the
following equation is given for the dependence of whole blood on hematocrit at a
temperature of 37◦ C
where c is sound speed in m/s and H is the hematocrit. At normal hematocrit con-
tent, this equation gives a value of c of 1,586 m/s. This is in close agreement with
values reported by other authors; e.g., 1,590 m/s (Hughes et al. 1979) and 1,584.2
m/s (Collings and Bajenov1987). The sound speed in whole blood increases with
temperature at a rate of c T = 1.3 m/s/◦ C.
The surface tension of whole blood at normal hematocrit content is 5.6×10–2
N/m (Lentner 1979). This value was, however, measured at 24◦ C and no data at
normal body temperature are available in literature. The density of whole blood is
approximately 1,060 kg/m3 (Lentner 1979).
the exception of the large polymers like fibrinogen or larger globulins, which are
reduced or not found at all in the synovial fluid due to the sieving action of the
synovial capillary walls. Synovial fluid can be distinguished from plasma by the
presence of hyaluronic acid and lubricin. These two molecules are the major deter-
minants of synovial fluid viscosity and are of key importance for one of its main
functions, which is to act as lubricant of the joint surfaces. Hyaluronic acid, or
hyaluronan, is the most abundant glycosaminoglycan in mammalian tissue. It is
present in high concentrations in connective tissue, such as skin, vitreous humor,
cartilage, and umbilical cord, but the largest single reservoir is the synovial fluid of
the diarthrodial joints, where concentrations of 0.5–4 mg/ml are achieved (Laurent
and Fraser 1992; Fraser et al. 1997). The high concentration of hyaluronic acid in
synovial fluid is essential for normal joint function, because hyaluronan confers
exceptional viscoelasticity and lubricating properties to synovial fluid, particularly
during high shear conditions. Under dynamic loading of diarthrodial joints, shear
thinning and a reduction in viscosity occur because of decreased physical entangle-
ments of hyaluronan molecules and their realignment to directions more parallel
with the axis of articulation. These unique non-Newtonian rheological proper-
ties of hyaluronan not only reduce wear and attrition of articular cartilage during
joint motion (Balazs et al. 1967; Balazs and Denlinger 1985) but also stabilize
joints at low shear rates (Cullis-Hill and Ghosh 1987). At high loads, however,
hyaluronan is not an effective lubricant. Here lubricin, which interacts with surface-
active phospholipids, seems to have an important role (Simkin 1985). Furthermore,
hyaluronan in the synovial fluid also bonds the opposing surfaces of the joints
to each other. This creates tensile strength with little or no shear strength and
enables opposing surfaces to slide freely across each other but limits their distrac-
tion (Wooley et al. 2005). The volume of the synovial fluid in normal human joints
is quite small with approximately 0.5–2.0 ml (Dewire and Einhorn 2001; Mason
et al. 1999). The synovial fluid undergoes continuous turnover by trans-synovial
flow into synovial lymph vessels. As a result, water and protein in the synovial
fluid are replaced within a period of 2 h or less. The turnover of hyaluronan is
considerably slower with complete replacement of hyaluronan within about 38 h
(Mason et al. 1999). The density of the synovial fluid is ρ = 1008–1015 kg/m3
(Duck 1990).
Rheological studies have documented three types of non-Newtonian proper-
ties for the synovial fluid: shear-thinning, elasticity, and rheopexy. King (1966)
seems to be the first who tested synovial fluids of bullocks using a cone-and-plate
rheometer. He found that, at very small shear rates (<10–1 s–1 ), the apparent vis-
cosity of the synovial fluid from the knee joint is constant at a value of about
10 Ns/m2 and then decreases with increasing shear rate. King also observed that
the knee joint fluid has a larger apparent viscosity than that of ankle fluid. For
example, the apparent viscosity of the ankle joint fluid shows a zero shear vis-
cosity of about 10–1 Ns/m2 which manifests for values of the shear rate of up to
1 s–1 . At very large values of the shear rate the apparent viscosity of both knee
and ankle joint fluids tends to become equal to that of water. Similar rheological
1.4 Particular Non-Newtonian Fluids 39
studies were later conducted by Davies and Palfrey (1968) using synovial fluids
obtained from patients with joint effusions. They confirmed the shear-thinning
character of synovial fluid viscosity and presented some evidence that the low-
est values of the apparent viscosity were obtained in the case of synovial fluids
taken from patients with rheumatoid arthritis. Synovial fluid rheology has long
been utilized in the study of rheumatic diseases (see, for example, ScottBlair et al.
1954) and significantly lower viscosities are often noted in these cases (Gomez
and Thurston 1993; Schurz 1996). Under inflammatory conditions of arthritic dis-
eases, such as osteoarthritis or rheumatoid arthritis, high molar mass hyaluronic
acid is degraded by reactive oxygen species leading to a reduction of the syn-
ovial fluid viscosity. The smaller viscosity of the synovial fluid impairs its lubricant
and shock absorbing properties leading finally to deteriorated joint movement
(Soltés et al. 2006).
Dynamic tests on the rheological properties of synovial fluid were conducted by
Balazs and his co-workers using both healthy and arthritic human synovial fluids
(Balazs 1968; Gibbs et al. 1968). They found that the synovial fluids of both healthy
young and old subjects when exposed to shear stress at low frequencies behave
as viscous fluids, but when the frequency increases, the fluids become more and
more elastic. At a given frequency, the values of the storage modulus G and the
loss modulus G become equal and the transition from the viscous fluid to elastic
body occurs. For healthy young persons (27–34 years) the cross-over value is about
0.2 Hz, but increases to about 1 Hz for old persons (52–78 years). Similar results
were reported by Rwei et al. (2008). The importance of this transition from vis-
cous to an elastic state is that it occurs at a frequency rate that is present in joints
under various types of movement. When a person loads the knee in a standing up
position, the input frequency is low and the viscous component of the synovial fluid
predominates over the elastic one. When the person is walking, running, or jumping,
the input frequency becomes faster and faster and the elastic component becomes
dominant. It absorbs the mechanical energy and thereby protects the cartilage and
the synovial cells from mechanical damage. Balazs and co-workers also noted that
the synovial fluid from healthy young donors shows more elasticity than that of old
persons. On the other hand, the arthritic human synovial fluid loses almost all of its
elastic properties. They explained this result by the lower concentration, lower aver-
age molecular weight, and changes in the conformation of the hyaluronan molecules
in the arthritic joint fluid.
Oates et al. (2006) indicated that, at small shear rates (γ̇ ≤ 10s−1 ), the syn-
ovial fluid is rheopectic, i.e. the stress grows in time during steady shear. At high
shear rates, rheopexy was still observed but it is significantly less pronounced
than at low shear rates. This flow characteristic is caused by protein aggregation,
and the total stress is enhanced by entanglement of this tenuous protein network
with the long-chain polysaccharide sodium hyaluronate under physiological con-
ditions. This structure builds faster under quiescent conditions and applications of
steady shear retards structure growth, with slower rates of structure growth at higher
shear rates.
40 1 Non-Newtonian Fluids
1.4.3 Saliva
Saliva is mainly composed of water (99.5%), proteins (0.3%) and inorganic and
trace substances (0.2%) (Humphrey and Williamson 2001; van Nieuw Amerongen
et al. 2005). The proteins in saliva are mainly constituted by glycoproteins, enzymes,
immunoglobulins, and a wide range of peptides, such as cystatins, statherin, his-
tatins, proline-rich proteins, with antimicrobial activities (van Nieuw Amerongen
et al. 2005). The inorganic fraction of saliva contains the usual electrolytes (sodium,
potassium, chloride and bicarbonate) of the body fluids but at different concentra-
tions making saliva a hypotonic fluid. Saliva is produced by the contra-lateral major
glands, i.e. parotidglands (Par), submandibular glands (SM), and sublingual glands
(SL), and minor salivary glands present in the mucosa of the tongue (von Ebner
glands), cheeks, lips and palate (Pal) (Silvers and Som 1998; Young and van Lennep
1978). Whole saliva is formed primarily from salivary gland secretions, but also
blood, oral tissues, microorganisms, and food remnants can be contributors to the
salivary fluid (Schipper et al. 2007).
Whole saliva is also a pseudoplastic fluid, i.e. the viscosity of saliva decreases
upon increasing shear rate (Schwartz 1987; Vissink et al. 1984; van der Reijden
et al. 1993; Levine et al. 1987). For example, the apparent viscosity of whole saliva
at a shear rate of γ̇ = 0.02s−1 is η = 100 mPa·s and decreases at η = 2.5 mPa·s
at γ̇ = 95s−1 (van der Reijden et al. 1993). The main reason for the shear thin-
ning character of whole saliva is the presence of large glycoproteins, like mucins,
causing a weak gel character of saliva (Veerman et al. 1989). This is supported by
different studies showing that the viscosity of Par saliva, which does not contain
high molecular weight mucins, is shear rate independent with a viscosity slightly
higher than that of water (η = 1.3 mPa·s at γ̇ = 230s−1 ) (Veerman et al. 1989;
Levine et al. 1987). In addition, treatment of saliva by homogenisation destroys the
weak gel and resulted in a 3 to 4 fold decrease in viscosity (Veerman et al. 1989).
Another parameter affecting saliva viscosity is the pH. Lowering the pH resulted in
a decrease in viscosity of whole unstimulated saliva and a small viscosity increase of
stimulated saliva (Nordbo et al. 1984). The viscous component η of viscoelasticity
of whole saliva dominates the elastic component η. Reported values in literature
are η = 1.5 mPa·s and η = 0.6 mPa·s at shear rates between 1 and 300 s–1 and at
a temperature of 37◦ C (Levine et al. 1987).
The viscosity of SM and Pal saliva was shown to be hardly dependent on the
shear rate opposite to SL saliva showing a clear shear-thinning behaviour (Levine
et al. 1987). Moreover, at similar viscosity, SM saliva has a lower elasticity than SL
saliva. Typical values are η = 0.4–0.6 mPa·s for SM saliva and η = 1.8–4.9 mPa·s
for SL saliva (Levine et al. 1987). The high viscosity at low shear rates of SL saliva
prevents dehydration of the mucosa of the floor of the mouth. On the other hand,
the high elasticity of SL saliva, in combination with appropriate adhesion to the oral
mucosa, may provide a high retention of SL saliva.
Rantonen and Meurman (1998) investigated the effect of collection time and
within-subject variations of viscosity and flow rate of whole saliva. Unstimulated
saliva viscosity showed the minimum viscosity at the end of the afternoon
1.4 Particular Non-Newtonian Fluids 41
Cells are the fundamental structural and functional unit of tissues and organs. There
are about 200 different types of cells in the human body. A typical cell consists
of a membrane, a cytoplasm (i.e. fluid-like cytosol, structural cytoskeleton and
dispersed organelles), and a nucleus which contains the chromosomal DNA. The
cell membrane consists primarily of a phospholipid bilayer with many embed-
ded proteins that serve a host of functions: channels, gates, anchoring sites, and
receptors for target molecules. In many cells, the structural integrity of the cell
membrane is augmented by a sub-membranous cortical network or layer of actin
filaments. The cytosol makes up about 70% of the cell volume and is composed
of water, salts and organic molecules. The cytoskeleton is a dynamic structure
that maintains cell shape, protects the cell, enables cellular motion, and plays
important roles in both intracellular transport and cellular division. Actin fila-
ments, intermediate filaments and microtubules are the three primary structural
proteins of the cytoskeleton. Specifically, actin filaments are about 7–9 nm in
diameter and thought to be extensible and flexible. They form by the polymeriza-
tion of globular, monomeric actin (G-actin) into a twisted strand of filamentous
42 1 Non-Newtonian Fluids
actin (F-actin) having a barbed end and a pointed end. The filament grows at
the barbed end, whereas polymerization occurs preferentially at the pointed ends.
Intermediate filaments are often described as rope-like structures about 10 nm in
diameter that appear to play an important structural role throughout the cytoplasm.
Microtubules exist as long cylinders about 25 nm in diameter, and they appear
to have a higher bending stiffness than the other two primary filaments. They
are polymerized filaments constructed from monomers of α- and β-tubulin in a
helical arrangement. Microtubules are highly dynamic, undergoing constant poly-
merization and depolymerization, so that their half-lives are typically only a few
minutes (Mitchison and Kirschner 1984). Organelles are membrane-bound com-
partments within the cell that have specific functions. For example, mitochondria
provide the cell with usable energy to perform its many functions. The smooth
and rough endoplasmic reticulum are sites for the synthesis of proteins, lipids and
steroids. Finally, the lysosomes and perioxisomes are responsible for the hydrolytic
degradation of various substances within the cell. The ability of a cell to produce
and remove various substances within the confines of its cell membrane as well
as within the extracellular matrix in which it resides is fundamental to much of
its activity.
The rheological characteristics of the cell cytoplasm have been studied by sev-
eral methods, and some of them are discussed in Sect. 1.3.3. One popular approach
to measure cytoplasmic viscosity was the direct observation of the displacement
of microinjected submicronic magnetic particles and macromolecules in the cell
(see, for example, Valberg and Albertini 1985; Dembo and Harlow 1986). Valberg
and Feldman (1987) reported a comprehensive study of the cytoplasmic viscos-
ity of pulmonary macrophages. They found that the apparent viscosity at higher
shear rates (5×10–2 s–1 ) is 254 Pa·s, while at very low shear rates (10–3 s–1 ) the
corresponding value is 2,745 Pa·s. The marked shear dependence of η indicates
that the cytoplasm is distinctively non-Newtonian with a pseudoplastic characteris-
tic of apparent viscosity. Similar results have been later reported by Bausch et al.
(1998) for 3T3 murine fibroblasts (η = 2×103 Pa·s), Bausch et al. (1999) for J774
macrophages (η = 2×102 Pa·s), and Sato et al. (1984) for the cytoplasmic viscos-
ity of the axoplasm of squid axon (η = 104 –105 Pa·s). The cytoplasm of other cell
types, such as, leukocytes and neutrophils, has similar properties (Evans and Yeung
1989; Heidemann et al. 1999). However, large regional variations in viscosity have
been found within a cell (Yanai et al. 1999; Laurent et al. 2005). These high values
are a consequence of the mechanical barriers imposed by the mesh-like structure of
the cytoskeletal network. Much smaller values were reported when only the aqueous
domain of cell cytoplasm was investigated. Typical values vary in the range 2×10–3
to 5×10–2 Pa·s (Lepock et al. 1983; Mastro and Keith 1984).
The rheology of cytoplasmic extracts prepared from Xenopus laevis eggs was
investigated by Valentine et al. (2005). At macroscopic length scales, cytoplasm
is a soft viscoelastic solid with an elastic modulus in the range of 2–10 Pa, and
a considerable viscous modulus of 0.5–5 Pa. Actin and microtubules cooperate to
withstand shear deformation. Disruption of the microtubule network significantly
weakens the elastic response, and the disassembly of actin filaments completely
References 43
prevents gelation. To measure the microscopic properties of the extract, they used
a multiple particle tracking technique to observe the thermal motions of embedded
colloidal particles. At microscopic length scales, the elastic filaments do not con-
tribute and the sample is predominantly viscous with an apparent viscosity of about
20 mPa·s.
Fabry et al. (2001, 2003) performed dynamic tests using magnetic twisting
cytometry to measure the frequency dependence of the storage modulus, G (ω), and
the loss modulus, G (ω), of the cytoskeleton. The storage modulus was observed to
increase with increasing frequency, ω, according to a power law, G ∝ ω0.2 . The loss
modulus also increases with increasing frequency and follows the same power law
in the range of 0.01–10 Hz. Above 10 Hz, however, the same power-law behaviour
was not observed. For ω < 103 Hz, the storage modulus is larger than the loss modu-
lus indicating that the elastic component dominates the viscoelastic properties of the
cytoplasm. For ω > 103 Hz, the loss modulus becomes dominant. Experiments were
also performed by introducing various drugs into the cell in order to create contrac-
tion or relaxation in the cytoskeleton. Similar qualitative properties were observed.
The storage modulus increased with increasing frequency as a power law and the
loss modulus also increased with increasing frequency with the same power law
and same exponent up to frequencies of 10 Hz.
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Chapter 2
Nucleation
to its equilibrium radius (Epstein and Plesset 1950). Therefore, a liquid would be
free of bubbles after a short period of time. This does not imply that gas bubbles
could not serve as cavitation nuclei. It does imply, however, that in order for gas
bubbles to serve as cavitation nuclei, they must be stabilized at a size small enough
to prevent their rising to the surface of the liquid, yet large enough so that they
will grow when exposed to negative pressure as low as a few bars. In other words,
a stabilization mechanism must exist for a gas bubble before it can act as a cavi-
tation nucleus. Various types of stabilizing skins have been proposed. These skins
usually consist of contaminants which somehow deposit themselves on the bub-
ble’s surface and counteract the surface tension. Fox and Herzfeld (1954) proposed
that surface active organic molecules could form a rigid skin around a gas bubble.
This skin would be impermeable to gas diffusion and would be mechanically strong
enough to withstand moderate hydrostatic pressures. Rather than the rigid skin of
organic molecules proposed by Fox and Herzfeld, Yount (1979, 1982) has devel-
oped a stabilization theory in which the dissolution of gas bubbles is halted by a
non-rigid organic skin. This so-called varying-permeability model, which employs
a skin of surface-active molecules to stabilize the nucleus, has been mainly applied
to bubble formation in supersaturated liquids. Although this model was originally
used to explain bubble formation in gelatin upon rapid decompression, Yount noted
that it can be applied to bubbles in water as well. It can also be applied to poly-
mer solutions because polymers have surfactant properties. Surfactants present a
barrier to mass transport and reduce the surface tension at a liquid-gas interface
(Borwankar and Wassan 1983). Both mechanisms increase the stability of nuclei
against dissolution (Porter et al. 2004). Furthermore, since surfactants are prelevant
in biological systems, this model may be particularly important for applications
involving decompression sickness and medical ultrasonics.
In heterogeneous nucleation small pockets of gas are stabilized at the bottom of
the cracks or crevices found on hydrophobic solid impurities in the liquid (Strasberg
1959; Apfel 1970; Atchley and Prosperetti 1989). Liquids normally contain a large
number of solid impurities with a very irregular surface consisting of grooves or
pits (Crum 1979). As is schematically shown in Fig. 2.1, a crevice stabilized gas
nucleus can have an interface that is concave towards the liquid. Due to surface ten-
sion, the pressure of the gas in the nucleus can therefore be less than the pressure in
the liquid, and if gas diffuses from the nucleus, so long as the contact line is pinned,
the concavity will increase, reducing the pressure of gas. Hence such a nucleus can
persist without dissolving completely into the liquid. The origin of such nuclei has
been explained by considering the flow of a liquid onto a hydrophobic surface with
crevices (Atchley and Prosperetti 1989). The crevice model is useful for explain-
ing the hysteresis effect of pressurization on cavitation threshold (Crum 1980). The
cavitation threshold increases because pressurization causes the crevice to shrink
and gas diffuses into the surrounding liquid. After the pressure is released, a smaller
pocket of gas exists in the crevice requiring a larger negative pressure to produce
nucleation.
Another explanation of the origin and persistence of nuclei is that ordering of
liquid molecules adjacent to solid surfaces leads to local hydrophobicity in regions
of concavity of an otherwise non-hydrophobic surface (Mørch 2000). This explana-
tion suggests that the resulting voids have interfaces which are convex toward the
liquids, and that their persistence is due to a resonant behaviour forced by ambient
vibrations.
Cavitation nuclei are not always permanently stabilized. Short-lived nuclei can
also formed by radiation. Although many theories have been proposed to explain
this phenomenon, the one that seems to have the most experimental support is
the thermal spike model (Seitz 1958). In this model, a positive ion is created by
the radiation-matter interaction. This ion quickly liberates its energy, generating
neighbouring atoms that are thermally excited. If tension exists within the liquid,
this region can produce a vapour bubble that expands and eventually results in a
cavitation event.
where
4 2
Wmin = πr σ (2)
3 c
determines the nucleation barrier, which is equal to the minimum reversible work
required to form a critical size nucleus, σ is the surface tension, kB is the Boltzmann
constant, and J0 is a factor which does not depend on the critical radius rc and
changes only slightly with the depth of penetration into the metastable state. All
52 2 Nucleation
modifications introduced in the theory later do not change the general result of
the classical theory given by Eqs. (1) and (2) and concern only details of calcu-
lations of the kinetic prefactor J0 and the nucleation barrier Wmin in different cases
of metastable states (see, for example, Debenedetti 1996).
In the classical theory of homogeneous nucleation the critical radius and the
nucleation barrier can be calculated with the Gibbs equations (Landau and Lifshitz
1980)
2σ ν
rc = , (3)
μ(P) − μ (P)
16π σ 3ν2
Wmin = , (4)
3 [μ(P) − μ (P)]2
where P is the bulk phase pressure, v is a specific volume of the nucleus, and μ (P)
and μ(P) are the chemical potentials of the nucleus and of the metastable bulk
fluid phase, respectively. A nucleus with radius less than a critical size rc requires
energy for further growth and usually disappears without reaching the critical size.
A nucleus with radius larger than rc grows freely with decrease of free energy,
and a phase transition into a thermodynamically stable vapour phase takes place.
Equations (3) and (4) can be applied for the formation of liquid droplets in super-
cooled vapour as well as for the formation of vapour bubbles in superheated liquid
at moderate positive pressures and in the critical region. In metastable liquids at low
temperatures considerable negative pressures are observed. In this case, Eqs. (3) and
(4) are not more applicable. Particularly for large negative pressures the equations
for rc and Wmin developed by Fisher (1948) can be used
2σ
rc = − , (5)
P
16π σ 3
Wmin = . (6)
3 P2
However, these equations in turn fail at zero and small positive pressures where
they give an unphysical divergence rc → ∞ and Wmin → ∞. A better result in this
region can be obtained with the theory developed by Blander and Katz (1975). They
obtained that the nucleation barrier Wmin is defined by Eq. (2), and found for the
critical radius
2σ v ∼ 2σ
rc = = ∗ , (7)
PV − P (P − P) δ
2
ρV 1 ρV
δ∼
=1− + , (8)
ρL 2 ρL
where ρ L is the density of the liquid and ρ V the density of the vapour. Equations (7)
and (8) are accurate for values of P at least up to 0.1 MPa, but are not valid in the
critical region where the ratio ρV /ρL ∼= 1 is not small and analytical expansion (8)
is not more applicable.
In the theory of homogeneous nucleation the mean time of formation of a critical
nucleus in a volume V
tM = (JV)−1 (9)
determines the lifetime of the metastable state. The homogeneous nucleation limit
of the metastable state is determined as a locus of the constant lifetime tM = const.
Some attempts were made to obtain a relationship that describes the distribution
of cavitation nuclei in water. Gavrilov (1969) reported that the number of bubble
nuclei is inversely proportional to the nuclei radius. Ahmed and Hammitt (1972)
indicated that the distribution of cavitation nuclei can be described by
pV
N(v) = , (2.1)
4.838 σ v2/3 + pv
where N(v) is the number of nuclei of volume v, V the total gas content, σ the surface
tension, and p is the ambient pressure. If 4.838 σ v2/3 << pv then N(v) ∝ d−3 ,
and if 4.838 σ v2/3 >> pv then N(v) ∝ d−2 , where d is the gas nuclei diameter.
Shima et al. (1985) indicated that, in the range 2 μm < d < 20 μm, the gas nuclei
distribution in water can be described by
M
N(d) = , (2.2)
dn
where M is a constant. They found that the values of the exponent n lies between 2
and 4, in agreement with the results of Gavrilov (1969) who indicated n = 3.5. In
a later study, Shima and Sakai (1987) obtained a more general equation for the size
distribution of bubble nuclei in the form:
where r is the nuclei radius and M, n, K, and α are constants. They found good
agreement with the experimental results reported by Ahmed and Hammitt (1972),
Ben-Yosef et al. (1975), and Klaestrup-Kristensen et al. (1978).
Oba et al. (1980) and Shima et al. (1985) have measured the distribution of cavi-
tation nuclei in water and various polymer solutions using a Coulter counter. They
indicated that the size range of the nuclei is from 2 to 50 μm in radius, and the num-
ber of small nuclei below 7 μm represents more than 50% from the total number of
nuclei.
Oba et al. (1980) investigated the influence of polyethylene oxide concentra-
tion on the nuclei size distribution (Fig. 2.2). They found that the number of nuclei
increases with the polymer concentration for nuclei diameters smaller 14 μm. For
a diameter of about 12 μm, the number of bubble nuclei is one order of magnitude
larger than in the case of water. However, for nuclei diameters larger than 14 μm, a
significant reduction of the number of cavitation nuclei was observed. For a diam-
eter of 35 μm, the number of nuclei in the 100 ppm polyethylene solution is one
order of magnitude smaller than in the case of water.
2.2 Nuclei Distribution 55
Shima et al. (1985) measured the cavitation nuclei distribution, in the range
2–20 μm, in three polymer aqueous solutions, namely a 100 ppm polyethylene
oxide (Polyox) aqueous solution, a 2,000 ppm hydroxyethylcelullose aqueous solu-
tion, and a 50 ppm polyacrylamide aqueous solution (Fig. 2.3). For nuclei diameters
larger than 3 μm they also found a decrease of the number of bubble nuclei
in comparison to the case of water. The largest reduction was observed in the
polyacrylamide and polyethylene solutions, while the results obtained in the hydrox-
yethylcelullose solution are almost similar to the case of water. They also indicated
that the scaling law between the number of bubble nuclei and the nuclei diameter is
not affected by the polymer additives.
The first attempts to detect cavitation in blood within the abdominal aorta of
dogs exposed in vivo to lithotripsy have not proved successful although cavita-
tion was observed in blood under in vitro conditions (Williams et al. 1988). Similar
observations have been made by Deng et al. (1996).
Lee et al. (1993) investigated bubble formation in the inferior vena cavae of dead
rats after 6–15 h exposures to air at 12.3 MPa and decompression to 0.1 MPa at
1.36 MPa/min. Bubbles were detected by light microscopy, buoyancy, and under-
water dissection. No bubbles were formed in 42 blood-filled vena cavae that were
56 2 Nucleation
isolated from the minor circulation by ligatures, but bubbles were always observed
in unisolated vena cavae. Their results indicate that nuclei are not present in blood,
even at supersaturations that are significantly higher than those experienced in vivo.
One explanation for this result is that the continuous filtration of impurities by the
body allows the presence of cavitation nuclei in only minute amounts, and only
in particular sites. This observation concurs with the finding that the cavitation
threshold for water doubles upon filtration to 2 μm (Greenspan and Tschiegg 1967).
More recently, Chambers et al. (1999) investigated the nuclei characteristics of
blood using a cavitation susceptibility meter in an ex vivo sheep model. This hydro-
dynamic method measures the nuclei threshold pressure by subjecting the fluid to
a certain characterized flow. All nuclei with a critical pressure higher than the min-
imum pressure within the device will cavitate, and the number of activated nuclei
was determined by counting the cavitation events. The nuclei concentration of blood
was measured to be at most 2.7 nuclei per litre and the authors estimated that the
radius of the nuclei is on the order of 0.3 μm. However, they noted that these values
may be even lower in an in vivo situation.
Chappel and Payne (2006) suggested that cavitation nuclei could originate from
tissues or microcapillaries and migrate into blood circulation. The contact between
adjoining endothelial cells on the capillary walls could be a site for crevice nuclei.
The effect of muscular contraction on crevices might be expected to squeeze the
gas pocket and potentially cause the release of bubbles. While the concept of in
2.3 Tensile Strength 57
vivo hydrophobic crevices remains a theoretical possibility, none have yet been
identified. No bubble formation was observed when isolated endothelium in con-
tact with blood was decompressed (Lee et al. 1993). The extravascular space could
be an alternative location: as extravascular gas nuclei expand, they might rupture
capillaries, thereby seeding the blood with gas (Vann 2004).
It has been also suggested that musculoskeletal activity could generate surface-
active molecules that stabilize the nuclei and increase their lifetime (Hills 1992).
On the other hand, there have been studies that demonstrate the beneficial effect
of surfactants on bubble elimination. The addition of surfactants to blood makes it
feasible to manipulate interfacial stresses and prevent or reduce formation of the
adhesion responsible for trapping intravascular gas bubbles. In vivo studies have
shown that the addition of surfactants favorably alters the patterns of deposition and
accelerate the rates of clearance of bubbles (Suzuki et al. 2004). While surfactants
could play a role first in nuclei stabilization, they could also be involved at last in
vascular bubble elimination.
Fig. 2.4 The bullet-piston method for estimating the tensile strength of liquids. (a) Schematic of
the cavitation threshold apparatus. (b) Pressure record obtained from a pressure transducer in a
experiment on a sample of distilled water. (c) Cavitation threshold of distilled water. Reproduced
with permission from Williams and Williams (2002). © IOP Publishing Ltd
References 59
in mechanically isolated ports in the wall of the tube. The main features of a typical
pressure record obtained from a pressure transducer in an experiment on a sample
of distilled water are shown in Fig. 2.4b, in which the data are presented in terms
of transducer output in unscaled ADC units (positive values correspond to positive
pressure and vice versa). A pressure pulse (feature “1” in Fig. 2.4b) is followed
immediately by a tension pulse (“2”) and thereafter the record comprises “sec-
ondary” pressure-tension cycles (“3–4”, “5–6”, etc.) associated with cavitational
activity. The method involves regulating a static pressure, Ps , in the space above the
liquid, Ps being increased gradually in a series of dynamic stressing experiments.
From the dynamic pressure records a measurement is made of the time delay, τ i ,
between the peak incident pressure (“1” in Fig. 2.4b) and the first pressure pulse
arising from cavity collapse (“3” in Fig. 2.4b). Under tension, cavities grow from
pre-existing nuclei within the liquid and eventually collapse and rebound, emit-
ting a pressure wave into the liquid as they do so. Hence the interval τ i , which
encompasses the attainment of maximum cavity radius and its subsequent decrease
to a minimum value, is reduced by increasing Ps (τ i therefore provides a conve-
nient measure of cavitational activity). The experiment involves the transmission of
tension by the liquid to the face of the piston and it follows that in the case of exper-
iments in which cavitation is detected, the magnitude of the tension transmitted by
the liquid is sufficient to develop a transient, net negative pressure in the presence of
a background static pressure Ps . Thus an estimate of the magnitude of tension capa-
ble of being transmitted by the liquid can be obtained from a knowledge of Ps . The
time delay, τ o , between pulses corresponding to “1” and “2” in Fig. 2.4b represents
the time required for the upward travelling pressure wave to return, as tension, to
the lower transducer location. It also represents the smallest time interval for which
a cavity growth-collapse cycle could occur (given that a bubble would have to grow
and collapse infinitely quickly in order that τ i = τ o ). Thus the tensile strength can
be estimated by extrapolation of the data in Fig. 2.4c to that value of the pressure Ps
at which τ i = τ o , this condition representing the complete suppression of cavitation.
Bullet-piston work has demonstrated a reduction of liquid effective tensile
strength in non-Newtonian polymer solutions, the reduction increasing with increas-
ing polymer concentration (Williams and Williams 2002). However, when this
system was investigated using an ab initio technique, the cavitation threshold was
found to be increased by the same polymer additive (Overton et al. 1984; Brown and
Williams 2000). When subjected to quasi-static stressing (in a modified Berthelot
tube) the presence of polymer made no discernible difference to the effective tensile
strength of the liquid (Trevena 1987).
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Chapter 3
Bubble Dynamics
The main goal of the investigations on bubble dynamics is to describe the velocity
field and the pressure distribution in the liquid surrounding the bubble. In this section
we describe the effect of the viscoelastic properties of the liquid on the behaviour
of cavitation bubbles situated in a liquid of infinite extent or near a rigid boundary.
As a special case, we will consider the interaction of individual cavitation bubbles
situated in water with boundary materials with elastic/plastic properties.
Due to the difficulty of the problem most of the theoretical work on bubble
dynamics in non-Newtonian fluids was restricted to the case of spherical bubbles.
The experimental studies, on the other hand, made use of high speed cameras to
observe the growth and collapse of both spherical and non-spherical bubbles in non-
Newtonian fluids. Two types of experiments have been conducted: in the first type, a
cavitation bubble is collapsed after its expansion by the ambient pressure in the sur-
rounding fluid. In this case, the bubble is generated by laser or electrical discharge.
Alternatively, a stable gas bubble, usually of a size large enough to be visible, is
compressed by a positive pressure pulse.
to p0 and the bubble begins to collapse due to the pressure difference between the
inside and outside of the bubble. The bubble keeps its spherical shape throughout the
motion and the centre of the bubble remains fixed and is the centre of a spherically
symmetric coordinate system. In principle, the quantities associated with the bubble
collapse, such as velocity and pressure, can be determined from the solution of the
conservation equations of continuum mechanics inside and outside of the bubble
joined together by suitable boundary conditions at the bubble interface. Neglecting
the effects of gravity, gas diffusion and heat conduction through the bubble wall, the
governing equations may be expressed as follows:
(i) Continuity:
∂p ∂(ρvr ) ρvr
+ +2 = 0, (3.1)
∂t ∂r r
(ii) Momentum:
∂vr ∂vr 1 ∂p 1
+ vr =− − (∇ · τ)r , (3.2)
∂t ∂r ρ ∂r ρ
where ν r is the radial component of the velocity field, ρ, the liquid density,
p(r, t) is the pressure in the liquid, and τ is the extra stress tensor.
(iii) Equation of state for the liquid:
A widely used equation of state for liquids is the Tait form:
n
p+B ρ
= , (3.3)
p∞ + B ρ∞
where the subscript ∞ refers to the values at infinity, and B and n are constants
having, for water, the values n = 7.15 and B = 3,049.13 atm.
(iv) Equation of state for the gas inside the bubble:
3κ
R0
pi = p0 , (3.4)
R
where κ is the polytropic index.
(v) Boundary conditions at the bubble wall (r = R(t)):
Kinematic boundary condition:
dR
vr (t) = = Ṙ, (3.5)
dt
Dynamic boundary condition:
2σ
pB (t) = pi (t) − − (τrr )r=R , (3.6)
R
where pB is the pressure on the liquid at the bubble wall and σ is the surface
tension.
3.1 Spherical Bubble Dynamics 65
these models have the main advantage of being tractable and, thus, they allow us to
obtain an elegant solution by reducing the problem to a non-linear differential equa-
tion. The “near field” is a region surrounding the bubble with typical dimension R,
the bubble radius, the “far field” scales with a typical length c∞ T, where c∞ is the
speed of sound in the liquid and T a characteristic time, such as the collapse time. If
one assumes that R is of the order ṘT, with Ṙ a typical radial velocity of the bubble
wall, the ratio of length scales is just the Mach number of the bubble wall motion.
Once cast in these terms it is clear that, to lowest order, the near-field dynamics
are essentially incompressible while the far field is governed by linear acoustics.
The picture becomes considerably more intricate for a non-linear viscoelastic liquid,
however (Khismatulin and Nadim 2002).
The analysis leads unambiguously to the following equation for the radius of a
spherical bubble situated in a linear viscoelastic liquid (Brujan 1998, 1999, 2001,
2009a):
∞
3 2 1 2 ...
1 ∂τrr 3τrr
RR̈ + Ṙ − R R + 6RṘR̈ + 2Ṙ = H −
3
+ dr, (3.9)
2 c∞ ρ∞ ∂r r
R
∞
3 1 ∂τrr 3τrr
RR̈ + Ṙ2 = H − + dr, (3.11)
2 ρ∞ ∂r r
R
∞
(R2 Ṙ) 1 (R2 Ṙ)2 1 ∂τrr 3τrr
− =H− + dr (3.12)
R 2 R4 ρ∞ ∂r r
R
3.1 Spherical Bubble Dynamics 67
to evaluate the first term and (3.11) to express the third derivative of the radius which
appears on expanding the second term, one finds
α+1 3 2 3α + 1 1−α R
RR̈ 1 − Ṙ + Ṙ 1 − Ṙ = H 1 + Ṙ + Ḣ
c∞ 2 3c∞ c∞ c∞
∞ ∞
1 1−α ∂τrr 3τrr 1 R d ∂τrr 3τrr
− 1+ Ṙ + dr − + dr,
ρ∞ c∞ ∂r r ρ∞ c∞ dt ∂r r
R R
(3.13)
which represents an extension of the general Keller–Herring equation to the case of
a bubble in a linear viscoelastic liquid. For a Newtonian liquid, by taking α = 0,
Eq. (3.13) becomes identical to the equation proposed by Keller and Kolodner
(1956), while the value α = 1 brings it into the form suggested by Herring (see,
for example, Trilling 1952). It will be noted that, by dropping terms in c−1 ∞ , Eq.
(3.13) reduces to Eq. (3.11), which is therefore seen to have an error of the order
c−1
∞ . The arbitrary parameter α (which does not seem to have any physical mean-
ing) must, of course, be of order 1 so as not to destroy the order of accuracy of the
approximate Eq. (3.13).
Because of the presence of the third time derivative of the radius, the form (3.9) of
the radial equation is hardly more attractive than (3.13), if for nothing else than for
the need to prescribe an initial condition for R̈. Actually, this is a minor difficulty
since, to the same order of accuracy in the bubble wall Mach number, an initial
condition for R̈ can be obtained by substituting the given initial conditions for R and
Ṙ in the incompressible formulation (6). However, in view of its uniqueness (Brujan
1999), it is proper to consider Eq. (3.9) the fundamental form of the motion equation
of a spherical bubble in a compressible linear viscoelastic liquid.
With reference to Eq. (3.13) it should be noted that a related equation is that due
to Gilmore (see, for example, Prosperetti and Lezzi 1986):
Ṙ 3 Ṙ Ṙ R Ṙ
RR̈ 1 − + Ṙ2 1 − =H 1+ + 1− Ḣ
C 2 C C C C
∞ ∞ (3.14)
1 Ṙ ∂τrr 3τrr 1 R d ∂τrr 3τrr
− 1+ + dr − + dr,
ρ∞ C ∂r r ρ∞ C dt ∂r r
R R
To close the mathematical formulation an equation for the shear stress in terms of
the rate-of-strain is necessary. Several examples on obtaining the equation of motion
for the bubble radius for some constitutive models are given below.
With this result and using the dynamic boundary condition (3.6), the equation of
motion for the bubble radius in terms of pressure is found to be
∞
3 2 1 2 ...
1 2σ 3 τrr
RR̈+ Ṙ − R R + 6RṘR̈ + 2Ṙ =
3
pi (t) − − p∞ − dr,
2 c∞ ρ∞ R ρ∞ r
R
(2)
where, in the case of an adiabatic evolution of the gas inside the bubble, pi (t) is
given by Eq. (3.4).
Example 3.2: Equation of Motion for Bubble Radius for a Newtonian Fluid
In the case of a Newtonian fluid
∂vr R2 Ṙ
τrr = −2η = 4η 3 , (1)
∂r r
and
∞
τrr Ṙ
3 dr = 4η . (2)
r R
R
Thus, the equation of motion for the bubble radius in a Newtonian fluid written in
terms of pressure becomes
3 2 1 2 ...
1 2σ Ṙ
RR̈ + Ṙ − R R + 6RṘR̈ + 2Ṙ =
3
pi (t) − − p∞ − 4η . (3)
2 c∞ ρ∞ R R
After some time of oscillation, due to acoustic and viscous dissipation, the
trajectory R = R(t) move towards an equilibrium position characterized by the equi-
...
librium radius of the bubble Re . This value may be obtained imposing Ṙ = R̈ = R =
0 in Eq. (3) to find
3.1 Spherical Bubble Dynamics 69
2σ 3γ −1 p0 3γ
e +
R3γ R + R = 0. (4)
p∞ e p∞ 0
Suppose now that the bubble oscillates with small amplitude. Then a solution R
of this equation may be given as
where Re is the equilibrium radius of the bubble. The linearized solution of the
motion equation valid to order c−1∞ is obtained by substituting Eq. (5) into Eq. (3)
and neglecting the...higher-order terms of δ and δ̇. If this procedure is carried out
a term containing δ appears in the resulting equation. To avoid this we note that,
since the error in Eq. (3) is of the order c−2∞ , it is sufficient to approximate this
term correctly to order 1. For this purpose, after introduction of (5) we differentiate
the incompressible
... equation in the form (3) with c∞ → ∞ and use the result to
eliminate δ to find
$ %
4η 4η 1 2σ
1+ δ̈ + + 3γ p∞ + (3γ − 1) δ̇
ρ∞ c∞ Re ρ∞ R2e ρ∞ c∞ R2e Re
(6)
1 2σ
+ 3γ p∞ + (3γ − 1) δ = 0.
ρ∞ Re
2 Re
The natural frequency of the damped oscillator defined by Eq. (5) may be derived
as
1 1 2σ 2η 2
f0 = 3γ p∞ + (3γ − 1) −
2π Reρ∞ Re ρ∞ Re
&&1/2 (7)
1 2η 3 2σ 2η 2
− 3γ p∞ + (3γ − 1) −4 ,
c∞ ρ∞ Re ρ∞ Re ρ∞ Re
R2 R̈ + 2RṘ2 (ξ ) ρ∞ 2 ...
ρ∞ R4 Ṙ2
p(r) = p∞ + ρ∞ − R R + 6RṘR̈ + 2Ṙ3 (ξ ) − ,
r c∞ 2 r4
(8)
where ξ = t − (r − R)/c∞ and, unless indicated, all the R have the argument t.
70 3 Bubble Dynamics
η0 − η∞
η = η∞ + √ n , (1)
1 + I2 / k
In this case
∞ ∞ ' √ )2
τrr Ṙ r−4 2 3 2 (( ((
3 dr = 4η∞ + 12R2 Ṙ (η0 − η∞ ) ,a = R Ṙ . (3)
r R 1 + a/r3n k
R R
With
a/r3n
y= (4)
1 + a/r3n
we have
∞ 0
r−4 1
= − a−1/n (1 − y)−1/n y(1/n)−1 dy, (5)
1 + a/r 3n 3n
R a/R3n
1+a/R3n
and writing
∞
(1 − y)−1/n = 1 + s+1
Cs+1/n ys+1 (6)
s=0
we find
∞ ! ' √ ( ( )n "−1/n
r−4 1 2 3 (Ṙ(
= 1 +
1 + a/r3n 3R k R
R
⎧ ! ' √ ( ( )n "−(s+1) ⎫
⎨ ∞
1 2 3 (Ṙ( ⎬ Ṙ
s+1
× 1+ Cs+1/n 1+ .
⎩ ns + n + 1 k R ⎭R
s=0
(7)
3.1 Spherical Bubble Dynamics 71
Thus, the final form of the equation of motion for bubble radius in an inelastic
shear-thinning fluid characterized by the Williamson rheological model is
3 1 2 ...
RR̈+ Ṙ2 − R R + 6RṘR̈ + 2Ṙ3
2 c
⎡∞ ! ' √ ( ( )n "−1/n
1 ⎣ 2σ Ṙ 2 3 (Ṙ(
= pi (t) − − p∞ − 4η∞ − 4 (η0 − η∞ ) 1 +
ρ∞ R R k R
⎧ ! ' √ ( ( )n "−(s+1) ⎫ ⎤
⎨ ∞
1 2 3 (Ṙ( ⎬ Ṙ
× 1+ s+1
Cs+1/n 1+ ⎦.
⎩ ns + n + 1 k R ⎭R
s=0
(8)
For η0 = η∞ = η (η being the Newtonian viscosity) this equation is identical
with that obtained for a Newtonian fluid. The equation describing the equilibrium
radius of the bubble is identical to that in a Newtonian fluid while the equation
describing the natural frequency of the bubble is similar to that in a Newtonian fluid
but with η∞ instead of η.
The equation describing the pressure distribution in the liquid surrounding the
bubble is in this case (see Brujan 1998):
R2 R̈ + 2RṘ2 (ξ ) ρ∞ 2 ...
ρ∞ R4 Ṙ2
p(r) = p∞ + ρ∞ − R R + 6RṘR̈ + 2Ṙ3 (ξ ) −
r c∞ 2 r4
! ' √ )n "−1 ! ' √ )n "−1/n
2 3 (( 2 (( R2 Ṙ 2 3 (( 2 ((
− (η0 − η∞ ) 1 + (R (
Ṙ + 4 (η0 − η∞ ) 1 + (R (
Ṙ
kr3 r3 kr3
⎧ ! ' √ ( ( )n "−(s+1) ⎫
⎨ ∞
1 2 3 (Ṙ( ⎬ R2 Ṙ
s+1
× 1+ Cs+1/n 1 + .
⎩ ns + n + 1 k R ⎭ r3
s=0
(9)
Example 3.4: Equation of Motion for Bubble Radius in Linear Elastic Fluid
We first consider the three-parameter, linear Oldroyd model given by
Dτrr Derr
τrr + λ1 = 2η err + λ2 , (1)
Dt Dt
where D/Dt = ∂/∂t + vr ∂/∂r, λ1 is a characteristic relaxation time (for the stress),
η, the viscosity coefficient, λ2 , a characteristic retardation time (i.e., relaxation time
for strain) and err = ∂vr /∂r is the strain rate. It should be noted that the assumption
of a single relaxation time λ1 is over simplistic, even if the polymers are monodis-
persed. Rather, one would expect a long chain to have a distribution of time scales,
corresponding to various subchains that compose the polymer. In principle, there
is no problem in incorporating such a distribution of time scales in the model, but
72 3 Bubble Dynamics
1 3
y= r − R3 , (2)
3
we find
D ∂ ∂ ∂ ∂ R2 Ṙ 2 ∂ ∂
= + vr = − R2 Ṙ + r = , (3)
Dt ∂t ∂r ∂t ∂y r 2 ∂y ∂t
and
2R2 Ṙ
err = − . (4)
3y + R3
The Oldroyd equation becomes
dτrr R2 Ṙ 2RṘ2 + R2 R̈
τrr + λ1 = 4η + λ2 , (5)
dt 3y + R3 3y + R3
with the solution (for λ1 = 0)
t
&
4η ξ −t R2 (ξ )Ṙ(ξ ) + λ2 R2 (ξ )R̈(ξ ) + 2R(ξ )Ṙ2 (ξ )
τrr = exp dξ . (6)
λ1 λ1 3y + R3 (ξ )
0
Using this last result we obtain the equation of motion for bubble radius in a three-
parameter, linear Oldroyd model as
3 1 2 ...
1 2σ 12η
RR̈ + Ṙ2 − R R + 6RṘR̈ + 2Ṙ3 = pi (t) − − p∞ −
2 c∞ ρ∞ R λ1
t 2
2 & " (7)
ξ −t R (ξ )Ṙ(ξ ) + λ2 R (ξ )R̈(ξ ) + 2R(ξ )Ṙ2 (ξ ) R
exp ln dξ .
λ1 R3 − R3 (ξ ) R(ξ )
0
The pressure equation in the liquid surrounding the bubble reads (Brujan 1999):
2
R R̈ + 2RṘ2 (ξ ) ρ∞ 2 ...
ρ∞ R4 Ṙ2
p(r) = p∞ + ρ∞ − R R + 6RṘR̈ + 2Ṙ3 (ξ ) −
r c∞ 2 r4
t
4η ξ −t - 2
.
− exp R (ξ )Ṙ(ξ ) + λ2 R2 (ξ )R̈(ξ ) + 2R(ξ )Ṙ2 (ξ )
λ1 λ1
0
1 1 1
× 3 − ln dξ . (8)
r − R3 − R3 (ξ ) R3 − R3 (ξ ) r3 − R3 − R3 (ξ )
3.1 Spherical Bubble Dynamics 73
(1 + λ1 s)Trr = −2η(1 + λ2 s)εrr , Trr (s) = L[τrr (t)], εrr (s) = L[err (t)]. (10)
t
τrr = −2 G(t − t̄)err (r̄, t̄)dt̄, (12)
0
where
−1 1 + λ2 s λ2 1 λ2 −t/λ1
G(t) = ηL =η δ(t) + 1− e , (13)
1 + λ1 s λ1 λ1 λ1
with G(t − t̄) the relaxation modulus and δ(t) the Dirac function. Using the last two
equations, the normal stress component in the r direction may be obtained as
t
λ2 1 λ2 −(t−t̄)/λ 1
τrr = −2η δ t − t̄ + 1− e err (r̄, t̄)dt̄. (14)
λ1 λ1 λ1
0
2R2 (t̄)Ṙ(t̄)
err (r, t) = − , (15)
r3 − R3 − R3 (t̄)
thus
t
λ2 1 λ2 −(t−t̄)/λ1 2R2 (t̄)Ṙ(t̄)
τrr = 4η δ(t − t̄) + 1− e dt̄, (16)
λ1 λ1 λ1 r3 − R3 − R3 (t̄)
0
74 3 Bubble Dynamics
and, therefore,
∞ t
τrr λ2 1 λ2
3 dr = 12η δ(t − t̄) + (1 − )e−(t−t̄)/λ 1
r λ1 λ1 λ1
R 0 (17)
2R2 (t̄)Ṙ(t̄) R
× ln dt̄.
R3 − R3 (t̄) R(t̄)
Using the last result, the equation of motion for the bubble radius in a Jeffreys fluid
is
$
3 2 1 2 ... 1 2σ
RR̈+ Ṙ − (R R + 6RṘR̈ + 2Ṙ ) =
3
pi (t) − − p∞
2 c∞ ρ∞ R
⎫
t
λ2 1 λ2 −(t−t̄)/λ1 2R2 (t̄)Ṙ(t̄) R ⎬
− 12η δ(t − t̄) + 1− e ln dt̄ .
λ1 λ1 λ1 R3 − R3 (t̄) R(t̄) ⎭
0
(18)
The pressure equation in the liquid surrounding the bubble reads (Shima et al.
1988):
R2 R̈ + 2RṘ2 (ξ ) ρ∞ 2 ...
p(r) = p∞ + ρ∞ − R R + 6RṘR̈ + 2Ṙ3 (ξ )
r c∞
t
ρ∞ R4 Ṙ2 λ2 1 λ2 −(t−t̄)/λ1
− − 4η δ(t − t̄) + 1− e (19)
2 r4 λ1 λ1 λ1
0
2R2 (t̄)Ṙ(t̄) R2 (t̄)Ṙ(t̄) r3 − R3 − R3 (t̄)
− ln dt̄.
r3 − R3 − R3 (t̄) R3 − R3 (t̄) r3
where U = (p∞ / ρ∞ )1/2 is of the order of the bubble wall velocity and T = R0 /U.
With these definitions the Gilmore formulation becomes
3.1 Spherical Bubble Dynamics 75
R∗ 3 2 R∗ R∗
R∗ R∗1−ε + R∗ 1 − ε = H∗ 1 + ε
C 2 C∗ C∗
∞
R∗ R Ṙ ∂τrr∗ 3τrr∗
+ε 1 − ∗ H∗ − 1 + ε + dr∗
C∗ C∗ C ∂r∗ r∗ (2)
R∗
∞
R∗ d ∂τrr∗ 3τrr∗
−ε + dr∗ ,
C∗ dt∗ ∂r∗ r∗
R∗
- .1/2
C∗ = 1 + ε2 (n − 1)H∗ , (3)
! (n−1)/n "
ε2 pB∗ + B
H∗ = −1 , (4)
(n − 1) p∞ + B
where ε is of the order of bubble wall Mach number. The nondimensional form of
Eq. (3.9) reads
∞
3 2 ∂τrr∗ 3τrr∗
R∗ R∗ + R − ε(R2∗ R 3
∗ + 6R∗ R∗ R∗ + 2R∗ ) = H∗ − + dr∗ , (5)
2 ∗ ∂r∗ r∗
R∗
3 ε
R∗ R∗ 1 − ε(α + 1)R∗ + R2
∗ 1 − (3α + 1)R∗ = H∗ 1 + ε(1 − α)R∗
2 3
∞
∂τrr∗ 3τrr∗
+ εR∗ H∗ − 1 + ε(1 − α)R + dr
∂r∗ r∗ (6)
R∗
∞
d ∂τrr∗ 3τrr∗
− εR∗ + dr∗ .
dt∗ ∂r∗ r∗
R
For example, for the three-parameter, linear Oldroyd model, the stress component
becomes
t∗
4η ξ ∗ − t∗
τrr∗ = exp
Re De De
0 (7)
&
R2∗ (ξ∗ )Ṙ(ξ∗ ) + χ De R2∗ (ξ∗ )R∗ (ξ∗ ) + 2R∗ (ξ∗ )R2
∗ ∗(ξ )
× dξ∗ ,
r∗3 − R3∗ + R3∗ (ξ∗ )
where χ = λ2 /λ1 .
The introduction of viscoelastic liquids into the bubble dynamics analysis
creates two independent sets of parameters: the Reynolds number, defined as
76 3 Bubble Dynamics
Re = Rmax ρ ∞ U/η, and the Deborah number which is defined as the ratio of the
characteristic time of the fluid and the characteristic time of the bubble collapse,
De = λ1 U/Rmax .
Fig. 3.1 Maximum dimensionless velocity of the bubble wall during first bubble collapse, Vmax /U,
where U = (p∞ /ρ ∞ )1/2 , (top) and maximum pressure at the bubble wall, pmax /p∞ , (bottom) versus
minimum bubble radius at the end of first bubble collapse, Rmin . The far-right points correspond
to an initial bubble radius R0 = 1 mm and the far-left ones to R0 =10–2 mm. The full symbols are
the results of incompressible formulation and the open ones of compressible formulation. Circles:
water, triangles: 0.5% hydroxyethylcelullose solution and squares: 0.5% carboxymethylcelullose
solution. The calculations were conducted for p0 /p∞ = 10–4 . Reproduced with permission from
Brujan (1998). © IOP Publishing Ltd
78 3 Bubble Dynamics
hand, it was found that, for values of the initial bubble radius R0 > 10–1 mm, sound
emission is the main damping mechanism in spherical bubble collapse.
Liquid compressibility plays an important role in the formation of shock waves
during the rebounding phase of the bubble. Hickling and Plesset (1964) where the
first to suggest, from numerical calculations in Newtonian liquids, that the amplitude
of the spherical acoustic wave is inversely proportional to the distance r from the
collapse centre. As can be seen in Fig. 3.2, in the range 10–2 mm < Rmax < 1 mm,
the 1/r law of pressure attenuation through the liquid is not affected by the shear-
thinning characteristic of liquid viscosity.
Fig. 3.3 The effect of Deborah number on the dimensionless maximum velocity attained during
the first collapse, |R∗ |min = |Ṙmin |/R0 , and dimensionless minimum radius at the end of the col-
lapse, R∗ min = Rmin /R0 , for χ = λ2 /λ1 = 10–1 . The filled symbols indicate the results obtained
using the incompressible formulation, the open ones using the compressible formulation. Circles:
Newtonian liquid, diamonds: De = 10–2 , squares: De = 10–1 , triangles (): De = 1, triangles
(∇): De = 10 and hexagons: inviscid liquid. Reproduced with permission from Brujan (1999).
© Elsevier B.V.
Tsujino et al. (1988b) and Shima et al. (1988), the three-parameter, linear Oldroyd
model was employed to represent the rheological behaviour of a viscoelastic liquid
(see Example 3.4). The effect of Deborah number on the behaviour of a spherical
bubble is illustrated in Fig. 3.3, which shows the maximum dimensionless velocity
of the bubble wall plotted as a function of the minimum bubble radius, for three val-
ues of the Reynolds number Re = 10, 102 , 103 and λ2 /λ1 = 10−1 . Figure 3.4 shows
the influence of the ratio λ2 / λ1 on the maximum dimensionless velocity of the bub-
ble wall and minimum radius of the bubble, for three values of the Reynolds number
Re = 10, 102 , 103 and De = 10. It can be seen that the liquid elasticity accelerates
the bubble collapse, in agreement with the predictions of Ting (1975), Tsujino et al.
(1988b), and Agarwal (2002) while the effect of liquid viscosity and retardation
time is to decelerate the bubble collapse. These results further indicate that, under
conditions comparable to those existing during cavitation, the effect of liquid rheol-
ogy on spherical bubble dynamics is negligible for values of the Reynolds number
larger than 102 and the only significant influence is that of liquid compressibility.
The noticeable effect of liquid rheology was found only for Reynolds-values smaller
than 102 . In both situations, as in the case of a shear-thinning fluid, the 1/r law of
pressure attenuation through the liquid is not affected by the viscoelastic properties
of the liquid.
The results presented by Fogler and Goddard (1970) show that fluid elasticity
can have an important effect on bubble collapse. However, for conditions similar to
80 3 Bubble Dynamics
Fig. 3.4 The effect of ratio χ = λ2 /λ1 on the dimensionless maximum velocity attained during
the first collapse, |R∗ |min = |Ṙmin |/R0 , and dimensionless minimum radius at the end of the col-
lapse, R∗ min = Rmin /R0 , for De = 10. The filled symbols indicate the results obtained using the
incompressible formulation, the open ones using the compressible formulation. Circles: Newtonian
liquid, diamonds: χ = 10–1 , squares: χ = 10–2 , triangles χ = 0, and hexagons: inviscid liquid.
Reproduced with permission from Brujan (1999). © Elsevier B.V.
cavitation, one would not expect to be in a parameter range where differences from
Newtonian response are appreciable. In fact, when the characteristic time for bubble
collapse is in the microsecond range, as it is for cavitation, Rayleigh–Plesset inertial
solution appears to be entirely satisfactory. An analysis of surface-tension driven
oscillations of a bubble was performed by Inge and Bark (1982), who also restricted
the rheology to linear viscoelasticity. They found that the effects of elasticity are
small, and comparable to viscous effects.
We close our discussion of spherical bubble dynamics in quiescent viscoelastic
liquids with the important theoretical contribution of Ryskin (1990). By incorporat-
ing the polymer-induced stress calculated using a “yo–yo” model which accounts
for the unravelling of the polymer molecules, Ryskin computed the growth and col-
lapse phase of a vapour bubble. He concluded that the growth of the bubble is not
affected by the polymer, but the final stage of collapse is. He showed that there is
a total arrest of the collapse, with the bubble wall velocity reduced to nearly zero,
when the bubble radius becomes about 10% of the radius at the initiation of collapse.
components instead of one and, therefore, the problem cannot be reduced to a single
differential equation.
Kim (1994) solved the continuity and momentum equations in a Lagrangian
frame for the study of the free oscillations of a spherical bubble in an upper convec-
tive Maxwell liquid (see Eq. (1.49)). He implemented the Galerkin-finite element
method for solving these equations and compared some of his results with those
obtained by Fogler and Goddard (1970). The significant parameters of his study are
the Reynolds and Deborah numbers. He found that, for values of the Reynolds num-
ber smaller than 10, the fluid elasticity accelerates the collapse in the early stage of
the collapse while in the later stages it retards the collapse. Figure 3.5 shows an
example of bubble oscillation for Re = 10. He also noted that, with increasing the
values of the Deborah number, the bubble behaviour follows closely that in an ideal
liquid. The differences between a viscoelastic and an ideal liquid becomes smaller
and smaller as the Reynolds number or the Deborah number increases. Figure 3.6
illustrates this trend for the case De = 0.02 and several values of Re between 1
and 10. Similar trends were reported by Brutyan and Krapivsky (1991) who used
an Oldroyd model, and Shulman and Levitsky (1987) and Jimenez-Fernandez and
Crespo (2006) who investigated the behaviour of spherical bubbles in an Oldroyd-B
liquid and upper convective Maxwell liquid, respectively.
Fig. 3.7 Bubble dynamics in water and the corresponding pressure signal measured at a distance
of 10 mm from the laser focus for a laser pulse energy EL = 10 mJ. The first frame was taken 15
μs after the moment of optical breakdown, and the frame interval is 20 μs. Frame width 4 mm
equilibrium state, in which the internal bubble pressure equals the hydrostatic pres-
sure. The increasing difference between the hydrostatic pressure and the falling
internal bubble pressure then decelerates the expansion and brings it to a halt. At this
point, the kinetic energy of the liquid during bubble expansion has been transformed
into the potential energy of the expanded bubble. The bubble energy is related to the
radius of the bubble at its maximum expansion, Rmax , and the difference between
the hydrostatic pressure, p∞ , and the vapour pressure, pv , inside the bubble by:
4π
EB = (p∞ − pv )R3max . (3.16)
3
The expanded bubble collapses again due to the static background fluid pressure.
The collapse compresses the bubble content into a very small volume, thus gener-
ating a very high pressure that can exceed 1 GPa for an approximately spherical
bubble collapse (Vogel et al. 1989; Brujan et al. 2008). The rebound of the com-
pressed bubble interior leads to the emission of a strong pressure transient into the
surrounding liquid that can evolve into a shock wave. Even a third pressure transient
generated during second bubble collapse can be observed in this figure.
The time from optical breakdown to the first collapse is denoted by 2Tc , where
Tc is the collapse time that is proportional to the maximum bubble radius Rmax . The
Rayleigh collapse time is given by (Rayleigh 1917)
/
ρ∞
Tc = 0.915Rmax , (3.17)
p∞ − pv
where ρ ∞ is the liquid density, and was derived by Lord Rayleigh for the case of
an empty bubble without surface tension and viscosity, collapsing under a constant
pressure. It has been found that for spherical laser-produced bubbles expanding and
contracting under the action of the static ambient pressure in water under normal
conditions, the expansion phase and the contraction phase are to a high degree sym-
metrical so that the time from generation to first collapse is twice the Rayleigh
collapse time.
84 3 Bubble Dynamics
that the bubbles generated in their experiments were extremely large, with a maxi-
mum radius Rmax > 1 mm. The negligible effect of polymer additives on growth and
collapse of spherical bubbles has also been noted by Hara (1983). More recently,
Bazilevskii et al. (2003) have investigated the growth and collapse of spherical bub-
bles with maximum radii of about 0.1 mm generated in polyacryamide aqueous
solutions in concentrations of up to 0.6%. They noted that the growth phase of the
bubble is not affected by the polymer additive and, at high polymer concentration,
they also observed a slight increase of the collapse time of the bubble in comparison
to the case of water.
It is worth noting here that a direct comparison between experiments and numer-
ical results is difficult owing to the limitations in the constitutive equations used
and/or in the rheological data presented in all of the above-mentioned studies. It is
clear, however, from the experimental work, that even a strong shear-thinning com-
ponent of fluid viscosity and a high degree of elasticity of the fluid surrounding the
bubble cannot influence the collapse of spherical bubbles dramatically. The maxi-
mum radius of the bubbles generated in these experiments is larger than 10–1 mm
and the viscosity of the polymer solutions used as testing liquids is smaller than
10–2 Pa·s, so that the Reynolds number associated with the bubble motion is larger
than 102 . Obviously, the collapse of such large bubbles is dominated by inertia,
irrespective of any details of fluid rheology. It should be also noted that a signifi-
cant reduction of the maximum bubble size can be obtained by using laser pulses
of picosecond or femtosecond duration. Such a short pulse offers the possibility
to produce bubbles with a maximum radius of the order of 10–2 mm. Using such
small bubbles, it is possible to achieve small enough values of Reynolds number to
detect the influence of liquid rheology even in the case of dilute polymer solutions.
Numerical predictions in spherical bubble dynamics is possible, but there is a need
for experimental results using well-characterised liquids which can be described by
more sophisticated constitutive models than those that have been used previously.
86 3 Bubble Dynamics
2σ
p0 = P0 + . (3.18)
R
Provided that the bubble in the viscoelastic liquid is subjected to a periodically
varying pressure, the pressure p∞ far from the bubble can be expressed by
where A is the ratio of the pulsating pressure amplitude to the static pressure and f
is the frequency of the pulsating pressure.
This section presents some general characteristics of the motion of a single gas
bubble driven sinusoidally in non-Newtonian liquids.
m = 2, 3, ..., are called ultraharmonics. It is clear from this figure that the resonances
are strongly damped or even suppressed with increasing polymer concentration.
Whereas the harmonic resonances of order 2/1 and 3/1, respectively, are found in
water and in all polymer solutions, the subharmonic resonance of order 4/1 is not
found in the 1% PEO solution while the subharmonic resonance of order 1/2 is
found only in water and in the 0.5% PEO solution. For f /f0 = 0.641, the ultrahar-
monic resonance of order 3/2 was found only in water. The numerical calculations
indicated that the rheological parameter which is influential in this respect is the
infinite-shear viscosity, η∞ . The larger the value of η∞ , the smaller are the values of
the normalized bubble radius during one period of bubble oscillation leading finally
to the observed damping of the resonances. We also note that the non-linearity of the
bubble oscillation has a softening effect. The values of f /f0 at the point of primary
resonance move to the low frequency side and this value increases with the polymer
concentration. For example, the value of f /f0 at the primary resonance is 0.8 for a
0.5% PEO solution, 0.855 for a 1% PEO solution and 0.865 for a 1.5% PEO solu-
tion, respectively. It was also found that the increase of polymer concentration leads
to a reduction of the maximum pressure inside the bubble. Similar observations
have been made by Shima et al. (1985) and Tsujino et al. (1988a) who consid-
ered the bubble oscillations in a Powell–Eyring liquid and in a Carreau-like liquid,
respectively.
88 3 Bubble Dynamics
Shima et al. (1986) obtained the frequency response curves of spherical bub-
bles using a three-parameter linear Oldroyd model (see Example 3.4). They found
that the harmonic and subharmonic resonances are more easily generated in elas-
tic liquids and the normalized maximum radius, (Rmax − R0 )/R0 , increases with the
relaxation time of the liquid λ1 (Fig. 3.11). For example, for A = 0.2, η = 0.1 Pa·s
and λ2 = 10−5 s, the values of (Rmax − R0 )/R0 at the primary resonance is with
a factor of 6 larger than in the case of a Newtonian liquid. On the other hand, the
increase of the retardation time λ1 leads to a decrease of the normalized bubble
radius and to a strong damping of the resonances (Fig. 3.12). In particular, the sub-
harmonic resonance of order 1/2 and the harmonic resonances of order 3/1 and 4/1
are the most affected ones. More generally, the authors noted that for λ1 /.λ2 > 10 the
values of (Rmax − R0 )/R0 are larger than the corresponding values in a Newtonian
liquid, while for λ1 /.λ2 < 1, (Rmax − R0 )/R0 is smaller. Similar trends have been
observed for the pressure at the bubble wall.
Recently, numerical investigations on the non-linear bubble oscillations in vis-
coelastic liquids have been carried out by Allen and Roy (2000a, b), using
the linear Jeffreys model, as well as the upper convective Maxwell model, and
3.1 Spherical Bubble Dynamics 89
Fig. 3.13 Normalized bubble radius, R/R0 , versus time for a bubble oscillating in an upper con-
vective Maxwell fluid for Re = 0.63, and two values of the Deborah number, De =1 (lower values)
and De = 2. Time is denoted in acoustic periods 1/f. The initial bubble radius is R0 = 1 μm, and the
amplitude and frequency of the pressure field are A = 0.4 and f = 3 MHz, respectively. Reproduced
with permission from Jimenez-Fernandez and Crespo (2005). © Elsevier B.V.
Due to the complexity of the problem the numerical investigations on the chaotic
oscillations of spherical bubbles in non-Newtonian liquids were restricted only to
the case of purely viscous liquids (Brujan 2009b). It was shown that the chaotic
oscillations of the bubble are suppressed by the polymer additives and the infinite-
shear viscosity of the liquid is the rheological parameter with the strongest influence
in this respect. This trend is illustrated in Fig. 3.14 which shows the bifurcation dia-
grams of a bubble oscillating in water and carboxymethylcellulose (CMC) solutions
for a value of the pressure ratio A = 0.95. The rheological data of the polymer solu-
tions modelled with the Williamson relationship are listed in Table 3.2. Saddle-node
bifurcations, period-doubling cascades and strange attractors occur when the bub-
ble oscillates in water (Fig. 3.14a). When the bubble oscillates in the 0.5% CMC
solution (Fig. 3.14c) no period-doubling cascades and strange attractors are visible
in the range of f /.f0 -values investigated. Only saddle-node bifurcations are observed
in connection with the resonances R2,1 and R1,1 and the ultraharmonic resonances
R3,2 , R5,2 while the subharmonic resonance R1,2 is suppressed. As the polymer con-
centration is further increased to 1% (Fig. 3.14d), even the saddle-node bifurcations
vanish and the bubble oscillates in a stationary state with a period equal to that of
the driving field.
Examples of chaotic oscillations of a single spherical bubble situated in a vis-
coelastic liquid are given by Jimenez-Fernandez and Crespo (2005) and Naude
and Mendez (2008). They concluded that liquid elasticity may enhance the chaotic
oscillations of bubbles even at moderate values of the driving pressure field. No
influence of liquid elasticity on the number of collapses in a fixed amount of time
was observed.
3.2 Aspherical Bubble Dynamics 91
Fig. 3.14 Bifurcation diagrams of a spherical bubble situated in water and carboxymethylcellulose
(CMC) aqueous solutions. (a) water, (b) 0.2% CMC solution, (c) 0.5% CMC solution, and (d) 1%
CMC solution. The initial bubble radius is R0 = 10–2 mm and the amplitude of the oscillating
pressure field is A = 0.95. Reproduced with permission from Brujan (2009b). © S. Hirzel Verlag
Table 3.2 Rheological data of carboxymethylcellulose (CMC) aqueous solutions modelled with
the Williamson relationship
While the events during bubble generation are not influenced by the viscoelastic
properties of the fluid, the subsequent bubble dynamics is primarily influenced by
the boundary conditions in the neighbourhood of the bubble and the properties of
the fluid. A spherical bubble produced in an unconfined liquid retains its spherical
shape while oscillating and the bubble collapse takes place at the site of bubble
formation. When the bubble oscillates under asymmetric boundary conditions, it is
usually exposed to pressure gradients. This leads to a faster collapse of the bubble
section exposed to a higher pressure and to the formation of a liquid jet even for
an initially spherical bubble. When the bubble collapses in the vicinity of a rigid
boundary, the jet is directed toward the boundary (Plesset and Chapman 1971; Blake
et al. 1986; Brujan et al. 2002). The pressure gradient causing the jet formation is
92 3 Bubble Dynamics
due to the low-pressure region between bubble and rigid wall developing during
bubble collapse. During the initial collapse phase, the bubble acquires the form of
a prolate spheroid. This shape also contributes to the formation of the liquid jet.
A bubble oscillating between two parallel rigid walls is subjected to two opposite
pressure-gradient forces and the collapse is characterised by the formation of two
liquid jets that are directed toward each wall (Chahine 1982).
Of utmost interest is the case of a bubble near a rigid boundary because bubbles are
the source of cavitation erosion. The use of a normalised distance γ = s / Rmax where
s is the distance of the bubble inception from the boundary has proven advantageous
to classify bubble dynamics near a plane rigid boundary. Bubbles with different Rmax
but the same γ -value exhibit similar dynamics, thus giving the chance to specify the
degree of asymmetry of bubble collapse: cavitation bubbles with a small value of γ
are more influenced by the boundary, thus collapsing with a more pronounced shape
variation, than those with a large value for which collapse is more sphere-like. This
statement, however, does not apply to bubbles too close to the boundary, where
γ ≈ 0 and the bubble adopts a hemispherical shape, i.e. approaches a spherical
symmetry again.
Fig. 3.15 Picture sequences of the behaviour of a laser-induced bubble near a rigid wall in water
and polymer solutions for γ = 3.17. Top: water; Middle: 0.5% carboxymethylcelullose solution;
Bottom: 0.5% polyacrylamide solution. Frame interval 4.8 μs, frame width 1.7 mm. Reproduced
with permission from Brujan et al. (1996). © S. Hirzel Verlag
Whereas in the case of water the maximum jet velocity is 104 m/s, only 63 m/s was
measured for the PAM solution.
In a previous experimental study, Chahine and Fruman (1979) indicated that
although bubble growth is not sensitive to addition of 250 ppm of polyethylene
oxide to water, the collapse sequence and the shape near a rigid boundary are appre-
ciable affected. In particular, they also observed that the polymer additive introduces
a retardation effect over the initiation of the re-entering jet developed during bubble
collapse.
Fig. 3.16 Picture sequences of the behaviour of a laser-induced bubble near a rigid wall in water
and polymer solutions for γ = 1.67. Top: water; Middle: 0.5% carboxymethylcelullose solution;
Bottom: 0.5% polyacrylamide solution. Frame interval 4.8 μs, frame width 1.7mm. Reproduced
with permission from Brujan et al. (1996). © S. Hirzel Verlag
radius of the shock waves, the time interval between the emissions was calculated
as t ≈ 100 ns. The first wave (the shock wave with the larger diameter indicated by
the black arrowhead) is created by the impact of the high-speed liquid microjet onto
the rigid wall, and the second one (indicated by the white arrowheads) as a con-
sequence of the strong compression of the bubble content at its minimum volume.
The microjet-induced shock wave is, however, so weak that it is barely visible on
the photographic frames.
Since it was substantiated that the viscoelastic properties of the surrounding liq-
uid might affect the collapse of a cavitation bubble situated near a rigid boundary,
further studies have investigated the dependence of the pressure amplitude of the
acoustic transients emitted during bubble collapse with γ (Brujan et al. 2004; Brujan
2008). In these studies, two polymer solutions were investigated, namely a poly-
acrylamide (PAM) aqueous solution and a carboxymethylcellulose (CMC) aqueous
solution, both in a concentration of 0.5%. The extensional properties, in the form of
an apparent Trouton ratio (Tr = ηe /η), for both polymer solutions were measured
in uniaxial extension using a Rheometric RFX opposed-jet apparatus with 1 mm
diameter nozzles. The general behaviour of the PAM solution is that it is extension
3.2 Aspherical Bubble Dynamics 95
Fig. 3.17 A high-speed photographic sequence in side view showing the propagation of the shock
waves emitted upon the collapse of a cavitation bubble attached to rigid boundary. The shock wave
indicated by the black arrowhead is generated at the impact of the liquid jet developed in an earlier
stage of bubble collapse onto the rigid wall. The shock wave indicated by the white arrowheads is
generated at the minimum bubble volume. The rigid boundary is located in the right-hand side of
each frame. Sequence taken with 200 million frames/s and an exposure time of 5 ns. Reproduced
with permission from Brujan et al. (2008). © Elsevier B.V.
rate thickening, which is a general characteristic for flexible polymers. The apparent
Trouton ratio for the PAM solution was initially at a value of Tr ≈ 4.5 at low exten-
sion rates and then it increased to attain a maximum of Tr ≈ 70 at extension rates
of ε̇ ≈ 4, 000 s–1 , indicating a strong elastic component. The apparent Trouton ratio
for the CMC solution was relatively constant at a value of about 5 for all the exten-
sion rates investigated, indicating a relatively less elastic behaviour of the polymer
solution.
Figure 3.18 shows the amplitude of the acoustic transients emitted during first
bubble collapse, pmax , as a function of γ in water and both polymer solutions. It can
be seen that the largest values of the maximum amplitude of the acoustic transients
are obtained in water. For the relatively less elastic 0.5% CMC solution, the bubble
dynamics do not differ substantially from that in water and the maximum amplitude
of the acoustic transients emitted during bubble collapse is almost similar to that in
water. For the elastic 0.5% PAM solution, however, a significant reduction of pmax
was observed. We further note that the most pronounced reduction of the shock
pressure in the PAM solution was observed for γ < 0.6 and γ > 1.5. Figure 3.19
shows that the velocity of the liquid jet developed during the final stage of bubble
collapse range from about 10 m/s up to 50 m/s. Furthermore, the jet velocity shows a
dependence on γ similar to the pressure amplitude of the acoustic transients emitted
during bubble collapse: There is a minimum for values γ ≈ 1 and the jet velocity
decreases with increasing the extensional viscosity of the liquid.
The effect of the viscoelastic properties of the liquid on the sound emission dur-
ing first bubble collapse can be understood in a heuristic manner. A spherical bubble
generated in a liquid of infinite extent retains its spherical shape while oscillating.
When the bubble is formed near a rigid boundary, the collapse is associated with the
formation of a high-speed liquid jet directed towards the boundary. However, exam-
ination of the high-speed photographic sequences shows that the bubble remains
near spherical for much of its collapse period (between 90 and 95% depending on
γ ), only developing significant non-sphericity at the end of the pulsation. The flow
is thus predominantly uniaxial in extension during most of the collapse and the vis-
cosity of both polymer solutions is significantly larger than that of water. Therefore,
a large part of the maximum potential energy of the bubble is dissipated during the
collapse phase due to an increased resistance to extensional flow which is conferred
upon the surrounding liquid by the polymer additive. Consequently, less energy is
available for bubble collapse, the bubble content becomes less compressed than in
the case of water, and the pressure amplitude of the shock wave is diminished. For
large γ -values, the retarding effect of the rigid boundary on the fluid during collapse
is small. Therefore, the bubble remains nearly spherical and the liquid jet develops
only in a very late stage of the collapse. For γ < 0.6, the bubble is nearly hemispher-
ical and the flow is directed towards the bubble center for most parts of the bubble
3.2 Aspherical Bubble Dynamics 97
surface, as in the case of a spherical collapse. In both cases, the bubble assumes
spherical symmetry for most of the collapse, thus the fluid elements experience a
strong uniaxial extensional flow and therefore the energy dissipation during bub-
ble collapse is the largest. The explanation for the significant reduction of the jet
velocity is similar as for the acoustic transients emitted during bubble collapse. The
presence of the polymer additive confers on the solution an ability to sustain higher
extensional stresses than its Newtonian counterpart. This enhanced resistance to
extensional deformation reduces the intensity of the re-entrant liquid jet developed
during bubble collapse. For γ < 0.6 and γ > 1.5, where the spherical symmetry is
preserved during most of bubble collapse, the extensional flow becomes dominant
and the reduction of the jet velocity is the largest.
Cheny and Walters (1999) have also reported studies of the role of fluid vis-
coelasticity in the development of liquid jets. In their work, the addition of small
amounts of polyacrylamide to a Newtonian solvent was found to lead to an order-
of-magnitude reduction in the length of the ascending vertical jet formed when
a sphere is dropped into a reservoir of liquid. By analysing the evolution of the
shape of these jets, Cheny and Walters concluded that the deformation of the fluid
involved substantial elongation. While it is clearly important to bear in mind the dif-
ferent circumstances involved in the work described by Cheny and Walters and that
described herein, the role played by elongation during the evolution of the jets in
these different experiments is noteworthy, particularly in the case of non-Newtonian
fluids.
The development of computer codes that would permit the calculation of bubble
collapse in a viscoelastic fluid and near a rigid boundary has been slow. Owing to
the difficulties involved in implementing both moving boundaries and viscoelastic-
ity, resolution has not been possible anywhere near the experimentally attainable
limit, even with present-day computers. Numerical simulations could contribute to
a better understanding of the dynamics by providing pressure contours and velocity
vectors in the liquid surrounding the bubble which are not easily accessible through
experiments.
When a bubble is initiated between two parallel rigid walls an annular flow is devel-
oped during bubble collapse. For a sufficiently small distance between the walls,
the annular flow leads to bubble splitting and the formation of two opposing liquid
jets directed towards each wall (Chahine 1982). On the other hand, for a sufficiently
large distance between the walls the bubble achieves a prolate shape during collapse
leading to the formation of two high-speed liquid jets of equal velocity directed
towards the bubble centre (Brujan et al. 2005). Chahine and Morine (1980) con-
ducted several tests using bubbles generated in water, and 125 and 250 ppm of
polyethylene oxide, respectively. They found that, although the growth phase of
the bubble is unaffected by the polymer additive, the lengthening effect on the oscil-
lation period of the bubble is significantly reduced in the case of polymer solutions
and the departure from sphericity of the bubbles is considerably delayed. No results
were presented by these authors with respect to the influence of polymer additive on
the velocity of the liquid jets formed after bubble splitting.
Virtually all of the previous observations and analyses have focussed on bubble
collapse in a quiescent liquid, despite the fact that a number of experimenters have
commented on the deformation of cavitation bubbles by the flow (see, for example,
Blake et al. 1977). Some of the early observations of individual travelling cavitation
bubbles by Knapp and Hollander (1948) make mention of the deformation of the
bubbles by the flow.
A detailed investigation of the effect of a controlled shear flow on the deformation
of laser-generated bubbles was conducted by Kezios and Schowalter (1986) using
polyacrylamide (PAM) and polyethylene oxide (PEO) solutions in concentrations of
up to 2,000 ppm. The main purpose of their work was to understand the role played
by a pre-existing stress field at the moment when cavitation bubbles are generated.
They demonstrated that the departure from sphericity is significantly reduced in
polymer solutions, in particular in the highly elastic PAM solutions. They also noted
that increasing the concentration beyond a critical value reverses the results and they
3.2 Aspherical Bubble Dynamics 99
speculated that this can be caused by the relative increase of the solution viscosity
as compared to its elasticity.
Ligneul (1987) also performed experiments with spark-generated bubbles in the
shear layer developed by a rotating cylinder. By comparing the behaviour in water
and solutions of polyethylene oxide with 50 and 250 ppm concentration, he con-
cluded that the influence of the polymer additive is to maintain sphericity during
bubble collapse. The effect of viscoelasticity on cavitation characteristics in flow
between eccentric cylinders in relative rotation has been reported by Ashrafi et al.
(2001) who found that for low speeds of rotation, the liquid’s free surface departed
progressively from the initial horizontal (rest) configuration. With further increase in
rotational speed, a provocative fingering mechanism appeared, generating a series of
cavities, the number of which increased with rotational speed and eccentricity. The
elastic liquids were found to generate more cells than their Newtonian equivalents,
the shape of the cavities exhibiting distinctive cusp-like extremities. In this study,
fluid elasticity was found to promote cavitation.
Not only properties of the liquid surrounding the bubble and distance to the bound-
ary, but also the elastic properties of the nearby boundary material strongly influence
bubble dynamics. Gibson (1968) observed 40 years ago that under certain conditions
the liquid jet formed during bubble collapse near an elastic boundary as well as the
bubble migration are both directed away from the boundary. Since jet impact and the
high pressures developed during bubble collapse near a rigid boundary were known
as majors factors causing cavitation erosion, the use of compliant boundaries was
considered as a means of preventing erosion. This conclusion was also supported by
Gibson and Blake (1982) who examined the behaviour of spark-generated bubbles
in the vicinity of rigid boundaries with rubber coatings. Blake and Gibson (1987)
observed that, for some range of coating properties, no re-entrant jet towards or
away from the boundary is developed during bubble collapse. In this case, the bub-
ble collapses from the sides forming an hour-glass shape which can eventually lead
to bubble splitting. Similar observations were made by Shima et al. (1989), Duncan
and Zhang (1991), Duncan et al. (1996), Shaw et al. (1999), and Kodama and Tomita
(2000).
102 3 Bubble Dynamics
Fig. 3.23 Interaction of a laser-produced bubble with an elastic boundary with elastic modulus
E = 0.25 MPa for γ = 1.14. The boundary is located at the top of each frame. A liquid jet
directed away from the boundary develops during bubble collapse. Frame interval 20 μs, frame
width 3.5 mm. Reproduced with permission from Brujan et al. (2001a). © Cambridge University
Press
Fig. 3.24 Interaction of a laser-produced bubble with an elastic boundary with elastic modulus
E = 0.25 MPa for γ = 0.62. The boundary is located at the top of each frame. The elastic boundary
is compressed during bubble expansion and elevated during bubble collapse. The collapse results in
bubble splitting with the formation of two liquid jets in opposite directions. The liquid jet directed
towards the boundary penetrates the elastic boundary. Frame interval 20 μs, frame width 3.5 mm.
Reproduced with permission from Brujan et al. (2001a). © Cambridge University Press
Fig. 3.25 Interaction of a laser-produced bubble with an elastic boundary with elastic modulus
E = 0.25 MPa for γ = 0.04. The boundary is located at the top of each frame. Strong jet-like
ejection of boundary material and suppression of liquid jet penetration into the boundary are the
main features of the interaction. Frame interval 20 μs, frame width 3.5 mm. Reproduced with
permission from Brujan et al. (2001a). © Cambridge University Press
the collapse of the oblate bubble then results in an annular jet, bubble splitting,
and the formation of two axial jets in opposite direction. When the opposing forces
are not equally strong, the bubble splits into unequal parts, and the jet originating
from the larger bubble part is stronger than the other jet in opposite direction. In the
limit, however, where one force is much stronger than the other, only one axial jet is
formed. For large γ -values, only an axial jet flow directed away from the boundary
104 3 Bubble Dynamics
Fig. 3.26 Jetting behaviour of bubbles near polyacrylamide samples with different water content
and elastic modulus, respectively: 95% ↔ 0.017 MPa, 85% ↔ 0.124 MPa, 80% ↔ 0.25 MPa, 70%
↔ 0.4 MPa, 60% ↔ 1.04 MPa, 50% ↔ 2.03 MPa. Symbols: , no jet formation; , liquid jet away
from the boundary; ∇, liquid jet towards the boundary; ♦, liquid jets away from and towards the
boundary; , liquid jets away from and towards the boundary, with jet penetration into the PAA
sample; , liquid jets away from and towards the boundary, and jet-like ejection of PAA material;
, liquid jets away and towards the boundary, with liquid jet penetration into the boundary and jet-
like ejection of PAA material; , liquid jet away from the boundary and jet-like ejection of PAA
into the liquid. The dashed line surrounds the bubble splitting region, and the dotted line denotes
the state where the “centre of gravity” of the two-bubble system does not migrate. Reproduced
with permission from Brujan et al. (2001b). © Cambridge University Press
was observed (Fig. 3.23). This is because the flow induced by the rebounding PAA
sample is stronger than the Bjerknes attractive force caused by the low pressure
between bubble and boundary. With decreasing γ -value, the strength of the Bjerknes
force increases faster than the flow from the boundary. The highest jet velocity is
achieved for γ -values around γ = 0.6, where an asymmetric annular jet leads to
the formation of a strong axial jet towards the elastic boundary. Photographic series
taken with 5 million frames/s yielded a peak velocity for the jet directed towards
the boundary as high as 960 m/s. This value is ten times higher than the jet velocity
reached near a rigid boundary at a similar γ -value (Brujan et al. 2001b).
Figure 3.26 gives an overview of the jetting behaviour as a function of the elastic
modulus of the boundary E and the normalized bubble-boundary distance γ (Brujan
et al. 2001b). In the region between 85 and 70% water content, corresponding to an
elastic modulus of 0.12 MPa < E < 0.4 MPa, the elastic response of the deformed
boundary is particularly strong. The rebound of the boundary after its deforma-
tion during bubble expansion leads to the formation of a jet flow directed away
from the boundary – either as a unidirectional jet or as one component of a pair
of jets flowing in opposite directions. An unidirectional liquid jet directed away
3.3 Bubbles Near an Elastic Boundary 105
Fig. 3.27 Jet velocity for bubbles collapsing near polyacrylamide samples with different water
content and elastic modulus (95% ↔ 0.017 MPa, 85% ↔ 0.124 MPa, 80% ↔ 0.25 MPa, 70% ↔
0.4 MPa, 60% ↔ 1.04 MPa, 50% ↔ 2.03 MPa) and dimensionless bubble-boundary distance γ
for jets flowing towards the elastic boundary. The jet velocity is mediated over 1 μs. Reproduced
with permission from Brujan et al. (2001b). © Cambridge University Press
from the boundary is only observed for very large and very small γ -values. In the
intermediate γ -range, bubble splitting occurs and, besides the jet away from the
boundary, a fast jet directed towards the boundary is formed. A characteristic fea-
ture of the bubble-splitting-region is the extremely high velocity of the jet directed
towards the boundary (Fig. 3.27). The high jet velocity results in a penetration of the
PAA samples with water content between 70 and 85%. With larger elastic modulus
(E = 2.03 MPa, at 50% water content), the bubble dynamics starts to resemble the
behaviour near a rigid wall: the PAA is so stiff that the jet is always directed towards
the boundary. With a smaller elastic modulus (E = 0.017 MPa, at 95% water con-
tent), the behaviour becomes more similar to the dynamics in an infinite liquid. The
elastic response of the boundary is, however, still strong enough to cause formation
of a liquid jet directed away from the boundary.
Using sophisticated numerical calculations Klaseboer and Khoo (2004), Pei et al.
(2005), Klaseboer et al. (2006), and Turangan et al. (2006) were able to simulate
many of the dynamical features of bubble oscillations near elastic boundaries. This
includes formation of the annular flow, bubble splitting, and the generation of the
liquid jets flowing in opposite direction. An example is shown in Fig. 3.28 for the
case of a bubble oscillating near an elastic material with an elastic modulus E =
0.405 MPa when the relative distance between bubble and boundary is γ = 0.88.
Very recently, Miao and Gracewski (2008) investigated numerically the interac-
tion of cavitation bubbles with elastic boundaries by combining finite element and
boundary element codes. The interesting result of their work is the characteriza-
tion of the bubble behaviour situated in an elastic tube and in a sound-irradiated
106 3 Bubble Dynamics
Fig. 3.28 Numerical simulation of the behaviour of a cavitation bubble situated near an elastic
interface for γ = 0.88 and E = 0.405 MPa. The dimensionless times are 0.00, 0.773 (largest defor-
mation of the interface), 0.973 (near maximum bubble volume), 1.594, 1.809, 1.889, 1.916 (bubble
splits up), and 1.920 (downward jet developing in lowest bubble). Reproduced with permission
from Klaseboer and Khoo (2004). © American Institute of Physics
liquid. Figure 3.29 illustrates an example of the bubble and tube shapes when they
are exposed to an ultrasound frequency of 1 MHz and an ultrasound pressure of
0.2 MPa. This situation is very similar to that encountered in the medical applica-
tion of ultrasound contrast agents (see Chap. 6). The authors found that the presence
of the tube inhibits bubble expansion and the maximum equivalent bubble radius
Fig. 3.29 The behaviour of a bubble situated in an elastic tube and in an ultrasonically irradiated
liquid. Bubble and tube shapes and hoop stress distribution within the tube wall are illustrated at a
series of time points. The inner tube radius is 4 μm, the elastic modulus of the tube is 10 MPa, and
the initial bubble radius is 1 μm. Reproduced with permission from Miao and Gracewski (2008).
© Springer Science + Business Media
3.4 Bubbles in Tissue Phantoms 107
decreases with decreasing the tube radius. The maximum hoop stress in the tube
occurs at the inner tube surface, well before the bubble reaches the maximum radius.
During the initial collapse stage the bubble takes an elongated shape in a direction
perpendicular to the tube axis that leads to the formation of a radial jet in the final
collapse stage.
An important issue that has only recently received attention is the influence of the
mechanical properties of biological tissue on the stress wave and cavitation dynam-
ics following pulsed laser ablation and optical breakdown. Jansen et al. (1996),
Asshauer et al. (1997), and Delacretaz and Walsh (1997) presented first studies on
holmium-laser-induced bubble formation in more realistic tissue phantoms. Vogel
et al. (1999) compared the optical breakdown dynamics in water and real tissue.
They observed that the optical breakdown in corneal tissue is accompanied by a
strong tensile stress wave which is absent in water. Moreover, the bubble expansion
phase is shortened and the stress wave originating from the bubble collapse in water
is missing.
In a very recent study, Brujan and Vogel (2006) investigated the dynamics of
laser-induced cavitation bubbles in tissue phantoms consisting of transparent gels
of polyacryalmide (PAA) with a water content of 95, 85, 80 and 70%, respectively.
The measured values of the elastic modulus, E, density, ρ, sound velocity, c0 , and
yield strength, Y0 , of the polyacrylamide samples are shown in Table 3.3.
Figure 3.30 shows a collection of high-speed photographic records of the bub-
ble dynamics and the corresponding hydrophone signals for a value of the laser
pulse energy EL ≈ 1 mJ. The hydrophone signals were recorded simultaneously
with the documented image series. With increasing elastic modulus of the samples,
both maximum size and oscillation period of the bubble decrease. For the PAA
sample with 70% water content (Fig. 3.30d), the bubble dynamics is characterized
by a strongly damped behaviour where no pronounced collapse and rebound are
observed after bubble expansion. The largest pressure transient is produced during
optical breakdown. This transient is followed by a weaker pressure transient associ-
ated with the first bubble collapse. In the case of water, the second transient is almost
as high as the first one. In contrast, for the PAA sample with 70% water content, the
pressure signal is characterized by the absence of a transient emitted during bubble
collapse, which is a consequence of strong damping of the bubble oscillation.
Table 3.3 Values of the elastic modulus E, plastic yield strength at large strain rates Y0 , density
ρ, and sound velocity c0 of the PAA samples at 20◦ C and ambient pressure
Sample Water PAA-95% water PAA-85% water PAA-80% water PAA-70% water
Fig. 3.30 Cavitation bubble dynamics in water and polyacrylamide samples with different water
content c, and the corresponding pressure signal measured at a distance of 10 mm from the laser
focus. The laser pulse energy was about 1 mJ. (a) Water, EL = 0.93 mJ; (b) c = 95%, EL =
1.36 mJ; (c) c = 80%, EL = 1.24 mJ; (d) c = 70%, EL = 1.05 mJ. The first frame was taken 15
μs after the moment of optical breakdown, and the frame interval is 20 μs. Frame width 4 mm.
Reproduced with permission from Brujan and Vogel (2006). © Cambridge University Press
At equal laser pulse energy, the maximum radius of the cavitation bubble
decreases with decreasing water content of the sample, i.e. with increasing elas-
tic modulus (Fig. 3.31). The scaling law for the bubble size in the PAA samples is
the same as that for water, namely, the maximum bubble radius is proportional to
the cube root of the laser pulse energy. This scaling law applies, however, only to
laser pulse energies larger than 2 mJ, well above the breakdown threshold.
The damping of the bubble oscillation in PAA samples results in a reduction of
the amplitude of the stress transient emitted upon bubble collapse. The amplitude
reduction is shown in Fig. 3.32 where the amplitude of the transient emitted during
the first bubble collapse is plotted as a function of the laser pulse energy. In water
and PAA sample with 95% water content, the measured values are fitted by a curve
3.4 Bubbles in Tissue Phantoms 109
(pc − p0 ) = aELb , with a = 1 and b = 0.38 for water, and a = 0.73 and b = 0.4 for the
PAA sample with 95% water content. For the PAA sample with 80% water content,
the energy dependence is quite different. Here, the measured values are fitted by a
curve (pc − p0 ) = a(EL − EL,c )b , with a = 0.61, b = 0.34, and EL,c = 1.01 mJ.
The fit parameter EL,c can be interpreted as a critical value of the laser pulse energy
which determines the behaviour of the bubble: strongly damped behaviour occurs if
EL ≤ EL,c , and damped oscillatory behaviour if EL > EL,c .
110 3 Bubble Dynamics
∞
2σ τrr − −τθθ
pi − p∞ − = −2 dr. (3.20)
R r
R
One can now chose a constitutive equation to characterize the material, substi-
tute it into the integral in Eq. (3.20), measure pi and R and determine rheological
parameters appearing on the right-hand side of (3.20). Because the stress cannot be
measured at the bubble wall, one must accept an integrated result, and hence a con-
stitutive assumption must be invoked over the range of integration of the right-hand
side of Eq. (3.20). In comparing experiment and theory, Pearson and Middleman
(1977a, b) found it expedient to define an apparent extensional viscosity
3R pi − p∞ − 2σ
R
ηE,app = , (3.21)
4Ṙ
and they found from experiments on bubble collapse in dilute polymer solutions that
good agreement was obtained between Eq. (3.21) and the results predicted for exten-
sional viscosity by the Tanner rupture model and a corrotational Maxwell model
(Schowalter 1978). However, stretch rates were below 10 s–1 .
In a subsequent paper, Papanastasiou et al. (1984) developed a robust numeri-
cal scheme that is compatible with a KBKZ constitutive equation. The equation of
motion was solved by a Galerkin weighted-residual method using a finite element
solution. Inertia was also neglected in their calculations. They checked the numeri-
cal results by evaluating rheological parameters from the measurements of Pearson
and Middleman of shear and normal stress differences for a hydroxypropylcellu-
lose solution. With these data they predicted the extensional behaviour shown in
Fig. 3.33. Although the deformation rates, ε̇ = 2Ṙ/R, are rather small, the good
3.5 Estimation of Extensional Viscosity 111
dL 1
ε̇ = , (3.22)
dt L(t)
where dL/dt is the velocity of extenson with reference to the tip of the jet and L(t) is
the instantaneous length of the jet, and an uniaxial extensional viscosity as
σE
ηE = , (3.23)
ε̇
where σ E is the tensile stress in the liquid. To determine the average value of the
tensile stress, σ E , developed in the jet, they estimating the tensile force from a
knowledge of the liquid mass which replaces the annihilated volume of the gas
bubble (based on its maximum diameter prior to collapse) and the subsequent
deceleration of this mass of liquid (which forms the jet) during the jet’s extension.
From a knowledge of the jet’s diameter, this force provides an estimate of the
average tensile stress, σE , sustained by the liquid during its residence within the
extensional flow, the latter being characterized by an average value of the rate of
112 3 Bubble Dynamics
Fig. 3.34 Calculated values of the extensional viscosity, ηE , (normalized by the shear viscosity, η)
for a Newtonian glycerol/water mixture and solutions of xantham gum. The broken line indicates
the case of a Newtonian liquid (for which the Trouton number has the value 3). Reproduced with
permission from Barrow et al. (2004a). © American Society of Mechanical Engineers
extension, ε̇. The dominant feature in the jet dynamics is the high rate of exten-
sion, of the order of 103 s–1 , that characterize the jet flow. They investigated the
extensional viscosity for a Newtonian glycerol/water mixture and solutions of xan-
than gum in a maximum concentration of 50 ppm. The polymer solutions showed
enhanced levels of resistance to extension, with values of ηE two orders of mag-
nitude larger that the Newtonian counterpart (Fig. 3.34). A notable result of their
investigations is the finding that the technique is sensitive to the influence of
extremely small concentrations of high molecular weight polymeric additive (as
low as 5 ppm for xanthan gum).
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Chapter 4
Hydrodynamic Cavitation
where p is the modified pressure drop over a length L of the tube, D is the tube
diameter, and v is the average velocity over the cross section of the tube. The friction
factor is essentially a dimensionless pressure gradient, and it is a function only of
the Reynolds number Re = ρvD/η for fully developed flow of Newtonian fluids.
At the very tiny polymer concentrations of interest in drag reduction, the viscos-
ity and density of the polymer solution differ only slightly from those of the pure
4.1 Non-cavitating Flows 119
solvent. Nonetheless, the effect of the polymer additive is to lower the value of the
friction factor at a given Reynolds number, especially in the turbulent region. The
amount by which the friction factor is lowered is a measure of the amount of drag
reduction. Figure 4.1 shows the friction factor for water with and without a small
amount of polyethylene oxide. Whereas the addition of only 5 ppm of polyethylene
oxide to water gives a 40% reduction in f at Re = 105 , the viscosity of the solution
is only 1% greater than the viscosity of the water alone.
The mechanisms of polymer drag reduction in turbulent flows have been under
investigation for several decades. In spite of the large amount of observational
data available, the physical mechanism of drag reduction by polymers still remains
unclear.
Den Toonder (1995) and den Toonder et al. (1995) discussed the role of exten-
sional viscosity in the mechanism of drag reduction by polymer additives. The aim
of this paper was to test a hypothesis introduced by Lumley (1969), who was the first
to suggest that the molecular extension of polymers is responsible for drag reduc-
tion. Lumley argued that this extension will take place in the flow outside the viscous
sublayer, causing an increase in effective viscosity there. Using general scaling argu-
ments, Lumley showed that then a reduction in overall drag will occur. Den Toonder
et al. (1995) presented the results of a direct numerical simulation with a simplified
polymer extension criterion to increase the viscosity locally. It was found that a mere
increase in effective viscosity outside the viscous sublayer is in itself not enough to
Fig. 4.1 Friction factor for dilute aqueous solutions of polyethylene oxide. In the turbulent regime,
the curves for the polymer solutions lie below that of the solvent and illustrate drag reduction.
Reproduced with permission from Wang (1972). © American Chemical Society
120 4 Hydrodynamic Cavitation
of the polymer with turbulent flow is still the object of study, but this phenomeno-
logical description is consistent with experimental observations of drag reduction,
including the recent work of Warholic et al. (1999), and White et al. (2004).
Consider the flow through an orifice as illustrated in Fig. 4.2. Where the streamlines
converge in approaching the orifice, they continue to converge beyond the upstream
section of the orifice until they reach the section ab where they become parallel.
Commonly this section is about 0.5d from the upstream edge of the opening, where
d is the diameter of the orifice. The section ab is then a section of minimum area
and is called the vena contracta. Jet velocity is defined as the average velocity at
the vena contracta. The velocity at this section is practically constant across the sec-
tion except for a small annular region around the outside. The pressure is practically
constant across the diameter of the jet wherever the streamlines are parallel, and
the pressure must be equal to that in the medium surrounding the jet at that sec-
tion. The increased velocity in the vena contracta is accompanied by a reduction in
pressure. Beyond the vena contracta the streamlines commonly diverge because of
frictional effects. In this region the velocity is transformed back into pressure with
slight friction loss.
An essential characteristic of flows through an orifice is the pressure drop result-
ing from a sudden change in diameter. A significant reduction of the pressure drop
was observed when small amounts of polymers have been added to water. Figure 4.3
illustrates the dimensionless pressure drop
2pt
Kt = , (4.2)
ρv2
Fig. 4.3 Dimensionless pressure drop Kt against Reynolds number Re for orifices. The data con-
tain both the forward (front → back) and backward (back → front) flow results. The orifice was
pasted over a hole of 1 or 3 mm in diameter, D, drilled in a base plate of length L and, thus,
the forward and backward flows are not identical. Solid line shows the prediction of the Navier–
Stokes equation, and a broken line is the line of Poiseuille flow. Reproduced with permission from
Hasegawa et al. (2009). © American Institute of Physics
4.2 Cavitating Flows 123
against Reynolds number, Re = ρvD/η, where pt is the pressure drop across
the orifice, ρ is the liquid density, η is the liquid viscosity, and v is the liquid mean
velocity, for the case of water, a 50/50 mixture of glycerol and water with a viscosity
of 10–2 Pa·s, and a viscoelastic polyethylene oxide (PEO) solution with a viscosity
similar to that of water. The solution of PEO produced a lower pressure drop than
water and the glycerol/water mixture. Hasegawa et al. (2009) considered the effect
of several factors, including orifice shape, deformation of orifice foil, wall slip, tran-
sition, and liquid elasticity but they results suggest that the significant reduction in
pressure drop may be caused by wall slip or the elasticity induced in a flow of high
extensional rate.
A relative flow between an immersed object and the surrounding liquid results in
a variation in pressure at a point on the object and the pressure p0 in the undis-
turbed liquid at some distance from the object, which is proportional to the square
of the relative velocity, v0 . This can be written as the negative of the usual pressure
coefficient Cp , namely,
p0 − p
−Cp = , (4.3)
ρv20 /2
p0 − pmin
(−Cp )min = . (4.4)
ρv20 /2
p0 − pmin
σ = . (4.5)
ρv20 /2
This relationship has been universally adopted as the parameter for comparison
of cavitation events. However, the presence of gas nuclei, boundary layers, and tur-
bulence will modify and often mask a departure of the critical pressure for cavitation
occurrence from pv . The cavitation number assumes a definite value at each stage
of development of cavitation on a particular body. For inception, σ = σi , while for
advanced stages of cavitation, σ < σi . The cavitation inception number, σi , and the
values of σ at subsequent stages of cavitation depend primarily on the geometry of
the immersed object past which the liquid flows.
It should be noted here that, depending on the way the experiments are performed
– either by decreasing the pressure from a non-cavitating situation until cavita-
tion is reached or by increasing the pressure from a cavitating situation until the
non-cavitating condition is achieved – the inception, σi , or desinent, σd , cavitation
numbers are obtained. The conditions that mark the boundary between no cavitation
and detectable cavitation are not always identical. For example, the pressure of dis-
appearance of cavitation has been generally found to be greater, and less variable,
than the pressure of appearance (Knapp et al. 1970).
The most complex factor contributing to the cavitation inception and develop-
ment is the bubble dynamics, which is closely associated with the size, distribution
and content of nuclei in a fluid. Based upon the assumption that the total gas con-
tent is composed of its dissolved and undissolved (free) components (Holl 1970;
Rood 1991), the latter can act as cavitation nuclei, while the dissolved gas content
affects the number, size and growth of the nuclei. Therefore, both forms of gas con-
tent play important roles in the development of cavitation bubbles in terms of the
number, size and distribution of these bubbles. These parameters influence the pres-
sure field of the flow and hence the inception of cavitation. The effect of the gas
content on cavitation inception has been investigated by many investigators (see, for
example, Holl 1960; Kuiper 1981; Arndt and Keller 1991). Tanibayashi et al. (1998)
have indicated that the inception number of cavitation of a cylinder decreases with
decreasing dissolved gas content. In a recent paper, Keller (2000) has demonstrated
the effect of water quality on two-dimensional hydrofoils and head forms.
The effect of the free-stream turbulence on the inception of cavitation has been
realized by several investigators during tests with various bodies and its importance
has been reported in a limited number of papers. A high turbulence level is known to
cause early transition of the boundary layer, which, in turn, can lead to the complete
elimination of the laminar separation. Arndt and George (1979) showed that the
viscous effects associated with the laminar separation and transition of the bound-
ary layer had a major effect on the inception of cavitation. The level of turbulence is
expected to influence the inception of cavitation when the turbulence level can cause
significant change in transition and laminar separation (Huang 1986). Keller (1979)
indicated that the level of free-stream turbulence could be responsible for variations
in the inception results of identical bodies tested in different facilities. Gates and
Acosta (1979) analysed the results of experiments on an ellipsoidal head form and
drew attention to the differences in the measured inception values, which could be
as high as 300% for the same body tested in different tunnels. Gates and Acosta
(1979) also related the differences to the variations in the levels of turbulence and
126 4 Hydrodynamic Cavitation
2 (pr − pv )
σ = , (4.6)
ρv2j
4.2 Cavitating Flows 127
where pr is the pressure in the tank where the jet is discharging and vj is the
mean velocity of the jet. At the largest concentration, the polymer solution shows
an increase of the infinite shear viscosity of about 25% as compared to that of
water and a reduction of the surface tension with about 10%. His results indicate
a sharp decrease of the incipient cavitation number when the concentration of the
polymer solutions was increased up to 10 ppm; afterwards the reduction was not
as rapid.
Baker et al. (1976) obtained the desinent cavitation number, σd , instead of the
inception cavitation number, σi , as in the case of Hoyt. Data were obtained for
confined water jets generated by a 50.8 mm diameter sharp-edged orifice and a
contoured nozzle of the same diameter. Data were acquired over a range of total
air content from 2.0 to 12.0 ppm in water and a polyethylene oxide (WSR-301)
aqueous solution in concentration of 100 ppm. The jet velocity was kept constant at
9.1 m/s resulting in a Reynolds number of 6×105 , larger than in the case of Hoyt
experiments. Both in water and polymer solution the desinent cavitation number
increases with the total gas content. The polymer caused a reduction in the desinent
cavitation number and the reduction increased with air content. For example, for
a total gas content of 10 ppm, the desinent cavitation number is about 1.1 in the
case of water and about 0.8 in the case of a 100 ppm polyethylene oxide aqueous
solution. However, below an air content of 4.0 ppm, the desinent cavitation number
was apparently independent of air content. The differences in cavitation behaviour
between Baker et al. (1976) and Hoyt (1976) results may be due to the larger size
of the orifice, by near a factor of 10, the reduction of the jet velocity, by a factor
of three, and the choice of desinent instead of the incipient cavitation number as
a reference. In the case of pure water, an increase of the gas content resulted in a
strong decrease of σd , especially for supersaturated conditions.
Arndt et al. (1981) suggested an alternative explanation of the differences
between Baker et al. (1976) and Hoyt (1976) results based on the difference in the
hydrodynamic behaviour of jets depending on the values of the Reynolds number.
His analysis is based on the fact that, for equal Reynolds number, the order of mag-
nitude of the strain rate in the contraction of small nozzles will be larger than for the
large nozzles. This effect is expected to lead to a significant viscoelastic influence
on the pressure field which can explain the inhibition of cavitation.
Oba et al. (1978) investigated the effect of polymer additives on cavitation in
water flow through an orifice. Polyethylene oxide with a molecular weight 3×106
in concentration of up to 100 pmm was used as a test fluid. The rheological prop-
erties of the polymer solution are, however, not provided but it is well known that
dilute solutions of flexible polymers, such as polyacrylamide or polyethylene oxide,
exhibit very high values of the extensional viscosity. The orifice, with a diame-
ter, d, of 8 mm, was mounted in a pipe with an inner diameter, D, of 20 mm so
that the area ratio, d2 /D2 , is 0.16. The cavitation number in their experiment was
defined as
2 (pds − pv )
σ = , (4.7)
ρv2t
128 4 Hydrodynamic Cavitation
where pds is the pressure 25.4 mm downstream from the orifice, and vt is the mean
throat velocity. The ranges in test conditions were 137–142 kPa for the upstream
pressure, 2 × 104 – 2.6 × 104 for the Reynolds number upstream the orifice, and
7–12◦ C for the fluid temperature. The relative air content α/αs , where α is the
total gas content and α s the saturated gas content, was measured before each test
and varied over a range of 1.1–1.16. During each test the polymer degradation
was negligible since the testing time was less than 10 min. They results indi-
cate that very small amounts of polymer additives effectively suppress both the
inception and the development of cavitation (Fig. 4.4). Near inception, cavitation
bubbles were observed along the jet boundary 1D–2D downstream the orifice. With
a decrease in the occurrence zone of cavitation, bubbles gradually approach the
orifice, and the bubbles increase in size as well as in number. In any polymer solu-
tion tested, cavitation bubbles consist of non-spherical bubbles, such as irregular
surface-, string-, as well as massive bubbles, and fine spherical bubbles. The occur-
rence of the fine spherical-, the irregular spherical as well as the string bubbles are
strongly suppressed by the polymer additives.
Oba et al. (1978) also investigated the influence of polymer additives on cavita-
tion noise. They used a PZT probe fixed 40 mm downstream of the orifice where the
maximum shock pressure was observed. Their results are illustrated in Fig. 4.5 for
σ = 0.38. A relatively small amount of polymer (10 ppm) results in a considerable
reduction of the time averaged value of shock pressures, P̃sm , at 2–3 kHz. They also
found a noticeable increase at 800 and 5 kHz, and a significant downward shift in
the frequency where P̃sm is a maximum. The reduction of P̃sm seems to be related to
Fig. 4.4 Desinent cavitation number as a function of the polymer concentration. Also included
in this figure are the results obtained by Hoyt (1976) and Baker et al. (1976). Reproduced with
permission from Oba et al. (1978). © American Society of Mechanical Engineers
4.2 Cavitating Flows 129
Fig. 4.5 Shock spectra for various polymer concentrations. Reproduced with permission from
Oba et al. (1978). © American Society of Mechanical Engineers
the fact that the cloud of fine bubbles are suppressed by the polymer. On the other
hand, the increase of P̃sm at 800 kHz is qualitatively related to an increase in irreg-
ularity, size and number of massive bubbles, while the increase of P̃sm at 5 kHz to
an increase in the number of string bubbles. In the 50 ppm solution, P̃sm increases
at 400 kHz and then decreases for larger frequencies. They explained this result by
observing that the number of fine bubbles as well as the number of string bubbles is
considerable reduced in the polymer solution.
The effect of polymer additives (both drag-reducing and non drag-reducing) on
jet cavitation was also studied by Hoyt and Taylor (1981) using a nozzle of only
2.92 mm diameter. Solutions of the drag-reducing additives, polyacrylamide and
polyethylene oxide, at concentrations of 25 ppm, decreased the cavitation inception
number and greatly changed the appearance of the cavitation bubbles. Solutions of
the non drag-reducing polymer, Carbopol, produced cavitation bubbles having the
same appearance on pure water and did not change the inception number. In pure
water, the cavitation appearance resembles ragged groups of small bubbles with
the overall impression of sharpness and roughness, but in drag-reducing polymer
solutions the bubbles are larger, rounded, and of completely different appearance.
The effect of polymer additives on cavitation inception on blunt bodies was first
investigated by Hoyt (1966). Subsequent studies have been conducted by Ellis
(1967), Ellis and Hoyt (1968), Ellis et al. (1970) and Baker et al. (1973) in homoge-
neous solutions, and van der Meulen (1973, 1976) and Gates and Acosta (1979) for
injected solutions.
Ellis and co-workers (1967, 1968, 1970) conducted a series of experiments to
investigate the effect of polymer additives on both cavitation inception and its
appearance on a hemisphere-nosed cylindrical body in a blowdown water tunnel.
130 4 Hydrodynamic Cavitation
Using a stainless steel test body with a diameter of 6.35 mm, Ellis and co-workers
detected the inception of cavitation in two ways. A laser beam was adjusted to just
graze the surface of hemisphere nose in the region where cavitation first appears.
Light scattered by the cavitation bubbles was detected by a photocell sensing light
at about 90◦ from the laser beam direction. This method of cavitation detection
was checked by acoustic observation, and very good agreement was obtained. The
cavitation number was defined as
2 (p∞ − pv )
, (4.8)
ρv2∞
where p∞ and v∞ are the pressure and liquid velocity upstream the body, respec-
tively.
Tests were made with water (passed through a 0.4 μm filter), 50 and 100-ppm
polyethylene oxide and a suspension of alga, porphyridium aerugineum. All tests
were made with water containing the same amount of dissolved air, 17 ppm, and
Table 4.1 gives the inception data obtained (averages of 4 runs). It can be seen that
the polymer content of the water has a large effect on the cavitation inception point.
The appearance of the cavitation bubble is also changed by the presence of
polymers. There also seems to be a noticeable difference in the appearance of
steady-state cavities in flows containing polymer solutions compared with obser-
vations at the same cavitation number in water (Hoyt 1966). The cavitation bubbles
generated in polymer solutions are more striated, and appear to collapse less
violently than the bubbles generated water.
Walters (1972) has shown a similar lowering of cavitation inception index on
a disk and he noted that the higher-frequency noise content of the bubble col-
lapse spectra was diminished. Under very intense cavitation, the polymer solution
produced a higher level of radiated noise at higher frequencies than water.
Van der Meulen (1973) has shown that cavitation inception on a hemispherical-
nosed stainless steel body in a water tunnel is greatly reduced by the presence
of polyethylene oxide, while a Teflon-coated body shows a much smaller effect.
In other work, Huang (1971) noted that the cavitation inception reduction with
polyethylene oxide was much smaller when a large (100 mm in diameter) model
was used in a water tunnel.
Table 4.1 Cavitation inception number for different polymer (polyethylene oxide) concentration
for a hemispherical-nosed cylindrical body
In an attempt to interpret these results, van der Meulen (1976) and Gates and
Acosta (1979) visualized the boundary layer along the surface of the body in the
region of separation. They noted that the polymer additives remove the laminar sep-
aration by stimulation of transition causing transition to turbulence at much lower
Reynolds numbers than the pure solvent. This conclusion is further substantiated
by the observation that there is essentially no effect on the cavitation characteristics
of a Schiebe body on which there is no laminar separation. Moreover, as indicated
by Gates and Acosta (1979), tripping the boundary layer transition on the hemi-
spherical headform has been demonstrated to be more effective than the polymer
additives in delaying cavitation occurrence. It seems, therefore, that the polymer
additives act by modifying the behaviour of the boundary layer and have little effect
on the behaviour of individual bubbles at inception.
In a different type of experiments, Brennen (1970) investigated the influence
of dilute polymer solutions (polyethylene oxide Polyox WSR 301, polyacrylamide
Separan AP30, and guar gum) on the characteristics and appearance of the interface
of well developed cavities generated behind a cylinder and spheres. He observed
that the polymers caused a wavy instability of the wetted surface flow around the
headforms at the initiation of the cavity. This instability can be related to the effect
of the polymers on the transition and separation mentioned above.
Bazin et al. (1976) presented result on the effect of the injection of very concen-
trated (5,000 and 10,000 ppm) solutions of polyethylene oxide on the surface of a
cylinder downstream of the stagnation point. They found that the injection of the
polymers inhibits the development of cavitation and that the noise level at inception
stage is significantly reduced by the polymer additive.
Ting (1978) investigated the influence of two drag-reducing polymers (polyethy-
lene oxide PEO-FRA, and hydrolyzed polyacrylamide PAM-273) on cavitation
inception around cylinders mounted on a rotating circular disk. One cylinder was
placed 11.43 cm from the center of the disk and the other one at 13.02 cm, the angle
between them being 90◦ . The cavitation number in this experiment was defined as
2 (p − pv )
σ = , (4.9)
ρu2
where the velocity u is the product of the disk rotating speed ω and the radial dis-
tance r where the cavitation inducer is located from the center of the disk. The
cavitation inception number was plotted against a Reynolds number defined by
Re = ρrωd/η, where d is the diameter of the cavitation inducer and η is the
viscosity of water.
The inception cavitation number as a function of the Reynolds number for the
polyethylene oxide solution is plotted in Fig. 4.6. The filled symbols represent data
corresponding to the inside cylinder (r = 11.43 cm) and the open symbols are those
corresponding to the outside cylinder (r = 13.02 cm). It is clear that the polymer
additive has a strong effect in reducing the values of the cavitation inception number.
The suppression effect generally increases with increasing polymer concentration.
For example, for the 500 ppm Polyox solution, the cavitation inception number is
132 4 Hydrodynamic Cavitation
reduced to about 65% of that in water for Re = 105 . Similar results were obtained in
the case of the polyacrylamide solution (Fig. 4.7). However, for the largest concen-
tration, polyacrylamide seems to be more effective over a larger range of Reynolds
numbers as a result, probably, of its capacity to sustain high shear rates with moder-
ate degradation. Ting also noted that the appearance of cavitation bubbles in polymer
solutions was more transparent than in water and showed a regular and smooth wavy
pattern, as demonstrated by the experiments conducted by Brennen (1970).
The suppression of cavitation inception in polymer solutions was explained by
Ting (1978) by an increased extensional viscosity of polymer solutions due to the
hydrodynamically interacting stretched molecules. He noted that when a fluid ele-
ment is approaching the stagnation point of the cylinder, the flow field is one with
a high deceleration rate. The axisymmetric compression that develops in the stag-
nation region generates high extensional stresses that lead to the suppression of
cavitation inception. High flow gradients also develop as the fluid flows around the
cylinder introducing high viscoelastic stresses which change the overall flow field.
Reitzer et al. (1985) investigated the flow around a cylinder in an open loop
tunnel. A 1,000 ppm polyethylene oxide solution was ejected upstream of the test
4.2 Cavitating Flows 133
section with a flow rate such that the concentration of the polymer solution in the
test section reached a concentration of 3 ppm. The main results of this study are
summarized in Fig. 4.8, where the acoustic pressure is plotted as a function of the
Reynolds and cavitation numbers. The Reynolds number was calculated from the
mean velocity of the liquid upstream the cylinder, the viscosity of water and the
diameter of the cylinder. At the very low polymer concentration used in their exper-
iment (3 ppm) the viscosity of the solution was approximated to the viscosity of
water. Before cavitation inception (Zone I; σ > 8.7), a low level acoustic pressure,
slightly increasing with the Reynolds number, was observed at high cavitation coef-
ficients. This acoustic pressure was attributed to the background noise of the tunnel.
At a Reynolds number of Re = 85,000 (corresponding to σ = 8.7), inception of
the cavitation occurs in water and the collapse of isolated bubbles has been visually
observed. Beyond this value of the Reynolds number, cavitation develops and the
acoustic pressure increases up to a maximum (Zone II; 8.7 > σ > 4.3), after which it
decreases to a minimum corresponding to a Reynolds number of 1.24 × 105 (Zone
III; 4.3 > σ > 3.2). The noise then increases very sharply, reaches another maxi-
mum much larger than the previous one (Zone IV; 3.2 > σ > 2.7), and decreases
134 4 Hydrodynamic Cavitation
Fig. 4.8 Acoustic pressure as a function of cavitation and Reynolds numbers for water and a 3 ppm
polyethylene oxide aqueous solution. Reproduced with permission from Reitzer et al. (1985).
© Elsevier B.V.
as sharply as it had increased (Zone V; σ > 2.7). The most important observation
in the polymer solution concerns the inception of the cavitation, which is delayed
from Re = 8.5 × 105 to Re = 1.05 × 106 (corresponding to σ = 5.1). The poly-
mer solution completely inhibits zone II, which is replaced by the continuation
of zone I, while zone III, where the noise was decreasing in the case of water, is
replaced by an increasing region that fits perfectly zone IV. From these data the
authors conclude that the suppression of cavitation associated with the presence
of the polymer molecules is more likely due to the modification of the flow field
around the cylinder than an effect of the macromolecules on the dynamics of indi-
vidual bubbles. However, no information on the size of the cavitation bubbles is
provided. As we already discussed in the previous chapter only bubbles with a max-
imum radius smaller than 10–1 mm will be affected by the viscoelastic properties of
the surrounding liquid.
Vortical structures occur in a wide range of flows. These vary from the eddies in
turbulent flows that occur randomly in time and space to more developed vortices
that occur at the tips of hydrofoils and lifting surfaces (also called tip vortex) and
at the hubs of propellers (also called hub vortex). Tip vortex cavitation is typically
4.2 Cavitating Flows 135
observed as the first form of cavitation in propeller flows. The prediction of the onset
of this type of cavitation is particularly important in the design of “silent” propellers,
as cavitating vortex represents a significant source of noise.
pmin − p0
(Cp0 )min = 2 , (4.10)
2 ρ 2π a
1
where (Cp0 )min = −2 if a Rankine model is used and (Cp0 )min = −1.74 if a Lamb
vortex is used. Classical theory for an elliptically loaded lifting surface shows that
the strength of the vortex is related to the lift coefficient CL and the mid-span chord
length c0 ,
CL
= , (4.11)
U∞ c0 2
where Cp0 depends on the circulation distribution. Thus, cavitation inception scales
with lift (and hence circulation) and the inverse of the vortex core radius. The
determination of the core radius remains, however, a difficult problem. Despite the
uncertainty in the relationship for core radius, numerous studies indicate that σi
scales with Rem , where m is generally accepted to be approximately 0.4. It should
be noted here that the conditions of inception in the vortex core are sensitive to
other parameters such as turbulence, water quality, and confinement. The influence
of water quality, i.e. nuclei and dissolved gas content, on tip vortex cavitation was
proved by several studies (Arndt and Keller 1991; Gowing et al. 1995). As for the
effect of turbulence, Arndt et al. (1991) reached the conclusion that no complete
correlation is possible without knowledge of the fluctuating levels of pressure in the
vortex flow. Figure 4.9 gives a typical example of the effect of confinement on tip
136 4 Hydrodynamic Cavitation
Fig. 4.9 Visualizations of tip vortex cavitation in water for various values of tip clearance, e. The
position of the wall is indicated in right-hand side of the photographs. (a) e = 50 mm, (b) 20 mm,
(c) 13 mm, (d) 4 mm, (e) 2 mm, (f) 0.5 mm. Reproduced with permission from Boulon et al.
(1999). © Cambridge University Press
vortex cavitation in water. For a value of the cavitation parameter of 2.6, in the case
of Fig. 4.9a, no cavitation occurs in the tip vortex as long as tip clearance remains
above 20 mm. For a clearance of about 20 mm, a continuous vapour core suddenly
appears. It is stable, but not attached to the tip, as shown in Fig. 4.9b. As the tip
clearance is further reduced, the vapour core extends towards the foil tip and attaches
4.2 Cavitating Flows 137
to the tip (Fig. 4.9c). For even smaller values of the clearance (Fig. 4.9d), in addition
to the tip vortex cavitation, a leading-edge cavity originates in the laminar separation
bubble. The cavitating vortex is highly disturbed by the development of turbulence
and it is barely visible for a clearance of only 2 mm (Fig. 4.9e). For highly confined
flows (Fig. 4.9f), leading-edge cavitation, as well as tip vortex cavitation, practically
vanish.
In the general case of a non-Newtonian fluid the radial pressure gradient for a
linear vortex is given by
p∞ − pv
σ = 2
, (4.14)
0.5ρU∞
138 4 Hydrodynamic Cavitation
where p∞ and U∞ are the pressure and velocity of the unperturbed flow, respec-
tively. Cavitation desinence was determined visually and checked against noise
measurements. Two hydrofoils of elliptical shape and symmetrical cross section
were employed for generating the tip vortex. The first hydrofoil has a maximum
chord of 40 mm and a half span of 60 mm and was provided with a 1 mm diam-
eter injection orifice at the tip of the wing. The second hydrofoil has a maximum
chord of 30 mm and a half span of 40 mm. Tests were conducted without and with a
1,000 ppm polyethylene oxide (Polyox WSR 301) solution ejection at the tip of the
large foil, with pure water, and with an homogeneous solution of the same polymer
with a concentration of about 10 ppm. They found that at equal incidence angle the
desinent cavitation number with polymer ejection and in the homogeneous polymer
solution is smaller than in pure water (Figs. 4.10 and 4.11).
The measurements of the lift of the foil indicated that it was significantly reduced
in the homogeneous polymer solution. The tangential velocities were also consid-
erably reduced in both the core and the potential region. However, lift coefficients
were not affected by the ejection process. In this case, the maximum tangential
velocity of the vortex decreases, the size of the viscous core increases and the inten-
sity of the vortex remains constant during polymer solution ejection. These results
indicate that the mechanism of cavitation inhibition with polymer ejection from the
tip of a hydrofoil and in homogeneous polymer solution is completely different. In
the case of polymer ejection, it is due to a local modification of the tangential veloc-
ities of the vortex core without changing the lift (and hence circulation) of the foil.
In the case of an homogeneous polymer solution, it is due to the modification of the
lift (and hence circulation) of the foil and the associated change of the tangential
velocities. Equal mass ejection rates of water, and water/glycerine solutions did not
alter the tip vortex conditions. Cavitation inhibition was thus associated solely with
the viscoelastic properties of the polymer solutions. It was further speculated that
Fig. 4.10 Desinent cavitation number versus incidence angle for water and semi-dilute poly-
mer (Polyox WSR 301) ejection. Reproduced with permission from Fruman and Aflalo (1989).
© American Society of Mechanical Engineers
4.2 Cavitating Flows 139
Fig. 4.11 Desinent cavitation number vs the incidence angle for water and homogeneous polymer
(Polyox WSR 301) ejection. Reproduced with permission from Fruman and Aflalo (1989). ©
American Society of Mechanical Engineers
the jet from the ejection orifice swells in such a way that the roll-up of the potential
flow occurs over an apparently rounded tip.
The results obtained by Fruman and Aflalo (1989) have been confirmed by
Chahine et al. (1993) in the case of polymer (Polyox WSR 301) ejected through
orifices at the tip of the blades of a 29-cm-diameter propeller. With a polymer
concentration of 3,000 ppm they were able to achieve critical cavitation number
reduction of about 35%. As an example, Fig. 4.12 shows the cavitation number
at inception as a function of the polymer concentration for the pure water condi-
tions, for water/glycerin solution injection, and for Polyox solution injection. The
viscoelastic properties of the polymer solution injected in the vortex core play a sig-
nificant role in thickening the viscous core of the tip vortex and, thus, reduce the
pressure drop at the vortex center without affecting circulation or lift.
To obtain more information on the effect of polymer additives on the suppression
of tip vortex cavitation, Fruman et al. (1995) conducted experimental investigations
with an elliptical hydrofoil having a NACA 16020 cross section, a 3.8 aspect ratio,
and a maximum chord length of 80 mm. They also conducted axial and tangential
velocities measurements very close to the foil tip. The velocity profiles were mea-
sured along a direction, y, parallel to the span, positive outboard passing through the
vortex axis. The downstream distance, x, was measured relative to the tip of the foil
which was taken as the origin. Measurements were conducted for x /cmax of 0.125,
0.25, 0.5 and 1, where cmax is the maximum chord (Fig. 4.13).
In this experiment, the polymer (polyethylene oxide Polyox WSR 301) solu-
tion was ejected through a port with a diameter of 1 mm situated at the foil tip.
Figure 4.14 shows the nondimensional axial, Va V∞ , and tangential, Vt V∞ ,
velocity for an angle of attack of 10◦ and a free stream velocity V∞ = 12.5 m/s. The
tangential velocities indicate a solid-body rotation region, where velocities increase
140 4 Hydrodynamic Cavitation
Fig. 4.12 Influence of the concentration of injected Polyox solutions on tip vortex cavitation
inception and comparisom with water and water/glycerin solution injection. Reproduced with
permission from Chahine et al. (1993). © American Society of Mechanical Engineers
Fig. 4.13 Schematic of the test arrangement in the experiment of Fruman et al. (1995)
linearly with distance from the vortex axis, an intermediate transition region, and
a potential region, where velocities are inversely proportional to the distance to
the vortex axis. Only minor modifications of the tangential velocity profiles occur
during water ejection. In contrast, the ejection of the polymer solution causes a sig-
nificant reduction of the maximum tangential velocity and an appreciable increase in
the size of the viscous core while the potential region remains unchanged. The radius
of the viscous core increases significantly by about 70% near the tip of the foil. On
the other hand, ejection of water or polymer solution causes a reduction of the axial
velocities in the viscous core region. Very close to the tip, the effects of polymer
solution are significantly larger than those of water. However, the effect of polymer
additive becomes smaller and smaller when the distance from the foil tip increases.
4.2 Cavitating Flows 141
Fig. 4.14 Tangential and axial velocities as a function of distance to the vortex axis for dif-
ferent axial stations. Polymer (polyethylene oxide) concentration 1,000 ppm. Reproduced with
permission from Fruman et al. (1995). © Japan Society of Naval Architects and Ocean Engineers
142 4 Hydrodynamic Cavitation
The authors concluded that jet swelling caused by the relaxation of normal stresses
associated with the viscoelastic properties of the polymer solution is responsible for
the thickening of the viscous core which, in turn, causes the inhibition of the tip
vortex cavitation.
Latorre et al. (2004) carried out a theoretical analysis of tip vortex cavitation
inception based the Rankine vortex model. In their analysis, the bubbles were
assumed to be spherical and the non-Newtonian features of the polymer solution
were assumed to only affect the vortex core radius. Their analysis shows that while
polymer injection causes instability in small bubbles, its main effect is an increase
in tip vortex core radius, resulting in the delay of tip vortex cavitation inception.
Very recently, Zhang et al. (2009) investigated numerically the dynamics of a
propeller tip vortex in water and in polymer solutions. Polymer injection, simulated
with inclusion of polymer effects only in the tip vortex centerline region, results
in higher pressures at the vortex center than in pure water. The pressure along the
vortex centerline was found to first decrease then increase for both water and the
polymer solutions. Starting from the propeller tip, polymer stresses along the vortex
centerline increase dramatically and reach a maximum in the region close to the min-
imum pressure point. This pressure rise can explain tip vortex cavitation suppression
with polymer injection, in agreement with previous experimental observations.
Table 4.2 Incipient cavitation number and air content for tests in a vortex chamber
measured in a large tank situated downstream of the vortex chamber and used to
determine the incipient cavitation number using, instead of pressure drop across the
chamber as in Hoyt (1978), the kinematic head at the exit section. In contrast to the
results of Hoyt (1978), for a polyethylene oxide aqueous solution in concentration
of 10 ppm, the cavitation onset was advanced as compared to the case of water.
It should be noted, however, that because of the different definition of the cavita-
tion number, direct comparison of these results is difficult. If it is accepted that the
drag reducing properties of the polymer solution should increases, at equal pressure
drop, the flow rate, the results by Hoyt (1978) should correspond to a much larger
inhibition effect. On the other hand, the velocity measurements indicated that the
tangential velocity increased, as compared with pure water, when moving from the
wall towards the center of the vortex. This increase was large enough to justify the
enhanced cavitation characteristics of the flow.
Bismuth (1987) also performed experiments by ejecting, through an orifice of
1 mm diameter situated at the end opposite to the evacuation, semi-dilute solutions
of polyethylene oxide with a concentration of 10 ppm. The main result of his study
is that the polymer ejection significantly inhibits cavitation onset. In well developed
cavitation stages, the vapour tube that occur on the chamber axis in the case of pure
water is made to disappear over increased distances when the rates of ejection of the
polymer solution increase.
A vortex chamber with tangential injection was also used by Barbier and Chahine
(2009) in order to generate a central line vortex and observe its structure in water
and various solutions of polymer and corn syrup. Measurements of the velocities,
pressures, and thus the cavitation number were conducted using a particle image
velocimetry system, pressure gauges, and Pitot tubes. Experiments were performed
using water, different dilute concentrations of polymer (Polyethylene oxide Polyox
WSR 301) solutions, and solutions with different concentrations of corn syrup for
a large range of Reynolds numbers. The measurements and observations showed
that cavitation inception at the vortex center was delayed when polymer and corn
syrup solutions are used as compared to the experiments in water. However, contrary
to reported observations with tip vortices, here the large scale vortex was found to
rotate faster in the polymer and corn syrup solutions. This did not match with the
previous observations of cavitation inception delay in the case of polymers and the
conventional thinking about the relationship between pressures and velocities in a
vortex line. This may be due to the observations that the velocity fluctuations and
the turbulent kinetic energy in the viscous core region increased significantly in the
polymer and corn syrup solutions.
of gas may interrupt the film, producing film rupture or cavitation. Dowson et al.
(1980) propose a simple classification of the cavitation phenomena based on the
main mechanism that governs it. They consider that there are two types of cavi-
tation: “vaporous cavitation” and “gaseous cavitation”. The first type occurs when
the lubricant pressure is reduced to its vapour pressure. The second is encountered
when the lubricant pressure falls below the saturation pressure and dissolved gases
are emitted from the solution. A pressure reduction below ambient conditions may
either encourage suspended bubbles of gas to grow or draw gas into the lubricating
film from an external source such as atmosphere. This form of gaseous cavitation is
called ventilation (Dowson et al. 1980).
The flow between a moving and a fixed wall separated by a micron size gap is
characterized by very large pressure gradients in the flow direction. It is, therefore,
expected that the extensional flow prevailing in the vicinity of the gap will promote
the occurrence of an elastic contribution and modify the conditions for cavitation
onset and development.
Narumi and Hasegawa (1986) were probably the first who investigated the influ-
ence of the viscoelastic properties of non-Newtonian fluids on cavitation in very
confined space. They considered the flow between a flat glass and a convex lens
with a radius of curvature of about 2 m. The Newtonian fluids in their experiment
consisted in a 10% glycerol aqueous solution (with a viscosity η = 1.08 mPa·s) and
a 30% (η = 3.51 mPa·s) and 50% (η = 11.3 mPa·s) starch syrup aqueous solution,
respectively. The non-Newtonian fluids are polyethylene oxide aqueous solutions in
concentration of 100 and 200 ppm. The polymer solutions have a constant viscosity
and elastic properties. The viscosity of both polymer solutions is similar to that of
water. Their results indicate that the viscoelastic effects in the thin film flow leads
to a significant displacement of the point of cavitation from the centre of contact
(where film thickness is a minimum) and enhanced film thicknesses.
Ouibrahim et al. (1996) have investigated the influence of polymer additives on
cavitation generated in very confined spaces comprised between a rotating cylinder
of radius R and a stationary flat plate, with a minimum gap, e, down to 5 μm. The
test fluids are water and a 600 ppm polyethylene oxide (Polyox WSR 301) aque-
ous solution, known to be a very effective drag reduction agent in dilute solution.
The polymer solution displays a slightly shear-thinning behaviour and the shear
viscosity, for large shear rates (>103 s–1 ), is 2.05 mPa·s. The cavitation number is
defined as
Pref − pv
σ = , (4.15)
0.5ρ (ωR)2
where ω is the cylinder tangential velocity and Pref is a reference pressure. The
gap, e, was varied between 5 and 20 μm while the tangential velocity, U = ωR,
of the rotating cylinder was varied from zero to 22 m/s. The absolute pressure
was decreased from 105 Pa to 8 × 103 Pa. It should be noted here that, for all
experimental conditions, the product, (e/R)Re, where Re is the Reynolds number
calculated with U and e, is much smaller than unity as lubrication theory requires.
4.2 Cavitating Flows 145
More recently, Seddon and Mullin (2008) studied the cavitation phenomenon in
the lubrication layer between a rotating heavy sphere and a nearby wall of a rotating
drum in a Newtonian fluid (silicone oil with a nominal kinematic viscosity of 103
mm2 /s), a shear-thinning fluid (high molecular weight silicone oil with a zero-shear
viscosity of 1.3 × 104 mm2 /s), and a viscoelastic fluid (0.025% polystyrene Boger
fluid with a zero-shear viscosity of 2.4 × 104 mm2 /s, and a relaxation time of about
3 s). Images of the vapour cavities in all three fluids are shown in Fig. 4.16. For
the Newtonian fluid, an almost circular cavity was found between the sphere and
wall in the downstream region of the flow. In the shear-thinning fluid, a pair of sta-
ble symmetric cavities was formed adjacent to each other separated by a tongue
of fluid that was able to stretch across the cavity site and form a stable liquid
bridge. However, the most intriguing cavitation occurred in the viscoelastic fluid
because its increased elasticity allowed several tongues of fluid to stretch across
the cavitation site in order to create many long thin cavities. In this case, a hierar-
chical structure of cavities was formed that was unstable and constantly changed
shape.
Fig. 4.16 Examples of vapour cavitation in the downstream region of the lubricating layer between
a sphere and wall. (a) and (d) are in the Newtonian fluid, (b) and (e) are in a shear-thinning fluid,
and (c) and (f) are in a viscoelastic fluid. The scale-bar on image (a) represents 2 mm. The direction
of flow is shown by the white arrow in (d). Reproduced with permission from Seddon and Mullin
(2008). © American Institute of Physics
4.2 Cavitating Flows 147
fluids, must be used in future experiments in order to ensure that changes in the flow
kinematics are associated purely with fluid elasticity and cannot be confused with
effects due to shear-thinning viscosity.
There have been many recent attempts to estimate the extensional viscosity of
mobile liquids. It must be noted, however, that generating a purely extensional flow
in the case of mobile fluids is virtually impossible. The most that one can hope to do
is to generate flows with a high extensional component and to interpret the data in a
way which captures that extensional component in a consistent way through a suit-
able defined extensional viscosity and strain rate. An unambiguous determination of
the extensional viscosity of dilute polymer solutions is thus very difficult, perhaps
impossible. However, since the extensional viscosity of dilute solutions of poly-
mers exhibit very high values, the experimental methods with only semi-quantitative
capabilities may be sufficient in some practical applications.
In the case of an extensional flow, the elastic component of a non-Newtonian fluid
has the net effect of adding a positive pressure to the Newtonian contribution which
leads to a reduction of the incipient cavitation number. The added pressure can be
estimated from the difference of incipient cavitation numbers at equal Reynolds
number.
Ouibrahim et al. (1996) used the flow in a very confined space comprised
between a rotating cylinder of radius R and a stationary plate (see Sect. 4.2.5) to
determine the extensional viscosity of a 600 ppm aqueous solution of polyethylene
oxide. For this particular case, the added pressure, Pe , is given by
1 (( (
Pe = σip − σiw ( ρ(ωR)2 , (4.16)
2
where σip and σiw is the inception cavitation number in the case of polymer solution
and water, respectively, and ω is the angular velocity of the cylinder. The values of
Pe are plotted in Fig. 4.18, together with an estimate of the extensional viscosity,
defined as
Pe
μe = , (4.17)
∂u/∂x
where ∂u/∂x(≈ 70ω) is the maximum extensional strain rate. The results obtained
by Ouibrahim et al. (1996) indicate that the elastic pressure contribution increases
with the strain rate increasing while the extensional viscosity decreases. The latter
is up to four orders of magnitude larger than the shear viscosity of water (a Trouton
ratio as high as 104 ).
A general characteristic of flexible polymers (such as polyethylene oxide) is that
they are extension rate thickening (Barnes et al. 1989). However, Stokes (1998) has
150 4 Hydrodynamic Cavitation
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Chapter 5
Cavitation Erosion
Fig. 5.1 Mass loss rate as a function of the exposure time to cavitation
The duration of this stage can vary with cavitation resistance of material. There is
no significant modification of surface morphology during this period. Attenuation
stage is the final stage in which the decrease of erosion rate depends on many fac-
tors like material properties, and interaction between liquid flow and worn surface.
This stage of cavitation occurs only under certain conditions. During cavitation tests
with magnetostrictive devices, no significant attenuation stage has been observed
for aluminium, copper based alloy, carbon steel, stainless steel, and titanium based
alloy.
A comprehensive review of cavitation erosion in Newtonian liquids is given by
Young (1989).
been published by Basedow and Ebert (1978). When solutions of polystyrene, poly-
acrylates, and nitrocellulose were exposed to ultrasound in organic solvents, an
irreversible reduction of the viscosity was observed (Schmid and Rommel 1939;
Schmid 1940). The initial decrease of viscosity slowed down as a function of soni-
cation time, and a limiting value of the viscosity was reached. Similar observations
have been made by Henglein and Gutierrez (1988) on the degradation of poly-
acrylamide in aqueous solutions. The ultrasonic degradation of a polymer solution
is a non-random mechanical process resulting from hydrodynamic processes aris-
ing from cavitation. Polymer chains cleave preferentially near their center, higher
molecular weight fractions degrade faster than ones of lower molecular weight, and
a lower molecular weight limit exists below which no further degradation occurs
(Basedow and Ebert 1978). The role of cavitation in the degradation of polystyrene
in toluene and of hydroxyethylcellulose in water was first demonstrated by Weissler
(1950, 1951), who observed that no depolymerization occurred at intensities below
the threshold for cavitation and in solutions that had been degassed to prevent cavi-
tation. In some cases frictional forces between polymer and solvent molecules may
be sufficient for chain scission, and both mechanisms may occur simultaneously.
The important conclusion of these studies is that ultrasonic cavitation degrades the
polymer. Therefore, in this type of experiments, the test liquid must be discharged
from the test vessel and, at the same time, replaced by fresh test liquid in order to
avoid the alteration of the physical properties of polymer solution.
Ashworth and Procter (1975) seem to be the first who conducted experiments on
cavitation damage in polymer solutions. They used copper test specimens placed
at 1.3 mm below the tip of an ultrasonic probe. Both in 100 and 1,000 ppm poly-
acrylamide solution they observed an increase of the cavitation erosion rate. For
example, after exposure for 60 min to cavitation, the weight loss of the copper spec-
imen in a 1,000 ppm polyacrylamide aqueous solution is almost two times larger
than that in water.
158 5 Cavitation Erosion
In a later paper, Shapoval and Shal’nev (1977) reported the results on cavitation
damage generated after a cylinder placed in a cavitating pipe. They found that the
weight loss decreased by an addition of 300 ppm polyacrylamide into water.
Shima et al. (1985) conducted similar experiments to those performed by
Ashworth and Procter, but used polyethylene oxide instead of polyacrylamide and
placed the aluminium test specimen attached to the vibrating rod. They also re-
circulated the polymer solutions in the test vessel in order to avoid the polymer
degradation. The polymer concentrations they used are 100, 500, and 1,000 ppm,
respectively. During the first 15 min of the test, the weight loss in all polymer solu-
tions is slightly larger than that in water. After 60 min of exposure to cavitation, they
observed that the addition of small amounts of polymer (100 ppm) shows almost a
similar behaviour to that in water and the weight loss decreases significantly with
increasing the polymer concentration (Fig. 5.3). For example, the weight loss in the
1,000 ppm polyethylene oxide solution is three times smaller than that in water;
for a fully degraded solution the results are very close to those for pure water.
A stringy erosion pattern was found at the largest concentration of the polymer
solution (1,000 ppm).
In a subsequent study, Tsujino (1987) reported similar results from cavitation
damage experiments using a 1,000 ppm polyethylene oxide aqueous solution. He
further noted that when the amplitude of the vibrating horn is decreased from
38 to 25 μm, both in water and in the polymer solution the mass loss from the test
specimen decreases (Fig. 5.4).
Tsujino et al. (1986) performed experiments on cavitation erosion using several
polymer aqueous solutions of varying elasticity levels (Fig. 5.5). For the poly-
mer solutions with the highest levels of elasticity (guar gum, polyacrylamide, and
polyethylene oxide (Polyox)) they found a clear reduction of the weight loss in
comparison to the case of water after 60 min of exposure to cavitation. For example,
in a 1,000 ppm polyethylene oxide solution, they noted a reduction of the weight
loss with about 70% in comparison to the case of water. As in the previous experi-
ments, the authors observed that, during the initial period of exposure to cavitation,
the weight loss in all these solutions is larger as compared to water. This feature
is very pronounced in the case of polyacrylamide and polyethylene oxide aqueous
solutions. For the inelastic polymer solutions (carboxymethylcellulose and hydrox-
yethylcellulose), however, they found similar results to the case of water. Similar
observations have been made by Urata (1998) who concluded that water dissolved
polymers can suppress the cavitation erosion when the molecular weight of the
polymer exceeds a certain level.
Tsujino et al. (1986) also investigated the influence of polymer additives on the
damaged area, Ad , of the specimen surface (Fig. 5.6). In water, the test specimen
was uniformly damaged so that the damaged area reaches a nearly constant value
Fig. 5.7 Erosion pattern on an aluminium specimen after exposure to cavitation in water [(a) and
(d)], 0.1% PAA solution [(b) and (e)], and 1% PAA solution [(c) and (f)]. Frame width is 2.5 mm in
(a), 16 mm in (b) and (c), 0.85 mm in (d), and 2.5 mm in (e) and (f). Reproduced with permission
from Brujan et al. (2008). © Elsevier B.V.
solution, and 1% PAA solution, respectively. Figure 5.7d–f show specific regions of
the specimen surface at increased magnification using a scanning electron micro-
scope which provides visible contrast even with small depth differences. Damage
patterns after 80 min exposure to cavitation in polymer solutions differ signifi-
cantly from those in water. In water, the test specimens developed heavily-eroded
areas with cavernous damage structures comprising holes over 0.8 mm in depth,
in addition to which were smaller crater-like damage structures which occurred
extensively over the specimen surface, with diameters of 10–40 μm and depths of
2–20 μm. The structure of the damage pattern changes distinctly as the polymer con-
centration is increased. At the highest polymer concentration, the damage consists
of isolated, individual craters with large regions of the surface apparently undam-
aged. Whereas in water the pits cover the specimen homogeneously, nearly all pits
accumulate along a few isolated lines at large polymer concentrations, the damage
pattern appearing string-like. An increase of the polymer concentration leads to a
decrease of the diameter of individual craters and whereas in water the maximal
diameter of individual craters was 40 μm, it was 35 μm in the 0.1% PAA solution,
and only 20 μm in the 1% PAA solution. The scanning electron micrographs shown
in Fig. 5.8 reveal the morphology of the smallest craters found on the specimen.
Both in water and in all the polymer solutions, several holes can be seen within the
main indentation, e.g. the crater illustrated in Fig. 5.8a consists of two almost cylin-
drical holes, the first with a diameter of 25 μm and the second with a diameter of
16 μm. Even a third hole, with a diameter of 5 μm, can be seen at the bottom of this
indentation. This observation suggests that even the smallest craters on a boundary
5.2 Mechanisms of Cavitation Damage in Newtonian Fluids 163
Fig. 5.8 Morphology of the craters developed on an aluminium specimen surface after exposure
to cavitation for 80 min in water [(a) and (b)] and 1% polyacrylamide aqueous solution [(c) and
(d)]. Frame width is 60 μm in (a) and (c) and 30 μm in (b) and (d). Reproduced with permission
from Brujan et al. (2008). © Elsevier B.V.
surface act as nucleation sites. Microscopic gas pockets, which are entrapped at the
bottom of the craters, can grow to relatively large sizes during the expansion phase
of the sound field. When the localized conditions change back to positive pressure,
the potential energy gained in cavity growth is converted into kinetic energy as the
interface accelerates to smaller radius. Although the total energy of the cavitation
event may be small, the concentration of this energy into a very small volume results
in an enormous energy density, with a large potential for damage. The examination
of the damage pattern in polymer solutions showed the same gross result although
not so prominent as in the case of water. It was also found that the weight loss
decreases with increasing the polymer concentration and is one order of magnitude
smaller in the 1% polyacrylamide solution than in the case of water.
where ρ, c and v are the density, sound speed, and jet impact velocity, respectively,
and subscript S refers to solid and subscript L refers to liquid. Such pressures are
a consequence of the conservation of linear momentum at the impact site. Usually,
ρS cS >> ρL cL , so PWH = ρL cL v. If the target is of the same acoustic impedance, the
pressure is half this value. This loading at the impact site, in the case of a cylindrical
jet, lasts only for a short period, τ , that it takes a release wave, generated at the
contact edge of the jet, to reach the impact axis. This time can be expressed as
τ = r/c where r is the radius of the jet. For example, a water-hammer pressure of
about 150 MPa lasting 20 ns is generated by an impact velocity of 100 m/s with
a jet radius of 30 μm. However, a number of experiments on bubble dynamics in
water have cast doubt on this explanation. For example, Shutler and Mesler (1965)
suggested that the damage is caused by the pressure pulse occurring at the minimum
5.2 Mechanisms of Cavitation Damage in Newtonian Fluids 165
volume of a bubble collapsing near a rigid boundary. Fujikawa and Akamatsu (1980)
have reported experiments in which a photoelastic material was used to observe
cavitation induced stresses, while the associated acoustic pulses were also recorded.
They confirmed that impulsive stresses in the material were initiated at the same
moment as the acoustic pulse and concluded that the stress waves were not due
to a microjet. In more recent studies, Tomita and Shima (1986) and Philipp and
Lauterborn (1998) also suggested that the major causes of cavitation erosion are the
high pressures and temperatures reached inside a bubble collapsing very close to a
rigid wall.
Detailed studies of cavitation erosion of rigid materials, generated by individual
cavitation bubbles collapsing in a quiescent liquid, was conducted by Tomita and
Shima (1986) and Philipp and Lauterborn (1998). Tomita and Shima (1986) found a
circular damage pattern with many indentations around a circumference. Philipp and
Lauterborn (1998) observed two distinct damage patterns – a shallow pit damage
and a circular damage pattern – and concluded that damage generated during first
bubble collapse will occur for γ ≤ 0.7, whereas for 0.9 ≤ γ < 2 cavitation erosion
is due to the second collapse when the bubble is directly attached to the material
surface. They concluded that the largest erosive force is caused by bubble collapse
in direct contact with the rigid boundary, where pressures of up to several GPa and
temperatures of about 8,000 K are reached inside the bubble (see, also, Brujan and
Williams 2005). Bubbles in the range γ ≤ 0.3 and γ = 1.2 to 1.4 caused the greatest
damage. Interestingly, a significant reduction of the damage was observed for 0.5 ≤
γ ≤ 1.1. This is mainly provoked by the “splash” effect which was found to occur
after the liquid jet impact onto the rigid boundary (Tong et al. 1999; Brujan et al.
2002). When the liquid jet threads the bubble, the closeness of the boundary results
in a radial flow away from the jet axis. This flow collides with the flow induced by
the still contracting bubble and a “splash” is projected away from the boundary, in a
direction opposite to the liquid jet motion. During the final stages of collapse, a large
part of the kinetic energy of the radial flow into the bubble is transformed into kinetic
energy of a rotational flow around the bubble. The content of the bubble becomes,
therefore, less compressed and the sound emission is diminished. Experiments by
Vogel et al. (1989) and Tomita and Shima (1986) showed that the collapse pressure
is minimal around these γ -values. This way, the damage potential of the bubble
is diminished even when the bubble is in direct contact with the boundary at the
moment of the first collapse.
Although it is clear now that the liquid jet developed during bubble collapse does
not have a significant potential to produce erosion of metals, it can play an important
role in fragmentation of brittle objects, such as renal calculi, dental tartar or intraoc-
ular lens. On one hand, the yield strength of brittle materials is much lower than that
of metals. For example, Murata et al. (1977) reported compressive strengths of renal
calculi to vary from 2 to 17 MPa and Burns et al. (1985) obtained similar values
(2–8 MPa). Since impact velocities of the jet as small as 10 m/s develops localized
pressures of about 15 MPa, this mechanism can be considered as a likely contributor
to renal calculi disintegration. On the other hand, the action of pressure transients
on metal surfaces and on brittle materials is very different. Intracorporeal stones,
166 5 Cavitation Erosion
as well as dental tartar, are usually a conglomerate of crystalline and organic com-
ponents and small voids. They are acoustically inhomogeneous, with many zones
of different acoustic impedance. Whenever the pressure pulse coming from a zone
with high acoustic impedance propagates into a zone with smaller impedance, it
is partially reflected as a tensile wave. These waves have a high damage potential
because stones are about 5 times more susceptible to tensile stress than to pres-
sure (Rink et al. 1995). The very localized action of the pressure transient into the
material and the inhomogeneity of the pressure wave propagation may, additionally,
lead to shearing forces. Tensile stress and shearing forces will create cracks, enlarge
pre-existing cracks and voids and, finally, lead to fracture.
The distribution of the cavitation nuclei over the surface of the rigid surface is
also important because of interaction with adjacent bubbles. In a cloud of bubbles, a
greater probability for the occurrence of ultra-high-velocity jets is possible. Bubble-
splitting leading to the formation of high-speed liquid jets due to the presence of
other bubbles has been demonstrated by Blake et al. (1993). Another accelerating
effect on jet velocity may be the interaction of an acoustic transient emitted by bub-
bles when collapsing in the neighbourhood of the jetting bubble (Dear et al. 1988;
Bourne and Field 1992; Philipp et al. 1993) (Fig. 5.9). It is well known that a strong
acoustic transient hitting a bubble will induce collapse, forming a jet that completely
penetrates the bubble at its minimum volume. This process is independent of any
boundary in the bubble’s vicinity and the jet direction is the same as the propagation
direction of the acoustic wave. Dear et al. (1988) made cylindrical cavities in a gel
to observe the collapse of these cavities when they are impinged by a shock wave.
A striker was projected to impact the gel, and high-speed photography was used to
record the behaviour of the cavities and jet formation under such impact. For an
impact pressure of 260 MPa, a 3 mm bubble generated a jet with a velocity of about
400 m/s. Bourne and Field (1992) reported the results of a high-speed photographic
study of cavities collapsed asymmetrically by shock waves of strengths in the range
of 0.26–3.5 GPa. The collapse of a 3 mm cavity in gelatine under a shock of strength
0.26 GPa induces the formation of a jet with a velocity of 300 m/s. Under a shock
strength of 1.88 GPa, the jet velocity is up to 5 km/s for a 6 mm cavity. Philipp et al.
(1993) also used high-speed photography and observed jet formation in a gas cavity
induced by lithotripter-generated shock waves. They used peak shock pressures of
65 and 102 MPa and reported a maximum jet velocity of up to 800 m/s. Bourne
Fig. 5.9 A high-speed jet travels across a 6 mm cavity under a 1.88 GPa shock from a plane-wave
generator. The shock wave is visible at the bottom of each photographic frame as a dark band. The
jet travels at approximately 5 km/s. Reproduced with permission from Bourne and Field (1999). ©
The Royal Society Publishing
5.2 Mechanisms of Cavitation Damage in Newtonian Fluids 167
and Field (1995) carried out experiments on cavitation damage generated by shock
wave-bubble interaction. The craters observed on the specimen surface exposed to
cavitation in water are attributed to the impact of the shock-induced liquid jets onto
the material surface. The authors concluded that, in this case, the high pressure and
temperature of the gases inside the bubble, and the impact of the liquid jet onto the
boundary material are responsible for the destructive action of cavitation bubbles.
Theoretical and experimental studies confirmed that the pressure generated by
a multiple interaction can be much higher than that caused by a single bubble.
Hansson and Mørch (1980) performed numerical calculations along the collapse
of a hemispherical cluster of cavities, related to the experimental observations by
Ellis (1966). They showed that the collapse of each shell of cavities exposes the
next inner shell to the hydrostatic pressure field which in turn initiates its collapse.
At each stage, the energy of collapse is transferred to the inner shell resulting in
a steady build-up of pressure. They demonstrated that this increased the collapse
energy of the cavities at the centre of the cloud by an order of magnitude. An exam-
ple of shock wave emission during the collapse of a hemispherical cloud of bubbles
is shown in Fig. 5.10.
Fig. 5.10 Shock wave emission from a hemispherical cloud of bubbles attached to a rigid wall.
The shock waves are visible in frames 9–11. Sequence taken with 2 million frames/s. Frame width
2.56 mm. Courtesy of E.A. Brujan, T. Ikeda, K. Yoshinaka, and Y. Matsumoto
168 5 Cavitation Erosion
The situation is quite different for cavitation bubbles collapsing near elastic
materials (Brujan et al. 2001a, b). This case is representative for the interaction
between cavitation bubbles and biological tissues during medical applications of
lasers and ultrasound. Three different mechanisms may contribute to cavitation ero-
sion in this case, namely liquid jet penetration into the elastic material, jet-like
ejection of boundary material into the surrounding liquid, and elevation and tearing
of the material surface by the low pressure between bubble and boundary develop-
ing during bubble collapse. Liquid jet penetration into the material requires that the
pressure generated by the impact of the liquid jet onto the boundary is sufficiently
high to overcome the yield strength of the material. Jet-like ejection of the elastic
material has three prerequisites. First, the material must be sufficiently deformed to
allow geometric focusing effects during its rebound. Secondly, the elastic modulus
of the material must be sufficiently large so that the restoring force caused by the
elastic deformation is large enough to cause this jet formation. Finally, the plastic
flow stress of the material and the ultimate tensile strength of the material must be
exceeded. For bubbles close to the boundary, the late stage of the collapse is associ-
ated with a volcano-like uplifting of the boundary caused by the low pressure region
developing between the collapsing bubble and the boundary. Elevation of the mate-
rial surface has been also reported by Grimbergen et al. (1998), and Godwin et al.
(1998) pointed out the role of bubble dynamics for an enhancement of pulsed laser
ablation. While the suction force enhances the material removal only for very soft
materials, the elastic rebound plays a role also for materials with moderate strength,
and the jet impact can erode even hard materials with high mechanical strength.
where ρ∞ is the ambient density of the liquid and ρ that behind the shock. If the
pressure behind the shock is p, then by conservation of momentum it can be shown
that
Fig. 1 Normal-shock
configuration for (a) unsteady
and (b) steady reference
frame
where p∞ is the ambient pressure. Equations (1) and (2) can be solved provided that
the relation between pressure and density is known. We consider the Tait equation
of state
n
p+B ρ
= , (3)
p∞ + B ρ∞
where, for water, n ≈ 7 and B ≈ 300 MPa. Since the pressure behind the shock, p,
is much larger than the ambient pressure we get
p p
−1/n 1/2
v−u= 1− 1+ . (4)
ρ∞ B
If the impact is with a rigid surface, then u is zero, and (4) gives the impact
pressure in terms of the impact velocity. On the other hand, if we assume that the
surface responds as a rigid solid until a certain compressive stress is reached and
then behaves as a perfectly plastic solid, for which the stress will remain constant
at a value pY , Eq. (4) can be rewritten to give the velocity deformation u in terms of
the impact velocity v and the stress to produce plastic flow as
u = v − v0 , (5a)
where
pY pY
−1/n 1/2
v0 = 1− 1+ . (5b)
ρ∞ B
It is clear that the impact velocity must exceed a certain critical value v0 before
any plastic deformation can occur.
170 5 Cavitation Erosion
Up to this point we have assumed that the liquid mass is infinite in width. In
reality this will not be the case, and, as soon as the liquid strikes the surface, a
release wave will propagate from the edge of the liquid mass towards the impact
centre at the ambient sound speed c∞ (Fig. 2). Assuming the liquid mass to be a
cylinder of radius a, the pressure at the centre will decreases after a time a/c∞ from
the value given by (4) to the stagnation pressure ρ∞ v2 / 2, which will be an order of
magnitude smaller unless exceptionally high impact velocities are encountered.
To obtain the amount of deformation induced by jet impact we consider only
the centre of impact, where the only motion will be normal to the surface and the
depth of penetration has the maximum value. If it is assumed that the plastic flow is
established immediately, and that it ceases as soon as the release wave reaches the
centre, the time available for deformation will be simply equal to the time taken for
the wave to travel across the radius of the liquid cylinder; i.e. a/c∞ .
Since the deformation velocity given by (5) is constant, the depth d of penetration
at the center is given simply by the product of the velocity u from (5) and the time
available, i.e. by
d v − v0
= . (6)
a c∞
For aluminium with 99.5% purity, the static value of the plastic flow stress is
about 400 MPa and from (5b) it results that v0 is about 200 m/s. The correspond-
ing value of pY in dynamic tests is about 1,300 MPa and, in this case, v0 is about
1,100 m/s. These values are much higher than the impact velocity of the liquid jet
developed during bubble collapse near a rigid wall (around 80 m/s) and thus the jet
impact cannot produce a plastic deformation of the wall material. For a conical jet,
Lush (1983) has indicated that the impact pressure is p ≈ 2.9ρ∞ c∞ v. The pressure
developed by the impact of a conical jet with a velocity of 80 m/s is about 350 MPa,
which is again smaller than the plastic flow stress of aluminium. These consider-
ations suggest that only shock-induced jets can produce material damage because
their velocity (up to 5,000 m/s) is much higher than the critical value for plastic
deformation v0 .
With one exception (Ashworth and Procter 1975), all other experiments have indi-
cated an inhibition of cavitation erosion by polymer additives. This is particularly
obvious when the test specimen is exposed to cavitation for a long time (30 min
or longer). The largest inhibition was observed in the case of aqueous solutions of
flexible polymers such as polyacrylamide and polyethylelene. For short exposures
to cavitation (less than 15 min), the cavitation erosion in aqueous solutions of flexi-
ble polymers is slightly larger than in the case of water. Similar results to the case of
water have been observed in aqueous solutions of semi-rigid or rigid polymers such
as carboxymethylcellulose, hydroxyethylcellulose, and guar gum.
Three major factors can contribute to the reduction of cavitation erosion in
polymer solutions:
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174 5 Cavitation Erosion
Cavitation has been shown to play a key role in a wide array of novel therapeutic
applications of ultrasound and lasers. Sometimes the mechanical effects associated
with cavitation contribute to the intented surgical effect. More often, however, they
are the source of unwanted collateral effects limiting the local confinement of ultra-
sound and laser surgery. Whether the mechanical effects are wanted or unwanted, a
characterization of the cavitation effects is of interest for the optimization of the
surgical procedures. In this section we review the modeling studies and exper-
iments on cavitation effects that are most relevant in the context of diagnostic
and therapeutic applications of ultrasound and lasers in the cardiovascular system.
These include sonothrombolysis, diagnostic ultrasound with microbubble contrast
agents, ultrasound-mediated gene transfer and drug delivery, transmyocardial laser
revascularization, laser angioplasty, and gas embolotherapy.
Ultrasound has been in use for the last three decades as a modality for diagnostic
imaging in medicine. Recently, there have been numerous reports on the application
of ultrasound energy for targeting or controlling gene or drug release in the cardio-
vascular system. This new concept of therapeutic ultrasound combined with genes
and drugs has induced excitement in various medical fields. Ultrasound energy can
also enhance the effects of thrombolytic agents and anticancer drugs. Although ther-
apeutic ultrasound was considered a tool for hyperthermia or thermal ablation of
tumors, the major mechanism for the recent ultrasound-assisted gene transfer and
drug delivery is mainly mechanical and is induced by cavitation.
6.1.1 Sonothrombolysis
Sonothrombolysis is the concept of augmentation of clot lysis by application of
external ultrasound. The transducers employed for sonothrombolysis have varied
from 20 to 5,000 kHz employing both pulse and sweep modes with intensities
ranging from 0.5 to 90 W/cm2 . Ultrasound energy, used in combination with throm-
bolitic drugs, such as tissue plasminogen activator (t-PA), has a beneficial effect in
the dissolution of coronary thrombus. Recently, Polak (2004) has suggested several
mechanisms for the effect of t-PA and cavitation on the dissolution of thrombus as a
function of ultrasound energy (Fig. 6.1). At very low energies, ultrasound increases
the total amount and depth of penetration of t-PA in the clot. At slightly higher ener-
gies, ultrasound can increase the number of exposed enzyme binding sites on the
fibrin complex and causes reversible disaggregation of fibrin fibers thus increasing
fluid permeation and improving fibrinolytic efficacy. Temperature elevation gener-
ated by ultrasound may also be responsible for accelerating thrombolysis. At high
energies, ultrasound enhances clot thrombolysis through cavitation-induced direct
damage and induction of blood flow microstreaming. Cavitation nuclei exist within
clots and contribute partially or fully to sonothrombolysis (Everbach and Francis
2000). When ultrasound is applied, these nuclei vibrate and induce the occurrence
of acoustic cavitation which, in turn, can produce the dissolution of thrombus by
the high temperature and pressure generated during cavitation bubble collapse.
Invasive catheters and some transcutaneous devices generate enough ultrasound
energy to cause cavitation. For example, catheter-based ultrasound delivery systems
use an external transducer which delivers the ultrasound in a continuous or pulsed
Fig. 6.1 Mechanism of action of tissue plasminogen activator (t-PA) and possible mechanisms
of action of ultrasound energy in the dissolution of thrombus. Reproduced with permission from
Polak (2004). © Massachusetts Medical Society
6.1 Cavitation for Ultrasonic Surgery 177
mode. The rapid probe motion causes acoustic cavitation which has direct mechan-
ical effect on the clot. This system was tried clinically (Hamm et al. 1994), and
demonstrated that it could rapidly and effectively be used for treatment of patients
with acute thrombotic coronary artery occlusion. It has also been shown to help in
recanalization of chronic total occlusions of saphenous venous grafts (Rosenschein
et al. 1999) as well as native coronary arteries (Rees and Michalis 1995).
of human serum albumin produces albumin-stabilized air bubbles that are suffi-
ciently stable and small to pass the pulmonary capillaries (Keller et al. 1987).
However, they cannot resist arterial pressure gradients. Inert high-molecular-mass
gases with low diffusion coefficients and low solubility have been used, in the
second-generation contrast agents, to increase the stability of microbubbles under
higher pressure (Raisinghani and DeMaria 2002). The low diffusivity keeps the gas
in the bubble, and the low concentration of saturation results in rapid saturation of
the blood with the gas and an alteration of the equilibrium condition such that the
gas tends to remain in the microbubble. The gases found to most favourably exhibit
these properties are the sulphur hexafluoride and perfluorocarbon. Encapsulation
of high-molecular-mass gases with surfactants or proteins is now used with these
gases to control their size distribution and to further improve stability (Raisinghani
and DeMaria 2002). The imposition of a shell or another substance capable of alter-
ing the surface tension of a microbubble can both inhibit the diffusion of gas into
the blood and enhance the pressure gradient that a microbubble can tolerate before
dissolving. Several new agents in development use polymer shells whose thickness
and flexibility can be more precisely controlled. For cellular and molecular noninva-
sive imaging, microbubbles can be targeted to regions of disease either by intrinsic
properties of the shell constituents which interact with upregulated cell receptors, or
by surface conjugation of specific ligands or antibodies that bind to disease-related
markers (Klibanov 2006).
A number of microbubble ultrasound contrast agents are commercially avail-
able or are in development. The initially marketed ultrasound contrast agent,
AlbunexTM (Molecular Biosystems) is a room air bubble with an albumin shell and
a mean diameter of about 4 μm. OptisonTM (Mallinckrodt) represents the refine-
ment of AlbunexTM , and uses perfluoropropane with an albumin shell. EchovistTM
(Schering AG) is a first-generation contrast agent and consists of a suspension of
galactose microparticles in a solution of galactose at 20%. LevovistTM (Schering
AG) consists of an air microbubble galactose within a fatty acid. DefinityTM
(Bristol-Myers Squibb Medical Imaging) represents a perfluoropropane gas in a
liposome shell with a mean diameter between 1 and 3 μm, while ImagentTM
(Imcor) uses a surfactant to stabilize microbubbles filled with a combination
of perflurohexane and air. The mean diameter of ImagentTM microbubbles is
5 μm and the concentration is 5×108 microbubbles/ml. SonazoidTM (Nycomed
Amersham) consists of an aqueous dispersion of lipid-stabilized perfluorobutane-
filled gas microbubbles with median volume diameter of approximately 3 μm.
SonoVueTM (Bracco Diagnostics), or BR1, is a suspension of stabilized sulphur
hexafluoride microbubbles coated by a highly elastic phospholipid monolayer shell
with high bubble concentration (up to 5×108 bubbles/ml) and a mean diameter
of 2.5 μm. BR14 (Bracco Diagnostics) is a third-generation ultrasound contrast
agent that has undergone pre-clinical studies and is currently undergoing phase
II studies in humans. It consists of perfluorocarbon-containing microbubbles sta-
bilized by a phospholipid monolayer. The mean diameter of the microbubbles is
2.5–3.0 μm, and their mean concentration is 2 to 5×108 bubbles/ml. Targestar-P
agents (Targeson Inc.) are microbubbles composed of a perfluorocarbon gas core
6.1 Cavitation for Ultrasonic Surgery 179
encapsulated by a lipid shell. The agents are further stabilized and shielded by a
layer of polyethylene glycol. Agents are suspended in aqueous saline at a concen-
tration of approximately 1.5×109 particles/ml, and are packaged in glass vials with
a perfluorocarbon gas headspace. These microbubbles have a median diameter of
approximately 2.5 μm. Visistar-Integrin agents (Targeson Inc.) are also microbub-
bles composed of a perfluorocarbon gas core encapsulated by a lipid shell. The outer
shell is derivatized with a peptide that selectively binds endothelial avβ3 integrin.
The concentration of microbubbles is 1.5×109 particles/ml with median diameter
of approximately 2.5 μm. AI-700TM (Acusphere) is a perfluorocarbon gas contain-
ing microbubble coated by a polymer shell. The mean diameter of the microbubbles
is 2 μm and the concentration is 2×109 microbubbles/ml. BiSphereTM (POINT
Biomedical) consists of a double polymer/albumin wall shell encapsulating air using
bi-SphereTM technology. The inner shell, consisting of bio-degradable biopolymers,
provides physical structure and controls acoustic response, while the outer albumin
layer is designed to operate as a biological interface. The mean diameter of the
bubbles is 4 μm. The double layer of the bubbles provides them additional resis-
tance to ultrasound destruction. A new generation of ultrasound contrast agents with
a similar technology platform is PB127. This product is composed of biSpheres
containing nitrogen and has been engineered to break under specific ultrasound
conditions.
An important physical characteristic of the encapsulated microbubbles is that
they oscillate during sonification. These oscillations are used for specific imaging
techniques processing the resulting nonlinear signals with harmonic frequencies
at medium acoustic pressure (around 0.1 MPa), and microbubble disintegration
at high acoustic pressure (larger than 0.2 MPa) (von Bibra et al. 1999; Firschke
et al. 1997). At medium acoustic pressure, microbubble oscillation produces sta-
ble nonlinear scattering with harmonic echoes that can be used to augment signal
intensity of ultrasound contrast agents using various modalities, such as harmonic
B-mode, pulse inversion imaging modalities, and harmonic power Doppler imaging
(Firschke et al. 1997; Becher et al. 1997; Burns et al. 2000; Strobel et al. 2005). Sub-
harmonic (Shi et al. 1999) and ultra-harmonic (Basude and Wheatley 2001) imaging
methods have also been investigated. Current clinical applications of microbub-
bles, at medium acoustic pressure, include visualization of the cardiac chambers
during echocardiography, especially in assessing left ventricular size and systolic
performance at rest or during stress (Hundley et al. 1998; Rainbird et al. 2001),
thrombus imaging (Unger et al. 1998), enhancing tumor detection with ultrasound
(Ferrara et al. 2000), and obtaining information on microvascular blood volume
and velocity (Wei et al. 1998). At high acoustic pressure, oscillations lead to dis-
ruption of microbubbles, causing high energy broadband nonlinear scattering. This
phenomenon has been successful used for quantifying myocardial microperfusion
using refill kinetics (Leong-Poi et al. 2001; Hansen et al. 2005).
The success and versatility of microbubble contrast agents have caused them to
be the subject of several review articles on the topic of their use in diagnostic proce-
dures (Mayer and Grayburn 2001; Kaul 2001; Blomley et al. 2001; Raisinghani and
DeMaria 2002; Bull 2007; Dijkmans et al. 2004; Lindner 2004).
180 6 Cardiovascular Cavitation
In Eqs. (6.1) and (6.2) ρ L and ρ S are the densities of the liquid and shell, respec-
tively, R01 and R02 are the initial radii of interfaces 1 and 2, respectively, κ the
polytropic exponent, pg,eq the equilibrium pressure in the cavity, Re1 the unstrained
equilibrium position of interface 1, σ 1 and σ 2 are the interfacial tension at interfaces
1 and 2, respectively, GS is the modulus of rigidity of the shell, ρ L and ρ S are the
densities of the liquid and shell, respectively, μL and μS are the viscosities of the
liquid and shell, respectively, p0 the ambient liquid pressure, and pa is the acous-
tic pressure. Church (1995) indicated that the values of the shell parameters for the
6.1 Cavitation for Ultrasonic Surgery 181
3κ
3 2σ 2χ R0 3κ
ρ RR̈ + Ṙ2 = p0 + + 1− Ṙ
2 R0 R0 R c
2
Ṙ 2σ Ṙ 2χ R0 3Ṙ
− 4μ − 1− − 1− (6.3)
R R c R R c
Ṙ
− 12μS ε − (p0 + pa ).
R(R − ε)
In this equation, ρ is the density of liquid, R is the radius of the encapsulated bub-
ble, R0 the equilibrium radius, μ the liquid viscosity, μS the shell viscosity, χ the
shell elasticity, σ the interfacial tension, ε the shell thickness, and c the speed of
sound in the liquid. The estimated values of the shell parameters for the MP1950
microbubbles are χ = 0.5 N/m, ε = 1 nm, and εμs = 1 nm·Pa·s (Wu et al. 2003).
Chatterjee and Sarkar (2003) (see also Tu et al. 2008) also developed a model
of encapsulated microbubble dynamics that treats the thickness of the shell as infi-
nite small, but considers only the interfacial tension at the bubble interface. Sarkar
et al. (2005) refined this model to include a viscoelastic model of the interface that
includes the surface dilatational elasticity. In the incompressible limit their model
reads as (Sarkar et al. 2005):
$ % 3κ
3 2 2σ R0 Ṙ 2σ (R0 )
ρ RR̈ + Ṙ = p0 + − 4μ −
2 R0 R R R
! " (6.4)
s 2
2E R Ṙ
− − 1 − 4κs 2 − (p0 + pa ),
R RE R
where
⎧
⎪
⎪ 0 if R ≤ Rbuckling
⎨ 2
σ (R) = λ 2 R − 1 if Rbuckling < R < Rbreak-up . (6.6)
⎪
⎪ Rbuckling
⎩
σfluid if R ≥ Rruptured
The lower limit of the elastic regime is Rbuckling , while the upper limit radius is
fixed by the maximum surface tension before rupture of the shell Rbreak-up =
Rbuckling (1 + σbreak-up /λ)1/2 . When σbreak-up is reached the shell is ruptured and
the interfacial tension becomes equal to the surface tension of the fluid surround-
ing the microbubble. The values of the interfacial parameters are χ = 1 N/m, κs =
15×10–9 Ns/m, and σbreak-up > 1 N/m for SonovueTM microbubbles, while for the
BR14 microbubbles the corresponding values are χ = 1 N/m, κ s = 7.2×10–9 Ns/m,
and σ break-up = 0.13 N/m (Marmottant et al. 2005).
The translational motion of a microbubble in a fluid during insonation can be
studied by solving a particle trajectory equation (Dayton et al. 2002):
2 dur
ρb V Ẍ = −V∇pa − 2πρL R2 Ṙur − πρL R3 − 2πρL |ur |ur R2 cd , (6.7)
3 dr
where
In the above equations, Ẋ is the bubble translation velocity, ρb , ur , and V are the
density of gas inside the bubble, the relative velocity between the bubble and liquid
and the volume of the bubble, respectively. Cd is the drag coefficient determined by
Reynolds number of liquid around the oscillating bubble, as defined in Dayton et al.
(2002) and Watanabe and Kukita (1993):
! 0.63 1.38 "
24 2R|uL − ub | −4 2R|uL − ub |
cd = 2R|uL −ub |
1 + 0.197 + 2.6 × 10 ,
ν ν
ν
(6.9)
where ν is the kinematic viscosity of the liquid surrounding the microbubble. The
term on the left in Eq. (6.7) is the product of the mass of the bubble and its accel-
eration. The four terms on the right side of the equation describe the radiation force
on a highly compressible bubble as a result of the acoustic pressure wave, the added
mass as a result of the oscillating bubble wall, the added mass required to accelerate
a rigid sphere in the surrounding fluid, and the quasistatic drag force, respectively.
interface, the surface shear viscosity, μs , and the surface dilatational viscosity, κ s .
Consider, for simplicity, the case of a spherical bubble and a Newtonian interface,
i.e. an interface for which the relationship between the viscous part of the surface
stress and the surface rate of deformation is linear. The surface shear viscosity does
not come into play in the present situation, because of the radial motion of the
bubble. If the bubble surface is expanded at a constant dilatational rate
1 dA
λ̇ = , (1)
A dt
where A is the area of the bubble, the constitutive law for the isotropic part of the
surface stress is given by
dσ
χ= . (3)
d ln A
The variation of surface tension with the bubble radius R is thus expressed as
' )
R2
σ (R) = σ (R0 ) + χ −1 , (4)
R20
where R0 is the initial bubble radius. The balance of normal stresses at the interface
can now be written
2σ (R) Ṙ Ṙ
pl = pg − − 4μ − 4κs 2
R R R
(6)
∼ 2σ (R0 ) 1 1 Ṙ Ṙ
= pg − − 4χ − − 4η − 4κs 2 ,
R R0 R R R
with pl the liquid pressure, pg the gas pressure in the bubble, and μ the surrounding
liquid viscosity. Combining the Rayleigh-Plesset equation and a polytropic gas law
with the boundary condition (5) we obtain the model for the bubble dynamics as
6.1 Cavitation for Ultrasonic Surgery 185
3 1 2 ...
RR̈ + Ṙ2 − (R R + 6RṘR̈ + 2Ṙ3 )
2 c∞
(7)
1 2σ (R0 ) 1 1 Ṙ Ṙ
= pg − − ρ∞ − 4χ − − 4η − 4κs 2 ,
ρ∞ R R0 R R R
∇ · ν = 0, (1)
where v stands for both of the above velocities. From this it follows further that
where R10 and R20 are, respectively, the inner and the outer radii of the bubble shell
at rest.
Conservation of radial momentum yields
∂v ∂v ∂p ∂τrr 3τrr
ρ +v =− + + , (4)
∂t ∂r ∂r ∂r r
2σ1
pg (R1 , t) = pS (R1 , t) − τrrS (R1 , t) + , (5)
R1
186 6 Cardiovascular Cavitation
2σ2
pS (R2 , t) − τrrS (R2 , t) = ρL (R2 , t) − τrrL (R2 , t) + + p0 + pa (t), (6)
R2
where pg (R1 , t) is the pressure of the gas inside the bubble, σ1 and σ2 are the surface
tension coefficients for the corresponding interfaces, and pa (t) is the driving acoustic
pressure at the location of the bubble. Integrating Eq. (4) over r from R1 to R2 using
the parameters appropriate for the encapsulating layer and from R2 to ∞ using those
appropriate or the surrounding liquid, assuming that the liquid pressure at infinity
is equal to the hydrostatic pressure, p0 , and combining the resulting equation with
Eq. (2), one obtains
! ' 3 ) "
ρL − ρS R1 2 3 ρL − ρS 4R2 − R31 R1
R1 R̈1 1 + + Ṙ1 +
ρS R2 2 ρS 2R32 R2
⎡ ⎤
R2 S ∞ L
1 ⎢ 2σ1 2σ2 τrr (r, t) τrr (r, t) ⎥
= ⎣pg (R1 , t) − (p0 + pa ) − − +3 dr + 3 dr⎦
ρS R1 R2 r r
R1 R2
(7)
Assuming that the surrounding liquid is a viscous Newtonian fluid, τrrL (r, t) is written
as
∂v
τrrL = 2ηL , (8)
∂r
where ηL is the shear viscosity of the liquid. By using Eqs. (8) and (2), the second
integral term in Eq. (7) is found to be
∞
τrrL (r, t) R2 Ṙ1
3 dr = −4ηL 1 3 . (9)
r R2
R2
Consider now a viscoelastic shell whose rheology is described by the linear Maxwell
constitutive equation
∂τrrS ∂v
τrrS + λ = 2ηS , (10)
∂t ∂t
where λ is the relaxation time and ηS is the shear viscosity of the shell. Substituting
Eq. (2) into Eq. (10), one has
∂τrrS R2 Ṙ1
τrrS + λ = −4ηS 1 3 . (11)
∂t r
6.1 Cavitation for Ultrasonic Surgery 187
D(t)
τrrS = −4ηS , (12)
r3
and, therefore, the function D(t) obeys the equation
Using Eqs. (12) and (2), the first integral term in Eq. (7) is calculated as
R2
τrrS (r, t) D(t)(R320 − R310 )
3 dr = −4ηS . (14)
r R31 R32
R1
Resonance Frequency
The linear resonance frequency of microbubble oscillation f0 is the frequency at
which the bubble first harmonic response (linear amplitude-frequency response) has
a local maximum.
The linear resonance frequency of encapsulated microbubbles in the Church
model is (Church 1995):
$ %
1 ρL − ρS R01 −1/2 2σ1 2σ2 R301
f0 = 1+
ρS R201 3κp0 − −
2π ρS R02 R01 R402
! ' ) "&1/2 (6.10)
VS GS 1 2σ1 2σ2 3R301 R302
+4 3 1+ + 1+ 3 .
R02 4GS R01 R02 R02 VS
Equation (6.10) refers to a breathing mode of oscillation where the bubble sim-
ply pulsates. This is the frequency of oscillation of a zero-order spherical harmonic
perturbation upon a spherical bubble. Putting ρL = ρS = ρ, R01 = R02 = R0 ,
σ2 = 0, and GS = 0 in this equation yields the natural frequency of the bubble
in a Newtonian liquid (Lauterborn 1976). The resonance frequency of the encap-
sulated microbubbles increases approximately as the square root of the modulus of
188 6 Cardiovascular Cavitation
&1/2
1 3κ 2(σ + χ ) 2σ + 6χ 4μ + 12εμS /R0
f0 = p0 + − − . (6.11)
2π ρR20 R0 ρR30 ρR20
It can be seen that the resonance frequency of the microbubble increases with
increasing the shell elasticity and decreasing the thickness and viscosity of the shell.
The most influential parameter is, however, the shell elasticity (Wu et al. 2003).
WS
σS = , (6.12)
Iinc
with
4πr2 |PS |2
WS = , (6.13)
2ρc
and
|Pa |2
WS = , (6.14)
2ρc
where PS is the amplitude of the scattered wave at a distance r from the emission
center.
6.1 Cavitation for Ultrasonic Surgery 189
Fig. 6.3 Effects of liquid compressibility and viscoelasticity on the resonance frequency of
microbubble oscillation. Plots (a) and (b) show the resonance frequency as a function of bubble
radius for different values of sound velocity c for a Newtonian liquid and of relaxation time λ1 at
c = 1,500 m/s when the retardation time λ2 = 0, respectively. Other parameters are Gs = 88.8 MPa,
μs = 1.77 kg/(ms), and shell thickness 15 nm. Reproduced with permission from Khismatullin and
Nadim (2002). © American Institute of Physics
190 6 Cardiovascular Cavitation
The final form of the expressions for the scattering cross section depends on
the model used to describe the radial oscillations of the microbubble. The result-
ing expressions for a thick-shelled microbubble can be found in Khismatullin and
Nadim (2002) and for a thin-shelled microbubble in Wu et al. (2003). The numer-
ical results obtained by Church (1995), Khismatullin and Nadim (2002), and Wu
et al. (2003) indicate that the scattering cross section increases with increasing shell
elasticity and decreasing shell viscosity and thickness. Scattering is higher in a vis-
coelastic liquid than in a Newtonian liquid but this effect is minor as compared to
the shell effect (Fig. 6.5).
Fig. 6.6 Illustrating the transfer modalities of active substances (drugs or genes) to tissue using
microbubble ultrasound contrast agents. (a) Active substances are included in the gas-core region
of the microbubble, (b) Active substances are incorporated in the shell of the microbubble,
(c) Active substances are attached to the microbubble shell, (d) Microbubbles and the active
substances are co-administrated in the targeted region
6.1 Cavitation for Ultrasonic Surgery 193
substance were co-administered (Price et al. 1998; Song et al. 2002; Kondo et al.
2004) (Fig. 6.6d). The most widely investigated application is for gene transfer/gene
therapy. A second application is for drug and protein delivery. Finally, ultrasound
targeted microbubble destruction alone has been studied for therapeutic effects
without any transported substance.
Blood vessels are obvious targets for microbubbles and ultrasound, because
they are the first tissue exposed to the microbubbles. Several in vitro and in vivo
studies have been performed to evaluate transfection and the physiologic response
to ultrasound-target microbubble destruction in vessels. Cultured vascular smooth
muscle cells and endothelial cells were transfected with plasmids and microbubbles,
showing 3,000-fold higher expression than obtained with naked DNA alone (Lawrie
et al. 2000). Rat carotid arteries were transfected with anti-oncogene plasmids and
microbubbles, resulting in a significant reduction of intimal proliferation (Taniyama
et al. 2002a). Similarly, oligodeoxynucleotides were used with microbubbles to
reduce intimal proliferation in balloon-injured rat carotids (Hashiya et al. 2004).
Hynynen et al. (2001) has shown that transcranial application of ultrasound com-
bined with intravenous administration of microbubbles in rabbits reversibly open the
blood-brain barrier. They indicate that the mechanism responsible for opening the
blood-brain barrier is most likely due to cavitation of microbubbles with ultrasound.
Many potent drugs with severe adverse effects may be used more beneficially
if local concentrations could be increased while keeping systemic concentrations
low. Several studies demonstrated the potential for using ultrasound–microbubble
interactions to deliver therapeutically functional substances to treat various cardiac
pathologies through myocardial microcirculation. Figure 6.7 shows a schematic
diagram of drug delivery or gene therapy to the heart. A diagnostic ultrasound
transducer is placed on the patient’s chest. An ultrasound contrast agent bearing
drug or genetic material has been administered intravenously. As the microbubbles
enter the region of insonation, they distribute within the myocardial tissue via the
vascular bed. The microbubbles cavitate within the capillaries of the myocardial
tissue releasing the drug or genetic material (Unger et al. 2001). Vascular endothe-
lial growth factor bound to albumin microbubbles was delivered to the heart using
ultrasound. A 13-fold augmentation of cardiac vascular endothelial growth factor
uptake was seen compared with systemic vascular endothelial growth factor admin-
istration (Mukherjee et al. 2000). A study using lipid microbubbles with luciferase
protein demonstrated up to seven-fold augmented cardiac uptake of luciferase com-
pared with systemic administration (Bekeredjian et al. 2005a). In a rat model of
acute myocardial infarction, Kondo et al. (2004) utilized ultrasonic microbubble
destruction to transfer systemically injected hepatocyte growth factor plasmid into
myocardial cells to enhance capillary density and limit or negate left ventricular
remodeling. Erikson et al. (2003) used low-frequency ultrasound (1 MHz) to release
antisense oligonucleotides from albumin-shelled microbubbles, thereby facilitat-
ing oligonucleotide delivery to the myocardium. Recently, the vascular endothelial
growth factor protein and its encoding gene have been administered in a canine
(Zhou et al. 2002) and rat (Zhigang et al. 2004) model of myocardial infarction,
respectively. In vitro studies have shown that microbubbles contrast agents can also
194 6 Cardiovascular Cavitation
Fig. 6.7 Schematic diagram of drug delivery or gene therapy to the heart. Reproduced with
permission from Unger et al. (2001). © John Wiley and Sons
vector (Shohet et al. 2000). Three frames from a 1.3 MHz transducer destroyed
the microbubbles evident in the second-harmonic image, and three frame bursts
were triggered to allow refill of the tissue between scans. Expression of the reporter
gene was assayed in histological sections and by measurement of enzyme activity.
Staining and enzyme activity was detected in the myocardium after echocardio-
graphic destruction of the microbubbles mixed with the viral vector at about ten
times the levels found in controls (bubbles plus ultrasound, no vector; bubbles plus
vector, no ultrasound; vector alone, no bubbles, no ultrasound). Cavitation activity
was clearly responsible for the effect because the procedure involved destruction
of contrast agent microbubbles. However, it is uncertain whether the viral vec-
tor was delivered by sonoporation or by some other process. Echocardiographic
microbubble destruction followed by vector infusion generated about twice the gene
expression of controls, indicating that disruption of the endothelial barrier during
microbubble destruction might be a factor in the enhanced viral transduction.
The potential application of microbubble contrast agents as an adjuvant to throm-
bolytic therapy is also promising. Ultrasound at frequencies ranging from 20 to
3 MHz has been shown to enhance the thrombolytic efficacy of urokinase and
tissue plasminogen activator (Lauer et al. 1992; Francis et al. 1992; Tachibana
and Tachibana 1995; Porter et al. 1996). Acceleration of thrombolysis with ultra-
sound is probably due to local cavitation that may weaken the clot surface and/or
improve clot penetration by the fibrinolytic agents. This process can be enhanced
greatly by the presence of microbubbles. In vitro studies have shown that ultra-
sound energy at high acoustic pressures combined with microbubble administration
enhances the thrombolytic efficacy of urokinase from 1.5- to over 3-fold (Tachibana
and Tachibana 1995; Porter et al. 1996), and can even result in efficient clot lysis in
the absence of thrombolytic therapy (Porter et al. 1996).
The mechanisms by which ultrasound-contrast agent interactions induce an
increase in cell and microvessel permeability are poorly understood, although
several hypotheses exist. Postema et al. (2004) describe the different effects of
ultrasound on microbubbles and demonstrate these effects by experiments using
high-speed photography. Depending on the applied ultrasound amplitude and fre-
quency, effects such as stable oscillation of microbubbles, inertial cavitation,
coalescence, fragmentation, ultrasound induced damage of the shell causing gas
to escape from microbubbles (sonic cracking), and jetting are ascribed. Sustained
oscillatory motion of bubbles (stable cavitation) induces fluid velocities and exert
shear forces on the surrounding tissues and cells (Suslick 1988). In the presence of
a high-power, low-frequency ultrasound beam, microbubble contrast agents expand
and contract nonlinearly, a phenomenon known as inertial cavitation, which often
leads to bubble fragmentation (Chomas et al. 2000; de Jong et al. 2000; Boukaz
et al. 2005; Boukaz and de Jong 2007). An example of microbubble fragmenta-
tion is shown in Fig. 6.8 for the case of the experimental contrast agent MP1950
containing C4 F10 encapsulated by a phospholipid shell (Chomas et al. 2000). The
effects of various factors including the ultrasound driving frequency, pulse length,
peak negative pressure, bubble size and shell properties on the fragmentation of
microbubbles were investigated by Chomas et al. (2001) and Bloch et al. (2004).
196 6 Cardiovascular Cavitation
Fig. 6.8 Optical frame images corresponding to the oscillation and fragmentation of a contrast
agent microbubble. The initial diameter of the microbubble is 3 μm (frame (a)). The streak image
in frame (h) shows the diameter of the bubble as a function of time, and dashed lines indicate the
times at which the two-dimensional frame images in frames (a)–(g) were acquired relative to the
streak image. Reproduced with permission from Chomas et al. (2000). © American Institute of
Physics
Fig. 6.9 Illustrating the formation of a microjet during the collapse of a microbubble contrast
agent near a solid boundary. The microjet is indicated by the white arrow. The initial position of
the microbubble is indicated by the black arrow. It is 26.5 μm in the top sequence and 19 μm in
the bottom sequence. Frame size is 163 μm × 110 μm. Reproduced with permission from Prentice
et al. (2005). © Macmillan Publishers Ltd
Fig. 6.10 Microbubble translation under high-pulse repetition frequency ultrasound within micro-
tubes observed by a microscope video camera system at 240 frames/s. The microbubble with an
initial radius of 1.2 μm is moving fom the center of the microtube to the wall. Reproduced with
permission from Zheng et al. (2007). © Elsevier B.V.
198 6 Cardiovascular Cavitation
importance is the generation of highly reactive species, such as free radicals, that
can induce chemical transformations in the medium which may be involved in the
enhancement of permeability of endothelial cell layers. A significant increase in
free radical production in endothelial cells after exposure to ultrasound was demon-
strated by Basta et al. (2003). Finally, another mechanism by which the use of
encapsulated microbubbles could facilitate deposition of drugs and genes in a cell
is fusion of the phospholipid microbubble coating with the bilayer of the cell mem-
brane. This could result in delivery of the microbubble substances directly into the
cytoplasm of the cell (Dijkmans et al. 2004). All or a combination of these events
may alter, displace, or destroy cells, possibly resulting in cell microporation (Deng
et al. 2004) and gaps between neighboring cells. For example, Ohl et al. (2006)
demonstrated that the collapse of microbubbles cause membrane poration to cells
plated on a substrate through a complex sequence of events. When the jet developed
during bubble collapse impacts onto the boundary, it spreads out radially along the
substrate causing a strong gradient in the velocity component parallel with the sub-
strate. The resulting shear stress leads to the detachment of cells. Cells at the edge of
the area of detachment were found to be permanently porated, whereas cells at some
distance from the detachment area undergo viable cell membrane poration. The
high shear stress caused by violent microstreaming or microjets developed during
microbubble collapse may explain the maximum transfection efficiency and lowest
cell viability obtained at high ultrasound pressures (Wu 2002; Wu et al. 2002).
Several hypotheses on the mechanism of blood-brain barrier disruption with
microbubbles and ultrasound have been proposed (Sheikov et al. 2004). Since an
ultrasound wave causes microbubbles to expand and contract in the capillaries, the
expansion of larger microbubbles could fill the entire capillary lumen, resulting in
a mechanical stretching of the vessel wall which, in turn, could result in the open-
ing of the tight junctions. This interaction could create a change in the pressure in
the capillary to evoke biochemical reactions that trigger the opening of the blood-
brain barrier. Moreover, bubble oscillation may also reduce the local blood flow and
induce transient ischemia, which could also trigger blood-brain barrier opening.
Extensive reviews of the therapeutic applications ultrasound-targeted microbub-
ble destruction, including ultrasound–microbubble interactions, are currently avail-
able in literature (Lindner 2004; Unger et al. 2004; Liu et al. 2006; Chappell and
Price 2006; Bekeredjian et al. 2005b, 2006; Ferrara et al. 2007; Shengping et al.
2009).
Whenever laser pulses are used to ablate, cut, or disrupt tissue inside the human
body, cavitation bubbles are produced that interact with the tissue. In cardiovascular
laser applications, this situation is encountered in myocardial laser revascularization
and laser angioplasty.
Fig. 6.11 A series of pictures illustrating the interaction of a holmium laser pulse with a polyacry-
lamide sample in water environment. The energy of the laser pulse is 12 J and the pulse duration is
2.2 ms. Times indicated are delay times of the photograph relative to the onset of the laser pulse.
Reproduced with permission from Brinkmann et al. (1999). © IEEE
Fig. 6.12 A series of pictures illustrating the interaction of a CO2 laser pulse with a polyacry-
lamide sample in water environment. The power of the laser pulse is 800 W and the pulse duration
is 15 ms. Times indicated are delay times of the photograph relative to the onset of the laser pulse.
Reproduced with permission from Brinkmann et al. (1999). © IEEE
lead to a structural deformation of the tissue adjacent to the ablation site that is much
more pronounced than the ablative tissue effect itself and compromises the high pre-
cision of the original ablation. In addition, the authors concluded, from experiments
on porcine heart tissue, that the orientation of the myocardial fibrils significantly
influences the dynamics of cavitation bubbles, the shape of the ablated cavities, and
202 6 Cardiovascular Cavitation
the thermo-mechanical collateral damage areas. Deep and straight channels were
found for fibrils running perpendicular to the endocardium, while much smaller but
widely dissected tissue was found for horizontal channels.
The fragmentation of cavitation bubbles during implosion may result in many
gaseous microemboli that may persist briefly in the circulation. The formation of
such microemboli, during transmyocardial laser revascularisation on human sub-
jects, was observed in the middle cerebral artery by von Knobelsdorff et al. (1997).
However, none of the patients exhibited major neurological deficits on the first day
after surgery, indicating that transmyocardial laser revascularisation does not cause
significant cerebral ischemia. The authors explained this result by the very small
size of the induced microemboli. Indeed, Feinstein et al. (1984) found that only
arterial emboli larger than 15 μm lead to temporary oclusion of more than 1 min,
whereas emboli of less than 10 μm in diameter pass the capillary vasculature unre-
stricted. Multiple microembolic signals were also detected in the ophthalmic artery
during transmyocardial laser revascularisation in pigs by Gerriets et al. (2004). They
demonstrated that the microembolic load can be reduced by ventilation with 100%
oxygen and by decreasing the laser pulse energy.
308 nm emitted from an optical fibre at the catheter tip vaporizes atheromatous
tissue. This technique requires direct contact of the fibre tip to the obstructive
plaque. Main indications for pulsed laser angioplasty are diffuse and long coronary
lesions and total coronary occlusions (Haude et al. 1997). Rotational atherectomy
is another approach for removing atheromatous plaque from coronary arteries. This
technique uses a diamond-studded burr spinning at 50,000–200,000 rpm to excavate
calcified or fibrotic plaque, allowing microscopic debris to embolize to the coro-
nary capillary bed. Although directional atherectomy and excimer-laser angioplasty
usually result in larger lumen diameters than percutaneous transluminal coronary
angioplasty, these treatments have not reduced the rates of acute complications or
restenosis after coronary angioplasty (Topol et al. 1993; Appelman et al. 1996).
Furthermore, no multi-center, randomized trials proving the superiority of rota-
tional angioplasty over percutaneous transluminal coronary angioplasty have been
reported.
Fig. 6.13 Dilatation and invagination of a silicone tube after a dye-laser pulse. Pulse energy
70 mJ, pulse duration 3 μs, initial diameter of the tube 5 mm. Pictures taken with 50,000 frames/s.
Reproduced with permission from Vogel et al. (1996). © Springer Science + Business Media
6.2 Cavitation in Laser Surgery 205
reduces the incidence of arterial wall ruptures and prevents intimal hyperplasia for-
mation. Both concepts can, however, only lead to a gradual decrease of cavitation
effects, because they do not avoid ablation taking place in a liquid environment. To
avoid this limitation, Vogel and co-workers (1996, 2001, 2002) introduced a tech-
nique for the reduction of cavitation effects produced by short laser pulses. The
laser pulse is divided into a pre-pulse with low energy and an ablation pulse with
higher energy, separated by time intervals of 50–100 μs. The pre-pulse creates a
small bubble at the application site, and the ablation pulse is applied when this bub-
ble is maximally expanded and can be filled by the ablation products of the main
pulse. With a suitable energy ratio between pulses, the ablation products will not
enlarge the bubble generated by the pre-pulse, and the maximal bubble size remains
much smaller than after a single ablation pulse. In this manner, no additional cav-
itation effects are induced, and tissue tearing and other mechanical side effects are
minimal. The reduction of the cavitation bubble size by a pre-pulse is illustrated in
Fig. 6.14. In addition, the transiently empty space created by the pre-pulse between
Fig. 6.14 Illustrating the concept of double pulses for reduction of cavitation effects in a silicone
tube. (a) Pre-pulse alone, (b) pre-pulse (delivered in frame 1) and ablation pulse (delivered in frame
6). The initial diameter of the tube is 5 mm. Pictures taken with 50,000 frames/s. Reproduced with
permission from Vogel et al. (1996). © Springer Science + Business Media
206 6 Cardiovascular Cavitation
the optical transmission and the artherosclerotic plaque surface improves the optical
transmission to the target and thus increase the ablation efficiency.
The occurrence of cavitation was also observed during high-speed rotational
angioplasty (Zotz et al. 1992). In an in vitro study with a burr of 1.25 mm diameter
spinning at 160,000 rpm the authors observed that the mean size of the cavitation
bubbles in distilled water was 90 ± 33 (between 52 and 145) μm. They also noted
that the production of bubbles was more pronounced in fresh human blood than in
distilled water, probably because red blood cells act as cavitation nuclei.
Implantation of a mechanical heart valve has been used as a surgical treatment for
various heart valve diseases, where the genuine valve, due to stenosis or insuffi-
ciency, compromises ventricular function. Despite the usual success of this surgical
therapy, patients still face the risks of blood cell damage, thromboembolic events,
and material failure of the prosthetic device (Johansen 2004). Many different
mechanical valves are or were available for implantation which can be classified
into three main groups: cage ball valve (Starr-Edwards, Smeloff-Cutter), tilting disk
valve (Bjork-Shiley, Medtronic-Hall), and bileaflet valve (Carbomedics, Carpentier-
Edwards). In 1976, cavitation was first suggested to be related to erosion of titanium
struts of a caged ball mechanical heart valve (Zubarev et al. 1976) but it was only
in the mid 1980s that cavitation has clinically been found to cause valve failure and
valve fragment embolization (Deuvaert et al. 1989; Alvarez and Deal 1990). An
example of cavitation pattern is given in Fig. 6.15 for the case of a rigidly mounted
bileaflet valve (Rambod et al. 1999). Clouds of bubbles occur in various locations
along the peripherial circumference of the leaflets and along the gap between the
leaflets.
Fig. 6.15 The sequence of microbubbles formation in a 29 mm bileaflet valve at closure. (a) End-
diastolic period (<1 ms prior to complete closure, (b) the burst at the instant of closure and
formation of clouds of microbubbles (t0 ), (c) dissipation of clouds at about t0 + 5 ms, (d) and
(e) pressure recovery and growth of persisting microbubbles at approximately t0 + 8 ms.
Reproduced with permission from Rambod et al. (1999). © Springer Science + Business Media
208 6 Cardiovascular Cavitation
micrometers, while Hwang (1998) noted that the oscillation period of the cavitation
bubbles typically last a few microseconds. Recently, Takiura et al. (2003) demon-
strated that the emitted light from cavitation bubble collapse is in the same locations
where bubbles have been seen to collapse.
All of the above-mentioned in vitro studies on cavitation in mechanical heart
valves have used the valve fixed in a rigid mounting, which does not allow motion of
the valve housing. Obviously, this experimental model does not describe accurately
the in vivo conditions. Wu et al. (1995) examined how the compliance in mounting
a mechanical heart valve influences the flow field around the valve. They compared
a rigid and a flexible mounting of the valve in the mitral position of a pulsatile mock
flow loop. They found that the velocity of the occluder as it approaches the housing
was similar in both cases, but the rebound of the occluder was much stronger when
the valve was mounted rigidly than when it was mounted in a flexible material. Valve
holder flexibility was also investigated by Chandran and Aluri (1997). In contrast to
the results reported by Wu et al., they found that the flexibility of the valve holder
did not affect pressure field close to the inflow surface of the leaflet at the instant
of valve closure. Moreover, they found that leaflet closing velocity is an important
factor for cavitation initiation if magnitudes are compared only for the same valve
model.
In vivo investigations on cavitation in mechanical heart valves were conducted by
Zapanta et al. (1996) who measured high-frequency pressure fluctuations in valves
that had undergone implantation of a left ventricular assist device equipped with a
mechanical heart valve. These pressure fluctuations, which are a consequence of
the transient bubble collapse, provide information on the intensity and duration
of the cavitation phenomenon (Garrison et al. 1994). The most interesting con-
clusion of their work is that the pressure signals observed in vivo were similar to
those observed in vitro where cavitation was visually demonstrated. Dexter et al.
(1999) found no transient negative pressure spikes in goats with pericardial valves.
However, transient pressures below the vapour pressure of blood were detected in
goats in which mechanical heart valves were implanted. Paulsen et al. (1999) mea-
sured high-frequency pressure fluctuations, in the frequency range 35–150 kHz, in
the first intraoperative study of patients. They also found high-frequency pressure
fluctuations in patients with mechanical heart valve implant and no signals in the
patients with normal or bio-prosthetic heart valves. Similar results were reported by
Andersen et al. (2003).
When the occluder approaches the housing during closure fluid is squeezed out into
the space between occluder surface and the housing surface forming a low pressure
region where cavitation occurs (Bluestein et al. 1994; Zhang et al. 2006; Lee and
Taenaka 2006). Later, Zapanta et al. (1998) found that the cavitation intensity is
influenced by several features that take place during valve closure. They noted that
occluder closing velocity, deceleration time, occluder density, and valve geometry
could affect the likelihood and intensity of cavitation. Their findings suggest that a
rigid occluder, closing at high velocity and decelerating rapidly, is more prone to
cause cavitation than a flexible leaflet that is slowly decelerated. Cavitation may be
also generated in the core of the vortices where significant pressure decrease occurs
towards the vortex core. During mechanical heart valve operation such vortices may
form at the edge of the valve occluder at closure (Avrahami et al. 2000; Manning
et al. 2003; Rambod et al. 2007). Both squeeze flow and vortex cavitation are seen
as a cloud of bubbles at the circumferential lip of the occluder. Another mechanism
of cavitation inception is given by the sudden stop of the valve occluder as it reaches
the valve housing. In this case, blood is subjected to tension and the pressure may
drop sufficiently to induce the formation cavitation bubbles on the occluder orifice
(Hwang 1998).
The collapse of cavitation bubbles can lead to damage of the mechanical heart valves
structures and to some biological unwanted collateral effects such as formation of
microemboli (microbubbles), thromboembolic complications, and blood cell dam-
age. Scanning electron microscopy of the explanted valves revealed confined areas
of pitting and erosion on the leaflet and the housing (Klepetko et al. 1989). On
the other hand, clinical studies using transcranial Doppler ultrasonography have
shown the presence of microemboli in the cranial circulation of some mechanical
heart valve patients (Georgiadis et al. 1997; Deklunder et al. 1998; Nötzold et al.
2006). Transesophagial echocardiography of mechanical heart valve patients has
shown images of bright, mobile signals, also considered to be gas bubbles, near
the valve (Levy et al. 1999; Girod et al. 2002). In vitro studies performed to inves-
tigate the relationship between dissolved gas concentration and the incidence of
bubble formation after valve closure (Biancucci et al. 1999) indicate that stable gas
microbubbles can form during mechanical heart valve operation. The microbub-
ble likely form from the combined effects of gaseous nuclei formed by cavitation,
low-pressure regions associated with regurgitant flow, and the presence of CO2 , a
highly soluble blood gas. Levy et al. (1999) suggested cavitation to be responsible
for the formation of microbubbles. They observed such microbubbles in patients
with mechanical heart valves implants but not in patients with biological valve
implants. Furthermore, they observed that increased systolic ventricular function
increased the number of the detected microbubbles. Milo et al. (2003) demonstrated
microbubble formation in vortices under physiological conditions during in vitro
210 6 Cardiovascular Cavitation
experiments with mechanical mitral valve prostheses. Large cavitation bubbles dis-
integrated rapidly into microbubbles with a stability of several cycles in the system.
Bachmann et al. (2002) demonstrated in vitro that stable microbubble formation
occurs in the core of vortices at the closing rim of Bjork-Shiley valves. They also
observed cavitation in these vortices but stable microbubbles only appeared once
the cavitation bubbles collapsed. A similar observation was reported by Lin et al.
(2000). Potthast et al. (2000) also supported the idea that cavitation is the key factor
in the appearance of gaseous microemboli at heart valve prostheses as they found
a relationship between dP/dt and the number of stable microbubbles detected by
ultrasonography as high-intensity transient signals. However, Girod et al. (2002)
reported that the microbubbles observed in the left atrium of mechanical mitral
valve patients are most likely induced by degassing of CO2 in blood rather than
a cavitation phenomenon. A third type of collateral effects induced by cavitation
is the release of cell content into the blood as a consequence of the destruction of
blood cells by cavitation bubble collapse (Johansen 2004). One important released
agent is the tissue factor from ruptured monocytes and platelets. It is well known
that the tissue factor is the primary initiator of blood coagulation and thereby plays
an important role in thrombogenesis and thromboembolic complications (Rapaport
and Rao 1995; Sambola et al. 2003). The release of tissue factor into the blood-
stream may be responsible for thrombus formation seen in patients with mechanical
heart valve implants (Johansen 2004).
Gas embolism occurs when gas enters vascular structures and can result in morbid-
ity or death (Murphy et al. 1985; Bull 2005). The most common gas embolism
is air embolism, but the medical use of other gases, such as nitrogen, carbon
dioxide, and nitrous oxide, may also result in the formation of cardiovascular
bubbles consisting of other gases. Emboli may enter the cardiovascular system
during neurosurgical procedures (Porter et al. 1999), cardiac surgical procedures
using extracorporeal bypass (Ziser et al. 1999), through central venous (Halliday
et al. 1994) and hemodialysis catheters (Yu and Levy 1997), or can be produced
by the disintegration of cavitation bubbles generated during transmyocardial laser
revascularization, laser angioplasty and mechanical heart valve operation, as we dis-
cussed previously. The mechanisms underlying gas-embolism-induced injuries are
not completely understood. One explanation is that the microbubbles lodge in the
microcirculation, occluding flow and inducing transient local ischemia (Herren et al.
1998; Kort and Kronzon 1982). Another possible explanation is that injury is pri-
marily due to thrombo-inflammatory response activated by microbubble damage to
the endothelium or interactions of blood proteins or platelets with the microbubble
interface (Ryu et al. 1996; Helps et al. 1990). This likely occurs over a longer time
scale than transient ischemia, and both mechanisms may play important roles in gas
embolism.
6.4 Gas Embolism 211
Fig. 6.16 A schematic illustration of the gas embolotherapy technique to kill tumors. A stream
of encapsulated superheated dodecafluoropentane liquid droplets goes into the body by way of an
intravenous injection. The droplets are small enough so that they do not lodge in vessels. Once the
droplets reach their destination, they are hit with high intensity ultrasound and expand into a gas
bubbles that lodge in the blood vessel
Several studies have been performed on the threshold and efficiency of vapor-
ization using different acoustic parameters. It is currently hypothesized that there
are two main methods for vaporizing droplets. The first mechanism is vaporiza-
tion within the core of the droplet resulting from the transmitted ultrasonic field
interacting with the dispersed medium. Vaporization via this mechanism seems
to be supported from high-speed photography images taken by Kripfgans et al.
(2004) (see, for example, Fig. 6.17). The second mechanism is vaporization due
to inertial cavitation in or near the droplet. During the collapse of an inertial cav-
itation bubble a secondary shock-wave is emitted which causes vaporization of
the droplet. Support for multiple mechanisms is further assisted when compar-
ing the acoustic pressure thresholds that induce vaporization. Using short pulses
Kripfgans et al. (2000) found the vaporization threshold to decrease with increasing
frequency. On the other hand, Giesecke and Hynynen (2003) found the vaporiza-
tion threshold to increase with increasing frequency, similar to an inertial cavitation
threshold curve.
In a recent experimental study, Calderon et al. (2006) investigated the evolu-
tion of cardiovascular gas bubbles in a microfluidic model bifurcation. Their work
was motivated by the potential treatment of cancer by tumor infarction using gas
embolotherapy. The interesting result of their investigations is that the critical driv-
ing pressure below which a bubble will lodge in a bifurcation is significantly less
than the driving pressure required to dislodge it. The authors estimated that gas
bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter,
and concluded that bubbles may potentially be used to reduce blood flow to tumor
microcirculation. There are two states in which bubbles lodged at the bifurcation
6.4 Gas Embolism 213
(Fig. 6.18). Bubbles usually lodged when the bubble’s front and back menisci con-
tacted the wall (Fig. 6.18a). Most of the bubbles lodged in this state originally, and
as the pressure was increased, the bubble either dislodged or lodged again at a higher
pressure in a different state. In Fig. 6.18b the rear meniscus appears to stretch and
eventually prevents the bubble from moving. This lodging state is more common in
the microchannels with the bifurcation angle of 110◦ , in which the lodged bubble
could withstand higher pressure than in the 78◦ bifurcation. In some instances, when
the driving pressure was increased to dislodge the bubble, the shorter portion of the
bubble in the daughter branch returned and the rear meniscus bulged such that the
bubble lodged in just one branch (Fig. 6.18c).
Acoustic droplet vaporization is a fast process (of the order of microseconds),
and the phase change of droplets to bubbles and their subsequent rapid expansion
in a confined space may potentially result in sufficiently large normal and shear
stresses to rupture blood vessels and damage the vessel endothelium. The acoustic
vaporization procedure was numerically investigated by Ye and Bull (2004), in the
case of a rigid-walled tube, in order to assess the risk of vessel damage during gas
embolotherapy. They demonstrated that, for a given initial bubble size, the maxi-
mum pressure at the vessel wall increases with the initial bubble pressure, and that
the maximum occurs early in the bubble expansion. The vessel wall is therefore
214 6 Cardiovascular Cavitation
Fig. 6.18 Various states of bubble lodging in a bifurcation model. Reproduced with permission
from Calderon et al. (2006). © American Institute of Physics
exposed to the highest risk of rupture at the beginning of the bubble expansion. The
authors also noted that the initial bubble size has the largest effect on shear stress. To
minimize the potential of damaging the endothelium, smaller bubbles relative to the
diameter of the blood vessel are favored. The overall magnitude of the shear stress
is much less than that of the pressure. In a subsequent study, Ye and Bull (2006)
indicated that wall flexibility can significantly influence the wall stresses that result
from acoustic vaporization of intravascular perfluorocarbon droplets, and suggests
that acoustic activation of droplets in larger more flexible vessels may be less likely
to damage or rupture vessels than activation in smaller and stiffer vessels.
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Chapter 7
Nanocavitation for Cell Surgery
T2 (r)
β(T)
p(r) = dT, (7.1)
K(T)
T1
where T1 is the temperature before the laser pulse, T2 (r) the temperature of the
plasma after the laser pulse, which depends on the location within the focal volume,
β the thermal expansion coefficient, and K the liquid compressibility. The time-
and space-dependent pressure distribution p(r, t) due to the relaxation of the initial
7.1 Cavitation Induced by Femtosecond Laser Pulses 227
Fig. 7.1 Radius-time curve of the cavitation bubble produced by a single femtosecond laser pulse
focused at a numerical aperture NA = 1.3 that leads to a peak temperature of Tmax = 200◦ C at
the focus center. The radius of the bubble nucleus is R0 = 91.1 nm. The temperature at the wall of
the nucleus is Twall = 145◦ C and the mean temperature averaged over all volume elements within
the bubble nucleus is Tmean = 168◦ C. The radius versus time curve in (a) was calculated under
the assumption that the vapour pressure within the bubble is given by the mean temperature within
the nucleus and decays due to heat diffusion (the size of the bubble is much smaller than the focal
volume). The curve in (b) was calculated assuming that the vapour pressure drops adiabatically
during bubble expansion (the size of the nucleus is comparable to the size of the focal volume). In
this figure τ represents the oscillation time of the bubble. Reproduced with permission from Vogel
et al. (2005). © Springer Science + Business Media
Fig. 7.2 Bubble radius Rmax as a function of dimensionless pulse energy EL /Eth for different
wavelengths at numerical apertures NA = 0.9 (•) and NA = 0.8 (). Reproduced with permission
from Vogel et al. (2008). © American Physical Society
Historically, the first method used for tumor therapy is the photodynamic therapy,
also known as photochemotherapy (Wilson 1986; Henderson and Dougherty 1992).
This method involves cell destruction caused by means of toxic singlet oxygen and
other free radicals that are produced from a sequence of photochemical and photobi-
ological processes. These processes are induced by the reaction of a photosensitizer
with tissue oxygen upon exposure to a specific wavelength of light in the visible or
near-infrared region. Although many chemicals have been reported for photochem-
ical therapy, porphyrin-based sensitizers (Moan 1986; Vicente 2001) lead the role
in clinical applications because of their preferential retention in cancer tissues and
due to the high quantum yields of singlet oxygen produced. Porphyrin-based ther-
apy can only be used for tumors on or just under the skin or on the lining of internal
organs or cavities because it absorbs light shorter than 640 nm in wavelength. For
deep-seated tumors, second generation sensitizers, which have absorbance in the
near-infrared region, such as core-modified porphyrins (Stilts et al. 2000), chlorins
(Spikes 1990), or naphthalocyanine (Bonnett 1995), have been introduced. A well-
known limitation of photodynamic therapy is that it requires tissue oxygenation for
production of singlet oxygen as a toxic agent, while malignant tissues are usually
hypoxic (Wilson 2002). Also, due to nonspecific accumulation of the photochemical
agents in normal cells, photodynamic therapy may cause toxic side-effects.
An alternative to photodynamic therapy is the photothermal therapy in which
photothermal agents are employed to induce local heating of cellular struc-
tures (Anderson and Parrish 1983; Jori and Spikes 1990). Tumors are selectively
230 7 Nanocavitation for Cell Surgery
destroyed in this case because of their reduced heat tolerance compared to normal
tissue, which is due to their poor blood supply. Hyperthermia causes irreversible cell
damage by loosening cell membranes and denaturing proteins. When the photother-
mal therapy agents absorb light, electrons make transitions from the ground state
to the excited state. The electronic excitation energy subsequently relaxes through
non-radiative decay channels. This results in the increase in the kinetic energy lead-
ing to the overheating of the local environment around the light absorbing species.
The photoabsorbing agents can be natural chromophores in the tissue (Morelli et al.
1986) or externally added dye molecules such as indocyanine green (Chen et al.
1995) or naphthalocyanines (Jori et al. 1996). The choice of the exogenous pho-
tothermal agents is made on the basis of their strong absorption cross sections and
highly efficient light-to-heat conversion. This greatly reduces the amount of laser
energy required to achieve the local damage of the diseased cells, rendering the
therapy method less invasive.
It was recently established that laser-induced local heating of cellular structures
using either pulsed or continuous laser radiation and mediated by light-absorbing
nanoparticles may provide precisely localized damage that can be limited to single
cells (see, for example, West and Halas 2003). Accumulation of light-absorbing
The key idea of plasmonic photothermal therapy is that nanoparticles locally con-
vert optical energy into thermal energy through their unique mechanism of plasmon
resonance. When a spherical nanoparticle, with a diameter much smaller than the
wavelength of light, is irradiated with an electromagnetic field at a certain frequency,
a resonant oscillation of the metal free electrons across the nanoparticle is induced.
This oscillation is known as the surface plasmon resonance (Kreibig and Vollmer
1995). The frequency of surface plasmon resonance absorption is dependent on the
metal composition, nanoparticle size and shape, and dielectric properties of the sur-
rounding medium. The resonance lies at visible frequencies for the noble metals
gold and silver (Link and El-Sayed 2003). Gold is, however, the metal of choice
for biomedical applications. The most important factor motivating the use of gold
nanoparticles is their facile bioconjugation and biomodification (Katz and Willner
2004). Further, spherical gold colloids can easily be made in a wide range of sizes
by facile chemistry involving the reduction of gold ions in solution (Turkevich et al.
1951). The ability of gold nanoparticles to convert strongly absorbed light efficiently
into heat can be exploit for the selective photothermal therapy of cancer (Khlebtsov
et al. 2006), and bacterial (Zharov and Kim 2006) and viruses infection (Sain et al.
232 7 Nanocavitation for Cell Surgery
• For T < TLV , where TLV is the liquid vaporization temperature, only acoustic
waves are generated;
• For TLV ≤ T < TNPM , where TNPM is the nanoparticle melting point (for gold
~1,060◦ C), shock wave emission and formation of a cavitation bubble are the
main feaures of the interaction (Fig. 7.4);
• For TNPM ≤ T < TNPB , where TNPB is the nanoparticle boiling point (for gold
~2,700◦ C), melting of the nanoparticle occurs, while
• For T > TNPB , gold vapour around liquid drops are generated.
Fig. 7.4 Schematic representation of shock wave emission and cavitation bubble formation
following laser irradiation of gold nanoparticles
7.2 Cavitation During Plasmonic Photothermal Therapy 233
where R is the bubble radius, ρ the liquid density, κ the polytropic exponent, and
the term with pi,eq describes the pressure evolution inside the bubble for the varying
radius. The authors performed the numerical integration of this equation to fit the
measured values of the bubble radius as function of time. An example is shown in
Fig. 7.6 for a value of the laser power of 1,300 J/m2 .
In a subsequent study, Kotaidis et al. (2006) investigated the evolution of cavi-
tation bubbles generated by a 50-ns, 400-nm laser excitation of 9- and 39-nm gold
nanoparticles in water. Their results are given in Fig. 7.7 where the bubble volume
is plotted versus the laser fluence. An extrapolation of the results reveals a threshold
below which no bubble is generated. The threshold value is 300 J/m2 for a particle
diameter of 9 nm and 80 J/m2 for a particle diameter of 39 nm.
Fig. 7.6 Bubble radius and pressure transients of the water vapour inside the bubble as calcu-
lated from the Rayleigh-Plesset equation together with the measured radii. The first maximum in
pressure at 650 ps marks the bubble collapse, the following modulations are only expected for
oscillatory bubble motion. The parameters used in the numerical calculations are R0 = 7.2 nm,
pi,eq = 0.3 GPa, η = 0.15×10–3 kg/m·s, while the initial values are R = 4.5 nm and Ṙ = 90 m/s.
Reproduced with permission from Kotaidis and Plech (2005). © American Institute of Physics
Studies by Lapotko
Laser-induced generation of cavitation bubbles in water around plasmonic nanopar-
ticles was also studied by Lapotko (2009a) using optical scattering methods. The
behaviour of cavitation bubbles was investigated for values of the laser pulse dura-
tion, τp , of 0.5 and 10 ns at a wavelength λ = 532 nm. All experiments were
performed in a response mode for a single laser pulse. Several types of gold
nanoparticles and their clusters were used as plasmonic heat sources: spherical gold
nanoparticles with diameters, d, of 30 and 100 nm (with a plasmon resonance peak
at 530 nm), gold nanorods with dimensions 14 nm × 45 nm (with plasmon reso-
nance peaks at 532 nm and 750 nm), and silica-gold shells with outer diameters of
60 and 170 nm and with broad extinction spectra. All samples were studied as water
suspensions in closed micro-volumes confined to a glass sample chamber with a
diameter of 9 mm and variable height from 10 to 1,000 μm. The concentration of
nanoparticles was adjusted so as to provide a mean interparticle distance of 8 μm.
In addition to single nanoparticles, aggregates of nanoparticles were prepared by
adding 40% of acetone and re-suspending the nanoparticles in water. The nanopar-
ticle cluster was defined as the aggregate with the interparticle distance smaller than
the nanoparticle size and containing at least several nanoparticles.
Both single nanoparticles and their clusters generated bubbles starting from a
specific threshold of the laser fluence. For τ p = 0.5 ns, λ = 532 nm, and spher-
ical nanoparticles, this fluence level was almost one order of magnitude lower
for nanoparticle clusters (0.088 J/cm2 ) relative to that for single nanoparticles
(0.72 J/cm2 ). This is probably because clusters generate bubbles at a much lower
initial laser-induced temperature, and therefore the clusterization of nanoparticles
significantly improves the efficacy of bubble generation.
A 20-fold increase of the laser pulse length caused an increase in the bubble
generation threshold fluence in all the nanoparticles and their clusters studied. The
bubble threshold ratio for 10 ns/0.5 ns pulses varied in the range from 13 (for sin-
gle 30-nm nanoparticles) to 24 (for single 100-nm nanoparticles). This means that
despite the significantly decreased intensity of the long laser pulse the efficacy of
the bubble generation turned out to be relatively small. This could be due to the
increased thermal losses in the case of the long pulse. It may also be possible that
the bubble scatters the incident long pulse thus decreasing its actual fluence.
The increase of the spherical nanoparticle diameter from 30 to 100 nm resulted in
a several-fold decrease on the bubble threshold fluence. For example, for τp = 0.5 ns
the bubble threshold fluence is about 1.1 J/cm2 for d = 30 nm and only 0.4 J/cm2 for
d = 100 nm. Even a stronger effect was observed for gold nanorods (a bubble thresh-
old fluence of about 0.35 J/cm2 for τ p = 0.5 ns) despite the fact that the 532 nm band
does not provide maximal optical absorbance for this geometry. Minimal thresholds
were achieved with nanoparticle clusters regardless the type of the nanoparticles
(spheres and two different types of shells). The increase of the cluster size low-
ered the bubble generation threshold. Gold 60-nm nanoshell clusters of 500–700 nm
yielded the lowest bubble threshold fluence of 12 mJ/cm2 . Therefore, nanoparticle
clusters may be considered as the best solution for minimizing the vaporization
thresholds fluence and temperature.
236 7 Nanocavitation for Cell Surgery
As the bubble oscillation time is much longer than the duration of a short laser
pulse, Lapotko also investigated the effect exerted by a pulse train with that made
by a single pulse. He exposed single spherical nanoparticles with a diameter of
30 nm to paired short pulses with a variable interval: 1 and 6.5 ns. For an interval of
6.5 ns, two pulses did not influence the threshold fluence levels and the oscillation
time of the bubbles. At a shorter interval of 1 ns the bubble generation threshold
decreased by a factor of 1.7, and the bubble oscillation time increased by a factor
of 1.5 relative to the values obtained with a single pulse. Therefore the pulse train
mode may additionally increase the efficacy of the bubble generation and may also
lead to a decrease in the initial laser-induced temperature of a nanoparticle.
Although it was not possible to directly measure a maximal diameter of bubbles,
it can still be estimated by the measuring the bubble oscillation time and using the
Rayleigh formula (Eq. (3.17)) to convert the oscillation time into maximum bubble
radius. Whereas in the case of single 30-nm nanoparticles the bubble oscillation
time is about 18 ns, the corresponding value obtained in the case of clusters of 30-
nm of nanoparticles is about 420 ns. The diameter of bubbles, generated from single
nanoparticles, with a minimal oscillation time (15–20 ns) was estimated to be at
about 180 nm. Nanoparticle clusters generate a much bigger cavitation bubble with
a maximum diameter of about 4 μm. It is also interesting to note that bubbles with
an oscillation time shorter than 15 ns were never detected, irrespective of the type
of nanoparticles and laser pulse fluence.
In a second experiment, Lapotko (2009b) studied the influence of the laser pulse
duration on bubble evolution in uniformly absorbing micro- and macrosamples:
single red blood cells and in a solution of hemoglobin. The influence of the pulse
duration was similar to that found for gold nanoparticles, although the increase of
the bubble threshold fluence for the10-ns pulse was smaller than that in the case
of nanoparticles. For the red blood cells it was 8.4 times smaller while for the
homogeneous solution of hemoglobin it was 2.9 times smaller.
The results obtained by Lapotko (2009a, b) clearly indicate that the mechanism
of bubble generation depends on many factors related to the laser pulse duration,
nanoparticle size and shape, and nanoparticles aggregation state. An increase in the
size of nanoparticles as well as the shortening of the laser pulse duration leads to
a significant decrease in the threshold fluence. Clusterization of nanoparticles sig-
nificantly improves the conditions of bubble generation by decreasing its threshold
fluence and increasing its oscillation time, and hence the maximal size of the bubble.
Vasiliev et al. (2009) studied the evolution of cavitation bubbles generated by
three types of gold nanoparticles: spheres with a diameter of 30 nm (plasmon res-
onance at 520 nm), gold rods with a diameter of 14 nm and length of 45 nm
(transverse plasmon resonance at 530 nm and the main longitudinal plasmon res-
onance at 750 nm) and shells consisting of the silica core and gold shell with the
outer diameter of 170 nm. All nanoparticles were prepared as water suspension at
a concentration of 2.5 × 1011 /ml which provide an average inter-particle distance
of 1.7 μm. The nanoparticles were irradiated with a 10-ns, 532-nm laser pulse
and the detection of the cavitation bubbles in the sample liquid (water) was per-
formed using a photothermal microscope. They found that the energy threshold for
7.2 Cavitation During Plasmonic Photothermal Therapy 237
bubble generation is 8 J/cm2 for gold nanorods, 1.8 J/cm2 for gold nanospheres and
70 mJ/cm2 for gold nanoshells. The latest value is 25 times lower than the threshold
obtained for an homogeneous model (without nanoparticles). The authors also noted
that, at a fluence of 63 mJ/cm2 , the oscillation time of the bubble is 50 ns for the gold
nanorods, 20 ns for gold nanospheres, and 200 ns for the gold nanoshells. According
to the Rayleigh formula these values correspond to a maximum bubble diameter of
about 500 nm in the case of gold rods, 200 nm in the case of gold spheres, and 2 μm
for gold shells. Similar results were reported by Lapotko (2009b).
Fig. 7.8 Optical microscope images of gold nanoparticle aggregation and bubble formation
induced by laser irradiation (a–c). Bubble diameter plotted as a function of time after the laser
is turned off (d). Reproduced with permission from Liu et al. (2010). © IOP Publishing Ltd
238 7 Nanocavitation for Cell Surgery
optical absorption of the gold nanoparticles, which aggregate at the bubble inter-
face. When the laser is turned off, the bubble shrinks during the first few minutes
as the temperature decreases, as shown in Fig. 7.8d. The bubble then remains con-
stant in size once the temperature equilibrates with room temperature. Without gold
nanoparticles in the suspension, no bubble formation was observed even for laser
exposures of 10 min.
Dayton et al. (2001) investigated the oscillations of bubbles with a maximum
radius of 1.5 μm that were phagocytosed by leukocytes and stimulated by a
rarefaction-first, one-cycle acoustic pulse with 440 ns duration. By means of streak
photography and high-speed photography with 100 million frames/s they observed
that phagocytosed bubbles expanded about 20–45% less than free microbubbles in
response to a single acoustic pulse of the same intensity. The difference is most
likely due to the viscoelasticity of the cytoplasm and cytoskeleton.
∞
3 2 1 2σ 3 τrr
Rb R̈b + Ṙb = pb (t) − − p∞ − dr, (7.3)
2 ρl R ρl r
Rb
with
kTb (t) a
pb (t) = − 2 , (7.4)
Vb (t) − b Vb (t)
where kB is the Boltzmann constant, a and b are the constants of the van der Waals
equation of state, and Tb (t) and Vb (t) are defined as
Rg /cv
Tb (t) Vb (t) − b
= , (7.5)
Tcl (t) Vcw − b
and
4 3
Vb (t) = π Rb − R3np , (7.6)
3
where Rg is the universal gas constant and cv is the specific heat.
The initial values of the temperature and pressure inside the bubble are those
at the critical point of the liquid surrounding the nanoparticle, Tcl and pcl , respec-
tively. The initial value of the bubble radius, Rb,0 , is obtained by assuming that the
excessive light energy absorbed by the nanoparticle during the laser pulse is spent
on boiling at the critical point. The amount of evaporated water can be estimated as
mb = 4π R3b,0 − R3np ρcl /3 = (F − Fc ) σabs /Ecl , (7.7)
and thus
2
3 (F − Fc ) σabs
Rb,0 = 3 + R3np . (7.8)
4πρcl Ecl
In the above equations, Ecl is the internal energy of the liquid at the critical point,
ρ cl is the critical density of the liquid, F is the laser fluence, and Fc is the critical
laser fluence required to heat the nanoparticle to the boiling temperature Tboil , which
in the case of short laser pulses (χl τL << R2np , where χ l is the thermal diffusivity
of the liquid) is given by (Egerev et al. 2009)
For long laser pulses (χl τL >> R2np ), the expression for the critical laser fluence
becomes (Egerev et al. 2009)
240 7 Nanocavitation for Cell Surgery
Here, Vnp , cnp , and ρnp are the volume, specific heat capacity, and density of the
nanoparticle. The term σabs represents the absorption cross section given by
2π
∞
( (2 ( (2
σabs = (2n + 1) (an ( Cn + (bn ( (n + 1)Cn−1 + nCn+1 , (7.11)
k0 |ε| n=1
2
with
-√ √ √
.
Cn = Im ε∗ j n k0 Rnp ε jn−1 k0 Rnp ε∗ , (7.12)
where an and bn are the Mie coefficients for the transmitted field, k0 = 2π/λ is the
wave number, jn is the Riccati-Bessel function, and the superscript ∗ indicates the
operation of complex conjugation.
The mathematical formulation proposed by Egerev et al. (2009) requires the
knowledge of the optical absorption cross section for the determination of the initial
bubble radius. It is well known that the optical absorption and scattering prop-
erties of gold nanoparticles can be tuned by changing their size and shape (Jain
et al. 2006). For example, gold nanospheres with a diameter of 20 nm show essen-
tially only surface plasmon enhanced absorption with negligible scattering (Jain
et al. 2006). However, when the nanoparticle diameter is increased from 20 to
80 nm, the relative contribution of surface plasmon scattering to the total extinc-
tion of the nanoparticle increases. Thus, larger nanoparticles are more suitable for
light-scattering-based applications.
Calculations show that, for gold nanoparticles irradiated at λ = 532 nm, the max-
imum absorption corresponds to the nanoparticles with radius of 10–40 nm (Jain
et al. 2006). This is the optimal size of a gold nanosphere to achieve maximum
energy absorption per unit volume for the specific incident laser wavelength. For a
gold nanosphere with a radius of 10 nm the calculated optical cross-section equals
the geometrical cross-section. The calculated optical cross-section increases with
the diameter of the nanospheres and is about three times larger than the geometrical
cross-section for a nanoparticle radius of 40 nm (Jain et al. 2006).
Another interesting property of gold nanoparticle surface plasmon resonance is
its sensitivity to the local refractive index or dielectric constant of the environment
surrounding the nanoparticle surface. The nanosphere plasmon resonance shifts to
higher wavelengths with increasing refractive index of the surrounding medium
(Lee and El-Sayed 2006). The nanoparticle surface plasmon resonance can also
be red-shifted by the self-assembly or aggregation of nanoparticles (Sönnichsen
et al. 2005). Oraevsky (2008) has indicated that for a nanoparticle inside a bubble
irradiated at the wavelength close to its plasmon resonance optical absorption, the
absorption cross section can be approximately estimated as equal to its geometric
cross section.
7.2 Cavitation During Plasmonic Photothermal Therapy 241
It is also worth noting here that, for very short laser pulses, the critical laser
fluence is independent of the pulse shape. Furthermore, for a specific value of the
pulse duration there is an optimal particle size, which has the minimal value of Fc .
For large particles, heat exchange with the surroundings is negligible, and Fc ∝ Rnp .
In contrast, for small particles (χl τL >> R2np ), Fc ∝ R−1
np (Egerev et al. 2009).
The first thorough study using pulsed laser radiation and gold nanospheres was
performed in 2003 by Lin and co-workers for selective and highly localized pho-
tothermolysis of targeted lumphocytes cells (Pitsillides et al. 2003). Lumphocytes
incubated with gold nanoparticles conjugated to antibodies were exposed to
nanosecond laser pulses (Q-switched Nd:YAG laser, 565 nm wavelength, 20 ns
duration) showed cell death with 100 laser pulses at an energy of 0.5 J/cm2 . Adjacent
cells just a few micrometers away without nanoparticles remained viable. Their
numerical calculations showed that the peak temperature lasting for nanoseconds
under a single pulse exceeds 2,000 K at a fluence of 0.5 J/cm2 with a heat fluid layer
of 15 nm. The cell death was attributed mainly to the cavitation damage induced by
the generated cavitation bubbles around the nanoparticles.
In the same year, Zharov et al. (2003) performed similar studies on the
photothermal destruction of K562 cancer cells. They further detected the laser-
induced bubbles and studied their dynamics during the treatment using a pump–
probe photothermal imaging technique. Later they demonstrated the technique
in vitro on the treatment of some other type of cancer cells such as cervical
and breast cancer using the laser induced-bubbles under nanosecond laser pulses
(Zharov et al. 2004, 2005b, c). Recent work has demonstrated the treatment modal-
ity for in vivo tumor ablation in a rat (Hleb et al. 2008). Intracelullar bubble
formation resulted in individual tumor cell damage.
The formation of cavitation bubbles around nanoparticles also caused physical
damage to the Staphylococcus aureus bacterium as confirmed by the images pre-
sented by Zharov et al. (2006) (Figs. 7.10 and 7.11). At relatively low laser energies,
they observed a very slight penetration of nanoparticles in the cell wall (Fig. 7.11b)
compared to the control without laser exposure (Fig. 7.11a). Higher laser energies,
or the formation of nanoparticle clusters, led to a deeper penetration of nanopar-
ticles inside the bacterial wall (Fig. 7.11c). High laser energy and/or formation of
nanoclusters coupled with multi-pulse exposure produced local cell-wall damage
(Fig. 7.11d) and finally complete bacterial disintegration (Fig. 7.11e, shows frag-
mented bacteria). These data demonstrate that, despite the relatively high thickness
and density of the bacterial cell wall, bubble formation around nanoparticles may
potentially cause irreparable damage to bacteria.
The photothermolysis of living EMT-6 breast tumor cells triggered by gold
nanorods was investigated by Chen et al. (2010). In the absence of gold
nanoparticles, the cells survived under the excited energy fluence of 93 mJ/cm2 .
However, cell mortality was observed at 113 mJ/cm2 energy fluence. Results of
242 7 Nanocavitation for Cell Surgery
Fig. 7.10 Images of Staphylococcus aureus with attached gold nanoparticles: (a) phase contrast
image; (b) photothermal image of bacteria alone; (c) photothermal images of bacteria with 40-nm
gold particles irradiated at a laser fluence of 0.4 J/cm2 ; and (d) photothermal images of bacteria
with 40-nm gold particles irradiated at a laser fluence of 2 J/cm2 . Dashed lines represent the bac-
terial boundary in (c) and (d). Arrows in (d) indicate photothermal images of single nanoparticles,
whereas the arrowhead shows a bubble around one nanocluster. Reproduced with permission from
Zharov et al. (2006). © Elsevier B.V.
Fig. 7.11 Images of Staphylococcus aureus conjugated with gold nanoparticles before (a) and
after (b–e) multilaser exposure of 100 pulses, wavelength of 532 nm, and pulse duration of 12 ns at
a different conditions: (b) laser fluence of 0.5 J/cm2 and no clusters; (c) laser fluence of 0.5 J/cm2
with clustered nanoparticles; and (d) laser fluence of 3 J/cm2 at one and several (e) nanocluster
numbers. A dashed line represents the bacterial boundary in (e). Arrows in (b) and (c) indicate
penetration of nanoparticles into the wall, and in (d), arrows indicate local cell-wall damage.
Reproduced with permission from Zharov et al. (2006). © Elsevier B.V.
the cells with gold nanoparticles, under excitation at energy fluences of 113 and
93 mJ/cm2 , are shown in the series of images in Fig. 7.12; the images were taken
within a period of 60 s. Upon reaching an energy fluence of 113 mJ/cm2 , the whole
cell was seriously destroyed (Fig. 7.12a–d). At an energy fluence of 93 mJ/cm2 , a
discernible internal explosion phenomenon occurred upon excitation (Fig. 7.12e–h).
Meanwhile, the formation of characteristic cavities (shadows indicated by arrows)
was especially pronounced at nanoparticle cluster locations (cluster size between 2
and 3 μm). The diameter of the cavities can reach as large as 10 μm. The results
showed that localized photothermal effect of gold nanoparticles was large enough
to trigger a considerable explosion, resulting in the formation of cavitation bubbles
inside cells. These bubbles are responsible for the perforation or sudden rupture
of plasma membrane. Their study also indicates that the energy threshold for cell
therapy depends significantly on the number of nanoparticles taken up per cell. For
an ingested gold nanoparticle cluster quantity N ∼ 10–30 per cell, it was found
that energy fluences larger than 93 mJ/cm2 led to effective cell destruction within
7.2 Cavitation During Plasmonic Photothermal Therapy 243
Fig. 7.12 Photothermolysis of the EMT-6 tumor cell triggered by gold nanoparticles under differ-
ent energy fluences. (a–d) 113 mJ/cm2 ; (e–h) 93 mJ/cm2 . The shadows indicated by arrows are
attributed to the formation of transient cavitation bubbles. The gold nanoparticles inside the cell
can be seen in (a) and (e). Reproduced with permission from Chen et al. (2010). © Elsevier B.V.
a very short period. As for a lower energy level (18 mJ/cm2 ) with N ∼ 60–100, a
non-instant, but progressive cell deterioration, was observed.
The photothermolysis of lung carcinoma cells (A549) triggered by gold
nanospheres with a diameter of 50 nm was investigated by Lukianova-Hleb et al.
(2010). They found that at laser fluences below the bubble generation threshold,
the nanoparticles in cells still were significantly heated by the laser pulse but did
not cause detectable damage to the cells. Also, the exposure of the cell to 16 pump
laser pulses (at 15 Hz frequency), instead of a single pulse, did not influence the
cell viability and the level of the damage threshold fluence, which suggests that the
cell damage results from a single event rather than from an accumulative effect of
the sequence of the bubbles. They concluded that the bubble damage mechanism is
mechanical and non-thermal: a single laser pulse induces an expanding bubble that
disrupts the cellular cytoskeleton and plasma membrane causing visible membrane
blebs.
Blebbing of the plasma membrane for various cell types was also observed by
Tong et al. (2007) (Fig. 7.13). The authors noted that bleb formation could not be
the direct product of cavitation, as the rates of growth were several orders of magni-
tude slower than the timescale for microbubble expansion. They hypothesized that
the blebbing response was due to the disruption of actin filaments, which form a
dense three dimensional network beneath the cell membrane to provide mechani-
cal support and sustain cell shape. However, an important conclusion of their study
is that the cell death is attributed to the disruption of the plasma membrane as a
244 7 Nanocavitation for Cell Surgery
Fig. 7.13 Photothermolysis mediated by gold nanorods with longitudinal plasmon resonances
centered at 765 nm. Cells were irradiated at 765 nm using a Ti:sapphire laser which could be
switched between fs-pulsed and cw mode. (a, b) Cells with membrane-bound gold nanorods
exposed to cw near infrared laser irradiation experienced membrane perforation and blebbing at
6 mW power. The loss of membrane integrity was indicated by EB staining (light grey, yellow
online). (c, d) Cells with internalized gold nanorods required 60 mW to produce a similar level
of response. (e, f) Gold nanorods internalized in KB cells labeled by folate-Bodipy (lighter grey,
green online) were exposed to laser irradiation at 60 mW, resulting in both membrane blebbing
and disappearance of the gold nanorods. (g, h) NIH-3T3 cells were unresponsive to gold nanorods,
and did not suffer photoinduced damage upon 60 mW laser irradiation. (i, j) Cells with membrane-
bound gold nanorods exposed to fs-pulsed laser irradiation produced membrane blebbing at 0.75
mW. (k, l) Cells with internalized gold nanorods remained viable after fs-pulsed irradiation at 4.50
mW, as indicated by a strong calcein signal (grey, green online). Reproduced with permission from
Tong et al. (2007). © Wiley-VCH Verlag GmbH & Co. KGaA
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Chapter 8
Cavitation in Other Non-Newtonian
Biological Fluids
In the previous chapters we have described the effects of cavitation in the cardio-
vascular system and cell surgery. There are an increasing number of biomedical
contexts where cavitation takes place in other non-Newtonian biological fluids, such
as saliva or synovial fluid. In saliva, cavitation occurs during some medical appli-
cations of lasers and ultrasound. In synovial liquid, cavitation is responsible for
the cracking noise emitted from joints and may also damage the articular cartilage.
In this chapter, we provide a qualitative description of cavitation and some of its
associated bioeffects encountered in clinical applications. The archival literature in
these cases is not as impressive as in the case of blood. Threshold conditions for
the onset of cavitation in various biological fluids require more precise definition,
preferably mathematical models underpinned by an extensive body of experimental
evidence. The conditions associated with the onset of morphological damage also
merit a more precise description. Nevertheless, we invite the reader to appreciate
how cavitational activity can help address some of the present therapeutic challenges
in several non-Newtonian biological fluids.
the periodontal attachment. In the attempt to create smooth roots, free of any deep
accretions, the hand instruments tear into the fragile periodontal ligament and scrape
off tooth structure. Unlike the curette, an ultrasonic scaler tip works from the top of
the deposit downward, so there is no need to violate the attachment. Thus, ultra-
sonic instrumentation is now the first choice over hand instrumentation for most
patients. The ultrasonic scaler has been used for about 30 years. In most practices
it is used primarily for gross removal of supra-gingival calculus. New super-thin
tips are now available that fit into deep pockets and small furcal areas where a stan-
dard curette is ineffective. Some manufacturers have designed machines with a far
wider power range, so they can create effective cavitation at the low power set-
tings needed for sub-gingival use (O’Leary et al. 1997). Ultrasonic scalers are now
the preferred method for sub-gingival debridement. Recent research has shown that
sub-gingival ultrasonic scaling not only removes calculus as well as traditional hand
instrumentation, but that it also kills bacteria and reduces the level of endotoxins.
Back in the early 70’s researchers noticed that the ultrasonic scaler cleaning abil-
ity dropped significantly when the water flow was interrupted. They speculated that
this was due to the irrigating effect of the water (Clark 1969). Later research indi-
cated that no matter which tip was used, and no matter at what angle it touched the
tooth, the amount of plaque-free surface increased by 500–800% when the water
was turned on (Walmsley et al. 1988). They noted that the dry tip removed plaque
only where it contacted the tooth. However, when a water cooled tip was used
they observed that surfaces as much as a half millimeter away from the tip were
completely plaque-free.
The tip’s high-frequency vibrations create cavitation bubbles. When the ener-
gized spray from the hand-piece contacts the tooth surface, these bubbles collapse
and release short bursts of energy which literally blast the plaque from the sur-
face and tear apart bacterial cell membranes in the process (Walmsley et al. 1988;
Lea et al. 2005; Felver et al. 2009). The ultrasound field generated by the scaler
is comprised of a series of compressions and rarefactions (regions of high and low
pressure) which cause small cavitation nuclei to expand and contract (Fig. 8.1a).
Inertial cavitation bubbles oscillate violently and may expand to many times their
original size before imploding. The collapse of such a bubble can result in shock
Fig. 8.1 Cavitation and acoustic streaming around an ultrasonic scaler. (a) The oscillating pressure
field causes a cavitation nucleus to expand and contract. (b) When the cavitation bubble is located
close to the scaler, it may collapse accompanied by the formation of a liquid jet
8.1 Cavitation in Saliva 251
waves associated with massive temperatures and pressures. If the bubble collapses
or implodes near to the surface of a tooth or a scaler tip then the collapse is asym-
metrical resulting in an inrushing jet of liquid targeted at the surface (Fig. 8.1b). This
jet of liquid is powerful enough to potentially remove calculus and other materials
from the tooth surface (Walmsley et al. 1984, 1988). Furthermore, the force of these
jets is enough to visibly roughen the metallic surface of the ultrasonic scaler tip.
A clear visualization of the spatial distribution of cavitation bubbles around
three scaler tips, observed using sonochemiluminescence from a luminol solution,
is given in Fig. 8.2 (Felver et al. 2009). The highest levels of cavitation activity
were observed around vibration antinodes close to the bend in each tip. Surprisingly,
while the displacement amplitude was greatest at the free end of the tip, little to no
cavitation was observed at the free end using luminol photography.
It is also interesting to note here that cavitation does not occur around pow-
ered tooth brushes. Lea et al. (2004) tested five commercial brushes and monitored
the formation of the hydroxyl radical that occurs during cavitation bubble collapse.
Operating the toothbrushes for periods up to 20 min resulted in no cavitational
activity being detected.
Cavitation bubbles can also be used for the delivery of antibacterial nanoparti-
cles into dentinal tubules. Persistent root canal infection has been associated with
bacterial presence in the dentinal tubules. Studies have shown that bacteria can
penetrate into dentinal tubules, and the depth of penetration varies from 300 to
1,500 μm (Love and Jenkinson 2002). However, the bacteria within the dentinal
tubules are inaccessible to the conventional root canal irrigants, medicaments, and
sealers because they have limited penetrability into the dentinal tubules. Although
the application of ultrasound produces better results compared with syringe irriga-
tion in cleaning and delivering irrigants into the anatomic complexities, ultrasonic
irrigation does not debride the root canal system completely.
In a very recent study, Shrestha et al. (2009) have indicated that the collaps-
ing cavitation bubbles treatment using high-intensity focused ultrasound can result
in a significant penetration up to 1,000 μm of antibacterial nanoparticles into the
dentinal tubules. The cavitation bubbles produced using high-intensity focused
ultrasound can be used as a potential method to deliver antibacterial nanoparticles
into the dentinal tubules to enhance root canal disinfection. The mechanism respon-
sible for the delivery of antibacterial nanoparticles is illustrated in Fig. 8.4 in the
case of a spark-generated cavitation bubble. The bubble grows to a maximum size
(with maximum radius of 3.3 mm) in a time of 0.46 ms (Fig. 8.4b). The collapse
of cavitation bubble (Fig. 8.4c–g) generates a high-speed jet, which moved toward
the channel at about 68 m/s. This jet delivers the bead of plaster (with a mass of
approximately 6 mg), which was originally placed about 2 mm from the top of the
channel, into the whole length of the channel (Fig. 8.4e–g).
254 8 Cavitation in Other Non-Newtonian Biological Fluids
Fig. 8.4 The collapse of a cavitation bubble with a maximum bubble radius of 3.3 mm on top
of a tubular channel of 3.3-mm diameter. The time is indicated at the bottom right. The bubble
collapses at time t = 0.73 ms with a jet speed of about 68 m/s. The rubber plaster balls are centered
initially 2 mm from the top of the channel opening. It can be seen from frames corresponding to
times t = 1.3 to t = 5.8 ms that the rubber plaster is pushed by the flow down the entire length of
the channel. Reproduced with permission from Shrestha et al. (2009). © Elsevier B.V.
Fig. 8.5 An air inclusion being compressed when a laser-induced cavitation bubble grows and
expands in an artificial root canal. The maximum compression of the air inclusion is visible in the
third frame. Reproduced with permission from Blanken et al. (2009). © John Wiley and Sons
256 8 Cavitation in Other Non-Newtonian Biological Fluids
(Väterlein et al. 2000). It is well known that the combined effects of the shock
waves and cavitational collapse induce harmful side effects on the adjacent biolog-
ical structures, such as that observed in lithotripsy (Delius et al. 1988). However,
macroscopical radiological and histological analysis at 0, 3, 12 and 24 weeks after
treatment showed no pathological changes in the joint cartilage.
Arthroscopic cartilage ablation (see, for example, Smith 1993) is another med-
ical application where cavitation takes place in the synovial liquid. The dynamics
of cavitation bubbles generated by a pulsed holmium laser radiation (wavelength
2.12 mm, pulse duration between 100 and 1,000 ps), transmitted through an opti-
cal fiber, and their impact on medical laser use for cartilage ablation have been
investigated by Asshauer (1996). Shock waves were observed at the bubble collapse
several hundred microseconds after the start of the laser pulse and peak pressures
up to several kilobars were measured. The observed complex bubble dynamics and
pressure transient generation was explained by a two stage model: in the first stage
of the bubble formation process, a water volume at the fiber tip is superheated by
the laser radiation, until an explosive vaporization induces an isotropic vapour bub-
ble expansion. In the second stage, a quasi-continuous ablation through the bubble
takes place. The relative importance of the second stage increases for higher fluences
and longer pulse durations, perturbing the initial nearly spherical symmetry of the
bubbles. The angle of incidence of the laser radiation was identified as an impor-
tant additional parameter for cartilage ablation. It was shown that shallow angles
of incidence reduce pressure transient amplitudes as well as thermal side effects of
cartilage ablation.
Ultrasonically induced cavitation may also have a clinical benefit to control syn-
ovial proliferation and inflammation or some other disorders of joints. Nakaya et al.
(2005) investigated the effect of a microbubble-enhanced ultrasound treatment on
the delivery of methotrexate (an antimetabolite and antifolate drug used in treat-
ment of cancer and autoimmune diseases) into synovial cells. They found that
the methotrexate concentration in synovial tissue was significantly higher in the
presence microbubbles while the synovial inflamation was less prominent. Saito
et al. (2007) reported that the expression of plasmid DNA and small interfering
RNA in the synovium was significantly enhanced by ultrasound in combination
with microbubbles. In a more recent study, Nakamura et al. (2008) observed that
ultrasound treatment in combination with microbubbles increased cellular uptake of
enzymes (histone deacetylase) into human rheumatoid synovial cells.
20 and 40 kHz, is used to emulsify or fragment the lens nucleus (whether it is emul-
sification or fragmentation depends on the hardness of the nucleus). The fragments
are then removed by means of an irrigation suction system that is integrated into the
phaco-tip. After the lens capsule is cleaned, the artificial lens is implanted and the
eye is closed again.
Manual extraction of the nucleus demands a large wound of approximately 9 mm
chord length. Phacoemulsification can be done through a smaller wound of approx-
imately 3 mm length. Wound length is also governed by the size of the intraocular
lens that is inserted. Conventional polymethylmethacrylate lenses require the pha-
coemulsification incision to be enlarged to 6 mm to allow their insertion. Intraocular
lenses made from different materials such as hydroxymethyl methacrylate or sili-
cone can be folded to allow their insertion. This further facilitates the use of small
incisions.
Besides the intended surgical effect, some unwanted collateral effects are
observed, such as damage of the corneal endothelium (Walkow et al. 2000), rupture
of the posterior capsule (Martin and Burton 2000) and damage of the phaco-tip itself
with metal particulate often left in the eye after surgery (Gimbel 1990; Kreiler et al.
1992). A typical lesion on human corneal endothelium is shown in Fig. 8.7. The
most serious ocular complication of phacoemulsification lens extraction is dropping
the nucleus into the vitreous cavity. This may result in visual loss due to inflamma-
tion and retinal detachment. Fortunately, this complication is unusual in experienced
surgeons and sight loss can be prevented by vitrectomy and nucleus removal.
Phacoemulsification predominates as the procedure of choice for cataract extrac-
tion. The reasons are rooted in improved outcome for the patient. The main
advantage is reduced corneal astigmatism after cataract surgery. Since the cornea
is the major refracting surface of the eye, minor disturbances to its shape may result
in marked astigmatism with serious consequences for vision. All corneal surgery has
the tendency to produce astigmatism with less intervention producing less distortion
than the more disruptive procedures. However, small cataract incisions produce less
astigmatism than large incision cataract surgery.
The phaco-tip vibrations are strong enough to generate both transient and stable
cavitation bubbles which probably produce most of the fragmentation and emul-
sification of the lens and which may also cause a removal of material from the
phaco-tip. An example of cavitation bubble formation as a result of phaco-tip vibra-
tions is illustrated in Fig. 8.8. Several authors cite the formation of free radicals
as evidence of cavitation during phacoemulsification. These species are thought to
be generated when the heat from the implosion of cavitation bubbles causes the
decomposition of water (Augustin and Dick 2004; Shimmura et al. 1992; Takahashi
et al. 2002). Holst et al. (1993) used a single photon counting apparatus and lumi-
nol in rabbit eyes to demonstrate chemoluminescence secondary to the production
of free radicals during phacoemulsification. They also obtained data correlating the
amount of free radicals produced with the amount of ultrasonic power used. Topaz
et al. (2002) demonstrated sonoluminescence under simulated phacoemulsification
in aqueous medium using electron paramagnetic resonance spectroscopy and pho-
ton detection. They also noted reduction of cavitation intensity and elimination of
sonoluminescence by saturation of the solution with carbon dioxide.
Cavitation around the phaco tip was also observed by Zacharias (2008). However,
his study found strong evidence that cavitation plays no role in phacoemulsification,
leaving the jackhammer effect as the most important mechanism responsible for the
lens-disrupting power of phacomeulsification.
Current surgical procedures, particularly ultrasound phacoemulsification for
cataract surgery and other operations involving the anterior chamber of the eye,
have benefited from the use of ophthalmic viscoelastic substances (Silver et al. 1992;
Behndig and Lundberg 2002). The primary goal of these substances is to protect the
corneal endothelium during surgical procedures. The viscoelastic substances should
offer minimal thixotropy in order to aid retention within the eye and yet, following
implantation, should possess high-equilibrium viscosity to ensure that there is an
appropriate maintenance of the ocular space (Andrews et al. 2005). The viscoelastic
properties of these substances may also reduce the cavitation intensity and, thus, the
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Index
Gibbs equations, 52 N
Gilmore equation, 67, 74 Nanoparticle, 225, 230–245, 253
Green fluorescent protein, 194 Normal stress coefficients, 8
Nucleation
H barrier, 51–52
Harmonic resonance, 87–88, 90 heterogeneous, 49–50
homogeneous, 49, 51–53
Hookean relaxation time, 20
rate, 51
Huggins slope constant, 12–13
Nuclei
Hyperbaric oxygen therapy, 211
distribution
Hysteresis, 6, 51
blood, 55–57
polymer solutions, 54–55
I water, 53–54
Imaging techniques, 179, 241 stabilization mechanisms, 50
Inception cavitation number, 127, 131, 135, Numerical methods, 11–12, 14, 17, 78, 80–82,
137, 145, 149 85, 87–90, 98, 105–106, 110, 119,
Incubation stage, 155 142, 148, 167, 181, 191, 213,
Internal energy, 239 226–229, 234, 241, 245
Intracorporeal stones, 165
Irrigant, 252–253 O
Opposed jet rheometer, 29–30
J Optical tweezer, 32–33
Jet formation, 91, 100–101, 104, 164, 166, Orifice flow, 121–123, 126, 148
168, 196 Orthognatic surgery, 256
Jet velocity, 92–93, 96–97, 104–105, 121,
P
127, 166
Period-doubling cascade, 90
Perturbation approach, 97
K Photodynamic therapy, 229
Keller-Herring equation, 67 Photothermal therapy, 225, 229–245
Kinetic spinodal, 227 Plasma, 34–38, 226, 242–243
Plasmonic photothermal therapy, 225, 229–245
L Plastic flow stress, 168, 170–171
Lamb vortex, 135 Polymer
Laminar separation point, 126 injection, 142
Laplace transform, 73 solutions
Laser fluence threshold, 231 dilute, 15, 82, 85, 110, 131, 149
Loss modulus, 9, 33, 39, 43 semi-dilute, 13, 138, 143
Loss tangent, 9 ultrasonic degradation, 156–157
Lumley hypothesis, 120 Polytropic index, 64
Pressure
attenuation, 78–79
M coefficient, 124, 135
Magnetic tweezer, 33 drop, 28, 118, 121–123, 139, 143, 228
Mark-Houwink equation, 13 gradient, 91–92, 102, 118, 137, 144,
Mean-square displacement, 32–33 178, 196
Mechanical heart valve, 206–210 Protein inactivation, 232
Membrane blebbing, 244
Metacarpophalangeal joint, 256–257 R
Microemboli, 202, 209–211 Rankine vortex, 142
Microrheology Rate of deformation tensor, 4, 11, 18, 23, 70
active methods, 32–34 invariants, 4, 65
passive methods, 32–33 Rayleigh-Plesset equation, 180, 184, 233, 234
Mie coefficients, 240 Red cell aggregation, 35
268 Index
Relaxation time, 1, 14, 17–18, 20–21, 41, Streamwise velocity fluctuations, 120
71–72, 88–89, 146–147, 186, 189 Stress
Resonance frequency, 86, 187–190 relaxation, 6, 21
Retardation time, 20, 71, 79, 81, 88–89, 189 tensor, 4, 7, 10, 18–19, 22–23, 64–65, 80
Riccati-Bessel function, 240 Subharmonic resonance, 87–88, 90
Root canal, 249, 252–255 Surface
infection, 253 dilatational viscosity, 65, 182, 184
plasmon resonance, 231–233, 240
S Surfactant, 50, 57, 65, 97, 178, 183, 211
Saddle-node bifurcation, 90 Synovial fluid
Saliva density, 38
elasticity, 40–41 elasticity, 38–39
relaxation time, 41 rheopexy, 38–39
structure, 40 structure, 39
viscosity, 40–41 viscosity, 38–39
Saturation pressure, 52, 144 Synovial proliferation, 258
Scattering cross section, 188, 191
T
Schiebe body, 131
Tensile strength
Secondary flow, 27–28
polymer solutions, 58–59
Shear rheometry, 25–29
water, 58–59
Shear waves, 120
Tensile stress, 57, 107, 111, 147, 166,
Shock
226–227, 245
-induced collapse, 99
Therapeutic ultrasound, 175
-induced jet, 99–101, 171
Thermal diffusivity, 239
pressure, 96, 128, 164, 166
Thermal expansion coefficient, 226
wave, 78, 82–83, 93–95, 99–101, 109, 164,
Thermo-elastic stress, 226
166–168, 171–172, 196, 212, 232,
Threshold fluence, 235–236, 243
245, 257–258
Thrombogenesis, 210
emission, 167, 232 Thrombolitic agents, 176
Sonoporation, 192, 195 Tissue
Sonothrombolysis, 175–177 ablation, 199–200
Specific heat capacity, 240 oxygenation, 229
Spherical acoustic wave, 78 plasminogen activator, 176, 195
Spherical bubble Tooth brush, 252
collapse time, 66, 76, 83–85, 99–100 Transmyocardial laser revascularisation,
dimensionless variables, 74 199–200, 202
energy, 63–68 Tribonucleation, 257
natural frequency, 71, 187 Trouton ratio, 11–12, 30, 94–95, 148–150, 172
pressure distribution, 71, 78, 147, 226
scaling laws, 84–85, 108–109 U
thermal effects, 81, 227 Ultraharmonic resonance, 87, 90
Spherical bubble dynamics Ultrasonic irrigation, 252–254
compressible formulation, 77, 79–80 Ultrasonic scaler, 250–251
general equations, 63–65 Ultrasound contrast agents, 106, 177–199
incompressible formulation, 66–67, 77, Ultrasound phacoemulsification, 258, 260–261
79–80, 86
Splash effect, 165 V
Squeeze flow, 209 Van der Waals equation, 239
Stagnation point, 29, 131–132 Vascular endothelial growth factor, 193
Stagnation pressure, 170 Vena contracta, 121
Stokes-Einstein relation, 32 Ventricular pressure, 206
Storage modulus, 9, 19, 33, 39, 43 Vibratory devices, 156
Strange attractor, 89–90 Viscoelastic effects
Index 269
die swell, 6 uniaxial extensional, 11, 17, 19, 24, 31, 111
Uebler, 6 volume, 4
Weissenberg, 6, 13–14, 28 zero-shear, 5, 12, 16, 29, 35, 70, 146
Viscoelastic shell, 186 Viscous adhesion, 257
Viscometric functions, 8 Viscous sublayer, 119
Viscosity Vortex
apparent, 4, 27–28, 35–36, 38–40, chamber, 142–143
42–43, 76 inhibition, 118, 123
biaxial extensional, 11–12 strength, 135
dynamic, 2, 9
infinite-shear, 5, 16, 35, 70, 76, 87
W
intrinsic, 12–13, 20, 29
Wall turbulence, 120
kinematic, 3, 146, 183
Wave number, 240
molecular weight, 13
planar extensional, 12 Weight loss, 155–160, 163
shear, 1–2, 5, 11–12, 16–17, 29–30, 35, 38, Weissenberg-Rabinowitsch equation, 28
65, 70, 76, 87, 90, 100–101, 112,
120, 127, 144–146, 149, 184, 186 Y
specific, 12 Yield strength, 107, 165, 168