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Isotonic solutions have an osomolality of 250 to 375 mOsm/L. Isotonic solutions have the same
osmotic pressure as plasma, creating constant pressure inside and outside the cells, which causes
the cells to remain the same (they will not shrink or swell) and does not cause any fluid shifts
within compartments. Isotonic solutions are useful to increase intravascular volume, and are
utilized to treat vomiting, diarrhea, shock, and metabolic acidosis, and for resuscitation purposes
and the administration of blood and blood products. Examples of isotonic solutions include
normal saline (0.9% sodium chloride), lactated Ringer’s solution, 5% dextrose in water (D5W),
and Ringer’s solution. It is important to monitor patients receiving isotonic solutions for fluid
volume overload (hypervolemia) (Crawford & Harris, 2011).
Although all IV fluids must be administered carefully, hypertonic solutions are additionally
risky.
An order for IV fluids may be continuous or as a bolus, depending on the needs of the patient. IV
solutions are available in 25 ml to 1000 ml bags. The frequency, duration, amount, and additives
to solution must be ordered by a physician or nurse practitioner; for example, an order may be
“give NS at 125 ml/hr.”
The most common types of solutions include normal saline (NS) and D5W. Patients may also
have medications, such as potassium chloride, thiamine, and multivitamins, added to IV
solutions. To discontinue an IV infusion, an order must be obtained from the physician or nurse
practitioner (Perry et al., 2014).
IV Administration Equipment
When a peripheral vein has a cannula inserted, an extension tubing is connected to the hub on the
cannula and flushed with normal saline to maintain patency of the cannula. Most peripheral
intravenous cannulas will have extension tubing, a short, 20 cm tube with a positive fluid
displacement/positive pressure cap attached to the hub of the cannula for ease of access and to
decrease manipulation of the catheter hub (Vancouver Coastal Health, 2008). The extension
tubing must be changed each time the peripheral catheter is changed. When the peripheral
cannula is not in use, the extension tubing attached to the cannula is called a saline lock.
Intravenous fluids are administered through thin, flexible plastic tubing called an infusion
set or primary infusion tubing/administration set (Perry et al., 2014). The infusion
tubing/administration set connects to the bag of IV solution. Primary IV tubing is either a macro-
drip solution administration set that delivers 10, 15, or 20 gtts/ml, or a micro-drip set that
delivers 60 drops/ml. Macro-drip sets are used for routine primary infusions. Micro-drip IV
tubing is used mostly in pediatric or neonatal care, when small amounts of fluids are to be
administered over a long period of time (Perry et al., 2014). The drop factor can be located on
the packaging of the IV tubing.
IV solution bags should have the date, time, and initials of the health care provider marked on
them to be valid. Add-on devices (e.g., extension tubing or dead-enders) should be changed
every 96 hours, if contaminated when administration set is replaced, or as per agency policy.
Intravenous solution and IV tubing should be changed if:
Primary and secondary administration sets (see Figure 8.4) should be changed regularly to
minimize risk and prevent infection (CDC, 2011; Fraser Health Authority, 2014). Change IV
tubing according to agency policy. Table 8.5 lists the frequency of IV tubing change.
Safety considerations:
Frequency of IV
Type of IV Tubing and Solution
Tubing Change
Infusions containing fat emulsions (IV solutions combined with glucose and amino
Every 24 hours acids infused separately or in a 3 in 1 admixture). Example: Total parenteral nutrition
(TPN).
4 hours or 4 units,
whichever comes first, Blood and blood products
or between products
A health care provider is responsible for regulating and monitoring the amount of IV fluids being
infused. IV fluid rates are regulated in one of two ways:
1. Gravity. The health care provider regulates the infusion rate by using a clamp on the IV
tubing, which can either speed up or slow down the flow of IV fluids. An IV flow rate for gravity
is calculated in gtts/min.
2. Electronic infusion device (EID) (see Figure 8.5). The infusion rate is regulated by an
electronic pump to deliver the fluids at the correct rate and volume. All IV pumps regulate the
rate of fluids in ml/hr. An IV pump (EID) is used for many types of patients, solutions, and
medications (Vancouver Coastal Health, 2008).
Table 8.6 Calculating the Drops per Minute (gtts/min) for an Infusion by Gravity
2. Determine the drop The drop factor is the amount of drops (gtts) per minute. IV tubing is either macro tubing (10, 1
factor on the IV gtts/min) or micro tubing (60 gtts/min). The drop factor (or calibration of the tubing) is always
administration set. packaging of the IV tubing.
3. Complete the
calculation using the To calculate ml/hr, divide 1000 ÷ 8 = 125 ml/hr.
formula.
Example: Infuse IV NS at 125 ml/hr. IV tubing drop factor is 20 gtts/min
125 X 20
60
4. Regulate IV infusion Observe and count the drips in the drip chamber and regulate for 42 gtts/min (one full minute).
using the roller clamp. divide 42 by 4 (rounded down from 10.4 to 10 gtts/min) to count for 15 seconds. The gtts/min
assessed regularly to ensure the IV is infusing at the correct rate (e.g., every 1 to 2 hours, if the
accidentally bumps the IV tubing, or if a patient returns from another department).
Regulate IV tubing by using a roller clamp
When an infusion is by gravity, there are several factors that may alter the flow/infusion rate
(Fulcher & Frazier, 2007). In addition to regulating the flow rate, assess the IV system to ensure
these factors are not increasing or decreasing the flow of the IV solution. These factors are listed
in Table 8.7.
May occur if the tubing is kinked or bent. Tubing may become kinked if caught
Tube occlusion
patient or on equipment, such as beds and bed rails.
Irritating or chilled fluids (fluids stored in the fridge) may cause a reflex action
Vein spasms vein to go into spasm at or near the intravenous infusion site. If fluids or medica
chilled, bring to room temperature prior to infusion.
Height of the fluid container The IV tubing drip chamber should be approximately 3 feet above IV insertion
If the cannula is located in an area of flexion (bend of an arm), the IV flow may
Location/position of IV cannula
when the patient moves around. To avoid this issue, replace IV cannula.
If the cannula punctures the vein, the fluid will leak into the surrounding tissue
Infiltration or extravasation
the flow, and swelling will develop.
Accidental touching/bumping of the Instruct the patient not to touch the roller clamp and to take care not to bump th
control clamp or raising arm above may accidentally change the flow rate. Instruct patient to keep hand/arm below
heart level elevated hand/arm will slow or stop an infusion running by gravity.
Needle or cannula gauge/diameter The smaller the needle or cannula, the slower the fluid will flow.
Assessing an IV System
All patients with IV fluid therapy (PIV and CVC) are at risk for developing IV-related
complications. The assessment of an IV system (including the IV site, tubing, rate, and solution)
(see Figure 8.6) often depends on what is being infused, the patient’s age and medical condition,
type of IV therapy (PIV or CVC), and agency policy. Generally, an IV system should be
assessed as described in Checklist 65.
Disclaimer: Always review and follow your hospital policy regarding this specific
skill.
Safety considerations:
2. Introduce yourself and explain the purpose of the This builds trust with patient and allows time for the
assessment. patient to ask questions.
6. Inspect the patient’s arm for streaking or venous Assess complications on hand and arm for signs and
cords; assess skin temperature. symptoms of phlebitis and infiltration/extravasation.
Kinks or bends in tubing may decrease or stop the
flow of IV fluids. Ensure tubing is not caught on
7. Assess IV tubing for kinks or bends. equipment or side rails on bed.
8. Check the rate of infusion on the primary and If solution is on an IV pump, ensure the rate is
correct and all clamps are open as per agency
secondary IV tubing. Verify infusion rate in
protocol.
physician orders or medication administration record
(MAR). If secondary IV medication is infusing, ensure clamp
on secondary IV tubing is open. The EID is unable to
distinguish if the primary bag or secondary bag is
infusing.
12. Document procedure and findings as per agency Timely and accurate documentation promotes patient
policy. safety.