Pathophysiology HACVD LDL and Tryglycerides

Damage to intimal endothelial cells

Platelets and Monocytes adhere to injured site

Abnormal proliferation of smooth muscles and connective tissue

Inflammation of blood vessels

Migration of monocytes beneath the endothelium and become macrophage

Permeability of endothelium

Formation of Atherosclerotic plaque (CXR: Atherosclerosis of thoracic aorta)

Narrowing of the blood vessel lumen

Blood flow Plaque hemmorrhage/rupture Vascular resistance

Afterload

Preload

Compensatory Mechanism: Myocardial Hypertrophy

Cardiomegaly

Increased O2 demands

Failure of O2 compensation

Cardiac Tissue Ischema

Cardiac Tissue Injury

Cardiac tissue Infarction

Decreased functioning contractile tissue

Cardiac output

Perfusion/Hypoperfusion

Systemic Hypoxia

Multiorgan Failure

Death