Pain intensity, Numerical rating scale (NRS)

Vitamin B12 Control

Study ID Mean SD Total Mean SD
2.6 0.7 25 7 1.7
1 Xǔ, Xu 2016
1.2 0.8 24 5.6 1.9
3.2 1.6 33 6.5 1.3
2 Xu, Lv 2013
6.1 1.2
3 Xu, Lv 2014 3.988 1.213 20 5.607 1.156
2.4 0.8 46 6.6 2
4 Xu,Tang 2016
1.4 0.9 45 5.9 2
cale (NRS) EuroQoL visual analogue scale
Control Vitamin B12 Comparator
Total Name of comparator Mean SD Total Mean
24 A0 intramusclar 1-3 days 78.6 7.5 25 31.3
25 B0 intramusclar 4-7 days 91.5 9.4 24 48
32 LD local lidocaine inj. 69.43 13.99 33 40.4
33 OT methylcobalamin 38.86
20 Local lidocaine inj. group 62.562 13.793 20 39.409
45 IE intramusclar 1-3 days 81.2 6.9 46 88.3
44 ES intramusclar4-7 days 37.1 23.2 45 45.4
logue scale Using Analgesics
Comparator Vitamin B12 Comparator
SD Total Event Total Event Total
19.6 24
22.3 25
15.025 32 3 33 26 32
14.508 33 25 33
14.286 20 1 20 14 20
8.6 45
22.8 44
 Vitamin B12 Ag
Antiviral drug Vitamin B12
Dose Route of admini
Study ID Mean
1mg in 2ml subcutaneous valacyclovir 1-3 days 64.4
1 Xǔ, Xu 2016
4-7 days 63.1
1mg in 2ml subcutaneous Acyclovir+ valacyclovir 66.82
2 Xu, Lv 2013

3 Xu, Lv 2014 1mg in 2ml subcutaneous Acyclovir+ valacyclovir 62.7

1mg in 2ml subcutaneous valacyclovir 1-3 days 63.6
4 Xu,Tang 2016
4-7 days 63.1

3
 Age Time since rash & pain (Days)
Vitamin B12 Comparator Vitamin B12 Comparator
SD Mean SD Mean SD Mean
8.2 64.4 8.2 1-3 day 1.958 0.842 2.042
8.2 63 7.4 4-7 day 5.5208 0.87 5.58
7.78 67.21 9.37 57.45 23.32 53.15

12.29 60.5 11.3 52.2 20.26 48.35

8.5 63.5 8.7 1-3 day 2.1375 0.812 2.0833
8.3 61.9 8 4-7 day 5.24583 1.0375 5.612

LD group 3 Xu, Lv 2014 LD group

Xu, Lv 2013
Mean SD Mean
66.75 10.98 49.65

Xu, Lv 2014 LD group COB group

Mean SD Mean SD
61.75 14.74 59.05 15.57
 Extent of rash
pain (Days) Limited rash Extensive rash
Comparator Vitamin B12 Control Vitamin B12
SD Event Total Event Total Event
0.75 11 25 10 24 14
0.8625 9 24 10 25 15
19.07

25.43
0.7792 17 46 16 45 29
1.121 17 45 16 44 28

LD group COB group

SD Mean SD
23.78 46 38.48
ash
Extensive rash
Vitamin B12 Control
Total Event Total
25 14 24
24 15 25

46 29 45
45 28 44