Name K Genetics Pedigree Worksheet A pedigree is a chart of a person’s ancestors that is used to analyze genetic inheritance of certain traits — especially diseases, The symbols used for a pedigree are: © _ female, unaffected (1) male, unaffected @ iemale, affected BE omale, affected ‘* Siblings are placed in birth order from left to right and are labeled with numbers. © Each generation is labeled with a Roman numeral. co Example: We would name an individual II-3 if he/she was in the second generation and the 3" child born » 6 Oem, 1 2.3 1, Identify the genotypes of the following individuals using the pedigree above (homozygous dominant, homozygous recessive, heterozygous). # Fl ne —homapyanus ctcessive * U4: No- hetero2yqous ¢ ILI: Na-heteroz yous ¢ MIL: _an= homozygous recessive 2. How can you know for sure that individuals II-3 and II-4 are heterozygous? “They Ore unaffected, out haw flected Children, so they must both Cacry the allele for the disorder, Which makes Hem hetero? yqous. 3. Is this trait dominant or recessive? How do you know? 4 Recessive. Since I-3 and HA are heterozyares and unaffected , the sunatferted allele is dominant , so the affected allele is recessive 4, Is this trait autosomal or sex-linked? How do you know? . tosomal, I-3 Cals) is unaffected (N) but has an affected laughter \f sf was X-laked, his dauahter would get his dominant unaffented allele, so she Could mot be afltotodan 4 cy O: dy o Lh @ Bh - teingon' 6 7 5 5. Which members of the family above are afflicted with Huntington's Disease?_J - |, Jl-2,3,'1, IL 6. There are no carriers for Huntington's Disease- you either have it or you don’t, With this in mind, is Huntington’s disease caused by a dominant or recessive trait? _Donainan't 7. Identify the genotypes of the following individuals using the pedigree above. (homozygous dominant, homozygous recessive, heterozygous) © Tl: _|h- heterozyaous © 1-3: _hedec 2yaoS © U-l:_}h- hom yay cecessive © Il-4: homoryadus creessiye 8. How many children did individuals I-1 and 1-2 have? __ 9. How many girls did Il-l and 11-2 have? _2 How many have Huntington's Disease? Tz w-4 i2 es 10. How are individuals 1-2 and {1-4 related? niece “ Ywncle 1-2 and IS? gcandosiser —dcanson 11, Brown eyes are a dominant eye-color allele and blue eyes are recessive. A brown-eyed woman whose father had blue eyes and whose mother had brown eyes marries a brown-eyed man whose parents are also brown- eyed. They have a son who is blue-eyed. Draw a pedigree showing all four grandparents, the two parents, and the son. Label all the genotypes. Bz brown b= blne % A+ least ons of Lr _— I-3 and 1-4 must be heteroaygons= Hitchhiker's Thumb CHO L w © ~ 0 HOO ' 2 3 4 u 12, The pedigree above shows a family’s pedigree for Hitchhiker’s Thumb, Is this trait dominant or recessive? How do you know? ‘Recessive Unatfectes onrents (Il -4 and TL-5) have affected Children 13. Is this trait autosomal or sex-linked? How do you know? _|\vtosomal has an ASfertod daughter, so he must be a Carriers 14, How are individuals III-1 and III-2 related? sine /Spuse > 15, Which 2 individuals have hitchhiker’s thumb?__1%-2 and IZ-4 16. Which 2 individuals must be carriers of hitchhiker’s thumb? J-4 and IL-5 17. Is it possible for individual IV-3 to be a carrier? How do you know? \f5, She Could have coceived the ceressive alicle From either parent 18. The pedigree to the right shows a family’s pedigree for colorblindness. Is this trait dominant or recessive? How do you know? ‘Pecessive 19, With this in mind, is this autosomal or sex-linked? How do you know? IC-ts (mele) is not a Cottier, loud has an affected son m 20. Why does individual IV-7 have colorblindness? 2 ceceived a C66 allele Sram ack paraiit 21. Why do all the daughters in generation II carry the 'V colorblind gene?_LDad_is Colorblind ,so they 91-2 34 5 6 7 8 Ol receive The (ECASSIVE Allele From WinA 22, Name 2 individuals in generation IV who are colorblind males. =\ aoa TW-S SSive