9/27/2020 4-Me h l Me hca hinone , Hi e No el Di co e

ea ch

Kine ic 4-Me Me ca e Bookma k

(Hi e Bee) (Rated as: e cellent)
04-05-03 00:31
No 423945 Hi bee ,

I' e been bo ed o e he la co le of da and had a fe f n eagen l ing

a o nd, o I ho gh I'd and make ome 1-(4-me h l hen l)-2-
me h lamino o anone h d ochlo ide, o 4-me h lme hca hinone a I o ei
o ld be commonl called. Com le ed i hin 48 ho , a ing f om ol ene. Each
e i a fi a em onl , and I' e incl ded gge ion fo he oced e if I
a em i again. The fi o e o k e nicel , b he ield kille i he final
e , gi ing 45%. Ho e e , hi ill co e ond o a 43% ield of od c f om
ol ene, o i ' no oo bad o e all:

P e a a f 4- e e e1

73g al mini m chlo ide

300mL dichlo oe hane
46mL o ion l chlo ide
54mL ol ene
600mL iced a e
200mL 5% NaOH ol ion
Magne i m lfa e

54mL (500mmol, 46g) ol ene a added o e 30 min e o a ol ion of 73g

(550mmol) anh d o al mini m chlo ide and 46mL (525mmol, 49g) o ion l
chlo ide in 200ml dichlo oe hane cooled ia an e e nal ice ba h. The ol ion a
allo ed o i fo a f he 1.5 ho a 20oC, and a hen ca ef ll added o
500mL i ed iced a e . The lo e dichlo oe hane la e a e a a ed off, and he
a eo la e e ac ed i h 2 50mL dichlo oe hane. The combined e ac e e
a hed i h 2 100mL 5% NaOH, 100ml a e , and hen d ied o e magne i m
lfa e. The ol en a emo ed, and he ke one ac m di illed a 123-126oC, o
gi e 1-(4-me h l hen l)- o an-1-one a a colo le oil.

Yield: 70.0g (95%)

C e : Wa h i h 3 100mL 5% NaOH in ead of 2 100mL.

DCM ho ld be a be e ol en , im l beca e i i ea ie o emo e nde
ac m.

4- e e e 2-b -4 - e e e 1,2

38mL 4-me h l o io henone

1mL 48% HB
14mL b omine
125mL glacial ace ic acid
650mL a e
300mL dichlo oe hane
Magne i m lfa e

To a ol ion of 38mL (250mmol, 37g) 4-me h l o i henone in 125mL glacial

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 1/8
9/27/2020 4-Me h l Me hca hinone , Hi e No el Di co e
ace ic acid a added 1mL 48% HB follo ed b , o e he co e of an ho , 14mL
(275mmol, 44g) elemen al b omine. The eac ion mi e, hich changed o a nice
ink colo d ing addi ion, a i ed fo a f he 1.5 ho , hen lo l o ed
in o 500mL ice-cold a e , i h i ling af e each ca ef l addi ion. The c eam-
colo ed eci i a ed od c a aken in 200mL dichlo oe hane, and he
a eo la e e ac ed i h 100mL dichlo oe hane. The combined e ac e e
a hed i h 2 250mL cold a e , hen d ied o e magne i m lfa e. The ol en
a emo ed nde ac m, aking ca e o kee he em e a e belo 50oC,
lea ing a oi e oil, 2-b omo-(4 -me h l hen l)- o an-1-one, hich olidified
almo immedia el on cooling, in o a kling a c al .

Yield: 57g (100%)

C e : T and kee he em e a e belo 30oC hen emo ing he ol en

colo ed c al indica e ome decom o i ion (abo e e e a e ligh colo , o
onl mild). DCM o ld be a be e e ac ion ol en ince i co ld be i ed off a
a lo e em e a e, ca ing le decom o i ion.

2-b -4 - e e e 1-(4- e e )-2-

e a a e d c de 3

13.5g me h lamine HCl in 15mL a e

7.9g odi m h d o ide in 20mL a e
11.4g 2-b omo-4 -me h l o io henone
6mL 37% HCl dil ed i h 24mL a e
115mL ol ene
225mL a e
Ace one

To a i ed ol ion of 11.4g (50mmol) 2-b omo-4 -me h l o io henone in 25mL

ol ene held a 20oC a added, o e 5 min e , 6.2g me h lamine in 35mL a e
( e a ed b adding a ol ion of 7.9g (198mmol) odi m h d o ide in 20mL cold
a e o a cooled ol ion of 13.5g me h lamine HCl in 15mL a e ). The mi e
a allo ed o i fo a f he 16 ho o
a 20-25 C, hen a o ed in o 150mL
ice-cold a e . The ol ene la e a e a a ed off, and he emaining f eeba e
e ac ed i h 2 20mL ol ene. The combined ol ene e ac e e a hed i h
3 25mL a e , and hen acidified i h 2 15mL dil e HCl. The combined acidic
e ac hen a hed ice i h 25mL ol ene and e a o a ed nde ac m o
d ne , allo ing an off- hi e olid o fo m. 20mL ace one a added and a
hea ed o boiling, fo ming a homogeno ol ion, hich a hen lo l cooled,
allo ing c al o eci i a e. The c al e e fil e ed and in ed i h a o nd
100mL ice cold ace one.

Yield: 4.8g (45%)

C e :T i ing fo 24 ho a 0oC, hich ill inhibi a ine fo ma ion. I

ma al o lo e he ield, b I'll ee ne ime I . I ' do b f l (IMHO) ha a
ield of o e 50% can be e ec ed fo hi hi d e , beca e of he ide eac ion
hich can and do occ .
Yield gi en befo e ec alli a ion, b af e concen a ion and e-fil e ing and
a hing of he 100mL ace one a he , hich o ided a f he 1g of od c .
Rec alli a ion i highl ecommended o emo e an emaining a ine, and can
be done f om ace one/me hanol.

1 S e 1 and 2 bo h ba ed on a n he i of a P o ale one analog e, 4-MPPH,

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 2/8
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P o ale one i h a he ane chain in ead of en ane. Thank o o endea ing
Nemo_Tene fo o iding he 4-MPPH n he i .
2 The in e media e b omoke one i i e a o e f l lach ma o , e en hen olid.
Take ca e i h a hing o gla a e af e he n he i , and lea e don' e ho
a e n il o ' e ho o ghl a hed e e hing i h cold a e fi .
3 Loo el ba ed on Po 289410 (fo 2: "Methcathinone and ephedrine from
propiophenone", Stim lants), al ho gh I ne e managed he 70-74% ield claimed
hen a em ing hi on b omob o henone.

Of co e hi od c co ld al o be ed ced in good ield o 4-me h le hed ine,

and hen e ea il made in o (4-me h l)-me ham he amine. If o e e o do
ha , I'd gge ed cing he b omoke one before adding he me h lamine. Thi
a , he me h lamino g o can be added nde m ch mo e igo o condi ion ,
e l ing in a highe ield. One a em a hi ga e a ield of a o nd 60%, b I'm
e i co ld be inc ea ed.

The bioa a en a he ell oo. I a a bi ca ed abo ha no ing 50mg

migh do, b ince I' e been almo con an l ab ing he (badl n he i ed) 1-
hen l-2-me h laminob an-1-one (i.e. me hca hinone i h a b l chain in ead of
he al o l), 50mg didn' do oo m ch. I ho gh I'd a ed m ime n il I
no ed ano he 100mg abo 30 min e la e , and hen i hi me. In en e he
all o e , la ing fo ell o e 30 min e . Since I ha e i e a high ca hinone
ole ance a he min e, I had ano he 100mg abo an ho la e , hen 100mg an
ho o o af e ha . Each ime I co ld feel he he of ene g coming ac o me,
and af e ha , a fan a ic en e of ell-being ha I ha en' go f om an d g
befo e e ce m belo ed ec a .

I'm ill feeling he effec no , ince I onl com le ed he n he i 6 ho ago,

and began he bioa a an ho la e .I' a f n d g, and al ho gh le o en
han me hca hinone ( nle m ole ance i reall high), i ' ea o make, and be
of all, legal! Ho ef ll omeone ill find hi of e, o a lea of in e e ...

Rhodi m C g a a ! Bookma k
(Chief Bee)
04-05-03 01:16 I'm im e ed! Yo ha e no onl e ed a ne d g, o ha e al o n he i ed i
No 423953 o elf com le el f om c a ch and i en a e book e am le of ha a
n he ic ie ho ld look like!

I ho e ha he end I ha e no iced he e d ing he la fe eek ill con in e,

he e ha been e e al eo le o ing ed jo nal a icle , no e on ac ical
labo a o oced e & e i men a ell a mo e han one eall nice o
com ila ion dige (Tho e dige feel like a o of "Hi e Ab ac " if o a k me).

Ba i m W ! Bookma k
(Hi e Addict)
04-05-03 11:40 Ha off fo o Kine ic. Ball and b ain , ha a nice combina ion. If onl o e ea
No 424045 oman

F eak

Kine ic Ne g... Bookma k

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 3/8
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(Hi e Bee)
04-05-03 11:52 Thank Rhodi m! I al ead had i i en , o I ho gh I'd o i in ca e
No 424046 omeone fo nd i ef l. I' e edi ed i ligh l , ince I no eali e I a a he o
of i hen I o iginall o e he o . If I o k o a be e oced e fo he hi d
e I'll o i , beca e he e a no iceable a ine in he a eo me h l-
me hca HCl ol ion e en af e a hing ice i h ol ene. The 100mL ace one
a he emo ed i , b I'd a he i a n' he e in he fi lace; ma be a 0oC
le ill fo m.

I hink ano he e imila ca hinone hich migh be in e e ing i he indane

analog e, a e ed b A holi m, b i ho a f ll i e . An oncho o ed
A holi m' commen on he final od c , hich o nd omi ing: Po 252116
(Antoncho: "Re: Short d ration Amphetamins", General Disco rse)

An a ,a o ha I can emembe f om la nigh :

400mg a i e alo o ake in one e ening, b i a n' oo long la ing o I ke

' o ing '. The he af e each line e e ama ing, and I emembe feeling e
m ch like I do hen coming on ec a , b fo ime ! Tha bea if l eak
feeling, hen o j hink 'oh, f ck, I feel o f cking good...' I ' mo e e ho ic
han I emembe m fi ime on he b ane me hca hinone analog e o be. I fel
e com elled o do hing , b I a com le el nable o kee m concen a ion
on li e a e ea che I a ing o do a he ime. I had a e ong ge o
ociali e, and almo en cl bbing, b ho gh be e of i .

An in e e ing effec a ha al ho gh I con med m final do e of 90mg onl 1

1/2 ho befo e going o bed, I a a lee i hin 30 min e o o, and oke
ha ing had abo 7 ho lee ; o all nhea d of fo me on im lan , and mo e
like he a I lee af e aking ec a . The e e e ac all ome f i al
hen I a ing o ge o lee , b I can' eall emembe m ch abo hem.
Thi mo ning I feel e no mal, j a bi i ed. I'm e once I ha e a ho e
and ome hing o ea I'll be back o no mal. Ma be hi co ld be a candida e fo a
Sho D a ion 'Am he amine'?

Edi : Thank Ba i m, al ho gh I'm no e ha ing ball and b ain o ld be ch a

nice combia ion if I ac all e e a oman.

Kine ic S P e ! Bookma k
(Hi e Bee)
04-05-03 21:00 Well i ned o m ace one a he o ided a f he g am of fl ff hi e
No 424130 od c af e concen a ion, a hing he a he ello c al ( a ine
con amina ion) a fe ime in ace one and d ing. I' e edi ed m o o gi e he
ield af e aking hi in o acco n , o he o e all ield i no 43% f om ol ene,
befo e ec alli a ion... Tha ' good eno gh fo me a lea .

Kine ic S Bookma k
(Hi e Bee)
04-05-03 21:33 To kee e l ing o m o n o , b I j had an idea hich eem ie
No 424141 omi ing if an one' illing o he n al o nding '4-me h l-4-
me h lamino e ', and ho ld gi e e good o e cellen ield in each e :

1,2) Follo m oced e fo he fi o e : bo h good/ e good ield .

3) S a he b omine fo an a ide: ho ld gi e a good ield, e eciall ince he

b omine i al ha- o a ke one. The e' obabl ome hing in TFSE fo hi al ead ;

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 4/8

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I'll ea ch in a min e.

4) Red ce he ke one and he a ide im l aneo l , o ibl i h odi m

bo oh d ide, o fo m 4-me h l hen l o anolamine.

5) Ada he anda d oced e f om hen l o anolamine o 4-me h lamino e ;

ho ld gi e an e al ield ince he me h l g o on' in e fe e.

An commen / gge ion ? Ri e ha a imila oced e o m e 3 and 4 in

../ hodi m /mda.a ide.h ml, o he ho ld al o o k nicel .

Oh, and I eall j ha e o a a big F ck Yo o he UK Go e nmen and hei

id d g la , ince I'm high a a ki e and he e' no hing he can do...

(... o , I reall had o ge ha off m che )

acid_egg ;-) Bookma k

(Hi e Bee)
04-05-03 23:50 e cool indeed!!
No 424159

Vi _Ve dega c g a a !!! Bookma k

(Hi e Bee)
04-06-03 01:57 Thi i fo o :
No 424188

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 5/8

9/27/2020 4-Me h l Me hca hinone , Hi e No el Di co e
Tha ' a onde f l iece of ionee ing e ea ch, cong a la ion man !!

Chee !

h :// .geoci ie .com/Holl ood/Se /6240/belak lf.j g

Kine ic T a ! Bookma k
(Hi e Bee)
04-08-03 23:27 Thank , e e one!
No 424851
Ho ef ll he e ill be mo e o come, j no a he a e Ba i m manage o o ...

Lilien hal I d be e e g e f e ... Bookma k

(Moderator)
04-08-03 23:58 I o ld be in e e ing o e if he MDMA-like o e ie ... A e o e abo i?
No 424865

Ba i m Ve f g Bookma k
(Hi e Addict)
04-09-03 10:11 I'll make a ba ch of i oo. I' e become e c io abo hi com o nd.
No 425021
F eak

Kine ic P e e Bookma k
(Hi e Bee)
04-09-03 19:42 I' e ne e kno ingl ied e MDMA, b ha e had on mo e han n me o
No 425142 occa ion 'ec a ' ill , hence I com a ed i o ec a , and didn' e he mo e
ecific e m 'MDMA'. I'm e ho e e ha of he a io ill I' e had o e he
a 2 1/2 ea , a lea ome e e mainl MDMA, o I feel j ified in com a ing
he o.

The fi bioa a a i en hil ill feeling he effec of he d g. The

com a i on o ec a a com a ing he ell being and gene al nicene I fel a
he ime o ho I al o feel on ec a , o in ha e ec , i a like ec a . I don'
hink i a he ame a ec a , b fo me a lea he e e e lea an a allel .

The lo ed- ne a n' iea ono nced, b I fel a ong ge o ociali e,

and I managed o end a e me age o a male f iend con aing 'lo e and h g ',
ome hing I ha e a endanc o do on ec a ...

The com le e lack of e id al in omnia al o made me hink he e a ome hing

o he han a e im lan o iding he h: af e con ming 600mg ( i h he
final 100mg aken a abo 10 m) on S nda nigh , I a able o lee f om
midnigh n il 11am i h onl a fe min e a ake in be een.

If I gi e hi o an one el e I'll e o back on ho he like i , b I ec ha

Ba i m ill ha e ied i b hen. I o ld defini el gge o e 3 a a lo e
em e a e, a 0oC, fo a longe e iod. I'm going o do e ac l hi omo o
( i ing fo 24 ho ), and al ho gh he ield ma be lo e , I'm e e he
i of he final al ill be inc ea ed. If he ield i lo e ing hi modifica ion, I
ecommend i ing fo a longe e oid i h no inc ea e in em e a e, beca e I
no kno ha hea ing ca e mo e ha m han o amino o io henone han i
h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 6/8
9/27/2020 4-Me h l Me hca hinone , Hi e No el Di co e
doe o he longe chain aminoke one i h he ame N- b i en , hich I
o iginall ba ed he n he i on.

Ba i m Ca be e? Bookma k
(Hi e Addict)
04-22-03 19:41 He e I a olling m h mb ai ing fo m 4-me h l o io henone o be
No 428701 deli e ed...Bo ing!!
I ddenl emembe ed ha I had ome 4-h d o o io henone. Oh bo ! I can
he me hod i h hi b a e in ead of j i ing he e looking id. Said and
done. Ha li inging a li le ne I a embled he gla a e, ga he ed he
chemical ...F ck, I ha e no b omine! No NaB o KB ei he . Wai a econd. I
ha e ome KI...Ha he KI/O one- em been ied fo he in e ion of iodine in
he be a- o i ion of a o io henone? Can' emembe ha I' e een ha .
Wha he hell, I'll i.

KI 2,5g (15 mmol)

4'-H d o o io henone, 2,26g (15 mmol)
O one, 9,21g (15 mmol)
Me h lamine, 1,5ml of a 40% a ol ion ( o ghl 20 mmol)
MeOH
Wa e

To a 250 ml o ndbo om fla k e i ed i h a magne ic i e a added 2,5g KI,

2,26g 4-OH- o io henone, 30ml MeOH and 20ml a e . All of he KI and mo of
he o io henone en in o ol ion i hin a co le of min e . 9,21g O one a
added in o ion of 1g. The em e a e o e af e each addi ion. The em e a e
a allo ed o each o 40 C befo e mild cooling a a lied. The colo changed
f om colo le o li h and ome iiodine f me a i ible. Then he colo
changed o a mo e ed-b o n and he em e a e d o ed back o oom em
a lidl . 50 ml cold a e ad added o he mi e. Thi ca ed a eddi h-b o n
olid o eci i a e hich a i ola ed b g a i fil a ion and a hed i h ome
a e . The fil a e had a o ange one.

The olid a an fe ed back o he in ed 250 ml fla k i h he aid of 150 ml

MeOH. Mo of he olid a ed ndi ol ed. 1,5 ml 40% a eo me h lamine a
added i h a inge d ing one min e. Almo immedia el he colo changed o
o ange, hen o a b igh ello i hin one min e, hen lo l o a ale ello and
finall af e fi e min e he ol ion a hick f om colo le c al . D ing he
addi ion of me h lamine he em e a e en f om 20-25 C. The olid a
emo ed b fil a ion and d ied o con an eigh .

Yield 2,9g of o ible 1-(4-h d o hen l)-2-me h lamino- o an-1-one

h d oiodide.

Can i be hi ea ? I ha e no idea e if ho e hi e c al eall a e he

ca hinone. B he e a e a fe ign indica ing hi . If he iodina ion a acked he
a oma ic ing he e o ld be no eac ion i h me h lamine, and he e a . If ho e
ed-b o n c al a j a mi e of f ee iodine and n eac ed 4-
h d o o io henone he e o ld be no eac ion be een he iodine and
me h lamine, and no d ama ic colo change, again he e a .

Can omeone hoo me do n, lea e. I j can' be hi ea . 40 min e f om

a o fini hed od c ..

F eak

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Kine ic A ca ' '! Bookma k

(Hi e Bee)
04-22-03 21:56 Wo , e cellen Ba i m! Wi ho j m ing o concl ion of co e , i ce ainl
No 428731 o nd like o ' e go ome hing a lea e embling he ca hinone.

I o ldn' be i ed a all if he me h lamine eac ed a ickl a i did. I

eac a he ickl i h he al ha-b omoke one, o he eac ion i h he
iodoke one ho ld be e en fa e .

I do ha e one gge ion/ e ion of ha o od c co ld con ain, ome hing

I' e j ho gh of, b I ho e I'm ong: Wha ' he ol bili of me h lamine
h d iodide in me hanol? Bo h of he me hca hinone de i a i e I' e made ha e been
ol ble in me hanol, e hi eci i a ed o of ol ion. Since o ed le han 2
e i alen of me h lamine, on' an libe a ed HI eac i h he f ee me h lamine
in ol ion befo e he me h lamine ha a chance o eac i h he iodoke one,
he eb gi ing a mi e of ca hinone od c and me h lamine HI? T o e i alen
of amine a e all ed, one a he f ee acid ' ca enge '.

Of co e he e m be a lea a man mole of ca hinone a he e a e

me h lamine HI, if he e i an me h lamine HI a all; no HI ill be gi en off if
nle a eac ion occ be een he f ee me h lamine and he iodoke one, o o
ho ld ha e at least 50% od c in he e. Ho ef ll I'm ong, and o ' e
managed (once again) an e cellen ield of lo el ec al ! I 'd bee onde f l
o ee ch a high ielding im le oced e in ead of he o e me hod I ed.
Kee da ed if/ hen o ha e he chance o do ome anal i of he od c .

Edi : Un ela ed o Ba i m' o k, I made ano he ba ch of hi a he eekend, b

changed he o k ligh l . In e 3, once he off- hi e olid i ob ained, i ho ld
be in ed ho o ghl i h cold THF, hich i i in ol ble in, o emo e all he
ello /o ange a ine. The hi e c al can hen be di ol ed in
me hanol/ace one, and once c alla ion i com le e, a e od c i ob ained
han b he e io me hod of ec alli ing ice f om ace one i ho he THF
a h.

Ano he oin o no e i he a he a id b ild of ole ance. Fo me a lea , he

'ec a -like' feeling I no ed he fi co le of ime I ied i a e e m ch
gone. J o e e a a a ning eall , 4-MMC i i e a bi le o en han mo
o he im lan , and i n' i able fo ma a hon eaking; I fo nd m elf aking
100mg a o ima el e e ho af e a co le of da olid e. I ill and b
ha I aid abo he fi eek I ied i ho gh, j be a a e ha i on' la !
The fi co le of ime e e e emel lea an , al ho gh a li le ho li ed.
Ma be ea ing i o ld be i e fo a longe la ing high.

h p ://chemi .mdma.ch/hi eboa d/no el/000423945.h ml 8/8