Gambar 2. Anemia Penyakit Kronik.

(A) Pemeriksaan darah perifer, gambaran anemia normokromik

normositik. (B, C) Pemeriksaan sumsum tulang dengan morfologi normal. (D, E) Pewarnaan Prussian-
blue pada zat besi, menunjukkan peningkatan besi histiocytic namun berkurangnya besi sideroblastik.
(Sumber: Anemia of Chronic Diseases, 2017)

A B C D
 Anemia

Reticulocyte Index

Low High
(Hyporigenerative anemia) (Acute hemorrhage or
Hemolytic anemia)

Biochemical or Clinical
Evidance of
Inflammation

Fe serum

Transferritin
Saturation <16%

Ferritin 30-100 Ferritin >100

Ferritin <30
ng/mL ng/mL
ng/mL

Determination of
soluble transferrin
receptor

sTfR/log
sTfR/log Ferritin
Ferritin <1
≥1

Iron Deficiency Anemia of Chronic Anemia Chronic

Anemia (IDA) Disease with True Disease (ACD)
Iron deficiency
(ACD + IDA)
 Anemia

Reticulocyte Index

Low High
(Hyporigenerative anemia) (Acute hemorrhage or
Hemolytic anemia)

Biochemical or Clinical
Evidance of Inflammation

Fe serum

Transferritin
Saturation <16%

Ferritin 30-100 Ferritin >100

Ferritin <30
ng/mL ng/mL
ng/mL

Determination of
soluble transferrin
receptor

sTfR/log Ferritin
sTfR/log Ferritin
<1
≥1

Iron Deficiency Anemia of Chronic Anemia Chronic

Anemia (IDA) Disease with True Disease (ACD)
Iron deficiency
(ACD + IDA)