Scribd Logo
Upload

Welcome to Scribd!

  • Aminotransferase

    Uploaded by

    Yunita Rapa
    11 views2 pages
    This document discusses transaminase enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). It provides information on their role in protein metabolism and how elevated levels can indicate liver damage or disease. Common causes of elevated ALT and AST levels are discussed, as well as differences in their typical elevation patterns from various hepatic conditions. Reference ranges for ALT and AST levels in adults are also provided.

    Original Description:

    Original Title

    aminotransferase

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document discusses transaminase enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). It provides information on their role in protein metabolism and how elevated levels can indicate liver damage or disease. Common causes of elevated ALT and AST levels are discussed, as well as differences in their typical elevation patterns from various hepatic conditions. Reference ranges for ALT and AST levels in adults are also provided.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    11 views2 pages

    Aminotransferase

    Uploaded by

    Yunita Rapa
    This document discusses transaminase enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). It provides information on their role in protein metabolism and how elevated levels can indicate liver damage or disease. Common causes of elevated ALT and AST levels are discussed, as well as differences in their typical elevation patterns from various hepatic conditions. Reference ranges for ALT and AST levels in adults are also provided.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    ໇ ໆ າ .

    ຌກສືກສາແພຈຎີ ຋ໆ ີ 5
    ຂຽຌໂຈງ: ຋ ສຸ ກຬຸ ຈຬຌ ເຌຄຢ ຎີ 2012-2013

    Transferase

    ກໆ ຽວກຍ alanine aminotransferase ແລະ aspartate amonotransferase ແມໆ ຌຉ຺ວກະຉຸ ຌຎະຉິກ ິ


    ລິງາເຆີໆຄອູ ໇ກຌວໆາ : Transaminase ຋ີໆເຂ຺າອວ
    ໇ ໆ ມກາຌ metabolism ຂຬຄ protein ຎະຉິກລ
    ິ ງ ໇ ໆ າ:
    ິ າຌິແມໆ ຌເຬີຌວ
    transamination ເຆີໆຄຎະຉິກລ
    ິ ງ ໇ ຌມີກາຌສ຺ໆຄ amino acid group ຅າກ amino acid ໄຎຫາ alpha-
    ິ າຌີແມໆ
    keto acid ແລະ ກະຉຸ ໇ຌກາຌສ຺ໆຄ amino acid ຅າກ keto acid ໄຎເຎຌ amino acid

    Transaminase alanine aminotransferase

    aspartate amonotransferase

    Transaminase ຅ະສຸ ຄເມືຬ຅ຸລຄມີກາຌຊືກ຋າລາງ ແລ໇ວ຅ະເອຈໃຫ໇ຉວ ໇


    ຺ ກະຉຸ ຌ໇ ຌີຬຬກ຅າກ຅ຸ
    ລຄຫລາງ

    Aspirate aminotransferase (AST) ຫລື (SGOT) ສຸ ຄສໆວຌຫລາງແມໆ ຌ Myocardiac


    infarction
    alanine aminotransferase (ALT) ຫລື (SGPT) ສຸ ຄສໆວຌຫລາງແມໆ ຌພະງາຈຉຍ

    Amino acid + alpha-ketoacid glutamate + pyruvate

    ຉ຺ວກະຉຸ ຌ໇ (transaminase)

    ກາຌຉີລາ຃າຏ຺ຌວິເ຃າະ

    ຃ໆາຎ຺ກະຉິ
    ເພຈງີຄ: 7–30 U/L (0.12–0.50 μkat/L SI units)
    ເພຈຆາງ: 10–55 U/L (0.17–0.91 μkat/L SI units)

    ກາຌກວຈ ກາຌຎະເມີຌ ALT ຅ະອໆວມກຍ AST ແມໆ ຌ຅ະກວຈຫຌ ໇າ຋ີໆຂຬຄຉຍ. ຎ຺ກະຉິແລ໇ວ຅ະມີຬຈ ຉາສໆວຌ 1:1

    ຊ໇າ AST > ALT ແມໆ ຌພ຺ຍໃຌ Hepatitis ຅າກ ເຫລ຺າ໇ (alcohol-induced hepatitis), cirrhosis
    ແລະmetastatic cancer ຂຬຄຉຍ

    ຊ໇າ AST < ALT ແມໆ ຌ຅ະເຫຌ຅າກ ກາຌຆືມເຆືຬ໇ virus, ຢາ(drug-induced hepatitis), hepatic
    obstruction due to causes other than malignancy
    ໇ ໆ າ . ຌກສືກສາແພຈຎີ ຋ໆ ີ 5
    ຂຽຌໂຈງ: ຋ ສຸ ກຬຸ ຈຬຌ ເຌຄຢ ຎີ 2012-2013

    ສາງເຫຈ຋ີໆເຎຌໄຎໄຈ໇ຂຬຄກາຌຏີຈຎ຺ ກະຉິຂຬຄenzyme
    ກລະຌີມກ ີ າຌເພີໆມຂືຌ໇
    Biliary obstruction
    Bone metastases
    Cholestasis
    Cirrhosis
    Congestive heart failure
    Eclampsia
    Hepatic ischemia
    Hepatic necrosis
    Hepatitis
    Infectious mononucleosis
    Liver cancer
    Muscle inflammation
    Obesity
    Pancreatitis
    Pulmonary infarction
    Reye’s syndrome
    Shock
    Trauma

    ຎຈໃ຅ຉໆ າຄ໅຋ີໆພາໃຫ໇ມກ
    ີ າຌຏິຈຎ຺ ກະຉິ
    ກາຌເກຍຉ຺ວຢໆາຄຍໆ ຊືກເອຈໃຫ໇ເມຈເລືຬຈແຉກ
    ຢາ຋ີໆພາໃຫ໇ມກ
    ີ າຌເພີໆມຂືຌຂຬຄ
    ໇ ALT ເຆໆ ຌ: ACE-inhibitors, acetaminophen, anticonvulsants,
    antibiotics, antipsychotics, benzodiazepines, estrogens, ferrous sulfate, heparin,
    interferons, lipid-lowering agents, NSAIDs, salicylates,thiazides. ກາຌເພີໆມຂືຌຂຬຄ
    ໇
    ໇
    enzyme ແມໆ ຌ຅ະມາ຅າກກາຌໃຆ໇ຢາຬີກເຆໆ ຌ: ຢາ statin ຢາຌີ຅ະພາໃຫ໇ enzyme ຂືຌ໇ 6 ຫາ 12 ຬາ຋ິຈ

    ຂຈ຅າກ: LAB interpretation by Jonh willium 2008

    You might also like