The Cori Cycle

Liver Skeletal muscle

glycogen glycogen

Glucose
in blood

glucose glucose

glucose-6-phosphate glucose-6-phosphate

NAD+ NAD+
NADH +H+ NADH +H+
pyruvate pyruvate

NADH+H+ NAD+
Lactate in
NAD+ blood NADH +H+
lactate lactate

Glucose can be synthesised Liver supplies glucose to

from lactate in the liver. contracting skeletal muscle, which
obtains ATP from the glycolytic
conversion of glucose into lactate.