Apoptosis and cancer signaling pathways

Bcl-2 signaling in cellular apoptosis p53 signaling in apoptosis and gene transcription

Cellular stress,
death stimulus DNA Cellular
damage stress
Caspase 3 Bcl-2 inhibitors p53
The bcl-2 family consist of pro- and
Caspase 9 Bcl-2 Gene regulation
anti-apoptotic proteins involved in Bax
intrinsic mitochondrial cell death. Apaf-1 Mitochondria
They regulate the release of apoptotic Cell cycle arrest, cell
Cyt-c growth inhibition,
factors into the cytoplasm including Bcl-2
metabolic stress
cytochrome C and Apaf-1, Mitochondria p53 is a critical tumour suppressive Cyt-c inhibition
by mediatingouter membrane Apoptosis transcription factor which responds
permeabilisation. This leads to to cellular stress by triggering cell
Apaf-1/Caspase 9 Apoptosis
activation of caspase-9 and cyclearrest and apoptosis through
the resulting caspase cascade. transcriptional regulation.

Death receptor signaling in apoptosis and gene transcription Inhibitors of apoptosis signaling in cellular apoptosis

TRAIL
TNFα
Apoptosis Pathway NF-κB Pathway

DR4/5
TNFR1 receptors

Caspase 8 ReIA
Bid IκBα
Smac-mimetic
Death domain (SH122)
TRADD IκBα
Mitochondria Smac
FADD
Cyt-c Pro-caspase 8 TRAF-2 Degradation
Death receptors (DRs) belong to BAX NF-κB Inhibitors of apoptosis (IAPs) are a Cyt-c XIAP
NF-κB
the tumour necrosis factor (TNF) conserved group of proteins containing cIAP-1
Caspase 3 BID IKK
family of cytokines which induce Baculovirus-IAP repeats involved in the
apoptosis. These receptors can regulation of apoptosis as well as a Caspase 9
activate caspases within seconds number of other cellular processes. Caspase 3 Apoptosis
causing apoptosis. Apoptosis Transcription PARP cleavage

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