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Clinical Uses of Cervical Vestibular-Evoked Myogenic
Potential Testing in Pediatric Patients
Guangwei Zhou, MD, ScD, Jenna Dargie, BS, Briana Dornan, AuD, and Kenneth Whittemore, MD
between July 2006 and July 2012. All selected cases had Data analysis
usable records, including physicians’ visit notes, clinical/ We exclusively used descriptive analysis in this study.
working diagnoses, imaging studies, and cVEMP outcomes. Age, sex, reasons for cVEMP test, referring physician, and
so on were summarized for all patients.
Conducting cVEMP Test and Other Audiologic
Evaluations
RESULTS
Prior to cVEMP testing, all patients had a hearing
evaluation with air and bone conduction threshold testing. General Information
Tympanometry and acoustic reflex thresholds were also Among the 278 patients included in this study, there were
obtained if clinically warranted. We used a commercial evoked 119 boys and 159 girls. The average age was 10.5 years (SD ¼
potential system (NavigatorPro, Natus Medical Inc., San 4.6), with the youngest at the age of 5 months. To better
Carlos, CA) to record cVEMP under a customized pediatric demonstrate patients’ makeup, we classified them into 6 age
protocol. All normative cVEMP parameters, including groups, from the youngest group of “Age 3 & Under” to the
threshold, amplitude and latencies, were established at our oldest group of “Age 16 to 18”, as shown in Figure 1. Notably,
facility. The details of the protocol can be found in our there were a significant number of children in each age group,
previous publications.24,37 Briefly, acoustic stimuli (500 Hz and even in the youngest group there were >20 children
tonebursts and/or clicks) were presented via insert phones or although the Age 13 to 15 group had the largest case number
bone oscillator. All cVEMP was recorded from sternocleido- at 72 (259% of the total). Similarly, we divided the numbers of
mastoid muscle. Head-turning is required to have sternocleido cVEMP testing conducted by calendar year, demonstrated in
mastoid muscle contracted and the contraction is monitored to Figure 2. As shown, we have conducted 30 to 50 cVEMP tests
ensure its appropriateness. For younger children, an assistant in pediatric patients each year, except the beginning year of
was employed to attract the patients’ attention, allowing them 2006. Of note, the number of cVEMP performed trended
to make a head turn to toys with colorful lights. To obtain toward to an increase in 2012 since the number in 2006 and
cVEMP thresholds, a stimulus level of 90 dB normal hearing 2012 reflected only 6 months of clinical work.
level (nHL) was used as the default starting intensity. The
stimulus intensity would decrease in steps of 10 dB or increase
in steps of 5 dB depending upon the presence or absence of VEMP Referrals
cVEMP, respectively. The lowest stimulus intensity at which a Various reasons for cVEMP testing were documented in
clear and repeatable wave was observed would be recorded as patients’ medical records and these were summarized in
the cVEMP threshold. Amplitude and latency were measured Table 1. As listed, the main reason for requesting a cVEMP
respective to the cVEMP response to stimuli presented at 90 test was to evaluate children’s dizziness, vertigo or balance
dB nHL. If no reliable response was found at the maximal issues, and accounted for almost 45% of the total requests. The
stimulation level, the cVEMP would be considered absent. For second leading reason for cVEMP testing in our facility was
patients with middle ear pathologies and conductive hearing pre- and postcochlear implant workup that accounted for nearly
loss, bone-conducted stimuli were also used to elicit cVEMP if 15%. Investigation of middle ear–related conductive hearing
air-conducted stimuli were not sufficient. loss and inner ear structural anomalies such as SSCD and EVA
70
21
60
Number of patients
50
29
40
18
30 22
18
51
20
11
28 30
10 20 18
12
0
Age 3 and under Age 4 to 6 Age 7 to 9 Age 10 to 12 Age 13 to 15 Age 16 to 18
Age
FIGURE 1. Enumerated data of pediatric VEMP test conducted in 6 age groups.
60
50
Number of patients
40 19
18 23
21
30
14
19
20
30 29 27
8 26
10 21
14
9
0
2006 2007 2008 2009 2010 2011 2012
Year
FIGURE 2. Numbers of pediatric VEMP test conducted in each calendar year at our facility from 2006 to 2012. Of note, the number
in 2006 and 2012 reflected only 6 months of clinical work.
by cVEMP testing, accounted for 13.7% and 11.9% respective- were present at the highest intensity of the stimuli, we would
ly. Twelve children with sensorineural hearing loss caused by call the cVEMP absent. If present, the cVEMP threshold would
unknown etiology underwent cVEMP testing because of a be determined along with the cVEMP latency and amplitude,
concern of possible coexisting vestibulopathy. Ten children as described in the method section. Abnormal cVEMP out-
with postconcussion syndrome also underwent cVEMP testing comes found in each referring category are summarized in
as a part of a comprehensive workup. The remaining 21 Table 3. As shown, abnormal cVEMP responses were found in
children, 7.5% of the total, were referred for other nonspecific all children with conductive hearing loss related to middle ear
complaints such as tinnitus or headache. pathologies, most had absent cVEMP responses to air-con-
In addition to tracking the reasons for cVEMP test, we ducted stimuli; however, robust cVEMP were present when
also looked over the referring physicians and their specialties. bone-conducted stimuli were used in these cases. Also, the
As shown in Table 2, the overwhelming majority of patients cVEMP seemed to be very responsive, at 94%, to inner ear
were referred by pediatric otolaryngologists (about 48%) and structural anomalies such as EVA and SSCD. Typical cVEMP
otologists/neurotologists (45%). Referrals by neurologists and findings related to EVA and SSCD included a lower cVEMP
neurosurgeons accounted for only 5%. Fewer than 3% of the threshold and higher amplitude. In children with cochlear
referrals originated from other specialists such as audiologists. implant(s), abnormal cVEMPs (absent cVEMP, elevated
cVEMP thresholds, and reduced amplitude) were found in 35
Outcomes of cVEMP in Pediatric Patients of 40 cases. Only 25% of children with complaints of dizziness
Among the 278 children in this study, only 3 children or vertigo had an abnormal cVEMP. Approximately two-thirds
were not able to complete cVEMP testing, mostly due to fears of the children with congenital hearing loss had abnormal
of recording electrodes and wires, or they were intolerant of cVEMP, indicating possible cochlear-vestibulopathy although
insert phones. VEMP results obtained from the remaining 275 the exact etiology is unknown. Overall, abnormal cVEMP
children were analyzed. If no repeatable cVEMP responses results were found in 54% of children who completed the test.
complaints. Although the sensitivity of cVEMP test may vary 17. Lin KY, Hsu YS, Young YH. Brainstem lesion in benign
depending upon medical conditions, it provides diagnostic paroxysmal vertigo children: evaluated by a combined ocular and
information in most cases. This noninvasive and low-cost test cervical vestibular-evoked myogenic potential test. Int J Pediatr
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where an evoked potential recording system is available. Most 18. Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch
importantly, pediatric professionals should embrace this SD. Vestibular evoked myogenic potential (VEMP) in patients with
cutting-edge technology and consider cVEMP testing before Meniere’s disease with drop attacks. Laryngoscope. 2006;
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patients. potentials (VEMP) can detect asymptomatic saccular hydrops.
Laryngoscope. 2006; 116:987–992.
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