Critical Appraisal for Therapy

Clinical Scenario:
Research Question (PICOM):
Search Terms:
Citation: 1st 2 authors et al, title, journal, date (including date of month), volume, page range.
(EX. Venkatesh et al. Adjunctive glucocorticoid therapy in patients with septic shock. NEJM 2018;
378(9):797-808.)

How serious is the risk of bias?

Did intervention and control groups start with the same prognosis?

Were patients randomized? Y/N (pg No. paragraph no, column)

?Was randomization concealed? Y/N (pg No. paragraph no, column)

Were patients in the study groups similar Y/N (pg No. paragraph no, column)
at baseline with respect to prognostic
factors?

Was prognostic balance maintained as the study progressed?

To what extent was the study blinded? Y/N (pg No. paragraph no, column)

Were groups prognostically balanced at the study’s conclusion?

Was follow-up complete? Y/N (pg No. paragraph no, column)

Were patients analyzed in the groups to Intention to treat

which they were randomized?
Was the trial stopped early? May indicate NA if not applicable

What are the results?

How large was the treatment effect? See FRISBE

How precise was the treatment effect? See FRISBE

How can I apply the results to my patient care?

Were the study patients similar to my

patient?

Adapted from Duke University and McMaster Evidence-based Practice Workshops and Users' Guide to the
Medical Literature 3rd Ed.
Were all patient-important outcomes SCRAPS
considered?

Are the likely benefits worth the NNT / NNH

potential harms and costs?

Clinical bottomline Author conclusion

Reviewer conclusion
Will you give to ur pt?

Reviewer:
Date:

Adapted from Duke University and McMaster Evidence-based Practice Workshops and Users' Guide to the
Medical Literature 3rd Ed.