AZD1222 ‘COVID-19 VACCINE STUDY IRB Approved at the Protocol Level Jul 23, 2020 ‘Are you interested in taking partin a clinical study evaluating an investigational vaccine for the prevention of COVID-19? ACOVID-19 vaccine study is enrolling now! ‘The AZD1222 COVID-19 VACCINE Study is researching an investigational vaccine for the prevention of COVID-19, the disease caused by the new coronavirus (SARS-CoV-2). The study will see how safe the investigational vaccine is and how well it works. Are you able to help? You may be able to take part in the AZD1222 COVID-19 VACCINE Study if you: «are 18 years of age or older ‘© are in good or stable health (you may have an underlying medical condition and still take part, if your disease is stable) «© have an increased risk of getting COVID-19 ‘© do not have a previously confirmed diagnosis of COVID-19. Participants willbe randomly assigned (by chance) to receive 2 injections of either the investigational vaccine or placebo. A placebo looks lke the investigational vaccine but contains no active vaccine. There is twice as much chance of receiving the investigational vaccine than of receiving placebo. Ifyou take part, you willbe in the study for approximately 2 years and will require up to 10 visits to our study center. Additional visits may be required if you develop symptoms of COVID-19 during the study. Your health will be monitored carefully by a team of doctors and nurses throughout the study. The study injections, health assessments, and medical tests related to the study will be provided at no cost to you. Please contact the study team today if you are interested in joining the AZD1222 COVID-19 VACCINE Study oF would like more information, By contacting us, you are under no obligation to take pat in the study. We look forward to hearing from you soon. West Virginia Research Institute PLLC at (304) 389-4455