Low Dose Immunotherapy (LDI)

Zach Schoening
What is LDI?
A dose of LDI is comprised of...

Combination of
Enzyme
specific antigens
(dependent on patient’s needs)
beta-glucuronidase
What is LDI?

LDI treats people who Taken by:

suffer from:
● Allergies ● Injection
● Autoimmune responses ● Sublingual (oral)
● Other various diseases
○ Lymes
○ Hashimoto’s
○ Multiple sclerosis
○ Etc
What is LDI?
● Dose every 7 weeks Destroy
Desensitize intracellular
TH2 function

Enzyme
(and antigen) 1 2 3 4

Attract T Enhance TH1

cells
LDI for Peanut Allergies
Group of Japanese scientists used
low-dose OIT to treat children with
anaphylactic peanut allergies
Why Focus on Peanut Allergies?

4.6% Solution?
Anaphylactic One of the most Significantly
reactions are common food affects the quality Low dose OIT
caused by peanuts ingredients of life for
in Japan individuals at
constant risk of
anaphylaxis
The Process
What they found

01 All children in the OIT group and 8 in the control

group had a history of anaphylaxis

02
Low-dose OIT induces immunological changes and
has the capability of achieving sustained
unresponsiveness in children with peanut
anaphylaxis
What they found
After the procedure:

33.3% 0%
Children in the OIT Children in the control
group displayed group showed
sustained sustained
unresponsiveness to unresponsiveness
their peanut allergy
Pros/Cons of LDI

Pros Cons
● More permanent solution ● Herxheimer’s Reaction
than taking traditional ● Relief not guaranteed
allergy medication
● Can significantly improve ● Could trigger a reaction
an individuals quality of life
● Cost effective (~$25/dose)
● Preventative solution rather
than reactionary (e.g.
EpiPen)