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Review article
Article history: This paper reviews the epidemiology of childhood stroke. Stroke is an important condition
Received 24 June 2009 in children. It is one of the top ten causes of childhood death and there is a high risk of
Received in revised form serious morbidity for the survivors. Epidemiological data are an integral part of disease
14 September 2009 understanding and high quality studies are required to ensure that this data is robust.
Accepted 17 September 2009 Incidence rates from population-based studies vary from 1.3 per 100,000 to 13.0 per 100,000.
Factors found to influence incidence rates include age, gender, and ethnicity but there are
Keywords: also many inherent differences between studies. Temporal analysis of mortality rates from
Child childhood stroke shows falling rates but there has been little long-term study of changes in
Epidemiology incidence rates. Improved epidemiological data should be a goal of the national and
Incidence international collaborative networks that are studying childhood stroke.
Mortality ª 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights
Stroke reserved.
Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
2. Incidence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
3. Mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
4. Age . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200
5. Gender . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
6. Ethnicity and geography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
7. Temporal trends . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202
8. Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
* Corresponding author. Tel.: þ44 117 3420202; fax: þ44 117 3420186.
E-mail address: finbar.ocallaghan@bristol.ac.uk (F.J.K. O’Callaghan).
1090-3798/$ – see front matter ª 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
doi:10.1016/j.ejpn.2009.09.006
198 european journal of paediatric neurology 14 (2010) 197–205
CVT ¼ cerebral venous thrombosis; SAH ¼ subarachnoid haemorrhage; NR ¼ not reported on cases used for calculation of incidence.
a Unable to be determined from published paper.
b Data in addition to that published in the paper provided by Dr Kleindorfer.
c Male to female ratio of underlying <15 yr old population was 1.44.
d Mean annual population at risk was not available in published paper but was calculated by AAM.
199
200 european journal of paediatric neurology 14 (2010) 197–205
that haemorrhagic stroke was responsible for over 70% of the 8%32 and 35%17 of all cases of childhood stroke. The incidence
deaths during the study periods. of perinatal stroke is estimated to be between 20 and 60 per
Neither mortality study investigated whether the declining 100,000 live births.35,36
mortality rates reflected changes in the incidence of child- Both studies of mortality also found that the greatest risk of
hood stroke or changes in case fatality rates. However, both death from childhood stroke was for children aged less than 1
emphasised that such declines could not be explained by year.30,31 The US mortality data did not allow separate anal-
changes in factors such as blood pressure, smoking and serum ysis of neonates but the last 15 years of data from England and
cholesterol levels that are linked to declines in adult stroke Wales did so and suggested that this youngest age group was
mortality rates.33 Risk factors for childhood stroke mortality only a minor component to the overall mortality in the under 1
that are yet to be identified may have an important influence year age group.31 A low mortality rate from neonatal stroke
on declining mortality rates,30 including the possibility of very appears to be incongruous with a very high incidence rate.
early life factors exerting influence in the pre or perinatal One explanation is that although the highest risk of stroke
period.31 occurrence is in the neonatal period there may be a lag
between stroke and death that results in most deaths occur-
ring after 1 month of age. Alternatively, stroke in the neonatal
4. Age period may have a lower case fatality rate than later stroke.
Both Fullerton et al.13 and Kirkham et al.16 found that after
There is considerable variation in the risk of childhood stroke the age of 1 year the risk of overall stroke fell to a nadir between
according to age. Five of the 6 studies with the largest number the ages of 5 and 9 years before rising again in adolescence.
of cases published the age distribution of cases.13,16–18,32,34 In Fullerton reported this age distribution pattern in the incidence
all of these studies the greatest risk of childhood stroke is for of both ischaemic and haemorrhagic stroke.13 The same pattern
children aged less than 1 year. In studies that analysed was also seen in the mortality studies in both the US30 and
neonates (aged under 1 month) separately, this group was England and Wales.31 A high incidence or mortality rate in
found to be at particularly high risk, responsible for between infancy, a lower rate in mid-childhood and then a rise in
Fig. 1 – Mean incidence of childhood stroke and 95% confidence intervals. If figures were available in the published papers
for 95% confidence intervals they were used for this figure. If not available they were calculated by AAM using the Poisson
distribution for studies with less than 100 cases and the normal approximation for studies with 100 or more cases.89
european journal of paediatric neurology 14 (2010) 197–205 201
adolescence is a pattern seen in other conditions in childhood difference. Oestrogen has vasodilatory and anti-inflammatory
such as bacterial meningitis, epilepsy and diabetes.37–40 There is effects that may offer relative protection from stroke to
evidence that suggests a link between preceding varicella females.52 Oestrogen levels are higher in girls than boys
infection and ischaemic stroke in children.41,42 Varicella infec- throughout childhood, even in the pre-pubertal period
tion is particularly linked to arteriopathy which is one of the (particularly during the ‘‘mini-puberty’’ of infancy).53,54 In
commonest causes of ischaemic stroke.43 It is, therefore, inter- addition to hormonal factors there may be inherent differ-
esting to note that the age-specific incidence rates of varicella ences between male and female cells of the central nervous
infection in temperate countries are highest between the ages of system in response to hypoxic/ischaemic insults. For
1 year and 10 years and the rates are low in infancy and example, neuronal cells derived from female animals cultured
adolescence.44–46 Hence, different varicella infection rates at in steroid-free media have been shown to be more resistant
different ages would not explain the patterns seen in childhood than male derived cells to a range of stimuli simulating
stroke reported by Fullerton et al.13 and Kirkham et al.16 hypoxic, ischaemic, and toxic insults.55,56
In a study of ischaemic stroke only, deVeber reported that Behavioural differences may also play a role in explaining
the highest risk of stroke was for children aged less than 1 year the male predominance. Arterial dissection is implicated in
and then progressively lower risk with increasing age so that a significant proportion of ischaemic strokes in children57,58
those aged 12–18 years were at lowest risk.34 Neither Barnes and follows physical activity or trauma (minor or major) in
et al.32 nor Steinlin et al.17 found a rise in stroke risk in over two-thirds of patients.59 A systematic review of pub-
adolescence but arguably the numbers of cases were too small lished cases of childhood cerebral arterial dissection found
to robustly allow this degree of stratification. over 75% of cases were male.59 Differences in sports and other
The different risk of stroke at different ages is likely to have physical activities may partially explain gender differences in
implications for the incidence rates reported by the various childhood stroke.
studies in Table 1 and Fig. 1. Studies not including neonates
are likely to find a lower incidence rate than if neonates had
been included. Also, if there is a rise in stroke risk in adoles- 6. Ethnicity and geography
cence then those studies with an upper age limit of 15 or 16
years may find a lower incidence than if people up to the age The epidemiology of childhood stroke has not been exten-
of 18 or 19 years were included as was the case in some sively studied outside of highly developed nations with only
studies. Of particular note, the largest study by Fullerton two of the studies listed in Table 1 being within less
et al.13 did not include children under the age of 30 days. The economically developed countries. The studies in developed
study with the lowest reported incidence for overall stroke not nations are almost all of relatively homogenous, predomi-
only excluded neonates and those over the age of 15 years but nantly white Caucasian populations. The notable exceptions
also excluded all children under the age of 1 year.10 are the studies by Satoh et al.12 and Chung and Wong15 which
studied populations that are almost exclusively (>98%) Japa-
nese and Chinese respectively. The US studies have less
5. Gender homogenous populations with variable proportions of chil-
dren of mainly white, Hispanic, African-American, or Asian
It is well known that age-specific stroke rates are higher in ethnicity. For example, the baseline population in Kleindorf-
adult men than women.47,48 Most of the population-based er’s study20 was 82% white and 15% African-America, whereas
studies of childhood stroke have reported the male to female it was 43% white, 39% Hispanic, 10% Asian and 7% African-
ratio. Kleindorfer et al.20 reported a male to female ratio of 0.8. American in Fullerton’s study.13 Although there have been
Satoh et al.12 and Zahuranec et al.49 both reported equal studies of childhood stroke in other population groups they
numbers of males and females. The other 9 studies all found have typically been small and not population based and,
an increased risk for males with a male to female ratio of therefore, have not been able to rigorously estimate the inci-
between 1.15 and 4.0 (see Table 1). The International Pediatric dence of stroke.60–62
Stroke Study (IPSS) found a male to female ratio of 1.49 The range of aetiological factors associated with childhood
amongst the first 1187 patients enrolled.50 Although the IPSS is stroke is very wide.63,64 It is very likely that the rates of many
not population based there is no reason to suspect a gender of these factors are very different in different parts of the
bias in the patients enrolled into the study. world and hence, the epidemiology is also likely to be
Studies of mortality from childhood stroke have also different. For example various hospital based series of child-
shown a preponderance of males. In the USA males were at hood stroke have found higher rates of associated infection in
increased risk of death from ICH (relative risk [RR] ¼ 1.21) and Saudi Arabia,65 moyamoya in Taiwan,66 and sickle cell disease
SAH (RR ¼ 1.30) but not ischaemic stroke (RR ¼ 1.02)30 whereas in Brazil67 than is typically seen in Western Europe58 or North
in England and Wales males were at increased risk of death America.13 It should be noted that, due to moyamoya being
from both ischaemic (RR ¼ 1.28) and haemorrhagic stroke relatively common in Japan, Satoh considered it as a special
(RR ¼ 1.28).31 entity of cerebrovascular disease and excluded cases from the
Increased levels of risk factors in men such as smoking and study of stroke incidence in Japan.12 Reported rates of risk
alcohol overuse are associated with an increased adult male factors are likely to be heavily influenced by the type and
risk of stroke.51 However, such factors cannot explain the range of investigations that are performed in order to eluci-
increased risk of stroke for male children. A number of date aetiology. As there is no universally agreed protocol for
intrinsic factors have been postulated to explain the gender the investigation of childhood stroke, large variations in the
202 european journal of paediatric neurology 14 (2010) 197–205
laboratory and neuroimaging investigations used in different 1999 showed a non-significant trend towards increasing inci-
studies and different countries are likely to be present. dence over time.20 There was a non-significant decrease in
Investigations may greatly depend on the ‘‘focus of interest’’ case mortality rate from the 1988–1989 period to the 1993–1994
of the research group or referral centre. Such differences may period and no change between the 1993–1994 and 1999
partly explain wide differences in reported rates of risk periods. Data from the Canadian Pediatric Ischemic Stroke
factors. For example the rates of abnormal vascular imaging Registry may also show increasing stroke incidence since the
or arteriopathy found in different studies vary from 18% to establishment of the registry in 1992.79 However, a decade is
over 60% and is at least partially explained by variations in the a short time period within which to examine such temporal
comprehensiveness of the vascular imaging performed.43,68–70 trends and there is a risk that apparent rising incidence may
Of the population-based studies, only that of Fullerton was be due to an ascertainment bias on account of improving case
sufficiently ethnically heterogeneous and large enough to ascertainment with time.
make direct comparisons between different ethnic groups An interpretation of a rising incidence rate may be that
living within the same country.13 This study found that the children are ‘‘truly’’ more likely to suffer a stroke than in the
risk of stroke for black children was twice that for white past. Alternatively, increasing use of sophisticated diagnostic
children. The relative risk for Hispanics compared to whites tools may be increasing the recognition and diagnosis of
was 0.76 but Asians and whites had equal risk. Blacks were at childhood stroke.80 For example, Kleindorfer found that the
increased risk compared to whites even when cases of sickle use of CT increased between the 1993–1994 period and the
cell disease were excluded. An increased risk of mortality 1999 period in the Cincinnati study.20 A number of the studies
from childhood stroke for blacks compared to whites was also that have estimated the incidence of childhood stroke19,28
found in the USA.30 collected cases prior to the ready availability of CT neuro-
As with gender disparities in stroke risk, the increased risk imaging in the late 1970s to early 1980s. Perhaps more
for black adults compared to whites is well known.71 This importantly, MRI and newer MRI modalities such as perfusion,
increased risk is typically attributed to higher rates of risk gradient echo, and fluid attenuated inversion recovery
factors such as smoking, diabetes, and hypertension.72,73 imaging are being used with increased frequency in childhood
Again, these adult risk factors are not found to play a role in stroke.81 Of particular note is diffusion weighted MRI which
childhood stroke and the finding of ethnic differences in has very high sensitivity for cerebral infarction, even within
stroke risk for children suggests the role of other aetiological a few minutes of the insult.82 The incidence of conditions that
influences such as genetic factors. For example, promoter mimic the presentation of stroke is unknown but it is likely to
polymorphisms in the nitric oxidase synthase 3 gene have be high.25 Although one study found that less than a quarter of
been found to be associated with increased stroke risk in children who are referred with suspected stroke to a well
young (15–44 years old) black women.74 established stroke team were ultimately given another diag-
nosis, MRI was frequently required to differentiate stroke
from stroke mimics even in cases with an abnormal CT scan.83
7. Temporal trends Hence, increased use of MRI and associated neuroimaging
techniques may have the effect of increasing the apparent
It has been suggested that the incidence of childhood stroke is incidence of childhood stroke by facilitating more frequent
increasing with time.75–77 In support of this suggestion it is diagnosis.75
noted34,76 that the reported incidence of childhood stroke Another factor that may facilitate recognition and diag-
increases from the study by Schoenberg et al.28 (1965–1974), to nosis of childhood stroke is heightened awareness,81 amongst
that of Broderick et al.78 (1988–1989) and finally to that of both the general population and medical professionals.
Giroud et al.11 (1985–1993) or deVeber18 (1992–1998). However, Intensive stroke awareness programmes in a number of
this progression does not robustly support the hypothesis that countries have probably increased the awareness of stroke
childhood stroke incidence is rising. As discussed, there is and its symptoms in the general population.84,85 There are
great variability in factors such as methodology, case defini- now a number of national and international collaborative
tion, and baseline population characteristics between groups studying childhood stroke79,86 and the number of
different studies. Hence, drawing any conclusions about the published articles on the subject of childhood stroke has been
temporal trends in childhood stroke incidence by making steadily rising which is likely to lead to greater awareness
comparisons between different studies is fraught with amongst medical professionals. Papers found on PubMed
difficulties. using the search terms ‘‘stroke AND children’’ make up
As discussed, mortality rates from childhood stroke in the a rising proportion of the total number of indexed papers. The
USA and England and Wales have been shown to be proportion in the 1970s was 9 per 100,000 papers, 32 per
declining.30,31 If incidence rates are indeed increasing and 100,000 in the 1980s, 43 per 100,000 in the 1990s and 55 per
mortality rates are falling then case fatality rates must also be 100,000 from 2000 to 2008.87
falling. The most plausible explanation for declining case Increasing survival of children with conditions known to
fatality rates is improved care post-stroke. predispose to stroke such as complex congenital heart
To examine temporal trends of incidence and case disease, meningitis and malignancy may be a factor that
mortality rates in a satisfactory manner requires the long- contributes to a ‘‘true’’ rise in the incidence of childhood
term study of the population of a fixed region using the same stroke.75 However, increased awareness of these risk factors
methodology throughout. Kleindorfer’s study of the Greater and improved management of conditions such as sickle cell
Cincinnati metropolitan area over 3 periods between 1988 and disease may ameliorate any such rise in incidence.88
european journal of paediatric neurology 14 (2010) 197–205 203
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