Name and classification of Onset, Peak, Duration, Mechanism of action Indication Contraindication

the drug Route

Generic Name: Routes of administration: PO, Metoclopramide causes General indications: Contraindications:
Metoclopramide IV, Topical antiemetic effects by  amebic hepatic  hypersensitivity
inhibiting dopamine D2 and abscess  hypersensitivity to
Trade name: Flagyl, Metric 21, Pharmacokinetics: serotonin 5-HT3 receptors in  intestinal amebiasis parabens
noritade the chemoreceptor trigger  trichomoniasis  first trimester of
Onset: zone (CTZ) located in the  retractory pregnancy
Classification: Nitroimidazole PO: unknown area postrema of the brain. trichomoniasis
IV: immediate Administration of this drug  bacterial infections Precautions:
Therapeutic class: Topical: unknown leads to prokinetic effects via caused by anaerobic  history of blood
antibacterial, antiprotozoal inhibitory actions on microorganisms dyscrasias: seizures or
Peak: presynaptic and postsynaptic  to prevent neurologic problems
Patient’s Dose: 1.5 mg slow IV PO: 1-2 hrs D2 receptors, agonism of postoperative  severe hepatic
stat IV: immediate serotonin 5-HT4 receptors, infection in impairment
Topical: 6-10 hrs and antagonism of muscarinic contaminated  pregnancy, lactation
Minimum Dose: PO: 250 mg reptor inhibition. This action colorectal surgery and children
TID Duration: enhances the release of pelvic inflammatory disease Drug interactions:
IV: 100mg/ml PO, IV, Topical: unknown acetycholine, causing  cimetidine
increased lower esophageal  phenobarbital
Maximum dose: PO: 750 mg sphincter (LES) and gastric  warfarin
TID 6-10 days tone, accelerating gastric  disulfiram
emptying and transit through  flourouracil
the gut. Metoclopramide
antagonizes the dopamine D2
receptors. Dopamine exerts
relaxant effect on the
gastrointestinal tract through
binding to muscular D2
receptors.