Patient > 6 mo

and <25 y with

suspected AIHA,
cITP or ES

Consent and
study inclusion

Initial form

Diagnosis of
Exclusion of non-immune
non-immune-
mediated cytopenia or
mediated
diagnosis of secondary cause
cytopenia

Clinical and Off-study

Treatment Accompanying
laboratory follow-up
documentation research
analyses after 1 year

Immune Genetic
phenotype incl. Intestinal diagnostics
Initial diagnostic Initial treatment
senescence, microbiome (clinical routine
CRF CRF (optional) cytokine Panel, analysis or off-study
other biomarkers
research
cooperation)
Regular Regular
Visit after 6 Visit after 6
follow-up follow-up
months, months,
(with every (with every
diagnostic CRF treatment CRF
study visit) study visit)

Visit after 12 Visit after 12

months, then months, then
yearly, yearly,
diagnostic CRF treatment CRF

Repeat at every
Repeat until
change or
1-4 years
termination of
after inclusion
treatment

End of study
(end of follow-
up or end of
SIC-Reg.org)
® sic-reg.org