Aipgmee Biochem MCQ

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AIPGME BIOCHEMISTRY NOTES 6. Which of the following vitamins does not
participate in oxidative decarboxylation
Topic - vitamins of pyruvate to acetyl CoA - (AIPGME
2013-2014)
1. Which of the following is a Water Soluble a) Thiamine
Vitamin? (AIPMG 2008) b) Niacine
A. Folic Acid c) Riboflavin
B. Vitamin A d) Biotin
C. Vitamin K Ans.D
D . Linolenic Acid
Answer is A 7. Riboflavin deficiency is assessed by -
(AIPGME 2013-2014)
2. Which Vitamin is required for a) Transketolase
carboxylation of clotting factors? b) Glutathione reductase
(AIPMG 2008) c) PDH
A. Vitamin A d) None
B. Vitamin D Ans.B
C. Vitamin E
D . Vitamin K 8.The mineral having action like vitamin £ -
Answer is D (AIPGME 2013-2014)
a) Calcium
3. Vitamin K is involved in post translation b) Iron
modification of: (AIPGME 2011) c) Selenium
A. Glutamate d) Magnesium
B. Aspartate Ans.C
C. Lysirie
D . Proline. 9.AH are true about Vitamin B12, except -
Answer is A (AIPGME 2013-2014)
a) Active form is methylcobalamine
4. Thiamine deficiency causes decreased b) Requires for conversion of homocysteine
energy production because: (AIPGME to methionine
2011) c) Requires in metabolism of methylmalonyl
A. It is required for the process of CoA
transamination d) Requires for conversion of pyruvate to
B. It is a co-factor for oxidative reduction lactate
C. It is a cb-enzyme for transketolase in Ans.d
pentose phosphate pathway
D . It is a co-enzyme for pyruvate 10. Major form of folk acid to transfer one
dehydrogenase and a-ketoglutarate carbon is- (AIPGME 2013-2014)
dehydrogenase in Tricarboxylic acid a) Methylene THF
pathway . b) Formyl THF
Answer is D c) Methyl THF
d) All
5.Which vitamin is required for transfer of 1- Ans.A
carbon unit - (AIPGME 2013-2014) 11. Which vitamin deficiency causes glossitis
a) Vitamin A and cheilosis - (AIPGME 2013-2014)
b) Folic acid a) Thiamin
c) Vitamin B12 b) Riboflavin
d) Niacin c) Folic acid
Ans.B d) Vitamin A
Ans.B
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12. Which Vitamin is involved in Redox a) Regulation of energy metabolism
reactions - (AIPGME 2013-2014) b) Carboxylation reaction
a) Pyridoxin c) Blood clotting
b) Biotin d) Protection of biological membrane from
c) Folic acid free radical damage
d) Riboflavin Ans.D
Ans.D
19. Niacin deficiency causes - (AIPGME
13. Riboflavin is a constituent of - (AIPGME 2013-2014)
2013-2014) a) Pigmentation
a) FMN b) Diarrhea
b) NAD c) Rash
c) PLP d) Lactic acidosis
d) THF Ans.B
Ans.A
20. Gastrectomy produces deficiency of which
14. Which of the following Vitamin is an vitamin - (AIPGME 2013-2014)
antioxidant- (AIPGME 2013-2014) a) Vitamin B6
a) Vitamin D b) Vitamin B12
b) Vitamin E c) Vitamin B2
c) Vitamin K d) Vitamin B,
d) Vitamin Bi Ans.B
Ans.B
21. Neurotoxicity is seen with excess of -
15.All are involved in energy metabolism (AIPGME 2013-2014)
except - (AIPGME 2013-2014) a) Vitamin B6
a) Vitamin B1 b) Vitamin B12
b) Vitamin B3 c) Vitamin B2
c) Vitamin B7 d) Vitamin C
d) Vitamin B12 Ans.A
Ans.D
22. All are true about vitamin E except -
16.The main function of Vitamin C in the (AIPGME 2013-2014)
body is - (AIPGME 2013-2014) a) Act as antioxidant
a) Coenzyme for energy metabolism b) Prevent lipid peroxidation of cell
b) Regulation of lipid synthesis membrane
c) Involvement as antioxidant c) Water soluble vitamin
d) Inhibition of cell growth d) Chemically tocopheral
Ans.C Ans.C
17. Erythrocyte transketolase activity is seen

in which vitamin - (AIPGME 2013- 23. Blood form of folic acid is - (AIPGME
2014) 2013-2014)
a) Riboflavin a) Folinic acid
b) Thiamine b) Pteroglutamate
c) Folic acid c) Methyl THF
d) Niacine d) None
Ans.B Ans.C
18. Major function of Vitamin E in the body -

(AIPGME 2013-2014)
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24. Not obtained from plant source - 30. Most important vitamin, which promotes
(AIPGME 2013-2014) wound healing - (AIPGME 2014-2015)
a) Cobalamine a) Vitamin C
b) Riboflavin b) Vitamin D
c) Thiamine c) Vitamin A
d) Vitamin A d) Niacin
Ans.A Ans. is 'a'
31. In humans, ascorbic acid cannot be
25. Vitamin not required in TCA cycle - synthesized because of - (AIPGME
(AIPGME 2013-2014) 2014-2015)
a) Niacin a) Deficiency of G6PD
b) Riboflavin b) Deficiency of xylulose kinase
c) Thiamine c) Deficiency of L-gulonolactone oxidase
d) Folic acid d) Deficiency of phosphoglucomutase
Ans.D Ans. is 'c'
26. Oxidation of lactate to pyruvate requires 32. Deficiency of which vitamin causes
which vitamin - (AIPGME 2013-2014) excretion of xantheurenic acid in urine -
a) Riboflavin (AIPGME 2014-2015)
b) Niacin a) Folic acid
c) Folic acid b) Pyridoxin
d) Biotin c) Niacin
Ans.B d) Vitamin B
Ans. is 'b'
27. The function of vitamin K largely depends
on which mineral - (AIPGME 2013- 33. FIGLU excretion test is used for
2014) assessment of deficiency of - (AIPGME
a) Selenium 2014-2015)
b) Calcium a) Vitamin B12
c) Iron b) Niacin
d) Magnesium c) Folic acid
Ans.B d) Pyridoxin
Ans. is 'c'
28. Vitamin involved in decarboxylation -
(AIPGME 2014-2015) 34. Co-enzyme used in transamination -
a) Biotin (AIPGME 2014-2015)
b) Pyridoxin a) NAD
c) Niacin b) Biotin
d) Thiamin c) Pyridoxal phosphate
Ans. is 'b' d) Riboflavin
Ans. is 'c'
29. Vitamin C is required for - (AIPGME
2014-2015) Topic - amino acids
a) Posttranslational modification 35. Which of the following does not undergo
b) Synthesis of epinephrine phosphorylation by protein kinases in
c) Tyrosine metabolism Eukaryotes:
d) All of the above A. Threonine
Ans. is 'd' B. Tyrosine
C. Serine
D . Asparagine
Answer isD
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36. Which of the following aminoacids in a 42.Polar amino acids are all except -
protein commonly acts as a potential O- (AIPGME 2013-2014)
Glycosylation site for attachment of an a) Glutamic acid
oligosaccharide unit. (AIPGME 2012) b) Histidine
A. Glutamine c) Glutamine
B. Cysteine d) Methionine
C. Serine Ans.D
D . Asparginine
Answer is C 43. Which is not Glucogenic - (AIPGME
2013-2014)
37. Amino acid carrying ammonia from a) Arginine
muscle to liver - (AIPGME 2013-2014) b) Histidine
a) Alanine c) Glycine
b) Glutamine d) Lysine
c) Arginine Ans.D
d) Lysine
Ans.A
44. Which is not ketogenic (AIPGME 2013-
38. Tryptophan is glucogenic & ketogenic by 2014)
producing - (AIPGME 2013-2014)
a) Acetyl CoA & alanine a) Leucine
b) Acetoacetate & fumarate b) Lysine
c) Acetoacetate & arginine c) Methionine
d) Arginine & alanine d) Tryptophan
Ans.A Ans.C >d
39. Amino acid with double chiral is - 45. Ninhydrin test is used for - (AIPGME
(AIPGME 2013-2014) 2013-2014)
a) Phenyalanine a) Bile salts
b) Threonine b) Amino acids
c) Tryptophane c) Nucleic acid
d) Tyrosine d) Lipids
Ans.B Ans.B
46.Essential amino acid amongst the

40.Neutral amino acid is - (AIPGME 2013- following - (AIPGME 2013-2014)
2014) a) Arginine
a) Aspartate b) Lysine
b) Arginine c) Threonine
c) Glycine d) All
d) Histidine Ans.D
Ans.C
47. Amino acid with double chiral is -
41.Essential amino acid is - (AIPGME 2013- a) Phenyalanine
2014) b) Threonine
a) Alanine c) Tryptophane
b) Serine d) Tyrosine
c) Arginine Ans.B
d) Proline
Ans.C
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48. Amino acid required for formation of 54. Amino acid which is optically inert-
thyroxine- (AIPGME 2013-2014) (AIPGME 2014-2015)
a) Tryptophan a) valine
b) Tyrosine b) alanine
c) Glutamine c) Glycine
d) Cysteine d) Threonine
Ans.B Ans. is 'c'
49. Not gluconeogenic- (AIPGME 2013- 55. Amino acids with extra NH3 (amino
2014) group) in strucuture - (AIPGME 2014-
a) Acetyl CoA 2015)
b) Lactate a) Aspartate
c) Glycerol b) Glutamate
d) Alanine c) Histidine
Ans.A d) Alanine
Ans. is 'c'
50. Amino acid with aliphatic side chain -
(AIPGME 2013-2014) 56. Strongest interactions among the
a) Serine following - (AIPGME 2014-2015)
b) Leucine a) Covalent
c) Threonine b) Hydrogen
d) Aspartate c) Electrostatic
Ans.B d) Van der Waals
Ans. is 'a'
51. Neutral amino acid is - (AIPGME 2014-
2015) 57. Which of the following amino acids is
a) Arginine purely (AIPGME 2014-2015)
b) Lysine a) Phenylalanine
c) Aspartate b) Leucine
d) Leucine c) Proline
Ans. is 'd' d) Tyrosine
Ans. is 'b'
52. Which one of the following can be a
homologous substitution for isoleucine 58. Which of the following side chains is least
in a protein sequence? (AIPGME 2014- polar (AIPGME 2009)
2015) A. Methyl
a) Methionine B. Carboxyl
b) Aspartic acid C. Amino
c) Leucine D . Phosphate
d) Arginine Answer is A
Ans. is 'c'
Topic - lipoproteins
53. Not an essential amino acid - (AIPGME 59. All of the following statements about
2014-2015) apoproteins are true Except (AIPMG
a) Arginine 2008)
b) Histidine A. Apoprotein A-I activates LCAT
c) Glutamate B. Apoprotein C-I activates lipoprotein lipase
d) Lysine C. Apoprotein C-II inhibits lipoprotein lipase
Ans. is 'c' D . Apoprotein C- II activates lipoprotein
lipase
Answer is C
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a) HDL
60. Which of the following types of b) LDL
hypertriglyceridemia is associated with c) VLDL
an increase in chylomicron and VLDL d) IDL
remnants? (AIPMG 2008) Ans.A
A. Type I
B. Typella 66. Endogenous triglycerides in plasma
C. Type III are maximally carried in - (AIPGME
D . Type IV 2013-2014)
Answer is C a) VLDL
b) Chylomicrons
61. All of the following statements about c) LDL
Lipoprotein Lipase are true, Except d) HDL
(AIPGME 2009) Ans.A
A. Found in adipose tissue
B. Found in myocytes 67. Which is an abnormal lipoprotein -
C. Deficiency leads to (AIPGME 2013-2014)
hypertriacylglycerolemia a) VLDL
D . Does not require CII as cofactor b) Chylomicron
Answer is D c) Lp (a)
d) LDL
62. Which of the following lipoproteins does Ans.C
not move Jow^Ms^a (AIPGME 2010)
A. VLDL 68.All are true about LDL except - (AIPGME
B. LDL 2013-2014)
C. HDL a) More dense than chylomicron
D . Chylomicrons b) Smaller than VLDL
Answer is D c) Transports maximum amount of lipid
d) Contains maximum cholesterol
63. Which of the following statements about Ans.c
High Density Lipoprotein (HDL) is
false: (AIPGME 2011)
A. HDL increases oxidation of LDL 69. Major apolipoprotein of chylomicrons -
B. HDL reduces foam cell production by (AIPGME 2013-2014)
LDL a) B-100
C: HDL is the best predictor of CAD b) D
D . HDL helps to clear lipids from atheromas c) B-48
Ans. is A d) None
Ans.C
64. All of the following are associated with
increased risk of atherosclerotic plaque 70. Concentration of which is inversely related
formation except: (AIPGME 2011) to the risk of coronary heart disease -
A. Apo E mutation (AIPGME 2013-2014)
B. Oxidized LDL a) VLDL
C. Increased homocysteine b) LDL
D . Increased Alpha 2 macroglobulin c) HDL
Answer is D d) None
Ans.C
65. Lipoprotein associated with carrying
cholesterol from periphery tissues to
liver is - (AIPGME 2013-2014)
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71. Maximum cholesterol is seen in - a) VLDL
(AIPGME 2013-2014) b) LDL
a) VLDL c) HDL
b) LDL d) Chylomicrons
c) HDL Ans. is 'd'
d) Chylomicrons
Ans.B 78. Lipoprotein involved in reverse
cholesterol transport- (AIPGME 2014-
72. VLDL is formed in (AIPGME 2013-2014) 2015)
a) Intestine a) LDL
b) Liver b) VLDL
c) From chylomicrons c) IDL
d) Blood d) HDL
Ans.B Ans. is 'd'
73. Lipid with highest mobility is - (AIPGME 79. Defect in type II hyperlipidemia –
2013-2014) (AIPGME 2014-2015)
a) HDL a) Apo-E
b) LDL b) Lipoprotein lipase
c) VLDL c) LDL receptor
d) Chylomicrons d) None
Ans.A Ans. is 'c'
74. Apolipoprotein E is rich in - (AIPGME 80. Lipoprotein associated with carrying

2013-2014) cholesterol from peripheral tissues to
a) Lysine liver is (AIPGME 2014-2015)
b) Arginine a) HDL
c) Histidine b) LDL
d) Methionine c) VLDL
Ans.B d) IDL
Ans. is 'a'
75. The dietary fats are transmitted from GIT
to adipocytes in the form of - 81. Highest mobility on electrophoresis -
(AIPGME 2013-2014) (AIPGME 2014-2015)
a) Diacyl glycerol a) HDL
b) Triacylglycerol b) VLDL
c) Fat misseles c) LDL
d) Chylomicrons d) Chylomicrons
Ans.D Ans. is 'a'
76. Primary hypercholesterolemia is - Topic - amino acid metabolism

(AIPGME 2013-2014)
a) Type I 82. Transfer of an amino group from an
b) Type Ha amino acid to an alpha-keto acid is done
c) Type lib by: (AIPGME 2011)
d) Type III A. Transaminases
Ans.B B. Oxidases
C. Transketolases
77. Which of the following is increased in D . Deaminases
lipoprotein lipase deficiency - Answer is A
(AIPGME 2014-2015)
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83. Cystine is formed by - (AIPGME 2013- 89.Catecholamines are synthesized from -
2014) (AIPGME 2013-2014)
a) Hydroxylation of cysteine molecule a) Tryptophan
b) Carboxylation of cysteine molecule b) Tyrosine
c) Peptide bond between two cysteine c) Methionine
molecule d) Histidine
d) Disulfide bond between cysteine molecule Ans.D
Ans.D
90.Transminatlon of Aspartate forms -
84.Protein catabolism is increased in - (AIPGME 2013-2014)
(AIPGME 2013-2014) a) Pyiuvale
a) Starvation b) Acetly-CoA
b) Burns c) Oxaloacetate
c) Surgery d) Alanine
d) All of the above Ans.C
Ans.D
91. Glycine is required in formation of all
85. Serotonin is derived from - (AIPGME except - (AIPGME 2013-2014)
2013-2014) a) Heme
a) Tyrosine b) Purines
b) Tryptophan c) Glutathione
c) Phenylalanine d) Thyroxine
d) Methionine Ans.D
Ans.B
92. Amino acid connot be used for glycogen
86. Melatonin is derived from - (AIPGME synthesis - (AIPGME 2013-2014)
2013-2014) a) Alanine
a) Tyrosine b) Threonine
b) Tryptophan c) Leucine
c) Glutathione d) Methionine
d) None Ans.C
Ans.B
93. H4-biopterin (tetrahydrobiopterine) is
87. Creatine is made up of all, except - required for metabolism of - (AIPGME
(AIPGME 2013-2014) 2013-2014)
a) Glycine a) Arginine
b) Alanine b) Lysine
c) Methionine c) Phenylalanine
d) Arginine d) Tryptophane
Ans.B Ans.C
88. Protein catabolism is increased in - 94. Which of the following is caused by

(AIPGME 2013-2014) defective transport of tryptophan -
a) Starvation (AIPGME 2014-2015)
b) Burns a) Hartnup disease
c) Surgery b) Maple syrup urine disease
d) All of the above c) Alkaptonuria
Ans.D d) Phenylketonuria
Ans. is 'a
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95. Melatonin is derived from - (AIPGME 101. Cystathionine lyase requires which
2014-2015) cofactor (AIPGME 2014-2015)
a) Tyrosine a) Thymine
b) Tryptophan b) Riboflavin
c) Phenylalanine c) Pyridoxine
d) Histidine d) Niacin
Ans. is 'b' Ans. is 'c'
96. NO is synthesized by - (AIPGME 2014- 102. Taurine is made from - (AIPGME 2014-
2015) 2015)
a) Uracil a) Glycine
b) Aspartate b) Tyrosine
c) Guanosine c) Cysteine
d) Arginine d) Phenylalanine
Ans. is 'd' Ans. is 'c'
97. Nicotinic acid is derived from - (AIPGME 103. If tyrosine level in blood is normal
2014-2015) without external supplementation,
a) Glutamine deficiency of which of the following is
b) Tryptophan ruled out - (AIPGME 2014-2015)
c) Glutathione a) Tryptophan
d) Phenylalanine b) Phenylalanine
Ans. is 'b' c) Histidine
d) Isoleucine
98. Niacin is synthesized from - (AIPGME Ans. is 'b'
2014-2015)
a) Arginine Topic - glycolysis
b) Histidine 104. Which of the following statement is true:
c) Tryptophan (AIPGME 2011)
d) Tyrosine A. Sulfonamides inhibit folate reductase
Ans. is 'c' irreversibily
B. Ethanol inhibits aldehyde dehydrogenase
99. Tyrosine enters gluconeogenesis by when used in methanol poisoning
forming which substrate - (AIPGME C. Acetylcholinesterase inhibition by
2014-2015) malathion can be reversed by increasing
a) Succinyl CoA the levels of
b) oc-ketoglutarate Acetylcholine
c) Fumarate D . Fluoroacetate competitively inhibits
d) Citrate Aconitase
Ans. is 'c' Answer is D
100. Fumarate of TCA is derived from 105. PFK-I inhibitor – (AIPGME 2013-2014)
transmination of which amino acid - a) AMP
(AIPGME 2014-2015) b) Citrate
a) Phenylalanine c) Glucose 6 phosphate
b) Methionine d) Insulin
c) Valine Ans. B
d) Glutamine
Ans. is 'a' 106. All the following cycles operate in
mitochondria except - (AIPGME 2013-
2014)
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b) Beta oxidation 112. Anaerobic glycolysis occurs in all places
a) Ketogenesis except - (AIPGME 2013-2014)
c) TCA cycle a) Muscles
d) EMP b) RBCs
Ans.D c) Brain
d) Kidney
107. Which of the enzyme of glycolysis is Ans.C
used in gluconeogenesis -(AIPGME
2013-2014) 113. Reducing equivalants produced in
a) Glucokinase glycolysis are transported from cytosol
b) PFK to mitochondria by - (AIPGME 2013-
c) Pyruvate kinase 2014)
d) Phosphotriose isomerase a) Carnitine
Ans.D b) Creatine
c) Malate shuttle
108. All the foUowing cycles operate in d) Glutamate shuttle
mitochondria except - (AIPGME 2013- Ans.C
2014)
a) Ketogenesis 114.Inhibition of glycolysis by increased
b) Beta oxidation supply of O2 is called - (AIPGME
c)TCA cycle 2013-2014)
d) EMP a) Crabtree effect
Ans.D b) Pasteur effect
c) Lewis effect
109. 2, 3 bisphosphoglycerate occurs in - d) None
(AIPGME 2013-2014) Ans.B
a) Liver 115. Enolase is inhibited by - (AIPGME
b) RBCs 2014-2015)
c) Kidney a) Fluoride
d) Brain b) Fumarate
Ans.B c) Iodoacetate
d) Arsenite
110. True about glycolysis are all except - Ans. is 'a'
(AIPGME 2013-2014)
a) Provide nutrition to cancer cells 116. Maximum energy is liberated by
b) Substrate level phosphorylation at pyruvate hydrolysis of- (AIPGME 2014-2015)
kinase a) Creatine phosphate
c) Two carbon end product is formed b) ATP
d) NADPH is formed by glyceraldhyde-3- c) Phosphoenol pyruvate
phosphate dehydrogenase d) Glucose-6-phosphate
Ans.C Ans. is 'c'
111. Instant energy to muscle is provided by 117. Enzyme of glycolysis involved in transfer
which pathway- (AIPGME 2013-2014) of inorganic phosphate - (AIPGME
a) HMP shunt 2014-2015)
b) Embden mtiyerhoff palhway a) Enolase
c) Cori cycle b) Aldolase
d) TCA cycle c) Phosphoglycerate mutase
Ans.B d) Glyceraldehyde-3-phosphate
dehydrogenase
Ans. is 'd'
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118. Not a common enzyme for glycolysis
and gluconeogenesis - (AIPGME 2014- 124. Number of ATP molecules and NADH
2015) formed in each cycle of glycolysis -
a) Aldolase (AIPGME 2014-2015)
b) Glucose-6-phosphatase a) 4 ATP , 2 NADH
c) Phosphoglycerate mutase b) 2 ATP , 2 NADH
d) Phosphoglycerate kinase c) 4 ATP , 4 NADH
Ans. is 'b' d) 2 ATP , 4 NADH
Ans. is 'a
119. Not a rate limiting enzyme - (AIPGME
2014-2015) Topic - enzymes
a) PFK .
b) HMGCoAreductase 125. All of the following enzymes are
c) HMG CoA synthase involved in oxidation - reduction
d) Aldolase reactions, Except (AIPGME 2009)
Ans. is 'd' A. Dehydrogenases
B. Hydrolases
120. Number of ATP produced by RBC when C. Oxygenases
Glycolysis occurs through Rapoport D . Peroxidases
Leubering pathway - (AIPGME 2014- Answer is B
2015)
a) 1 126. Following is true statement about
b) 2 enzymes- (AIPGME 2013-2014)
c) 3 a) In competitive inhibition Vmax unchanged
d) 4 but Km increased
Ans. is 'a' b) In uncompetitive inhibition Km unchanged
but Vmax increased
121. Specific inhibitor of succinate c) In uncompetitive inhibition Km unchanged
dehydrogenase - (AIPGME 2014-2015) but Vmax changed
a) Fluoroacetate d) In uncompetitive inhibition mixed increase
b) Arsenite of Vmax and Km value
c) Malonate Ans.A
d) Fluoride
Ans. is 'c' 127. Which of the following is a lyase -
(AIPGME 2013-2014)
122. In oxidative pathway , NADPH is a) Decarboxylase
produced in - (AIPGME 2014-2015) b) Synthetase
a) Cytosol c) Kinase
b) Mitochondria d) Oxygenase
c) Ribosome Ans.A
d) Peroxisomes
Ans. is 'a' 128. Substance which binds to substrate other
than catalytic enzyme is - (AIPGME
123. Which of the following enzyme does not 2013-2014)
catalyzes irreversible step in glycolysis - a) Competitive inhibitor
(AIPGME 2014-2015) b) Non-competitive inhibitor
a) Hexokinase c) Reversible inhibitor
b) Phosphoglycerate kinase d) None of the above
c) Pyruvate kinase Ans.B
d) Phosphofructokinase
Ans. is 'b'
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129 .Enzyme specificity is given by - a) EC-1
(AIPGME 2013-2014) b) EC-2
a) Km c) EC-3
b) Vmax d) EC-4
c) Both Ans.C
d) None
Ans.A 136. Which of the following is serine protease
- (AIPGME 2013-2014)
130. The mechanism by which mercury causes a) Pepsin
damage - (AIPGME 2013-2014) b) Trypsin
a) Binds to -SH group of enzyme c) Carboxypeptidase
b) Directly toxic d) None
c) Inhibits ETC Ans.B
d) Inhibits protein synthesis 137. Fastest acting enzyme - (AIPGME 2013-
Ans.A 2014)
a) LDH
131. Q10 in enzyme matches with - b) Trypsin
(AIPGME 2013-2014) c) Catalase
a) 2 d) None
b) 4 Ans.C
c) 8
d) 10 138. All have precursor form, except -
Ans.A (AIPGME 2014-2015)
a) Trypsin
132. Hexokinase is - (AIPGME 2013-2014) b) Chymotrypsin
a) Ligase c) Carboxypeptidase
b) Transferase d) Aminopeptidase
c) Oxidoreductase Ans. is 'd'
d) Reductase
Ans.B 139. Transferases are classified as - (AIPGME
2014-2015)
133. Chemical process involved in conversion a) EC-1
of nor- adrenaline to adrenaline - b) EC-2
(AIPGME 2013-2014) c) EC-3
a) Hydroxylation d) EC-4
b) Carboxylation Ans. is 'b'
c) Methylation Topic - Urea cycle
d) Dehydrogenation 140. Urea cycle occurs in: (AIPGME 2011)
Ans.C A. Liver
B. Gastrointestinal tract
134. Kcat/km is a measure of - (AIPGME C. Spleen
2013-2014) D . Kidney
a) Enzyme efficiency Answer is A
b) Speed of enzymatic reaction
c) Concentration of substrate 141. In urea cycle, hydrolysis of arginine
d) Enzyme turn over forms - (AIPGME 2013-2014)
Ans.A a) Citrulline
b) Ornithine
135. According to IUB system, hydrolases c) Carbomoyl phosphate
belong to which class - (AIPGME d) Arginosuccinase
2013-2014) Ans.B
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142.Which of the following pathway occurs

partly in mitochondria and partly in 148. Rate limiting step in urea cycle is
cytosol - (AIPGME 2013-2014) catalyzed by - (AIPGME 2014-2015)
a) Glycolysis a) Arginase
b) Kreb's cycle b) Argininosuccinase
c) Ketogenesis c) Carbamoyl-phosphate synthase
d) Urea cycle d) Ornithine transcarbamylase
Ans.D Ans. is 'c'
143. In urea cycle which defect is an X linked 149. Citrullinemia is due to deficiency of -
disease - (AIPGME 2013-2014) (AIPGME 2014-2015)
a) Ornithine transcarbamylase a) Argininosuccinate lyase
b) Aspartate transcarbamylase b) Argininosuccinate synthase
c) Arginase c) Arginase
d) Argininosuccinate synthase d) Ornithine transcarbamylase
Ans.A Ans. is 'b'
144. Source of ammonia in urine - (AIPGME

2013-2014) 150. Urease is a/an - (AIPGME 2014-2015)
a) Glutaminase a) Oxidoreductase
b) Urease b) Lyase
c) Glutamate dehydrogenase c) Ligase
d) Arginase d) Hydrolase
Ans.A Ans. is 'd'
145. Carbamoyl phosphate synthase I is used 151. Rate limiting step in urea cycle is
in - (AIPGME 2013-2014) catalyzed by - (AIPGME 2014-2015)
a) Purine synthesis a) Arginase
b) Pyrimidine synthesis b) Argininosuccinase
c) Urea cycle c) Carbamoyl-phosphate synthase
d) Uronic acid pathway d) Ornithine transcarbamylase
Ans.C Ans. is 'c'
146. In argininosuccinase deficiency, what 152. Imediate precursor of creatine -

should be supplemented to continue the (AIPGME 2014-2015)
urea cyce - (AIPGME 2014-2015) a) Carbamoyl phosphate
a) Aspartate b) Arginosuccinate
b) Arginine c) Guanidoacetate
c) Citrullin d) Citrulline
d) Argininosuccinate Ans. is 'c'
Ans. is 'b'
153. Urea is synthesized in all except -
147. Quaternary ammonium compound (AIPGME 2014-2015)
disinfectants are - (AIPGME 2014- a) Liver
2015) b) Brain
a) Anionic c) Kidney
b) Cationic d) Spleen
c) Neutral Ans. is 'd'
d) Gases
Ans. is 'b'
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154. Amino acid carrying ammonia from 160.Which of the component of respiratory
muscle to Iiver- (AIPGME 2014-2015) chain re acts directly with molecular
a) Alanine oxygen - (AIPGME 2013-2014)
b) Glutamine a) Cytb
c) Arginine b) CoQ
d) Lysine c) Cyt C
Ans. is 'a' d) Cyt aa3
Ans.D
Topic - electron transport chain
161. Which of the following is an inophor -
(AIPGME 2013-2014)
155. ATP is generated in ETC by - (AIPGME a) Carboxin
2013-2014) b) 2, 4 dinitrophonal
a) Na+ K+ ATPase c) Atractiloside
b) Na+ Cl" ATPase d) Valinomycin
c) FoF , ATPase Ans.D
d) ADP Kinase
Ans.C 162. NADH CoQ reductase is inhibited by -
(AIPGME 2014-2015)
156. Atractiloside act as - (AIPGME 2013- a) Rotenone
2014) b) Carbonmonoxide
a) Uncoupler c) Antimycin
b) Inhibitor of oxidative phosphorylation d) Atractyloside
c) Inhibitor of complex I of ETC Ans. is 'a'
d) Inhibitor of complex III of ETC
Ans.B 163. CO acts by inhibiting which component
of respiratory chain - (AIPGME 2014-
157.Natural uncoupler is - (AIPGME 2013- 2015)
2014) a) Cytochrome b
a) Thermogonin b) Cytochrome C oxidase
b) 2, 4 nitrophenol c) NADH CoQ reductase
c) 2, 4 Dinitrophenol d) Oxidative phosphorylation
d) Oligomycin Ans. is 'b'
Ans.A
164. Role of molecular oxygen in ETC -
158. Physiological uncoupler is - (AIPGME (AIPGME 2014-2015)
2013-2014) a) Transfer of reducing equivalent to CoQ
a) Thyroxine b) Transfer of reducing equivalent from
b) Free fatty acids cytosol to niitocnonSfia^
c) Thermogenin c) To act as last electron acceptor
d) All of the above d) Generation of ATP
Ans.D Ans. is 'c'
159. Which complex of ETC reacts directly 165. Which complex of ETC is not associated
with O2- (AIPGME 2013-2014) with liberation of energy - (AIPGME
a) I 2014-2015)
b) II a) Complex I
c) III b) Complex II
d) IV c) Complex III
Ans.D d) Complex IV
Ans. is 'b'
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166. Which of the following is not true 172. True about gluconeogenesis - (AIPGME
regarding ETC- (AIPGME 2014-2015) 2013-2014)
a) Occurs in mitochondria a) Occurs mainly in muscle
b) Generates ATP b) It is reverse of glycolysis
c) No role of inorganic phosphate c) Alanine & lactate both can serve as
d) Involves transport of reducing equivalent substrate
Ans. is 'c' d) Glycerol is not a substrate
Ans.C
167. Cyanide affects respiratory chain by -
(AIPGME 2013-2014)
a) Non-competitive reversible inhibition 173.Gluconeogenesis from lactate needs all
b) Competitive reversible inhibition except - (AIPGME 2013-2014)
c) Suicide irreversible inhibition a) Transport of lactate from muscle to liver
d) Non-competitive irreversible inhibition b) Conversion of lactate to pyruvate
Ans.D c) Transamination of pyruvate to alanine
d) None of the above
168.Cyanide affects respiratory chain by - Ans.c
(AIPGME 2013-2014)
a) Non-competitive reversible inhibition
b) Competitive reversible inhibition 174. Key enzyme of gluconeogenesis are all
c) Suicide irreversible inhibition except- (AIPGME 2013-2014)
d) Non-competitive irreversible inhibition a) Pyruvate carboxylase
Ans.D b) PEP carboxykinase
c) Pyruvate kinase
Topic - gluconeogenesis d) Glucose-6-phosphatase
169. Acetyl CoA can be converted into all of Ans.C
the following, Except (AIPGME 2009)
A. Glucose 175. Conversion of lactate to glucose requires
B. Fatty Acids all except - (AIPGME 2013-2014)
C. Cholesterol a) Pyruvate carboxylase
D . Ketone bodies b) Phosphofructokinase
Answer is A c) PEP carboxykinase
d) Glucose-6-phosphatase
170. Which of the following events does not Ans.B
occur when concentration of glucose in
the liver decreases: (AIPGME 2012) 176. Gluconeogenesis occurs in all except -
A. Inactivation of phosphofructokinase-2 (AIPGME 2013-2014)
(PFK-2) a) Liver
B. Activation of Fructose Bisphosphatase-2 b) Kidney
(Fructose 2, 6 Bisphosphatase) c) Gut
C. Increased levels of Fructose 2, 6- d) Muscle
Bisphosphate Ans.D
D . Increased levels of Glucagon
Answer is C 177. Which reaction uses propionic acid -
171. All are used in gluconeogenesis except - (AIPGME 2013-2014)
(AIPGME 2013-2014) a) Glycolysis
a) Oleate b) Gluconeogenesis
b) Succinate c) Glycogenolysis
c) Glutamate d) None
d) Aspartate Ans.B
Ans.A
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178.Which of the enzyme of glycolysis is a a) Pyruvate kinase
part of gluconeogenesis – (AIPGME b) Succinate thiokinase
2013-2014) c) Phosphoglycerate kinase
a) Pyruvate kinase d) All of the above
b) PFK Ans.B
c) Hexokinase
d) Phosphoglycerate kinase 184. The number of ATPs generated in krebs
Ans.D cycle are - (AIPGME 2013-2014)
a) 12
179. Not a step of gluconeogenesis - b) 24
(AIPGME 2014-2015) c) 15
a) Coversion of glucose-6-phosphate to d) 30
glucose Ans.B
b) Carboxylation of pyruvate
c) Coversion of oxaloacetate to 185. One Krcbs cycle generates how many
phosphoenolpyruvate ATP - (AIPGME 2013-2014)
d) Conversion of phosphoenolpyruvate to a) 6
pyruvate b) 12
Ans. is 'd' c) 24
d) 36
180. Regulating enzymes in Gluconeogenesis Ans.B
are all, except - (AIPGME 2014-2015)
a) Pyruvate carboxylase 186. NAD+ linked dehydrogenase is -
b) PEP carboxykinase (AIPGME 2014-2015)
c) PFK-1 a) PDH
d) Glucose-6-phosphatase b) G6PD
Ans. is 'c' c) Enoyl reductase
d) Succinate dehydrogenase
181. Glucagon stimulates – (AIPGME 2014- Ans. is 'a'
2015)
a) Gluconeogenesis 187. Substrate level phosphorylation in citric
b) Glycogenesis acid cycle is catalysed by - (AIPGME
c) Fatty acid synthesis 2014-2015)
d) Glycolysis a) Pyruvate kinase
Ans. is 'a' b) Phosphoglycerate kinase
c) Malate dehydrogenase
182. Which of the following step is specific d) Succinate thiokinase
for gluconeogenesis - (AIPGME 2014- Ans. is 'd'
2015)
a) Pyrovate to acetyl CoA 188. Source of energy in Kreb's cycle is -
b) Oxaloacetate to citrate (AIPGME 2014-2015)
c) Oxaloacetate to PEP a) NAD
d) Succinyl CoA to fumarate b) NADP
Ans. is 'c' c) NADPH
d) NADH
Topic - citric acid cycle Ans. is 'd'
183. Substrate level phosphorylation is seen in

reaction catalyzed by which enzyme of
citric acid cycle- (AIPGME 2013-2014)
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189. Coenzyme used in Kreb's cycle - 195. Number of ATP generated in one TCA
(AIPGME 2014-2015) cycle - (AIPGME 2014-2015)
a) NAD a) 2
b) NADP b) 8
c) NADPH c) 10
d) NADH d) 11
Ans. is -A" Ans. is 'c'
190. Substrate level phosphorylation in citirc Topic - purine metabolism

acid cycle is catalysed by - (AIPGME 196.Salvage pathway of purine nucleotide
2014-2015) synthesis are used by all except -
a) Pyruvate kinase (AIPGME 2013-2014)
b) Phosphoglycerate kinase a) Brain
c) Malate dehydrogenase b) Liver
d) Succinate thiokinase c) RBC
Ans. is 'd' d) Leukocytes
Ans.B
191. In citric acid cycle, NADH is produced
by - (AIPGME 2014-2015) 197. Orotic aciduria is due to deficiency of -
a) Succinate thiokinase (AIPGME 2013-2014)
b) Succinate dehydrogenase a) Decarboxylase
c) Isocitrate dehydrogenase b) Tyrosinase
d) Fumarase c) Isomerase
Ans. is 'c' d) Homogentisate oxidase
Ans.A
192. Which of the following glucogenic amino
acid enters the citric acid cycle at 198. In humans, end product of purine
succinyl CoA (AIPGME 2014-2015) metabolism - (AIPGME 2013-2014)
a) Phenylalanine a) Allantoin
b) Tyrosme b) Uric acid
c) Isoleucine c) CO2
d) Tryptophan d) None
Ans. is 'c' Ans.B
193. Pyruvate can be a substrate for 199. Gout is a metabolic disorder of -

(AIPGME 2014-2015) (AIPGME 2013-2014)
a) Fatty acid synthesis a) Purine
b) TCA cycle b) Pyramidine
c) Cholesterol synthesis c) Glycogen
d) All of the above d) Fatty acid oxidation
Ans. is 'd' Ans.A
194. T otal number of dehydrpgenases Krebs 200. Salvage purine synthesis refers to -
cycle - (AIPGME 2014-2015) (AIPGME 2013-2014)
a) 3 a) Synthesis of purine from ribose-5-
b) 2 phosphate
c) 4 b) Synthesis of purine from pyrimidine
d) 5 c) Synthesis of purine nucleotides from purine
Ans. is 'c' bases
Ans.C
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201. Uric acid is formed by - (AIPGME 2013- a) Adenine
2014) b) Uridine
a) Catabolism of proteins c) Thymine
b) Catabolism of ketones d) Guanine
c) Catabolism of purines Ans. is 'b"
d) Catabolism fo pyrimidines
Ans.C Topic -RNA
208. Normal role of Micro RNA is:
202. Nitrogen-9 of purine ring is provided by (AIPGME 2009)
- (AIPGME 2014-2015) A. Gene Regulation
a) Glycine B. RNA splicing
b) Aspartate C. Initiation of Translation
c) Glutamine D . DNA conformational change
d) CO2 Answer is A
Ans. is 'c'
209. Splicing Activity is a function of:
203. First product of purine metabolism - (AIPGME 2009)
(AIPGME 2014-2015) A. Mrna
a) Uric acid B. snRNA
b) Xanthine C. rRNA
c) (3-alanine D . t RNA
d) CO2 Answer is B
Ans. is 'b'
210. Which of the following factors is
204. Allantoin is the end product of responsible for deciding whether an
metabolism of - (AIPGME 2014-2015) antibody/ immunoglobulin will remain
a) Glycogen membrane bound or get secreted:
b) Purine (AIPGME 2011)
c) Pyrimidine A. RNA Splicing
d) Histidine B. Class Switching
Ans. is 'b' C. Differential RNA Processing
D . Allelic Exclusion
205. First purine nucleotide, which is Answer is C
synthesized in purine biosynthesis -
(AIPGME 2014-2015) 211. Which of the following statements
a) AMP regarding mature cytoplasmic
b) GMP messenger RNA is true: (AIPGME
c) IMP 2012)
d) UMP A. Transcribed from RNA is true:
Ans. is 'c' B. Has Thiamine in place of Uracil
C. Sugar is Deoxy Ribose
206. Salvage pathway of purine biosynthesis is D . Its molecular weight is more than hn-RNA
important for- (AIPGME 2014-2015) Answer is A
a) Liver
b) RBCs 212. Aminoacyl t-RNA is not require for -
c) Kidney (AIPGME 2013-2014)
d) Lung a) Proline
Ans. is 'b' b) Lysine
c) Hydroxylysine
207. Which of the following is a nucleoside - d) Methionine
(AIPGME 2014-2015) Ans.C
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213. Modified nucleotide is seen in - 219. Pseudouridine is seen in - (AIPGME
(AIPGME 2013-2014) 2014-2015)
a) tRNA a) DNA
b) rRNA b) mRNA
c) hnRNA c) rRNA
d) mRNA d) tRNA
Ans.A Ans. is 'd'
214. Synthesis of rRNA takes place in - Topic -Trace elements

(AIPGME 2013-2014)
a) Cytosol 220. Ceruloplasmin contains - (AIPGME
b) Nucleus 2013-2014)
c) Nucleolus a) Zn
d) Mitochondria b) Cu
Ans.C c) Se
d) Fe
215. RNA which contains codon for speicific Ans.B
amino acid - (AIPGME 2013-2014)
a) tRNA 221. Copper containing enzyme is -
b) rRNA (AIPGME 2013-2014)
c) mRNA a) Cytochrome oxidase
d) None b) Catalase
Ans.C c) LDH
d) None
216. Pseudouridine found in? (AIPGME Ans.A
2013-2014)
a) DNA
b) rRNA 222. Carboxypeptidase contains which
c) mRNA mineral - (AIPGME 2013-2014)
d) tRNA a) Copper
Ans.D b) Zinc
c) Iron
217. RNA is Present in - (AIPGME 2013- d) None
2014) Ans.B
a) Cytoplasm
b) Nucleus
c) Ribosome 223. Glutathione peroxidase contains -
d) All of the above (AIPGME 2013-2014)
Ans.D a) Cu
b) Se
218. RNA polymerase has which activity - c) Fe
(AIPGME 2014-2015) d) Hg
a) Primase Ans.B
b) Helicase
c) Ligase 224. Magnesium is not involved in -
d) T opoisomerase (AIPGME 2013-2014)
Ans. is 'a' a) Cellular oxidation
b) Membrane transport
c) Increased neuromuscular excitability
d) Glucose tolerance
Ans.C
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225. Alkaline phosphatase contains - Topics -Glycogen metabolism
(AIPGME 2013-2014)
a) Cobalt 231. In which of the following tissues, is
b) Zinc glycogen incapable of contributing
c) Iron directly to blood glucose? (AIPMG
d) Copper 2008)
Ans.B A. Liver
B. Muscle
226. Which of the following does not require C. Both
copper for action - (AIPGME 2013- D . None
2014) Answer is B
a) Tyrosinase
b) Superoxide dismutase 232. Phosphorylase b is maintained in an
c) Carbonic anhydrase inactivated state by (AIPMG 2008)
d) Ceruloplasmin A. ATP
Ans.C B. cAMP
C. Calcium
227. Which of the following trace element has D . Insulin
Vitamin E sparing effect - (AIPGME Answer is D
2013-2014)
a) Copper 233. Main enzyme for glycogen metabolism -
b) Iron (AIPGME 2013-2014)
c) Magnesium a) Glucose-6-phosphatase
d) Selenium b) Glycogen synthase
Ans.D c) PFK - 1
228. Which of the following major minerals is Ans.B
a com ponent of biological membranes
- (AIPGME 2013-2014) 234. Coris disease is due to defect in -
a) Potassium (AIPGME 2013-2014)
b) Sodium a) Branching enzyme
c) Calcium b) Debranching enzyme
d) Phosphorus c) Myophosphorylase
Ans.D d) Hepatic phosphorylase
Ans.B
229. Mineral required for cholesterol
biosynthesis - (AIPGME 2014-2015) 235. Branching enzyme is found in -
a) Fe (AIPGME 2013-2014)
b) Mn a) Glycogenesis
c) Mg b) Glucogenesis
d) Cu c) Glycogenolysis
Ans. is "c d) Glycolysis
Ans.A
230. Cofactor for dopamine hydroxylase -
(AIPGME 2014-2015) 236. The energy for glycogenesis is provided
a) Fe by - (AIPGME 2013-2014)
b) Mg a) GTP
c). Mn b) GDP
d) Cu c) UTP
Ans. is 'd' d) AMP
Ans.C
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237. Main source of energy in 1 min is - 243. Nieman pick disease is due to deficiency
(AIPGME 2014-2015) of - (AIPGME 2013-2014)
a) Glycogen a) Sphingomyelinase
b) FFA b) Ceramidase
c) Phosphates c) Galactosidase
d) Glucose d) Glucosidase
Ans. is 'a' Ans.A
238. Type VI glycogen storage disease is due 244. In Gaucher's diseases, there is deficiency
to deficiency of- (AIPGME 2014-2015) of - (AIPGME 2013-2014)
a) Muscle phosphorylase a) Glucocerebrosidase
b) Liver phosphorylase b) Glucokinase
c) Glucose-6-phosphatase c) Sphingomyelinase
d) Branching enzyme d) G-6PD
Ans. is 'b' Ans.A
239. Muscles cannot contribute to raising 245. Tay-Sach disease is due to deficiency of -
blood glucose by glycogenolysis due to (AIPGME 2014-2015)
lack of - (AIPGME 2014-2015) a) Hexosaminidase A
a) Glucokinase b) Hexosaminidase B
b) Phosphoglucomutase c) Sphingomyelinase
c) G-6-phosphatase d) a-galactosidase
d) Muscle phosphorylae Ans. is 'a'
Ans. is 'c'
246. Enzyme deficient in gangliosidoses -
240. Von Geirke's occurs due to deficiency of (AIPGME 2014-2015)
- (AIPGME 2014-2015) a) {S-glucuronidase
a) Glucose-6-phosphatase b) Iduronidase
b) Liver Phosphorylase c) P-galactosidase
c) Muscle phosphorylase d) Hyaluronidase
d) Debranching enzyme Ans. is 'c'
Ans. is 'a‘
247. For which of the following diseases is
Topic -Mucopolysaccharadoses enzyme replacement therapy available -
(AIPGME 2014-2015)
241. Enzyme replacement therapy is available a) Albinism
for - (AIPGME 2013-2014) b) Neimann-Pick disease
a) Gauchers disease c) Metachromatic leukodystrophy
b) Galactosemia d) Gaudier's disease
c) Fructosuria Ans. is 'd'
d) None
Ans.A 248. Which of the following is not a
glycerosphingolipid- (AIPGME 2014-
242. Krabbes disease is due to deficiency of - 2015)
(AIPGME 2013-2014) a) Lecithin
a) Sphingomyelinase b) Cardiolipin
b) Beta galactocerebrosidase c) Plasmalogens
c) Hexosaminidase d) Sphingomyelin
d) Arylsulfatase Ans. is 'd'
Ans.B
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249. Hunter syndrome is due to deficiency of 255. The major source of NADPH for fatty
- (AIPGME 2014-2015) acid synthesis - (AIPGME 2013-2014)
a) Beta galactosidase a)PPP
b) Sphingomyelinase b)TCA cycle
c) Iduronate Sulfatase c) Glycolysis
d) Hyaluronidase d) Glycogenolysis
Ans. is 'c' Ans.A
250. Sphingomyelinase Deficiency is seen in:

(AIPGME 2010) 256. What is essential for transfer of fatty acid
A. Niemann - Pick disease across mitochondrial membrane -
B. Farber's disease (AIPGME 2013-2014)
C. Tay Sach's disease a) Creatine
D . Krabbe's disease b) Creatinine
Answer is A c) Carnitine
d) None
251. Main part of surfactant is formed by - Ans.C
(AIPGME 2013-2014)
a) Dipalmitoyl phosphatidyl choline 257. Fatty acids used by all except -
b) Phosphotidyl-inositol (AIPGME 2013-2014)
c) Dipalmitoyl cephaline a) Liver
d) Dipalmitoyl serine b) Muscle
Ans.A c) Brain
d) Kidney
Topic -Fatty acid metabolism Ans.C
252. Which of the following is a 258. Rate limiting step in fatty acid synthesis is
cardioprotective fatty acid: (AIPGME (AIPGME 2014-2015)
2011) a) Production of acetyl CoA
A. Palmitic acid b) Production of oxaloacetate
B. Stearicacid c) Production of malonyl-CoA
C. Oleicacid d) Production of citrate
D . Omega-3 fatty acids Ans. is 'c'
Answer is D
259. Oxidation of very long chain fatty acids
253. All of the following metabolic functions takes place in - (AIPGME 2014-2015)
occur in the mitochondria, Except: a) Cytosol
(AIPGME 2012) b) Mitochondria
A. Beta-oxidation of fatty acids c) Ribosomes
B. Biosynthesis of fatty acids d) Peroxisomes
C. Protein synthesis Ans. is 'd
D . Citric acid cycle
Answer is B 260. Rate limiting step in fatty acid synthesis is
- (AIPGME 2014-2015)
254. Fatty acids are stored as - (AIPGME a) Production of acetyl CoA
2013-2014) b) Production of oxalocetate
a) Cholesterol c) Production of malonyl-CoA
b) Triglycerides d) Production of citrate
c) Sphingomyelin Ans. is 'c'
d) None
Ans.B
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Topic -Antioxidant 267. Following is true regarding sulhydryl
groups except- (AIPGME 2014-2015)
261. Oxidative examination is catalyzed by - a) They are present in coenzyme A and lipoic
(AIPGME 2013-2014) acid
a) Glutaminase b) They are present in Captopril and
b) Glutamine synthase penicillamine
c) Glutamate dehydrogenase c) They are not involved in reduction of
d) None of the above peroxides
Ans.C d) They are present in cysteine
Ans. is 'c'
262. True about Glutathione except -
(AIPGME 2013-2014) 268. Antioxidant property is seen in -
a) Tripeptide (AIPGME 2013-2014)
b) Formed from glutamic acid, glycine, a) Chromium
cysteine b) Selenium
c) Act as antioxidant in reduced state c) Magnesium
d) All of the above d) Iron
Ans.D Ans.B
263. All have antioxidant property except - Topic -DNA

(AIPGME 2013-2014)
a) Catalase 269. Mitochondiral DMA is - (AIPGME
b) Glutathione peroxidase 2013-2014)
c) Phosphorylase a) Closed circular
d) Superoxide dismutase b) Nicked circular
Ans.C c) Linear
d) Open circular
264. Whichofthe following has antioxidant Ans.A
property-(AIPGME 2013-2014)
a) Selenium 270.Not present in DNA - (AIPGME 2013-
b) Copper 2014)
c) Zinc a) Uracil
d) All b) Thymine
Ans.D c) Cytosine
d) Adenine
265. Glutathione requires which vitamin to Ans.A
act as antioxidant- . (AIPGME 2013- 271. Adenine in DNA binds with - (AIPGME
2014) 2013-2014)
a) Vitamin E a) Thymine
b) Nia'cin b) Guanine
c) Vitamin C c) Cytosine
d) Vitamin A d) Uracil
Ans.B Ans.A
272. Replication of mitochondrial DNA is
266. Antioxidant vitamin - (AIPGME 2014- caused by which type of DNA
2015) polymerase - (AIPGME 2013-2014)
a) Vitamin A a) a
b) Ascorbic acid b) p
c) Vitamin E c) S
d) All of the above d) y
Ans. is 'd' Ans.D
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273. At physiological pH DNA is - (AIPGME
2013-2014) 279.All are true about ketone bodies except -
a) Acidic (AIPGME 2013-2014)
b) Negatively charged a) Acetoacetate is primary ketone body
c) Amphipathic b) Synthesized in mitochondria
d) All of the above c) Synthesized in liver
Ans.D d) HMG CoA reductase is the rate-limiting
enzyme
274.Molecular interaction, found in the Ans.D
structure of DNA- (AIPGME 2013-
2014) 280.Ketone bodies are used by all except -
a) Hydrogen bond (AIPGME 2013-2014)
b) Glycosidic bond a) Brain
c) Covalent interactions b) RBCs
d) All of the above c) Skeletal muscles
Ans.D d) Hepatocytes
Ans.D
275. In DNA, Adenine pairs with (AIPGME
2014-2015) 281. Ketone body formation without
a) Guanine glycosuria is seen in - (AIPGME 2013-
b) Thymine 2014)
c) Cytosine a) Diabetes mellitus
d) Uraeil - b) Diabetes insipidus
Ans. is 'b' c) Starvation
d) Obesity
276. Most common physiological form of Ans.C
DNA (AIPGME 2014-2015)
a) A-form 282. Ketone bodies are not used by -
b) B-form (AIPGME 2013-2014)
c) Z-form a) Muscle
d) C-form b) Drain
Ans. is 'b' c) RBC
d) Renal cortex
Topic -ketone bodies Ans.C
277. Rothera's test used for detection of
(AIPGME 2010) 283. In liver, ethanol is converted to -
A. Proteins (AIPGME 2013-2014)
B. Glucose a) Methyl alcohol
C. Fatty Acid b) Pyruvate
D . Ketones c) Acetaldehyde
Answer is D d) Oxaloacetate
Ans.C
278. Which of the following enzymes is
common to the synthesis of cholesterol 284. Alcohol is metabolized by - (AIPGME
and ketone bodies: A HMG-Co 2014-2015)
(AIPGME 2012) a) Alcohol dehydrogenase
A Reductase b) MEOS
B HMG –Co A Lyase c) Catalase
C. HM G-Co A synthase d) All of the above
D . Thiokinase Ans. is 'd'
Answer is C
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Topic -PORPHYRIN 291. Heme synthesis requires - (AIPGME
2014-2015)
285. Heme is which porphyrin - (AIPGME a) Acetyl CoA
2013-2014) b) Succinyl CoA
a) Type I c) Malonyl CoA
b) Type II d) All of the above
c) Type III Ans. is 'b'
d) Type IV
Ans.C 292. End product of porphyrin metabolism -
(AIPGME 2014-2015)
286. All are true except - (AIPGME 2013- a) Albumin
2014) b) CO2&NH3
a) Porphyrinogens are coloured c) Bilirubin
b) Porphyrins emit flurorescence by UV light d) None
c) Pyrrole rings of porphyrins are jomd by Ans. is 'c'
methenyl bridges
d) Pyrrole rings of porphyrinogens are joind Topics- Collagen
by methylene bridge
Ans.A 293. Action of metalloproteinase - (AIPGME
2013-2014)
287. Heme is which porphyrin - (AIPGME a) Degradation of collagen
2013-2014) b) Polymerization of collagen
a) Type I c) Oxidation of collagen
b) Type II d) Stimulation of collagen
c) Type III Ans.A
d) Type IV
Ans.C 294. True regarding collagen synthesis is all
except - (AIPGME 2013-2014)
288.All are involved in bilirubin metabolism a) Synthesized in ribosomes as preprocollagen
except- (AIPGME 2013-2014) b) Hydroxylation of proline occurs in Golgi
a) ALA synthase apparatus
b) Heme oxygenase c) Hydroxylation of lysine occurs in ER
c) Biliverdine reductase d) Triple helix assembly occurs in ER
d) Glucuronyl transferase Ans.B
Ans.A
295. Type of collagen found in space of Disse
289. Rate limiting step in heme synthesis is in liver is - (AIPGME 2013-2014)
catalyzed by- (AIPGME 2014-2015) a) Collagen I & II
a) ALA dehydratase b) Collagen III & IV
b) ALA synthase c) Collagen II & III
c) UPG decarboxylase d) Collagen II & V
d) Ferrochelatase Ans.B
Ans. B
296. Type of collagen found in basement
290. Rate limiting step in porphyrine synthesis membrane is- (AIPGME 2013-2014)
- (AIPGME 2014-2015) a) Type I
a) ALA dehydratase b) Type II
b) ALA synthase c) Type III
c) UPG decarboxylase d) Type IV
d) Ferrochelatase Ans.D
Ans. is 'b'
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297. Most abundand type of collagen in C. Low pH of the stomach
human body- (AIPGME 2013-2014) D . Presence of a-osidie linkages
a) Type I Answer is B
b) Type III
c) Type IV 303. Which dissacharies are not broken down
d) Type VI in git - (AIPGME 2013-2014)
Ans.A a) Lactulose
b) Maltose
298. Which is denatured collagen in humans - c) Sucrose
(AIPGME 2013-2014) d) Lactose
a) Gelatin Ans.A
b) Homocollagen
c) Tropocollagen 304. Which dissacharies are not broken down
d) None in git - (AIPGME 2013-2014)
Ans.A a) Lactulose
b) Maltose
299. Which collagen produces sheets - c) Sucrose
(AIPGME 2013-2014) d) Lactose
a) I Ans.A
b) II
c) IV 305. Which is not a dietary fiber - (AIPGME
d) VI 2013-2014)
Ans.C a) Lignin
b) Lactulose
Topics -Digestive enzymes c) Pectin
d) Cellulose
300. All of the following are trypsin inhibitors, Ans.B
Except: (AIPMG 2008)
A. Alpha - 1 antitrypsin 306.All are endopeptidases except -
B. Alpha - 1 - antiproteinase (AIPGME 2013-2014)
C. Enterokinase a) Trypsin
D . Egg-white b) Chymotripsin
Answer is C c) Carboxypeptidase
d) None
301. JWhich^ofthafQllo Ans.C
.wjngjslmtxomponentsis-not-fermented
by gastrointestinal microorganisms Topic -Fasting feeding
(AIPGME 2009)
A. Lignin 307. After overnight fasting, levels of Glucose
B. Cellulose transporters are reduced in (AIPGME
C. Hemicellulose 2009)
D . Pectin A. Brain cells
Answer is A B. Hepatocytes
C. Adipocytes
302. Inulin like fructans are used as prebiotics D . RBCs
as they are non digestible. Resistance to Answer is C
digestion in the upper GI tract results
from (AIPGME 2010) 308. All of the following metabolic changes
A. Absence of digestive enzyme in the upper occur durng prolonged fasting when
GIT compared with fasting for 12 24 hours,
B. Beta configuration of anomeric C2 except: (AIPGME 2012)
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A. Brain use of ketone bodies increases Topic-Amino Acid metabolic disorders
B. Liver gluoneogenesis increases 314. Branched chain ketoacid decarboxylation
C. Muscle protein degradation decreases is defective in (AIPGME 2010)
D . Brain use of glucose decreases A. Maple Syrup urine disease
Answer is B B. Hartnup disease
C. Alkaptonuria
309.Which of the following metabolic events D . GM1 Gangliosidosis
will not occur following 12-24 hour of Answer is A
fasting: (AIPGME 2012)
A. Increase in Free Fatty Acids 315. Which of the following accumulates in
B. Increase in Ketone bodies maple syrup urine desease - (AIPGME
C. Decrease in Glycogen 2013-2014)
D . Decrease in Serum Proteins a) Leucine
Answer is D b) Valine
c) Isoleucine
310. Protein catabolism is increased in - d) All
(AIPGME 2013-2014) Ans.D
a) Starvation
b) Burns 316. Sweaty feet odor in urine is seen in -
c) Surgery (AIPGME 2013-2014)
d) All of the above a) Phenylketonuria
Ans.D b) Maple syrup urine
c) Isovaleric acidemia
311. During starvation, muscle uses - d) Alkaptonuria
(AIPGME 2013-2014) Ans.C
a) Fatty acids
b) Ketone bodies 317. Mousy odor of urine is seen in -
c) Glucose (AIPGME 2014-2015)
d) Proteins a) Alkaptunuria
Ans.A b) Phenylketonuria
c) Hartnup disease
312. Metabolic change seen in starvation are d) Albinism
all except- (AIPGME 2013-2014) Ans. is 'b'
a) Increased gluconeogenesis
b) Increased glycolysis 318. Cabbage-like odour is seen in -
c) Ketogenesis (AIPGME 2014-2015)
d) Protien degradation a) Alkaptonuria
Ans.B b) Phenylketonuria
c) Hartnup disease
313. Major source of energy for brain in d) Tyrosinemia
fasting/ starvation - (AIPGME 2014- Ans. is 'd'
2015)
a) Glucose 319. If urine sample darkens on standing: the
b) Glycogen most likely conditions is - (AIPGME
c) Fatty acids 2014-2015)
d) Ketone bodies a) Phenylketonuria
Ans. is 'C' b) Alkaptonuria
c) Maple syrup disease
d) Tyrosinemia
Ans. is 'b'
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Topic -ATP GTP 326. Okazaki fragments are formed during the
synthesis of: (AIPMG 2008)
320. Immediate energy supply for muscle A. ds DNA
contraction - (AIPGME 2013-2014) B. ssDNA
a) GTP C. mRNA
b) ATP D . t RNA
c) Creatine phosphate Answer is A
d) Fatty acid
Ans.C 327. The gaps between segments of DNA on
the laggin strand produced by
321. Immediate source of energy is - restriction enzymes are rejoined eale3i5y
(AIPGME 2013-2014) (AIPGME 2009)
a) Cori's cycle A. DNA Ligases
b) HMP B. DNA Helicase
c) ATP C. DNA topoisomerase
d) TCA cycle D . DNA phosphorylase
Ans.C Answer is A
322.Which of the following is high energy 328. Which of the following represents the
compounde (AIPGME 2013-2014) most charachteristic function of Type II
a) ADP Restriction Enzymes: (AIPGME 2012)
b) Glucose-6-phosphate A. Prevent folding of proteins
c) Creatine phosphate B. Remove formed DNA
d) Fructose-6-phosphate C. Prevent supercoiling
Ans.c D . Cut DNA at palindromic sites
Answer is D
323.Adenylate cyclase converts - (AIPGME
2013-2014) 329. Xeroderma pigmentation is caused due
a) ATP to ADP to a group of closely related
b) ADP to ATP abnormalities in - (AIPGME 2013-
c) ATP to cAMP 2014)
d) AMP to ADP a) Mismatch repair
Ans.C b) Base excision repair
c) Nucleotide excision repair
324. Which energy molecule gives 10.5 kcal/ d) SOS repair
molcculc- (AIPGME 2013-2014) Ans.C
a) ATP 330. Which enzyme polymerises okazaki
b) GTP fragments - (AIPGME 2013-2014)
c) Creatine phosphate a) DNA polymerase I
d) Glucose-6-phosphate b) DNA.polymerase II
Ans.C c) DNA polymerase III
d) RNA polymerase
325. Immediate energy supply for muscle Ans.C
contraction - (AIPGME 2014-2015)
a) GTP 331. Okazaki fragments are formed during -
b) ATP (AIPGME 2013-2014)
c) Creatine phosphate a) Transcription
d) Fatty acid b) Translation
Ans. is 'c' c) DNA replication
d) None
Topic -DNA replication Ans.C
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Topic -Epimer Topic -LFT
332. Epimers of glucose - (AIPGME 2013- 338. Which of the following liver enzymes is
2014) predominantly mitochondrial
a) Mannose (AIPGME 2010)
b) Glyceraldehyde A. SGOT(AST)
c) Fructose B. SGPT(ALT)
d) None C. GGT
Ans.A D . 5' Nucleotidase
Answer is A
333.Epimers of glucose - (AIPGME 2013-
2014) 339. Which is predominant in normal healthy
a) Mannose human - (AIPGME 2013-2014)
b) Glyceraldehyde a) LDH 1
c) Fructose b) LDH2
d) None c) LDH 3
Ans.A d) LDH4
Ans.B
334. Which of the following is Aldosugar -
(AIPGME 2013-2014) 340. Which is predominant in normal healthy
a) Fructose human - (AIPGME 2013-2014)
b) Erythrulose a) LDH 1
c) Glucose b) LDH2
d) None c) LDH 3
Ans.C d) LDH4
Ans.B
335 . Epimers of glucose - (AIPGME 2013-
2014) 341. AST/ALT > 2 occurs in deficiency of -
a) Mannose (AIPGME 2014-2015)
b) Glyceraldehyde a) Glucose-6-phosphotase
c) Fructose b) Branching enzyme
d) None c) Acid maltase
Ans.A d) Liver phosphorylase
Ans. is 'c'
336.Lactose on hydrolysis yeilds - (AIPGME
2013-2014) 342. True about acid phosphatase is -
a) 2 molecules of fructose (AIPGME 2014-2015)
b) 2 molecules of glucose a) Acts at pH 8-9
c) One molecule of glocuse and one molecule b) Prostate isoform is tartarate resistant
of fructose c) Erythrocyte isoform is inhibited by cupric
d) One molecule of glocuse and one molecule ions
of galactose d) All of the above
Ans.D Ans. is 'c'
337. Which of the following is an aldose sugar 343. Isoform of LDH in skeletal muscles -
- (AIPGME 2014-2015) (AIPGME 2014-2015)
a) Ribulose a) LDH-1
b) Fructose b) LDH-2
c) Glyceraldehyde c) LDH-3
d) All of the above d) LDH-4
Ans. is 'c' Ans. is 'd'
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Topic -Steroids Topic -Keratin
344. Chemical process involved in conversion
of progesterone to glucocorticoids is - 350. Keratin in skin is softer than keratin in
(AIPGME 2013-2014) nail because keratin in skin has:
a) Methylation (AIPGME 2012)
b) Hydroxylation A. Less number of disulphide bonds
c) Carboxylation B. Less number of salt bridges
d) None C. High sodium cotent
Ans.B D . Different affinity for water
Answer is A
345. All are required for conversion of
progesterone to estrogen except - 351.Keratin is a - (AIPGME 2013-2014)
(AIPGME 2013-2014) a) Globular protein
a) Lyase b) Cylindrical protein
b) 11-hydroxylase c) Fibrous protein
c) Reductase d) None of the above
d) Isomerase Ans.C
Ans.B
352.Keratin contains - (AIPGME 2013-2014)
346. All are steroids except - (AIPGME 2013- a) Arginine
2014) b) Histidine
a) Testosterone c) Lysine
b) Vitamin D d) All
c) Cholesterol Ans.D
d) Thyroxine
Ans.D 353. Which of the following is the major
proteoglycan of synovial fluid -
347. Precursor of all steroid hormones - (AIPGME 2013-2014)
(AIPGME 2014-2015) a) Chondroitin sulfate
a) Pregnenolone b) Dermatan sulfate
b) Deoxycortisol c) Heparan sulfate
c) Androstenedione d) Hyaluronic acid
d) Dehydroepiandrosterone Ans.D
Ans. is 'a'
354. Which of the following is a
348. Not occuring in Mitochondria - homopolysaccharide- (AIPGME 2014-
(AIPGME 2014-2015) 2015)
a) ECT a) Heparin
b) Ketogenesis b) Chitin
c) Urea cycle c) Hyaluronic acid
d) Steroid synthesis d) Chondroitin sulfate
Ans. is 'd' Ans. is 'b'
349. Which steroid is formed from cholesterol Topic -NORTHERN BLOT SOUTHERN
with out hydroxylation - (AIPGME BLOT
2013-2014)
a) Progesterone 355. Which of following techniques is used
b) Glucocorticoid for detection of variations in DNA
c) Mineralocorticoid sequence and Gene expression
d) Estradiol (AIPGME 2010)
Ans.A
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A. Northern Blot 361. α-helix of protein is - (AIPGME 2013-
B. Southern Blot 2014)
C. Western Blot a) Primary structure
D . Microarray b) Secondary structure
Answer is D c) Tertiary structure
d) Quaternary structure
356. Which of the following methods is most Ans.B
suited to assess function of a gene:
(AIPGME 2012) 362. Interaction involved in primary structure
A. Southern blot of protein - (AIPGME 2013-2014)
B. Northern blot a) Hydrogen bond
C. Gene knockout animals b) Disulfide bond
D . Transgenic animals c) Peptide bond
Answer is D and C d) Electrostatic bond
Ans.C
357. Southern blot is used to visualize -
(AIPGME 2013-2014) 363. Bond involved in formation of primary
a) RNA structure of protein/polypeptide -
b) DNA (AIPGME 2014-2015)
c) Protein a) Covalent
d) Antibody b) Peptide
Ans.B c) Disulfide
d) All of the above
358. Northern blot is used to detect - Ans. is 'a'
(AIPGME 2014-2015)
a) Protein 364. Alpha helix and Beta pleated sheet are
b) Immunoglobulin examples of- (AIPGME 2014-2015)
c) RNA a) Primary
d) DNA b) Secondary structure
Ans. is 'c' c) Tertiary
d) Quaternary structure
359. Western blot is used for - (AIPGME Ans. is 'b'
2014-2015)
a) DNA Topic -cell organelles
b) RNA
c) Sugar 365. Proteins are sorted by: (AIPMG 2008)
d) Protein A. Golgi Bodies
Ans. is 'd' B. Mitochondria
C. Ribosomes
Topic -PROTEIN STRUCTURE D . Nuclear Membrane
Answer is A
360. An Immunoglobulin molecule represents
the following level of organized protein 366.Membrane proteins are synthesized in -
structure: (AIPGME 2012) (AIPGME 2013-2014)
A. Primary structure a) Free ribosome
B. Secondary structure b) Bound ribosome
C. Tertiary structure c) Nucleolus
D . Quartenary structure d) Mitochondria
Answer is D Ans.B
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367. Protein biosynthesis occurs in - a) SDS-PAGE
(AIPGME 2014-2015) b) Ultracentrifugation
a) Cytoplasm c) Affinity chromatography
b) ER d) HPLC
c) Ribosomes Ans. is 'd'
d) Mitochondria
Ans. is 'c' Topic -Galactosemia
368. Ribosomes are attached to - (AIPGME 373. Enzyme defect in galactosemia -

2014-2015) (AIPGME 2013-2014)
a) Nucleus a) Uridyl transferase
b) RER b) Galactokinase
c) Smooth ER c) Epimerase
d) Mitochondria d) All of the above
Ans. is 'b' Ans.D
Topic -Chromatography 374. Glucose is converted to sorbitol by -

(AIPGME 2014-2015)
369. Method of chromatography in which a) Aldolase B
molecules that are negatively charged b) Aldose reductase
are selectively released from stationary c) Sorbitol dehydrogenase
phase into the positively charged d) UDP-Galactose-4-epimerase
molecules in mobile phase is termed as: Ans. is 'b'
(AIPGME 2010) 375. Lactose intolerance is due to - (AIPGME
A. Affinity chromatography 2014-2015)
B. Ion - Exchange chromatography a) Deficiency of Galactokinase
C. Adsorbtion chromatography b) Deficiency of Uridyl transferase
D . Size - Exclusion chromatography c) Deficiency of Lactase
Answer is B d) Deficiency of Enteropeptidase
Ans. is 'c
370. Ion exchange chromatography is based
on - (AIPGME 2013-2014) 376. UDP glucose is not used in - (AIPGME
a) Size 2014-2015)
b) Charge a) Uronic acid pathway
c) Solubility b) Glycogen synthesis
d) Polarity c) Galactose metabolism
Ans.B d) HMP shunt
Ans. is 'd'
371. Which of the following method of
protein sepa- ration is not dependent Topic -Hemoglobin
on molecular size - (AIPGME 2013- 378. All of the following are true about Sickle
2014) cell disease, Except (AIPGME 2009)
a) Gel filtration chromatography A.Single nucleotide change results in change
b) Ultracentrifugation of Glutamine to Valine
c) Ion-exchange chromatography B. RFLP results from a single base change
d) SDS-PAGE C. 'Sticky patch' is generated as a result of
Ans.C replacement of a non polar residue with
a polar residue
372. Proteins are separated on the basis of D . HbS confers resistance against malaria in
charge in - (AIPGME 2014-2015) heterozygotes
Answer is C
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379. (b) Sideling in 'HbS' disease is primarily
caused by (AIPGME 2009) 385. Intracellular receptors are present for -
A. Decreased Solubility (AIPGME 2014-2015)
B. Decreased Stability a) Estrogen
C. Altered Function b) Vitamin D
D . Altered O2 binding capacity c) Thyroxine
Answer is A d) All of the above
Ans. is 'd'
380.True statement about hemoglobin is -
(AIPGME 2013-2014) Topic -PCR
a) Each hemoglobin molecule is made of 4
polypep tides of each subunit 386. Prenatal diagnosis of Hemophilia is best
b) Two alpha and two beta subunits having a done by (AIPGME 2010)
O2 attached to each subunit A. PCR
c) Each hemoglobin molecule binds to only B. Linkage analysis
one O2 molecule C. Cytometry
d) Each hemoglobin has one heme molecule D . Microarray
Ans.a Answer is A
381. One gram of hemoglobin contains how 387. Enzyme used in PCR is - (AIPGME
much Iron - (AIPGME 2013-2014) 2013-2014)
a) 2 mg a) Reverse transcriptase
b) 3.4 mg b) Taq polymerase
c) 5 mg c) RNA polymerase
d) 6 mg d) None
Ans.B Ans.B
Topic -Hormones 388. Not a component of PCR - (AIPGME

2014-2015)
382.All the following are peptide based except a) Primer
- (AIPGME 2013-2014) b) Taq polymerase
a) ACTH c) DNA Polymerase
b) GnRH d) Restriction enzyme
c) Thyroxin Ans. is
d) TRH
Ans.c 389. sequence of steps in PCR- (AIPGME
383. Albumin binds with all except - 2014-2015)
(AIPGME 2013-2014) a) Construction —» extension —> annealing
a) Steroid —»Denaturation
b) Calcium b) Construction —> Denaturation ->
c) FFA annealing —> extension
d) Thyroxine c) Denaturation —> construction —>
Ans.NONE >D extension —» annealing
d) Extension —> construction —> annealing
384. Derivative of POMC- (AIPGME 2014- —> Denaturation
2015) Ans. B
a) Norepinephrine
b) Dopamine Topic -Pyrimidine metabolism
c) ACTH
d) Acetylcholine 390. Rate limiting step in pyrimidine synthesis
Ans. is 'c' - (AIPGME 2013-2014)
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a) Dihydro-orotase A. Fusion mediated by Ethylene Glycol
b) Ornithine transcarbomoylase B. Fusion mediated by Electric current
c) Aspartate transcarbomoylase C. Fusion mediated by viral transformation
d) Carbamoyl phosphate synthase-I D . Fusion Mediated by altering membrane
Ans.C viscocity
Answer is D
391. Hereditary orotic aciduria Type-I is due
to deficiency of - (AIPGME 2013-2014) 396.Two transgenic plants were genetically
a) Orotate phosphoribosyl transferase engineered using Recombinant DNA
b) Orotic acid decarboxylase technology. One plant was transformed
c) UMP synthase using a plasmid vector with GFP
d) All of the above (Green Fluorescent Protein) gene and
Ans.D another plaint was transformed with
Luciferase gene. Which of these two
392.Which of the following is not a plants will glow spontaneously in the
pyrimidine base - (AIPGME 2013- dark: (AIPGME 2011)
2014) A. Plant with GFP Gene
a) Cytosine B. Plant with Luciferase Gene
b) Uracil C. Both plants
c) Guaninc D . None of the above
d) Thyminu Answer is B
Ans.C
Topic -cell cycle
393.1st carbon of pentose sugar of nucleic
acid joins - (AIPGME 2013-2014) 397. DNA synthesis takes place in which
a) N-9 of pyrimidine phase of cell cycle - (AIPGME 2013-
b) N-l of pyrimidine 2014)
c) N-l of purine RNA is present in - a) G1
d) None of the above b) S
Ans.B c) G2
d) M
Topic -Bacteriophage Ans.B
394. All of the following statements about 398. DNA replication occurs in which phase
Lambda phage are true, Except of cell cycle - (AIPGME 2013-2014)
(AIPGME 2009) a) S phase
A. In Lysogenic phase it fuses with host b) Gl
chromosome and remains dormant c) G2
B. In Lytic phase it fuses with host d) M
chromosome and replicates Ans.A
C. Both Lytic and Lysogenic phases occur
together 399. DNA replication takes place in which
D . In Lytic phase it causes cell lysis and phase of cell cycle - (AIPGME 2014-
releases virus particles 2015)
Answer C a) M
b) Gi
395. Methods of fusing two cells in genetic c) G2
recombination technique include all of d) S
the following techniques, Except: Ans. is 'd
(AIPGME 2011)
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400. Which of the following groups of a) Liver
proteins assist in the folding of other b) Kidney
proteins? (AIPMG 2008) c) Intestine
A. Proteases d) Fat
B. Proteosomes Ans.B
C. Templates
D . Chaperones Topic -Electrophoresis
Answer is D
406. A protein with molecular weight of 100
401. All of the following represent disorders kD is subjected to SDS PAGE
or protein folding, Except: (AIPGME electrophoresis. The SDS PAGE
2011) electrophoresis pattern show two widely
A. Alzheimer's disease separated bands of20kD and 30kD after
B. Tuberculosis: addition of Mercaptoethanol. The true
C. Cystic fibrosis statement regarding this will be.
D . Creutzfeldt - Jakob disease (AIPGME 2009)
A. The protein has undergone complete lysis
Answer is B B. The protein is a monomer of 20kD and
3OkD protein
402. All are true about chaperones except - C. The protein is a dimer of two 20kD and
(AIPGME 2013-2014) 30kD proteins
D . The protein is a tetramer of 20kd and
a) Cause folding of proteins 30kD proteins
b) Are lipid in nature Answer is C
c) May have ATPase activity
d) Include heat shock proteins 407. Which of the following is used to study
Ans.B protein- protein interaction - (AIPGME
2013-2014)
Topic -Cholesterol metbolism a) Western blot
b) Affinity electrophoresis
403. Rate limiting step in cholesterol synthesis c) Thin-layer chromatography
- (AIPGME 2014-2015) d) None
a) beta-hydroxy-methyl glutaryl COA —> Ans.B
Mevalonic acid
b) AcetylCOA+CO2+ATP- 408. DNA restriction fragments are separated
>MalonylCOA+ADP+Pi by - (AIPGME 2013-2014)
c) L-Methyl malonyl COA -> Succinyl COA a) Paper chromatography
d) Lactose + H2O —> Glucose + Galactose b) Agarose gel electrophoresis
Ans. is 'a' c) Thin-layer chromatography
d) Ultracentrifugation
404. Rate limiting step in cholesterol synthesis Ans.B
- (AIPGME 2013-2014)
a) HMG CoA reductase Topic -Genetic code
b) HMG CoA synthase
c) Mevalonate kinase 409. All are characteristics of genetic code -
d) Squalene synthetase (AIPGME 2013-2014)
Ans.A a) Overlapping
b) Nonambiguous
405. In cholesterol transport which is not c) Universal
needed - (AIPGME 2013-2014) d) Degeneracy
Ans.A
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410. T otal mubers of codons are- (AIPGME Ans.C
2013-2014)
a) 60 416. Reducing sugar in urine can be detected
b) 61 by - (AIPGME 2013-2014)
c) 62 a) Benedicts test
d) 64 b) Fehling solution
Ans.D c) Glucose-oxidase test
d) All of the above
411. Which is non-sense codon - (AIPGME Ans.D
2013-2014)
a) UGG " Topic -Insulin
b) AUG
c) UGA 417. Insulin dependent glucose uptake is not
d) CCA seen in - (AIPGME 2014-2015)
Ans.C a) Skeletal muscles
b) Heart
Topic -HMP shunt c) Adipose tissue
d) Kidney
412. Which of the following metabolic Ans. is 'd'
pathways does not generate ATP:
(AIPMG 2008) Topic -Lac Operon
A. Glycolysis
B. TCA Cycle 418. CAP in Lac operon is an example of:
C. Fatty Acid Oxidation (AIPGME 2009)
D . HMP Pathway A. Positive regulator
Answer is D B. Negative regulator
C. Constitutive expression
413. HMP shunt occurs in all organs except - D . Attenuation
(AIPGME 2013-2014) Answer is A
a) Liver
b) Adipose tissue 419. TATA box is seen in - (AIPGME 2013-
c) RBC 2014)
d) Brain a) Promoter region
Ans.D b) Palindromic region
c) Enhancer region
414. Which of the following metabolic d) Silencer region
pathway in carbohydrate metabolism is Ans.A
required for synthesis of nucleic acids -
(AIPGME 2014-2015) 420. Number of structural gene in Lac operon
a) Gluconeogenesis - (AIPGME 2014-2015)
b) Glycolysis a) 3
c) HMP shunt b) 4
d) Glycogenesis c) 5
Ans. is 'c' d) 6
Ans. is 'a'
415. Insulin dependent entry of glucose is
seen in - (AIPGME 2013-2014) Topic -Mutations
a) Liver 421. Frame shift mutation does not effect
b) Brain complete amino acid sequence if it
c) Heart occurs in multiple of - (AIPGME 2013-
d) Kidney 2014)
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a) 1 Topic -Protein synthesis
b) 2
c) 3 427.Which of the following process in a
d) None vector is used to increase the yield of
Ans.C protein produced in recombinant
protein synthesis: (AIPGME 2011)
422. Which of the following is an example of A. Promoter induction
Trinucleotide repeat mutation - B. Origin of Replication
(AIPGME 2013-2014) C. Translation Initiation
a) Huntington's chorea D . Translation and Transcription inhibition
b) Fragile-X-syndrome Answer is A
c) Friedreich ataxia
d) All of the above 428. Initial amino acid in prokaryotic protein
Ans.D synthe sis - (AIPGME 2013-2014)
a) Arginine
423. All are examples of point mutation, b) Methionine
except -(AIPGME 2013-2014) c) Formyl-methionine
a) Silent mutation d) Alanine
b) Frame-shift mutation Ans.C
c) Missense mutation
d) Nonsense mutation 429. Enzjine involved in initiation of peptide
Ans.B chain synthesis- (AIPGME 2014-2015)
a) T opoisomerae
Topic -PHOSPHOLIPIDS b) Transformylase
c) RNA polymerase
424. Which of the following phospholipid has d) Peptidyl transferase
antigenic acitivity - (AIPGME 2013- Ans. is 'b'
2014)
a) Plasmalogen Topic -Bile salts
b) Cardiolipin
c) Phosphatidylcholine 430. Hay's sulpher test is used to detect which
d) Sphingomyelin of the following - (AIPGME 2013-
Ans.B 2014)
a) Bile salts in urine
425. Which of the following phospholipid has b) Reducing sugar in urine
antigenic acitivity - (AIPGME 2013- c) Ketone bodies in urine
2014) d) Urobilinogen in urine
a) Plasmalogen Ans.A
b) Cardiolipin
c) Phosphatidylcholine 431. Primary bile acid is- (AIPGME 2013-
d) Sphingomyelin 2014)
Ans.B a) Deoxycholic acid
b) Lithocholic acid
426. Which of the following is not a c) Chenodeoxycholic acid
phospholipid - (AIPGME 2013-2014) d) None
a) Lecithine Ans.C
b) Plasmalogen
c) Cardiolipin Topic -Diffusion
d) Ganglioside
Ans.D 432. Neutral molecules are transported by
(AIPMG 2008)
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A. Porin channels
B. Ionophores Topic -Lesch nyhan syndrome
C. Simple Diffusion
D . None of the above 438. A ten year old child with aggressive
Answer is C behavior and poor concentration is
brought with presenting complaints of
433. Which of the following statements about joint pain and reduced urinary output.
facilitated diffusion is true (AIPGME Mother gives history of self mutilitative
2009) behavior stating that he tends to
A. It is a form of active transport mutilate his fingers. Which of the
B. It requires a carrier protein following enzymes is likely to be
C. Rate of transport is proportionate to the deficient in this child (AIPGME 2009)
concentration gradient A. HGPRTase
D . Requires creatine phosphate B. Adenosine Deaminase
Answer B C. APRTase
D . AcidMaltase
Topic -GLUT receptors Answer is A
434. Glucose is transported in pancreas
through which receptor - (AIPGME 439. A 12 year old child presents with mental
2013-2014) retardation and history of self
a) GLUT 1 mutilation. Which of the following tests
b) GLUT 2 will help in determing the diagnosis:
c) GLUT 3 (AIPGME 2012)
d) GLUT 4 A. Serum Lead Levels
Ans.B B. Serum Alkaline Phosphatase Levels
C. Serum Lactate Dehydrogenase Levels
435. GLUT 2 receptors - (AIPGME 2013- D . Serum Uric Acid Levels
2014) Answer is D
a) Insulin dependent
b) Insulin independent Topic -Protein lab test
c) Found in cardiac muscle
d) Found in brain 440. All of the following assays are used for
Ans.B estimation of total serum protein,
except: (AIPGME 2012)
Topic -Karyotyping A. Biruret
436. Which of the following tests is not used B. Bradford
for detection of specific aneuploidy C. Lwry’s
(AIPGME 2010) D . Bromocresol green
A. FISH Answer is D
B. RT-PCR
C. QF-PCR 441. A protein solution on heating forms a
D . Microarray precipitate at about 40 c which
Answer is D redissolves at higher temperature. This
solution is likely to contain: (AIPGME
437. Sex determining region is located on - 2012)
(AIPGME 2014-2015) A. Bence Jones Protein
a) Long arm of Y chromosome B. Cryoglobulins
b) Short arm of Y chromosome C. Complement
c) Long arm of X chromosome D . Alpha-2 macroglobulins
d) Short arm of X chromosome Answer is A
Ans. is 'b'
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Topic -Bmr Topic -Rda
442. Energy Expenditure in Resting state 447. Which of the following statements about
depends on (AIPGME 2009) Recommended Dietary Allowances
A. Lean Body Mass (RDA) is true (AIPGME 2009)
B. Adipose tissue A. RDA is statistically defined as two standard
C. Resting Heart Rate deviations (SD) above Estimated
D . Exercise Average Requirement (EAR)
Answer is A B. RDA is defined as being equal to the
Estimated Average Requirement (EAR)
Topic -Calcium C. RDA is defined as being equal to Adequate
Intake (AI)
443. Which of the following is considered the D . RDA is defined as the recommended
active form of calcium: (AIPMG 2008) minimum requirement
A. Ionised Calcium Answer is A
B. Albumin bound Calcium
C. Phosphate bound Calcium Topic -Water metbolism
D . Protein bound Calcium
Answer is A 448.Metabolic water is - (AIPGME 2013-
2014)
Topic -Fructose metabolism a) Ingested water
b) Water infused iv
444. Fructose intolerance is due to deficiency c) Water produced by metabolism
of ? (AIPGME 2013-2014) d) None
a) Aldolase B Ans.C
b) Fructokinase
c) Triokinase
d) Aldolase A
Ans.A
Topic -Light dark cycle
445. Initiation of visual impulse is associated

with
A. Condensation of opsin with vitamin A
aldehyde
B. Photoisomerization and hydrolysis of
visual purple
C. NADP
D .  NAD
Answer is B
Topic -phase 1 phase 2 reactions
446. Which of the following is not a phase I

Reaction: (AIPGME 2012)
A. Oxidation
B. Reduction
C. Hydrolysis
D . Conjugation
Answer is D
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Aipgmee Biochem MCQ

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Dr.

Murali Bharadwaz Classes for MD Entrance Coaching Programe

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17. Erythrocyte transketolase activity is seen

18. Major function of Vitamin E in the body -

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46.Essential amino acid amongst the

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74. Apolipoprotein E is rich in - (AIPGME 80. Lipoprotein associated with carrying

76. Primary hypercholesterolemia is - Topic - amino acid metabolism

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88. Protein catabolism is increased in - 94. Which of the following is caused by

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142.Which of the following pathway occurs

144. Source of ammonia in urine - (AIPGME

146. In argininosuccinase deficiency, what 152. Imediate precursor of creatine -

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183. Substrate level phosphorylation is seen in

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190. Substrate level phosphorylation in citirc Topic - purine metabolism

193. Pyruvate can be a substrate for 199. Gout is a metabolic disorder of -

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214. Synthesis of rRNA takes place in - Topic -Trace elements

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250. Sphingomyelinase Deficiency is seen in:

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263. All have antioxidant property except - Topic -DNA

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368. Ribosomes are attached to - (AIPGME 373. Enzyme defect in galactosemia -

Topic -Chromatography 374. Glucose is converted to sorbitol by -

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Topic -Hormones 388. Not a component of PCR - (AIPGME

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Topic -Light dark cycle

445. Initiation of visual impulse is associated

Topic -phase 1 phase 2 reactions

446. Which of the following is not a phase I

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