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Understanding Bartonellosis Disease

Bartonellosis, also known as Carrion's disease, is caused by the bacterium Bartonella bacilliformis. It is transmitted by sandfly bites and found exclusively in Peru, Ecuador, and Colombia. The disease has two stages - an acute phase with symptoms like anemia and jaundice, and a chronic phase with splenomegaly, joint pain, and muscle pain. Without treatment, the mortality rate can be as high as 85%. Diagnosis involves blood tests and smears to detect the bacteria, and treatment consists of antibiotics like chloramphenicol or ciprofloxacin.

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Michelle San Miguel Feguro
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49 views2 pages

Understanding Bartonellosis Disease

Bartonellosis, also known as Carrion's disease, is caused by the bacterium Bartonella bacilliformis. It is transmitted by sandfly bites and found exclusively in Peru, Ecuador, and Colombia. The disease has two stages - an acute phase with symptoms like anemia and jaundice, and a chronic phase with splenomegaly, joint pain, and muscle pain. Without treatment, the mortality rate can be as high as 85%. Diagnosis involves blood tests and smears to detect the bacteria, and treatment consists of antibiotics like chloramphenicol or ciprofloxacin.

Uploaded by

Michelle San Miguel Feguro
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Davao Doctors College

Department of Medical Laboratory Science


CLINICAL HEMATOLOGY 1

BARTONELLOSIS

HISTORY EPIDEMIOLOGY

 1875- (Oraya Fever)  Carrion's disease is found only in:


 1885- Daniel A. Carrion (Perruvian Wart)  Peru,
 1905-Dr. Alberto Leonardo Barton Thompson  Ecuador, and
discovered the etiologic agent of “Carrion's disease”  Colombia

DEFINITION  It is endemic in some areas of Peru and is caused by


infection with the bacterium Bartonella bacilliformis and
 The human Bartonellosis "Carrion's disease" or "Peruvian transmitted by sandflies of genus Lutzomyia.
wart" is an infectious disease caused by a bacterium
Bartonella bacilliformis, which parasitizes red blood cells DIFFERENTIAL DIAGNOSIS
from human blood.
A health care provider diagnoses bartonellosis based
SIGNS & SYMPTOMS on:
FIRST STAGE (ACUTE PHASE)
 a medical history
 Hemolytic anemia
 Jaundice Taking a medical history is one of the first things a health care
 Pallor provider may do to diagnose bartonella.
 Nonpainful hepatomegaly  a physical exam
 Malaise A physical exam may help diagnose anemia.
 Lymphadeopathy
 blood tests
SECOND STAGE (CHRONIC PHASE) which measures the type and number of blood cells in the
 Splenomegaly body.
 Arthralgias
 Myalgias TREATMENT

Depending on the cause, a health care provider treats anemia


ETIOLOGY with one or more of the following treatments:
 Causative agent: proteobacteria Bartonella bacilliformis
 Main vector: female of the mosquito sandfly (Lutzomyia ACUTE STAGE TREATMENT
verrucarum)
 Transmission routes:  CHLOR AMPHENICOL
-By the bite of the mosquito - Antimicrobial agent as a beta lactam.
-Transfusion with infected blood - For the effective treatment of B. bacilliformis and
protect against any secondary bacterial infection.
PATHOGENESIS
CHRONIC STAGE TREATMENT
 The transmission of Bartonella species is with contact of
animals and vectors  CIPROFLOXACIN,
 [Link], which uses a polar flagellum  TETRACYCLINE
 Adheres to and invades RBCs.  ERYTHROMYCIN
 Rifampin
 Streptomycin
Possible Ponsequences IF NOT TREATED:

 If the infection is not treated, the mortality rate can be as


high as 85%.
 Purple thrombocytopenic- Complication Hematologic
recently reported that may occur with evolution
favorable.
 Complications have been reported neurological
 Acute hemolysis-Associated with fever, Parasitized
erythrocytes bartonellosis

Bartonellosis Diagnostics Test

 Reaction Polymerase Chain


 Blood smears stained with Giemsa
 Agar cultures and Cell cultures.
 Indirect fluorescent antibody test
 Western blot

REMEMBER!
 Human bartonellosis is bacterial infection by the genus
bartonella
 Bartonellosis caused by B. bacilliformis endemic in Peru,
Ecuador and columbia.
 Suspected vector: phlebotomine sand flies (Lutzomyia
verrucarum)
 About the disease, there are two classical clinical
presentation: acute and chronic phase.
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