ABIDAL, GRACE ALT-NCA2 

BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 

DRUG STUDY
NAME MECHANISM/MODE OF INDICATION AND SIDE EFFECTS/ADVERSE NURSING CONSIDERATION
ACTION CONTRAINDICATION EFFECTS

Generic Name: - Beta-adrenergic Indication: CNS​: fatigue, ● Always check a

Metoprolol blocking agent ● Hypertension, dizziness, patient's
with alone or with depression, apical pulse
Brand Name: preferential other drugs, headache, rate before
Lopresor effect on beta1 especially insomnia, mental giving a drug.
adrenoreceptors diuretics confusion, If it’s slower
Drug Located ● Immediate-relea nightmares, than 60
Classification: primarily on se tablets and short-term memory beats/minute,
Selective beta- cardiac muscle. injection: loss, withhold drugs
adrenergic blockers At higher Prevention of hallucinations and call the
doses, reinfarction in vertigo. prescriber
Therapeutic metoprolol also MI patients who immediately.
Action: inhibits beta2 are CV​: hypotension,
Antihypertensives receptors hemodynamically bradycardia, HF, ● In diabetic
located chiefly stable or edema, patients,
Dose: on bronchial within 3–10 palpitations, monitor glucose
100mg and vascular days of the stroke. level closely
musculature. acute MI drug masks
Frequency: Antihypertensiv ● Long-term GI​: nausea, common signs
Daily e action may be treatment of diarrhea, and symptoms of
due to angina pectoris constipation, heart Hypoglycemia.
Route: competitive ● Toprol-XL only: burn,
PO antagonism of Treatment of dry mouth, ● Monitor BP
catecholamines stable, flatulence, frequently;
at cardiac symptomatic CHF gastric pain, drug masks
adrenergic of ischemic, vomiting. common signs
neuron sites, hypertensive, and symptoms of
drug-induced or GU​: decreased shock.
ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
reduction of cardiomyopathic libido,
sympathetic origin erectile ● Beta blockers
outflow to the dysfunction. may mask
periphery, and tachycardia
to suppression Contraindications: Musculoskeletal​: pain caused by
of renin ● 2nd or 3rd hyperthyroidism
activity. degree AV Respiratory​: dyspnea, . In patients
block; sick wheezing, with suspected
sinus syndrome; bronchospasm. thyrotoxicosis,
decompensated Skin​: rash, pruritus taper off beta
heart failure; blocker to
clinically avoid thyroid
relevant sinus storm. Beta
bradycardia. selectivity is
Severe lost at higher
peripheral doses. Watch
arterial for peripheral
circulatory side effects.
disorders.
Cardiogenic ● Don’t confuse
shock. Asthma. metoprolol with
Pheochromocytom metaproterenol,
a (without misoprostol, or
α-blockade), metolazone
systolic BP
<100 mmHg.
Metabolic
acidosis.
Pregnancy (2nd
and 3rd
trimesters).
 ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 

NAME MECHANISM/MODE OF INDICATION AND SIDE EFFECTS/ADVERSE NURSING CONSIDERATION

ACTION CONTRAINDICATION EFFECTS

Generic Name: - May slow Indication: CNS: ​Anxiety, ● When starting

Nifedipine movement of ● To manage ataxia, confusion, and stopping
calcium into angina dizziness, nifedipine
myocardial and drowsiness, therapy, taper
Brand Name: vascular headache, it, as
Adalat smooth-muscle Contraindication: nervousness (possi- prescribed,
cells by ● Hypersensitivit bly extreme), over 7 to 14
Class and Category deforming y to a calcium nightmares, days.
Chemical class: calcium channel paresthesia, psy-
Dihydropyridine channels in blocker, chiatric ● For closely
derivative cell membranes, second- or disturbance, monitored
inhibiting third-degree AV syncope, tremor, hospitalized
Therapeutic class: ion-controlled block without weak- ness patients with
Antianginal, gat- ing artificial angina, dosage
antihyper- tensive mechanisms, and pacemaker, sick CV: ​Arrhythmias may be
disrupting sinus syn- (bradycardia, increased 10 mg
calcium release drome tachycar- dia), every 4 to 6
Dose: from chest pain, heart hours to
Adults. ​Initial: ​10 sarcoplasmic failure, control chest
mg t.i.d., increased reticulum. hypotension, pain.
over 1 to 2 wk as Decreasing palpitations,
needed. ​Maintenance: intracellular peripheral edema ● Because of the
10 to 20 mg t.i.d. calcium level drug's negative
Maximum: ​180 mg inhibits EENT: ​Altered taste, inotropic
daily, 30 mg/dose. smooth-muscle blurred vision, dry effect on some
cell mouth, epistaxis, patients,
Route: contraction and gingival frequently
P.O. (caps) dilates hyperplasia, nasal monitor heart
arteries, which congestion, rate and rhythm
decreases pharyngitis, and blood
ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
myocardial sinusitis, tinnitus pressure in
oxygen demand, patients who
peripheral ENDO: ​Gynecomastia, take a beta
resistance, hyperglycemia blocker or have
blood pressure, heart failure
and afterload. GI: ​Anorexia, or significant
constipation, left
diarrhea, dys- ventricular
pepsia, elevated dysfunction.
liver function test
results, hepatitis, ● Monitor fluid
nausea, vomiting intake and
output and
GU: ​Dysuria, daily weight;
nocturia, polyuria, fluid retention
sexual dys- may lead to
function, urinary heart failure.
frequency Also assess for
signs of heart
HEME: ​Anemia, fail- ure, such
leukopenia, positive as crackles,
Coombs’ test, dyspnea,
thrombocytopenia jugular vein
distention,
MS: ​Joint stiffness, peripheral
muscle cramps edema, and
weight gain.
RESP: ​Chest
congestion, cough,
dyspnea,respiratory
tract infection,
wheezing

SKIN: ​Dermatitis,
 ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
diaphoresis,
erythema multiforme,
flushing,
photosensitivity,
pru- ritus, rash,
urticaria

NAME MECHANISM/MODE OF INDICATION AND SIDE EFFECTS/ADVERSE NURSING CONSIDERATION

ACTION CONTRAINDICATION EFFECTS

Generic Name: - Organic nitrate Indication: CNS:​ Headache, ● Be aware that

Nitroglycerin and potent ● Chest pain apprehension, moisture on
vasodilator Stable blurred sublingual
Brand Name: that relaxes angina–reduces vision, weakness, tissue is
Gonitro, Minitran, vascular smooth oxygen demand vertigo, required for
Nitro-Dur, muscle by of myocardium dizziness, dissolution of
Nitrolimgual, unknown by reducing faintness. sublingual
NitroMist mechanism, preload tablets.
resulting in CV:​ Postural However,
Drug dose-related ● Variant angina hypotension, because chest
Classification: dilation of enhances oxygen palpitations, pain typically
 ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
Nitrates both venous and supply to tachycardia leads to dry
arterial blood myocardium by (sometimes with mouth, a
Therapeutic vessels. relaxing and paradoxical patient may be
Action: Promotes dilating bradycardia), unresponsive to
Vasodilators peripheral coronary increase in angina, sublingual
pooling of arteries syncope, and nitroglycerin.
Dose: blood, circulatory
0.4mg reduction of collapse. ● Assess for
peripheral Contraindications: headaches.
Frequency: resistance, and ● Hypotension GI:​ Nausea, Approximately
1 tablet under decreased (Systolic BP vomiting, 50% of all
tongue or in buccal venous < 90 mm Hg involuntary passing patients
pouch at first sign return to the or more than 30 of urine experience mild
of heart. mm Hg below and feces, abdominal to severe
anginal attack Both left baseline) pain, headaches
ventricular ● Recent use of dry mouth. following
Route: preload and phosphodiestera nitroglycerin.
Sublingual PRN afterload are se inhibitors Hematologic: Transient
reduced and (sildenafil Methemoglobinemia headache
myocardial [Viagra®] or (high usually lasts
oxygen vardenafil doses). about 5 min
consumption or [Levitra®]) after
demand is within past 24 Skin: ​Cutaneous sublingual
decreased. hours vasodilation with administration
● Recent use of flushing, and seldom
phosphodiestera rash, exfoliative longer than 20
se inhibitor dermatitis, min.
(tadalafil contact dermatitis
[Cialis®]) with ● Assess degree
within past 48 transdermal patch; of severity and
hours topical consult as
● Right allergic reactions needed with
ventricular with physician about
infarction ointment: pruritic analgesics and
ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
(inferior wall eczematous dosage
MI) eruptions, adjustment.
anaphylactoid
reaction ● Supervise
characterized by ambulation as
oral needed,
mucosal and especially with
conjunctival older adult or
edema. debilitated
patients.
Body as a Whole: Postural
Muscle hypotension may
twitching, pallor, occur even with
perspiration, cold small doses of
sweat; nitroglycerin.
local sensation in Patients may
oral cavity complain of
at point of dizziness or
dissolution of weakness due to
sublingual forms. postural
hypotension.

● Take baseline
BP and heart
rate with the
patient in
sitting
position before
initiation of
treatment with
transdermal
preparations.
One hour after
transdermal
ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
(ointment or
unit)
medication has
been applied,
check BP and
pulse again
with the
patient in
sitting
position.
Report
measurements to
the physician.

● Assess for and

report blurred
vision or dry
mouth.

● Assess for and

report the
following
topical
reactions.
Contact
dermatitis from
the transdermal
patch; pruritus
and erythema
from the
ointment.

● Be aware that
local burning
ABIDAL, GRACE ALT-NCA2 
BARBOZA, SHERILYN  
TAYSA, DIANA ROSE 
BSN3-NCA 
or tingling
from the
sublingual form
has no clinical
significance.

● Be alert for
overdose
symptoms:
Hypotension,
tachycardia;
warm, flushed
skin becoming
cold and
cyanotic;
headache,
palpitations,
confusion,
nausea,
vomiting,
moderate fever,
and paralysis.
Tissue hypoxia
leads to coma,
convulsions,
cardiovascular
collapse. Death
can occur from
asphyxia.