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STATEMENT OF THE PROBLEM

This study aims to determine the capabilities of chitosan-nanosilica-hydroxyapatite

nanofibers as bioscaffold for cartilage regeneration.

Specifically, this study is concerned with seeking answers to the following questions:

1. How can the unimmersed chitosan-nanosilica-hydroxyapatite nanofibers be

described in terms of

a) Toxicity; and

b) Mean Fiber Diameter

2. How can the immersed chitosan-nanosilica-hydroxyapatite nanofibers be

described in terms of

a) Toxicity; and

b) Mean Fiber Diameter

3. Is there a significant difference between the unimmeresed and immersed chitosan-

nanosilica- hydroxyapatite nanofibers in terms of mean fiber diameter?

4. Is there a significant difference between unimmeresed and immersed

chitosan-nanosilica-hydroxyapatite nanofibers be described in terms of Chemical

Structure?

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