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  • Lecture 5 - Drug Delivery PDF

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    Irsyad Muhammad Andre IPB
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    The document discusses controlled drug delivery and the objectives of controlled release technology. It aims to provide defined drug release kinetics, avoid toxic systemic levels through local delivery, improve patient compliance by avoiding repeated injections, and protect drugs from premature breakdown or elimination to improve bioavailability. It then describes different controlled release methods including diffusion controlled matrices and reservoirs, chemically controlled systems, and bulk eroding and solvent controlled delivery mechanisms.

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    The document discusses controlled drug delivery and the objectives of controlled release technology. It aims to provide defined drug release kinetics, avoid toxic systemic levels through local delivery, improve patient compliance by avoiding repeated injections, and protect drugs from premature breakdown or elimination to improve bioavailability. It then describes different controlled release methods including diffusion controlled matrices and reservoirs, chemically controlled systems, and bulk eroding and solvent controlled delivery mechanisms.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    30 views32 pages

    Lecture 5 - Drug Delivery PDF

    Uploaded by

    Irsyad Muhammad Andre IPB
    The document discusses controlled drug delivery and the objectives of controlled release technology. It aims to provide defined drug release kinetics, avoid toxic systemic levels through local delivery, improve patient compliance by avoiding repeated injections, and protect drugs from premature breakdown or elimination to improve bioavailability. It then describes different controlled release methods including diffusion controlled matrices and reservoirs, chemically controlled systems, and bulk eroding and solvent controlled delivery mechanisms.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 32

    Drug Delivery

    Lecture 5
    Robert S. Langer
    Advances in Controlled Drug Release
    Technology : An Overview

    MIT Lecture notes. DDS Controlled Release


    Usual case

    toxic

    ineffective
    Sustained release
    Controlled release – Ideal Case
    Objectives of Controlled Release
    • Provide defines drug release kinetics
    • Avoid toxic systemic levels (local delivery)
    → target specific tissue
    • Improve patient compliance by avoiding
    repeated injections
    • Protect drug from premature
    breakdown/elimination → improve in vivo
    bioavailability
    DIFFUSION CONTROLLED
    MATRIX

    - Well defines release kinetics


    - Can model diffusion release
    rigorously

    RESERVOIR - Non-degradable implants


    - Diffusion of macromolecules
    (Eg. Protein) usually too slow
    to be effective
    - Denger of “Dose Dumping” in
    Reservoir type systems
    CHEMICALLY CONTROLLED
    BULK ERODING
    - Can be injectable and
    degradable
    - Low danger of dose
    dumping

    - Often difficult to stop


    therapy until erosion is
    complete
    - Release will vary with
    time for bulk erosion
    SOLVENT CONTROLLED

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