Professional Documents
Culture Documents
COLLEGE OF MEDICINE
DEPARTMENT OF CLINICAL NEUROSCIENCES
NEUROLOGY I and II
Preceptorials
Course Syllabus
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DEPARTMENT OF CLINICAL NEUROSCIENCES
FACULTY
Section of Neurology
Erman C. Fandialan, MD, FPCP, FPNA Marietta C. Olaivar, MD, FPCP, FPNA
Head, Section of Neurology Residency Training Officer, Section of Neurology
Pia Teresa A. Camara-Chua, MD, DPCP, FPNA Rio Carla F. Pineda, MD, FPNA
Ma, Alma E. Carandang-Concepcion, MD, FPNA Rene B. Punsalan, MD, FPNA
Lex Lycurgus M. Castillo, MD, FPNA Ma Luisa Gwenn F. Pabellano-Tiongson, MD, FPNA
Evelyn Chua-Ley, MD, FPNA Maria Felicidad A. Soto, MD, FPNA
Belinda Lioba L. Mesina-Nepomuceno, MD, FPNA Ma. Katrina Margarita A. Zialcita, MD, FPNA
Section of Neurosurgery
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
NEUROLOGY I Preceptorials
LEARNING OUTCOMES
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
NEUROLOGY II Preceptorials
LEARNING OUTCOMES
7. Discuss the patient’s manifestations and disease process in relation to the basic disciplines:
a. Anatomy
b. Pathophysiology
c. Microbiology
d. Pharmacology
8. Apply the problem oriented approach in formulating management plans in terms of:
a. Diagnostics
b. Support plans
c. Treatment
9. Organize the data gathered into a legible, grammatically correct, accurate and concise case
discussion.
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
REMINDERS TO STUDENTS
1. The students’ evaluation sheet will be kept by the preceptor. If questions arise regarding their
grades, the preceptors will show the evaluation sheet for reference.
2. Allowable absence for any student is 20% of the total required class hours. An absent student
must present an excuse letter from the Infirmary. More than 20% of absence means an
incomplete grade. The student will have to make arrangements with the preceptor for
completion.
NOTE: The highest grade that can be given to a student is 94 and the lowest is 75.
4. In cases where the preceptor will be late for class, students should not leave the classroom until
the first third fraction of the scheduled class has passed.
5. The students should utilize their ward work time to interview and examined assigned patients in
the Neurology ward.
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WAIVER
1. That I have been informed during the orientation regarding the Department of Clinical
Neurosciences Policy on Grading System, based on the satisfaction of the following academic
requirements, namely, written exams, class participation, submission of papers, OSCE and class
attendance,
2. That I have been likewise informed during the Orientation about the Department’s Policy on
Absences particularly on the CHED ruling on Failure due to Absences (FA), whereby total absences
constituting 20% or more of the total required total attendance will result to FA (Failure due to
Absences),
3. That the College of Medicine’s Policies are likewise written in the Student’s Handbook ad
current/present Policies supersedes previous policies,
4. That it is my responsibility to inquire from the faculty involved or Department Head about my
deficiencies; and
5. That I endeavor to refer to and read the Student’s Handbook regarding the Department’s policies
on excused and unexcused absences as well as the conduct of special examinations.
IN WITNESS WHEREOF, I have set my hand at _____________________ this _____ day of _________
2018
________________________________
Affiant
Signature over Printed Name
_______________________________ _______________________________
Signature over Printed Name Signature over Printed Name
(WITNESS) (WITNESS)
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
HISTORY FORMAT
(Adapted from Medicine PD II Guidelines)
PATIENT PROFILE
• Purpose:
1. To discover what stimuli in the patient’s environment may be contributing to his illness.
2. To determine factors that may significantly influence diagnostic or therapeutic program for
the patient (ex. Financial resources).
3. To discover some information that may give important clue as to the cause of the patient’s
illness.
• The patient profile reveals the individual as a whole -- his personality, his mental make-up and his
reaction to his environment and his illness.
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SOURCE AND RELIABILITY
• Numerical grade or excellent-good-fair-poor
CHIEF COMPLAINT:
• Concise statement of complaint with duration
• Main reason for seeking consult
• Serves as a guide to the more detailed history
• Note: It is preferable to use a separate paragraph for each chronological period and in that
paragraph analyze all symptoms completely and note positive and negative information
closely related to the symptoms describe. All other significant positives and negatives should
be summarized separately in the last paragraph (4th component of the HPI).
• Day of admission or consultation should be the reference date (period) of the onset and
progression or appearance of other symptoms. It could be several minutes, few hours/several
hours, days weeks, months, or years prior to consultation or admission day.
• SYMPTOM ANALYSIS
o It is important to use a standard method of analyzing a symptom. One basic outline for
analyzing symptoms:
1. Onset
a. Date of onset
b. Manner of onset (gradual or sudden)
c. Precipitating and predisposing factors related to onset
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2. Characteristic
a. Character (quantity, quality, consistency, appearance)
b. Location and radiation (pain, cardiac murmur)
c. Intensity or severity
d. Timing (continuous or intermittent, duration of each, temporal relationship to
other events)
e. Aggravating and relieving factors
f. Associated symptoms
3. Course since onset
a. Incidence
i. Single acute attack
ii. Recurrent acute attack
iii. Daily occurrences
b. Effect of therapy
c. Progress
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____________________________________________________________________________________
The HPI if elicited thoroughly and accurately will have a predictive diagnostic value of 85% or even more.
How may one be confident that he has adequately accomplished the HPI?
This is done by going through the checklist of six items: 1. Components, 2. Sequence, 3. Temporal
relationships, 4. Analysis of Symptoms, 5. “Time holes”, and 6. ROS, by asking yourself…
It is very obvious that all the imaginable problems related to the thoroughness, accuracy, and
dependability of the HPI are covered by these.
_____________________________________________________________________________________
TEMPORAL PROFILE:
Max
The height of the symptom curve from the baseline will reflect the severity
of the same. The shape, slope of the symptom curve will also depict the behavior
of a symptom or sign over the cause of the illness, from 10 the|onset
P a gtoe consult or
admission.
The legend will be representing 2 or no more than 3 major symptoms of the
illness, with appropriate lines or colors, on the left side, below the diagram.
The “clinical horizon” (CH) and the time lines coincide (are one and the same)
with each other. A symptom curve that rises above it signifies its appearance or
INTENSITY OF
SYMPTOMS
0
Onset Admission
Legend:
_________ Symptom A
TIME FRAME
__ . __ . __ Symptom B (hours, days, weeks, months, as the case may be)
…………….... Symptom C
Guidelines:
1. As much as possible it is best to have the minimum number of symptom line (one or two or at
most three) to represent the temporal profile of several symptoms.
A temporal profile diagram of the HPI which is cluttered defeats its very purpose ie to show at a
glance the relationship of all the components during the course of the illness.
2. Should several symptoms have similar temporal profile, use only one symptom line to represent
all of them.
3. The graphic symptom line can be color coded or represented by symbols such as , ,-
-------- or *****
4. Should there be more than one problem or illness in the HPI, each problem/illness should be
represented by its own separate corresponding schematic diagram/temporal profile.
• The height, shape, slope and sharpness of the symptom curve will serve to depict the symptom’s
severity, acuteness, and tempo over the time frame where it occurs. Some examples:
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Continuous. Remittent.
The temporal profile offers a view of the “forest” (course of illness) as well as the “individual trees”
(components). The relationship of all components over the course of the illness is a great and inestimable
value for correct diagnosis.
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PAST MEDICAL HISTORY
• Convulsions
• Injuries
• Prior Hospitalizations; Prior Surgeries
• Hypertension, Diabetes, Stroke, Thyroid problems, Cardiac problems
FAMILY HISTORY
• Pedigree
• Health status of living relatives
• Cause of death of deceased relatives
• Heredofamilial diseases: cancer, diabetes, hypertension, allergy, mental illness, heart disease
SOCIAL/ENVIRONMENTAL HISTORY
• Educational attainment
• Occupation
• Adequacy of income (as appropriate)
• Typical day of patient (as appropriate)
• Vices: smoking, alcoholic beverage intake, illicit drug use/abuse
• Environment (as appropriate): state of hygiene, access to potable water, electricity, density of
population in neighborhood
REVIEW OF SYSTEMS
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
GENERAL SURVEY:
• Sensorium, distress, acute or chronically ill
VITAL SIGNS:
• Temperature per axilla/oral/rectal
• Pulse/Heart Rate
• Respiratory Rate
• Blood Pressure
ANTHROPOMETRICS:
• Weight
• BMI
SKIN:
• Color, moisture, turgor
• Rash: distribution, color, pruritus, description
• Lesions: description
• Hemorrhages: petechiae, ecchymoses, hematoma
• Nails, hair
EYES:
• Eyelids: ptosis
• Conjunctivae
• Sclerae
• Cornea
• Pupils
• Movements
• Exophthalmos/Enophthalmos
EARS:
• Lesions of external ear
• Discharge
• Tympanic membranes
• Mastoids
• Hearing
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NOSE:
• Patency
• Mucosa
• Septum
• Discharge
• Sinus tenderness
MOUTH:
• Lips
• Teeth
• Gums
• Mucosa
• Tongue
• Breath
• Salivary glands
THROAT:
• Tonsils
• Posterior pharynx
• Post-nasal drip
NECK:
• Thyroid gland, Vessels, Trachea, Stiffness, Masses
LYMPH NODES:
• Cervical, occipital, supraclavicular, axillary, inguinal, epitrochlear, others
BLOOD VESSELS:
• Pulses: location, quality
HEART:
• Inspection: precordium
• Palpation: point of maximum impulse, heaves, thrills
• Auscultation: S1, S2, S3, rate and rhythm
• Adventitious sounds: murmurs, gallop, clicks
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ABDOMEN:
• Inspection: contour, scars, peristalsis, blood vessels, hernia
• Auscultation: presence and number of bowel sounds
• Percussion
• Palpation: tenderness, rigidity, fluid, liver and spleen, kidneys
• Bladder
MUSCULOSKELETAL:
• Posture
• Deformities of extremities, spine
• Range of motion
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER
Aurora Boulevard, Quezon City
DEPARTMENT OF CLINICAL NEUROSCIENCES
Objectives:
1. To facilitate communication
2. To provide a baseline.
3. To direct testing and guide the physician on what laboratory tests to request for the patient.
4. To localize the lesion.
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Guidelines in the Performance of a Neurological Examination
I. Orientation
Person
Time of day Day of week Day of month
Month
Kind of place Name of place Floor
Room number
Geography
Capital of the Philippines, some provinces
Knowledge of current events
Calculation
5+6= 12 + 9 = 15 + 16 = 79 + 12 =
7–2= 12 – 4 = 30 – 13 = 100 – 17 =
3x2= 7x6= 8x9= 1 x 11 =
Problems
50 + 25 + 10 + 05 + 03 =
6 mangoes cost 54 cents, cost of 9 mangoes
3 packs of cigarettes at 27 cents each – change from $1.00
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IV. Name of Objects shown
V. Response to Request to
Close eyes
Raise hands
Touch your nose
Put ______ hand on ______ear
Put ______little finger on _____ knee
Put ______little finger on tip of nose and _____ thumb on _____ear
VI. Digit Span (Give each number once, at one digit per second without grouping. Continue
until patient fails digit or order of 2 numbers of some length)
Four things to recall: Blue, 75, Glass, Park (repeated until patient knows them)
Story:
Yesterday St. Joseph’s school burned down. Fortunately no children were in the school
at the time and 3 firemen were overcome with smoke and were brought to the ST. Luke’s
Hospital. (17 items underlined)
VII. Reading
The one best friend a man can have is his dog. The dog is faithful and true. When the day
is done he will curl up at your feet and sleep, content in the knowledge that you are his
friend as well. (25 items underlined)
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VIII. Write
Name
Spontaneous writing of 8 – 10 word sentence
Dictation: Today is a lovely day in __________
I hope that doctor will make me well soon.
Copy: This is the way I write today.
IX. Drawing
Circle Square Triangle
Clock with all the numbers and the hands at 7:20
Copy interlocking pentagon
XIII. Proverbs
CRANIAL NERVES
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VIII Rubbed fingers heard distance from AD____cm AS____cm
Tuning fork head AD:BC ____sec AC ____sec
AS:BC ____sec AC ____sec
With fork at vertex lateralizes to:
IX, X Uvula
Gag
XI SCM
Shrug
XII Tongue
Atrophy
Fasciculation
Deviation
Strength against cheek
Speech La La La Mi Mi Mi Go Go Go
Massachusetts Institute of Technology
Third Riding Artillery Brigade
MOTOR
Strength
0 - no muscle contraction detected
1 - a barely detectable flicker or trace of contraction
2 - active movement of the body part with gravity eliminated
3 - active movement against gravity
4 - active movement against gravity and some resistance
5 - active movement against full resistance without evident
fatigue. This is normal muscle strength
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Tone
Spasticity
Rigidity
Gegenhalten
Walk on tiptoe
Walk on heels
REFLEXES
Reflexes are usually graded on a 0-4 +scale (DTR’s)
4+ very brisk, hyperactive; often indicative of disease; often associated with clonus
(rhythmic oscillations between flexion and extension)
3+ brisker than average; possibly but not necessarily indicative of disease
2+ average; normal
1+ somewhat diminished; low normal
0 no response
SENSORY
Touch
Pin
Position (record error/trials and note degree of movement)
Finger Finger Wrist Elbow
Distal Phalanx Proximal Phalanx
R = at ______ R = at ____ R = at ____ R = at ______
L = at ______ L = at ____ L = at ____ L = at ______
Temperature
Graphesthesia
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Stereognosis: safety pin, paper clip, button, coin
Right ______ ______ ______ ______
Left ______ ______ ______ ______
Romberg’s
CEREBELLAR
Coordination:
Finger – to – nose Heel – to – shin
Alternating Pronation-Supination Tibial tapping
Hand-Patting Finger tapping
Nystagmus
Tremor
Gait Natural
Tandem walk along straight line
MISCELLANEOUS
Carotids : common
Internal
Vertebral arteries
Body temperature
Bruits : CCA ICA Subclavian Vertebral
Right _____ _____ _____ _____
Left _____ _____ _____ _____
Eyes
Skull
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THE NEUROLOGIC EXAMINATION
THE MENTAL STATUS EXAMINATION (MSE)
Most of the information needed in the examination of the mental status of the patient can be
gathered by the physician from the time he observes the patient walking into his clinic and throughout
the interview. In fact, sometimes a clinician can surmise that the mental status of the patient is “intact”
if the patient himself narrates his complaint and history to the physician and it is deemed relatively
accurate and plausible by the physician.
The way the examination is conducted and the questions that the physician chooses depends
largely on the educational attainment and employment background of the patient. For example, one
would not expect a patient who had not gone to school to be able to perform straightforward calculations.
However, if for example, this patient sells fruits and vegetables at the local market, his ability to calculate
can be assessed by relating it to a common problem that he encounters daily: “Sir, if you were selling
mangoes at P80/kilo and tomatoes at P40/kilo and I was to buy 3 kilos of mango and 2 kilos of tomato,
how much would I owe you?” In the same way, in the assessment of a patient who says that he is a
business firm’s account executive, one would not ask him to perform simple arithmetic problems such as
“2 + 2 = ?”.
Traditionally, the mental status exam has always been taught as compartmentalized to certain
“higher order cortical functions” (See Table 1). However, in practice, we find that it is easier to subdivide
the mental status examination into different lobes of the cerebral cortex. This aids in localization later
on, and helps with the organization and ease of examination.
Suffice it to say that the subdivision of the mental status examination into different lobar
functions in the cortex is not absolute. Though some areas of the cortex have been mapped out and
specific functions have been assigned to these specialized areas, many of the more complex functions of
the brain (such as arousal, verbal processing, etc) cannot be precisely pinpointed to one particular area,
rather, they are attributed to be a function of a network between several areas in the cortex. Therefore,
the format of the mental status examination we present here is not all encompassing, but it is the bare
minimum that is required for an adequate screening of patients.
FRONTAL: sensorium, speech, ability to follow commands, attention span, insight and judgment
By convention, many physicians like to rely on the Glasgow Coma Scale (GCS) to describe the
mental status of their patient. However, it is wise to remember that the GCS was developed to help in
the categorizing and prognostication of patients who suffered from head trauma. Obviously not all
neurologic patients that you will encounter have head trauma. Hence, the GCS should never be used as
a “replacement” for the actual description of the patient’s sensorium or the MSE. However, it may be
used as a guide to describe the patient’s sensorium, i.e. “The patient is awake, follows complex commands
but has no verbal output….” Actually describing the state of arousal of the patient gives a clearer picture
of the patient’s level of sensorium rather than the arbitrary number given by a GCS score.
The description of a patient’s level of arousal is further complicated by use of ambiguous words
such as drowsy, stuporous or obtunded. Universal definitions for these terms are found in neurology
textbooks, but it still appears very subjective and tends to differ between physicians. We then again,
suggest the use of descriptives of the patient’s best response to stimuli, as the examples below:
Drowsy – “The patient is drowsy, with unsustained eye opening to name calling, can follow simple
commands and has one-word answers to questions”
Obtunded – “The patient has unsustained eye opening to repeated shoulder tapping and name
calling, occasionally follows simple commands but no verbal output”
Stuporous – “The patient has unsustained eye opening on sternal rub, does not follow commands
and mumbles incoherently”
2. Speech
With regard to speech and the frontal lobe, what is being assessed is the fluency of the patient. The
Broca’s area or Broadmann area 44 is located in the inferior frontal lobe, and as such, the ability of the
patient to speak fluently is part of the examination of the frontal lobe (See Figure). Dysarthria, on the
other hand, which refers to the problem of articulation of words and syllables uttered by the patient; as
well as dysphonia, which refers to a nasal quality of the voice; are typically noted under the examination
of cranial nerves IX and X.
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4. Attention span
A patient’s ability to focus and concentrate on a task given is also assessed under the frontal lobe.
The most common way to do this is to ask the patient to perform Serial 7’s: ask him to subtract 7
repeatedly, beginning from 100 (i.e. 100 – 7 =?; 93 – 7 = ?; 86 – 7 = ?, and so on). However, here in the
Philippines, we are faced with many patients who have not gone to school. Therefore, one must be
creative in assessing a patient’s attention span. Alternative ways of assessing the attention span are: a)
asking the patient to name the days of the week forward from Sunday and then backward; and b) asking
then to name the months in a year from January and then backward from December.
In the neurological examination, no other portion will involve the concept of brain dominance
more than the examination of parietal lobe functions. This is one of the reasons why it is imperative to
include the handedness of the patient in the identifying data. Though about 98% of the population will
have left-brain dominance regardless of handedness, there is still that 2% chance that one may encounter
a patient with right-brain dominance. Hence, knowledge of the functions of the dominant versus a non-
dominant parietal lobe is important. Again, we reiterate that the examination outline here in this manual
is the bare minimum expected for the assessment of a patient’s mental status. If, however, a lesion is
localized to a particular lobe (i.e. left parietal lobe) the student is encouraged to read the chapter
Neurologic Disorders Caused by Lesions in Specific Parts of the Cerebrum in Adams & Victor’s Principles of
Neurology, 10th ed. so that a more complete and precise examination of the cortical lobar functions may
be conducted.
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One of the most interesting effects of a lesion in the non-dominant parietal lobe is the inability
of the patient to recognize the left part of his body as his own and a “neglect” or “inattention”
toward anything on the left. These patients, when their left hand is raised by the examiner, claim
that this hand is “not theirs” or is “unfamiliar”. Also, when double simultaneous stimulation is
done, i.e. stroking both arms lightly with the fingers, the patient claims only to be touched on the
right side. However, when tested one at a time, he can discern the touch.
Some ways of assessing hemineglect can be to ask the patient to look at a picture:
A patient with left hemineglect would miss seeing the two children on the left side of the
picture and say that he could only see a woman washing dishes with water spilling over the sink.
Sometimes, the simplest way of assessing neglect is to ask the patient to draw a line to bisect a
horizontal bar drawn by the examiner:
A patient with left hemineglect would place a line (gray dashed line) toward the right end on
the bar drawn by the examiner (black bar), because he cannot perceive the left extension of that
bar.
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Patients can sometimes lose the ability to explain or draw up the location of something
familiar (i.e. floor plan of their home). A way to assess this is to ask them to explain how to get
from their bedroom to the kitchen, for example, but this necessitates the presence of a
companion who can confirm the patient’s directions. Otherwise, a route familiar to both the
examiner and patient may be used, such as: “You live in Mezza apartments. Can you tell me how
you got to the UERM Emergency Room from your home?”
For constructional apraxia, the task is typically to copy a figure presented by the examiner:
Apraxias can also be tested by showing the patient a common object such as a pen, watch,
or cellphone and asking them to name that object and demonstrate its use.
3. Stereognosis
Stereognosis refers to the ability of the patient to identify familiar objects by feel. The
patient is instructed to close his eyes and the examiner tests one hand at a time by placing familiar
objects on the palm of the hand and asking the patient to name it. Use small objects that can fit
within the patient’s palm, like a button, coin, small key or paper clip. The same procedure is then
done on the other hand. It is important to note that some patients with parietal lobe lesions may
complain of hemisensory loss on the contralateral upper and lower extremities. However,
stereognosis may be still be checked accurately in patients who complain of about < 20% sensory
deficit.
4. Graphesthesia
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Graphesthesia refers to the ability of the patient to perceive letters and/or numbers
written on his palm. It is tested one hand at a time, with the patient’s eyes closed. The examiner
then draws either letters on numbers on the palm, and asks the patient what is being drawn. A
common mistake made by students is drawing upside down since they are usually sitting across
from the patient. A good reminder to the examiner is to reposition himself so that he is beside
the patient, and the drawing on the palm is right side up for the patient. Like stereognosis,
patients with about < 20% sensory deficit can still be tested for graphesthesia accurately.
1. Orientation
The patient’s orientation to three spheres: person, place and time is tested under the
temporal lobe. Usually, the most resilient of the three spheres is the orientation to person, as the
patient will least likely not recognize someone who is familiar to him (like a spouse or child),
whereas the patient commonly loses orientation to time, especially if confined in the hospital for
a long period of time.
2. Memory
Memory is also tested in three facets: immediate recall, recent and remote. For
immediate recall, three unrelated objects are shown to the patient and he is immediately asked
to repeat the names of the three objects and then checked again after a few minutes. A tip for
doing this test is to show the three objects at the beginning of the neurological exam, then ask
the patient if he remembers them at the end of your examination.
Recent memory can be tested by asking the patient questions like: “What did you have
for breakfast?”; “Where did you have dinner last night?” and have a companion confirm his
answers.
Remote memory is tested by asking “Where did you grow up?” “Who was your first grade
teacher?” “What was the name of your first pet?”
The patient’s fund of knowledge, to some degree also tests memory: “Who was the first
president of the Philippines?”
The occipital lobe is the visual cortex and is concerned with the processing of visual stimuli. Thus,
it is not actually vision that is tested here, but what is being seen. Commonly, we ask patients to name
everyday familiar objects like buttons, watches, pens, etc. In addition, we ask the patient to name his
family members to test his recognition of familiar faces; as well as basic colors to test color perception.
This concludes the basic examination of a patient’s mental status. Again, we encourage the
student to use this examination outline by lobe in order to aid in localization later on. Appendices are
attached, containing the traditional outline of the mental status exam, and as the student studies this, we
encourage him to associate each part with the particular cortical lobe concerned.
Appendices containing the outline for the Mini Mental Status Examination (MMSE) and Montreal
Cognitive Assessment (MoCA) Scale in Filipino are also included, however, the student is to remember
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that these scales are used in the assessment of patients with cognitive impairment and are not used to
replace the Mental Status Examination (MSE) as described in this manual.
I. Orientation
Person
Time of day Day of week Day of month
Month
Kind of place Name of place Floor
Room number
Geography
Capital of the Philippines, some provinces
Knowledge of current events
Calculation
5+6= 12 + 9 = 15 + 16 = 79 + 12 =
7–2= 12 – 4 = 30 – 13 = 100 – 17 =
3x2= 7x6= 8x9= 1 x 11 =
Problems
50 + 25 + 10 + 05 + 03 =
6 mangoes cost 54 cents, cost of 9 mangoes
3 packs of cigarettes at 27 cents each – change from $1.00
V. Response to Request to
Close eyes
Raise hands
Touch your nose
Put ______ hand on ______ear
Put ______little finger on _____ knee
Put ______little finger on tip of nose and _____ thumb on _____ear
VI. Digit Span (Give each number once, at one digit per second without grouping. Continue
until patient fails digit or order of 2 numbers of some length)
Four things to recall: Blue, 75, Glass, Park (repeated until patient knows them)
Story:
Yesterday St. Joseph’s school burned down. Fortunately no children were in the school
at the time and 3 firemen were overcome with smoke and were brought to the ST. Luke’s
Hospital. (17 items underlined)
VII. Reading
The one best friend a man can have is his dog. The dog is faithful and true. When the day
is done he will curl up at your feet and sleep, content in the knowledge that you are his
friend as well. (25 items underlined)
VIII. Write
Name
Spontaneous writing of 8 – 10 word sentence
Dictation: Today is a lovely day in __________
I hope that doctor will make me well soon.
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Copy: This is the way I write today.
IX. Drawing
Circle Square Triangle
Clock with all the numbers and the hands at 7:20
Copy interlocking pentagon
XIII. Proverbs
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Appendices
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Figure 2. Brodmann Areas
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CRANIAL NERVE EXAMINATION
(Adapted from DeMyer, 6th ed.)
Cranial Nerve II: Optic Nerve (Adapted from the 8-part Eye Examination c/o Ophthalmology Department)
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a. Materials: Pocket Snellen or Jaegger chart, Ophthalmoscope
b. Procedure – visual acuity, confrontational visual field testing, fundoscopic examination
Visual Acuity
Visual acuity refers to an angular measurement relating testing distance to the minimal
object size resolvable at that distance. The traditional measurement of distance acuity
refers to a visual test in which a target subtends a visual angle of 5 minutes of arc when a
subject is 20 feet away from the target. The most basic types of vision are the distance
and near visual acuity tests. Even though they test two different aspects of fine-detail
central vision, both tests share some conventions, such as the use of corrective lenses
and an established order for testing each eye.
PH OD
OS
36 | P a g e
1. With the patient wearing the habitual corrective lens for near and the near card
evenly illuminated, instruct the patient to hold the test card at the distance
specified on the card (usually 14 inches).
2. Ask the patient to occlude the poorer eye or the eye in complaint.
3. Ask the patient to say each letter or read each word on the line of smallest
characters that are legible on the card .
4. Record the acuity value for each eye separately in the patient's chart.
5. Repeat the procedure with the right eye occluded and the left eye viewing the
test chart
6. Repeat the procedure with both eyes viewing the test card
7. Record the binocular acuity achieved:
J OD _________
OS _________
The visual fields are routinely screened with the confrontation fields test. If macular
disease is suspected to be causing a central field visual field defect, a device called an
Amsler grid is used to test the central area of each eye’s visual field. If a visual defect is
detected by screening, further evaluation is conducted by manual or automated
procedures known as perimetry. For our purposes, we shall focus mainly on the screening
procedures.
1. Seat the patient and make sure the eye not being tested is occluded.
2. Seat yourself facing the patient at a distance of about 50 cm. Close your eye that
is directly opposite the patient’s occluded eye.
3. Ask the patient to fixate on your nose.
4. Finger movement. Test one eye at a time. Have the patient cover the other eye.
Hold up your left index finger at the inferior temporal quadrant, outside your own
peripheral visual field. Wiggle your finger and slowly move it toward the central
field of vision. Instruct the patient to say “Now” or “I can see it” as soon as he/she
sees the wiggling finger. Try to match the perimeter of the Pt’s visual field against
your own. Test all quadrants of each eye separately, each time starting at the limit
of the field. Perform the test on the other eye. Record your results.
5. Finger counting. After estimating the patient’s visual field, you can further test
the patient by asking the patient to count the number of fingers presented in each
of the four quadrants of the visual field. Test one eye at a time and instruct the
37 | P a g e
patient to cover the other eye. Start by holding your finger at the outer edge of
the patient’s visual field in the same manner as the initial testing. Next, randomly
hold up 1, 2 or 5 fingers in each of the four quadrants and instruct the patient to
identify the number of fingers seen. Perform the test on the other eye. Record
your results.
a. Test patients who have marked visual loss by waving your hand in each
quadrant individually and asking if the patient perceives the motion.
b. With patients who can only perceive light, test in each quadrant
individually for the ability to correctly determine the direction of light
projection by pointing a transilluminator or penlight toward the pupil
while keeping the patient’s other eye completely shielded.
2. Simultaneous finger counting. Present fingers simultaneously in opposite
quadrants, asking the patient to state the total number, using the following
combinations: 1 and 1, 1 and 2, and 2 and 2. This test can reveal a more subtle
field defect than finger counting in each quadrant separately.
Fundoscopic Examination
Examination of the eye posterior to the ciliary body and lens is important in assessing
overall ocular health and in diagnosing and monitoring specific optic nerve, retinal,
neurologic and systemic disorders. Ophthalmoscopy is the examination of the posterior
segment of the eye, performed with an instrument called the ophthalmoscope. The bright
lights that are used also mean that ophthalmoscopy should follow visual acuity
measurement.
The direct ophthalmoscope is a handheld instrument that consists of a handle and a head
with a light source, a peephole with a range of built-in dial-up lenses and filters, and a
reflecting device to aim light into the patient’s eye. It has a magnification of 15x and
provides an erect, virtual image of the retina. Its field of view is about 5 degrees and it
does not provide stereopsis.
38 | P a g e
5. Find the optic disc by following retinal blood vessels as they converge. The arrows
formed by vascular bifurcations point to the optic disc. Depending on the patient’s
refraction, the entire disc or only a portion of it will be visible in anyone view. Assess
the AV ratio and the cup:disc ratio. Look for venous pulsations.
6. From the optic disc, follow the optic disc outward to examine the superonasal,
inferonasal, inferotemporal and superotemporal areas around the posterior pole.
Note the vascular color, caliber, bifurcations, crossings and the surrounding
background. Take note of hemorrhages and exudates if present.
7. Examine the macular area for any irregularities.
8. Repeat steps 1-8 on the other eye.
Pupillary Examinations
The pupil is the window of the inner eye, through which light passes to reach retinal
photoreceptors. Because of its potential to reveal serious neurologic or other diseases,
examination of the pupil is an important element of a thorough ophthalmic evaluation. Pathologic
disorders can alter the size, shape, and location of the pupil, as well as the way the pupil reacts to
light and near-focus stimulation.
Eye movements can be monocular (one eye only) or binocular (both eyes together). Monocular
eye movements are called ductions and six terms are used to describe them:
Binocular eye movements are described as versions or vergences. Versions are normal binocular
eye movements in the same direction. (example: to the right, to the left, etc..) One muscle of each
eye is primarily responsible for the movement of that eye into a particular field of gaze. These two
simultaneously acting muscles are called yoke muscles, and their movement is said to be conjugate,
that is, they work at the same time to move the two eyes in the same direction. The six positions of
gaze in which yoke muxcles act together are known as the cardinal positions of gaze. They are right
40 | P a g e
and up, right, right and down, left and up, left, left and down. Vergences on the other hand are normal
disconjugate binocular eye movements in which eyes move in opposite directions.
The two primary types of vergences routinely evaluated are convergence. (the movement of both
eyes nasally), and divergence, (the movement of both eyes temporally). Binocular eye movements are
described as versions or vergences. Versions are normal binocular eye movements in the same
direction. (example: to the right, to the left, etc..) One muscle of each eye is primarily responsible for
the movement of that eye into a particular field of gaze. These two simultaneously acting muscles are
called yoke muscles, and their movement is said to be conjugate, that is, they work at the same time
to move the two eyes in the same direction. The six positions of gaze in which yoke muscles act
together are known as the cardinal positions of gaze. They are right and up, right, right and down, left
and up, left, left and down. Vergences on the other hand are normal disconjugate binocular eye
movements in which eyes move in opposite directions. The two primary types of vergences routinely
evaluated are convergence (the movement of both eyes nasally), and divergence, (the movement of
both eyes temporally).
Figure 1.
(from Demyer’s Techniques of Neurological Examination 6th ed.)
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Testing for Corneal Reflex (Afferent: Cranial Nerve V; Efferent: Cranial Nerve VII)
1. Test the corneal reflex using a wisp of cotton. Ask the patient to look to one side and a little
bit up. Approaching laterally, touch the cornea at the area of the corneo-scleral junction, and
observe for the eye to blink. Bring the cotton directly in from the side to avoid entering the
field of vision. That would cause a visually mediated flinch, not a corneal blink reflex .
2. Repeat this on the other eye.
43 | P a g e
(from DeMyer, 6th edition)
Testing for taste (anterior 2/3 of the tongue) – usually indicated if the patient presents with
peripheral facial palsy
Materials: Test substance (salt solution and sugar solution); cotton pledgets
Procedure:
1. Ask the patient to gargle with tap water to wash away any substances that may interfere
with the test substance. . Tell the Pt, “I want to place something on your tongue for you
to taste. Stick out your tongue and keep it out. When you recognize the taste, hold up
your hand.”
2. Place the test solution with a cotton pledget or applicator stick on the right or left half of
the patient’s tongue. Do not allow the patient to return the tongue to the mouth because
the saliva will diffuse the taste stimulus beyond the area selected for testing. Allow 15 to
20 seconds for the substance to dissolve and for the patient to respond. Take note
whether the patient identifies the taste correctly or not.
3. Ask the patient to repeat steps 1 and 2 on the untested half of the tongue.
4. Record your results.
Screening test
• Do otoscopy to ensure that the external auditory canals are open and that the eardrums are
normal
• Rubbing of fingers – a normal person should be able to hear the sound of rubbing fingers if placed
near the ear.
• Present a vibrating tuning fork to each ear and ask the Pt to compare the loudness.
• If the history suggests a cerebral lesion, test for auditory inattention to bilateral simultaneous
stimuli and sound localization by finger rustling (
44 | P a g e
Procedure:
i. Explain the procedure to the patient.
ii. Place the vibrating tuning fork in on the middle of the patient’s forehead or the vertex of
the skull
iii. Ask the patient if the sound is louder on one side or is heard midline.
iv. Record your results.
Se
Co
ns
nd
ori
uc
ne
tiv
ura
e
l
Test He
He
ari
ari
ng
ng
Lo
Los
ss
s
To
AB
To
N
NO
OR
Lateralization on Weber Test RM
M
AL
AL
ear
ea
r
45 | P a g e
AC
>B
C BC
Rinne but >A
dec C
rea
sed
46 | P a g e
4. Place your hands on both of the patient’s shoulders and press down. Observe from
the front and back and watch for scapular winging.
MOTOR EXAMINATION
In doing the motor examination, it is important to note the following points:
1. Strength
• Check both distal and proximal muscles
2. Tone
• Hypertonia: commonly seen in subacute or chronic corticospinal lesions
• Hypotonia: commonly seen in LMN lesion or acute UMN lesions
• Rigidity: commonly seen in basal ganglia disease
3. Bulk
• Wasting and extensive atrophy correlates with LMN abnormality
47 | P a g e
4. Fasciculations, tremors or involuntary movements
5. Tenderness: common finding in metabolic/inflammatory muscle disease
6. Grading
0 No muscle contraction is detected
1 A trace contraction is noted in the muscle by palpating the muscle while the patient attempts
to contract it.
2 The patient is able to actively move the muscle when gravity is eliminated.
3 The patient may move the muscle against gravity but not against resistance from the examiner.
4 The patient may move the muscle group against some resistance from the examiner.
5 The patient moves the muscle group and overcomes the resistance of the examiner. This is
normal muscle strength.
Procedure:
1. Note the position of the body that the patient assumes when sitting on the examination table.
2. Proceed in an orderly manner from the rostro-caudal direction. Start with the face, neck,
shoulders, arm, forearm, hand, chest, abdomen, thigh, leg, foot and toe sequence. Always
compare the right and the left sides of the body.
3. Test the flexor strength of the patient’s neck. To test neck flexion, place one hand on the patient’s
forehead and the other hand on the patient’s chest to provide bracing and counter pressure. Start
with the patient’s head strongly extended. Then, ask the patient to flex his neck and push against
your hand on his forehead.
4. Test the extensor strength of the patient’s neck. To test neck extension, place one hand on the
patient’s occiput and the other hand on the patient’s back to provide bracing and counter
pressure. Start with the patient’s head flexed, with the chin on the neck. Then, ask the patient to
extend his neck and push against your hand
5. Testing for pronator drift: Ask the patient to extend and raise both arms stretched out in front of
them. Ask the patient to keep their arms in place while they close their eyes and count to 10.
Watch for pronator drift.
6. To test for shoulder flexion, ask the patient to extend and raise both arms stretched out in front
of them. Push down on the proximal or distal part of the arms as the patient tries to resist.
7. To test for shoulder extension, ask the patient to extend and raise both arms stretched out in
front of them. Push down on the proximal or distal part of the arms as the patient tries to resist.
8. To test for shoulder abduction, ask the patient to hold the arms straight out to the sides. Push
down on the proximal or distal part of the arms as the patient tries to resist.
9. To test for shoulder adduction, ask the patient to hold the arms straight out to the sides. Push up
on the proximal or distal part of the arms as the patient tries to resist.
10. To test for internal rotation of the shoulder, ask the patient to raise his elbow so that the upper
arm is perpendicular to body, with forearm upright. Keeping the elbow in place, ask the patient
to rotate the shoulder so that the forearm and hand move downward to the ground. As the
48 | P a g e
patient does this, place your hand under the forearm and resist the patient’s downward
movement.
11. To test for external rotation of the shoulder, ask the patient to raise his elbow so that the upper
arm is perpendicular to body, with forearm parallel to the ground. Keeping the elbow in place, ask
the patient to rotate the shoulder so that the forearm and hand move upward perpendicular to
the ground. As the patient does this, place your hand on top of the forearm and resist the patient’s
upward movement.
12. To test elbow flexion, ask the patient to tightly flex the right forearm. The examiner’s left hand
braces the patient’s right shoulder while the right hand grasps the patient’s right wrist. Ask the
patient to resist and maintain elbow flexion as you try to extend the forearm. Do the same for the
patient’s left, using your left hand to grasp the wrist.
13. To test elbow extension, ask the patient to tightly flex the right forearm. The examiner’s left hand
braces the patient’s right shoulder while the right hand is placed under the patient’s right forearm.
Ask the patient to extend the elbow and push his forearm against your hand. Do the same for the
left, using your left hand to push against the patient’s let forearm.
14. To test wrist flexion, ask the patient to make a fist and flex the fist. With your fingers, hold the
patient’s fist and ask the patient to resist your effort to extend his fist.
15. To test wrist extension, ask the patient to hold his hand and extend the wrist. Place your palm
over the knuckles of the hand and ask the patient to resist the effort as you try to flex his wrist or
push his wrist downward.
16. To test finger flexion, test the patient’s grip by having the patient your fingers in their fist tightly
and instruct them not to let go you attempt remove them.
17. To test finger extension, ask the patient to hold out his hands with palms facing down and fingers
hyperextended. Examine the extensor strength of the patient’s fingers by asking him to maintain
finger extension by resisting your efforts to flex the finger. Match the strength of the patient’s
fingers using your corresponding fingers.
18. To test finger abduction and adduction, test the intrinsic hand muscles having the patient abduct
or “fan out” all of his fingers. Test each of the patient’s fingers by using your corresponding fingers
(patient’s index finger to examiner’s index finger, etc.). Ask the patient to push against your finger
as you push against his finger. Perform the maneuver or both sides, this way you can test finger
abduction and adduction
19. Test the strength of the thumb opposition by telling the patient to touch the tip of their thumb to
the tip of their pinky finger and ask the patient to resist your efforts to pry the fingers open..
20. Test radial abduction of the thumb. If the palm in horizontal, ask the patient to move his thumb
outward. If the palm is vertical, ask the patient to move his thumb upward. Then, instruct the
patient to resist your effort to move his thumb towards the palm.
21. To test palmar abduction, ask the patient to hold his palm up horizontal against the floor. Then,
instruct the patient to move the thumb 90 degrees upward such that the thumb is pointing up.
Ask the patient to resist your effort to move his thumb towards the palm.
49 | P a g e
22. To test hip flexion, ask the patient to lift the knee upwards and to try to resist your efforts as your
hand attempts to push the knee back down.
23. Test the extension of the hip by instructing the patient to press down on the examiner’s hand
which is placed underneath the patient’s thigh.
24. Test the adduction of the legs by placing your hands on the medial sides of the patient’s knees
and asking them to bring both legs together against your effort to push the knees apart.
25. Test the abduction of the legs by placing your hands on the lateral sides of the patient’ s knees
and asking the patient to move their knees laterally apart against your effort to push the knees
together.
26. With the hip and knee flexed at 90( ﹾpatient seated), test internal rotation of the knee by grasping
the ankle and asking the patient to abduct the ankle.
27. With the hip and knee flexed at 90( ﹾpatient seated), test external rotation of the knee by
grasping the ankle and asking the patient to adduct the ankle.
28. With the knee flexed at 90ﹾ, test flexion of the knee by grasping the patient’s ankle and asking
the patient to resist your efforts to straighten the leg
29. Test extension of the knee by grasping the patient’s ankle and asking the patient to straighten the
leg and resist your efforts as you try to flex the knee.
30. Test dorsiflexion of the ankle by placing your hand on top of the patient’s foot and asking the
patient to pull the foot up towards their face as hard as possible against your resistance.
31. Test plantar flexion of the ankle by placing your hand beneath of the patient’s foot and asking the
patient to press down (as if ‘’stepping on a gas pedal”) as hard as possible against your resistance.
32. Inversion is inward rotation of the foot. Test for ankle inversion by asking the patient to rotate
the foot inward such that the medial side of the ankle elevates.
33. Eversion is the outward rotation of the foot. Test for ankle eversion by asking the patient to rotate
the foot outward such that the lateral side of the ankle elevates.
34. Test for toe flexion by placing your finger beneath the patient’s big toe and asking the patient to
bend the toe against the resistance of your finger.
35. Test for toe extension by placing your finger on top of the patient’s big toe and asking the patient
to move the toe up (towards his face) against the resistance of your finger.
SENSORY EXAMINATION
The general senses tested in the Standard Neurological Examination (NE) consist of touch, pain,
temperature, position, vibration, and stereognosis. The history determines how far to extend the sensory
examination. For screening purposes, test only the dorsum of the hands and feet, in addition to the face.
50 | P a g e
A patient may manifest with a “spinal level” or a complaint of changes in sensory perception along a
dermatomal level and this warrants a more thorough testing of the different modalities of pain, light
touch and temperature. Refer to the dermatomal map of the human body and test the patient along these
levels to determine the most likely area where the deficit begins.
When testing for the different sensory modalities, test the right and the left side separately and
compare the results. Ask the patient regarding the quality of the sensation and quantify if the sensations
are equal. If unequal, ask the patient to quantify the degree of impairment on the abnormal side.
You can also test vibration sense by placing a vibrating the tuning fork near the nailbed of the
patient’s index finger. Place the finger pad of your index finger underneath the patient’s finger and ask
him to immediately report when the vibration stops or when he is unable to appreciate the vibration.
51 | P a g e
Normally, the examiner and the patient will have almost similar timing of cessation of vibration. Record
your results. Repeat the examination of the opposite index finger and on both big toes.
Two-point discrimination can be tested with a special pair of calipers, or a bent paper clip,
alternating randomly between touching the patient with one or both points. The patient should be able
to determine or discriminate the presence of two points at a certain distance, as follows: 2-4 mm on the
fingertips, 4-6mm on the dorsum of the fingertips, 8-12 mm on the palm, 20-30 mm on the dorsum of the
hand.
Examination of Graphesthesia
To test graphesthesia, ask the patient to close their eyes and identify letters or numbers that are
being traced onto their palm or the tip of their finger. Use any blunt tip, such as the cap end of a ballpoint
pen or the tip of the handle of the neuro hammer.
Examination of Stereognosis
To test stereognosis, ask the patient to close their eyes and identify various objects by touch using
one hand at a time.
Test also for tactile extinction on double simultaneous tactile stimulation. Instruct the patient to
close his eyes. Using a wisp of cotton or the fingers, the examiner lightly touches the patient’s cheeks, one
side at a time and asks which side is being touched. Next, both cheeks are touched. The patient should be
able to perceive both stimuli and answers. The procedure is repeated for the hands and feet. The examiner
may repeat the test several times to ascertain if the patient has tactile inattention to simultaneous
bilateral stimuli (double simultaneous stimulation)
52 | P a g e
REFLEXES
REFLEXES GRADING
very brisk, hyperactive; often indicative of disease; often
4+ associated with clonus (rhythmic oscillations between flexion and
extension)
brisker than average; possibly but not necessarily indicative of
3+
disease
2+ average; normal
1+ somewhat diminished; low normal
0 no response
b. Triceps: The triceps reflex is measured by striking the triceps tendon directly with the
hammer while holding the patient’s arm with your other hand.
c. Brachioradialis
d. Patella: With the lower leg hanging freely off the end of the chair, the “knee-jerk”
reflex is tested by striking the patellar tendon directly with the reflex hammer.
54 | P a g e
e. Achilles: The ankle reflex is elicited by holding the relaxed foot with one hand and
striking the Achilles tendon with the hammer and noting plantar flexion.
Babinski Variants
55 | P a g e
Chaddock The skin under and around the lateral malleolus is stroked in a circular fashion. The
stimulus may also be carried forward from the heel to the small toe.
Bing The dorsum of the big toe is pricked with a pin. The big toe withdraws into the pin when
abnormal, as opposed to being flexed away from the stimulus when normal.
Oppenheim apply heavy pressure to the anterior surface of the tibia, stroking down to the ankle
Gonda- Pull the fourth toe outward and downward for a brief time and release suddenly
Stransky
b. Hoffman’s sign
• “Babinski of the upper extremity”
• Procedure: The Hoffman response is elicited by holding the patient's middle finger between the
examiner's thumb and index finger. Ask the patient to relax their fingers completely. Once the
patient is relaxed, using your thumbnail press down on the patient's fingernail and move
downward until your nail "clicks" over the end of the patient's nail. The extension of the phalanx
stretches the flexor muscles, causing the fingers and thumb to flex.
c. Myerson’s sign
• Patient is unable to resist blinking when tapped on the glabella, the area above the nose and
between the eyebrows
• early sign of Parkinson’s disease
d. Clonus
• Clonus is a rhythmic oscillation of a body part, elicited by a quick jerk.
• Test clonus if any of the reflexes appeared hyperactive. Hold the relaxed lower leg in your hand,
and sharply dorsiflex the foot and hold it dorsiflexed. Feel for oscillations between flexion and
extension of the foot indicating clonus.
• To elicit wrist clonus, simply jerk quickly up on the patient’s hand.
CEREBELLAR EXAMINATION
Materials: None
56 | P a g e
(adapted from De Myer’s Techniques of Neurological Examination, 6th ed.)
Examination of Nystagmus
1. Ask the Pt look straight ahead and place your index fingers in the temporal fields. Ask the Pt to
look first at one finger and then the other and then ask the patient to look rapidly from one to the
other several times. Observe for the presence of jerky movements instead of smooth pursuit.
57 | P a g e
3. Examination of dysdiadochokinesia
• Instruct the patient to hold out his hands. Ask him to pronate and supinate the left hand over
the right palm as rapidly as possible. Repeat the procedure over the left hand. Test the hands
separately and together. The dystaxic hand overshoots one time, undershoots the next, and is
slower than normal.
• The “thigh-patting test” is another method to test for the presence of dysdiadochokinesia.
Instruct the patient to alternately slap the palm and back of the hand on the thigh, as rapidly
and rhythmically as possible. Make sure there is an audible spund heard with each pat. Test
each hand separately and then together. The examiner then sees and hears the slow rate and
dysrhythmia of the ataxic hand.
Examination of Hypotonia
1. At rest, the hypotonic patient assumes floppy postures and joint positions uncomfortable for a
normal subject—rag-doll or dumped-in-a-heap postures. In a normal person, muscle tone helps
to limit joint excursions. (Demyer, 2011)
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2. When walking, the hypotonic Pt presents a floppy, sagging, loose-jointed appearance. The arms
fail to swing properly, the knees may bend backward slightly (genu recurvatum), and the head
and trunk bob—a rag-doll gait, as seen in drunkenness. (Demyer 2011)
MENINGEAL EXAMINATION
Materials: None
Procedure:
1. Kernig’s Sign: performed with the patient supine and the hips and knees flexed. Knees are then
extended, and pain upon extension of the knees past 135 degrees indicates a positive Kernig’s
sign.
2. Brudzinski’s Sign: performed with the patient supine, the physician’s hand behind the patient’s
head, and his other hand on the patient’s chest. Flexing the patient’s neck will cause the patient
to flex his knees and hips, indicating a positive Brudzinski’s sign.
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PRINCIPLES OF LOCALIZATION
By: Dr. Rene Punsalan
LOCALIZATION
• It is a diagnostic exercise of determining from the signs (most often) or symptoms of the patient what
site of the nervous system has been affected by a certain disease process
• It is the determination of where in the nervous system the damage (~lesion) has occurred
A. APPROACH TO DIAGNOSIS
1) Data Gathering: Patient history , General physical examination (PE), Neurologic examination (NE)
2) Anatomic Localization
a) “WHERE is the lesion located?”
b) Can be one specific location, be multifocal, or be part of a diffuse process
3) Etiologic Diagnosis
a) “What is the NATURE of the lesion?”
B. BENEFITS OF LOCALIZATION
1. Localization directs diagnostic work-up
• The symptoms should direct the physician as to the appropriate diagnostic test to order
2. Limits the differential diagnosis
• In turn, this would also limit the diagnostic work-up
3. Estimates the extent / size of the lesion
4. May suggest the etiologic diagnosis
• Guards against going straight to a specific etiologic diagnosis
C. STEPS IN LOCALIZATION
1. List ALL abnormal neurologic signs
2. Determine ALL possible neuroanatomic correlates per sign
3. Find the “intersection”
D. LEVELS OF LOCALIZATION
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1. Meninges and cerebrospinal fluid (CSF)
2. The brain
(a) Supratentorial structures (above the tentorium cerebelli)
• Cerebral hemispheres
• Basal nuclei (found within the substance of the cerebral hemispheres)
• Diencephalon (thalamus, hypothalamus, subthalamus, & epithalamus)
3. Location:
(a) Intra-axial / Intramedullary: (within the substance of the brain or spinal cord,
respectively)
• e.g. Intraparenchymal hemorrhage or infarct, brain tumor (such as glioma)
• Is it focal: Cerebrum? Ventricular cavities or passage ways? Basal nuclei / ganglia?
Brainstem, cerebellum, or SC?
• Is it multifocal or diffuse?
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
Aurora Boulevard, Quezon City
NEUROLOGY I and II Preceptorials
School Year 2018-2019
REMINDERS TO STUDENTS
1. The students’ evaluation sheet will be kept by the preceptor. If questions arise regarding their
grades, the preceptors will show the evaluation sheet for reference.
2. Allowable absence for any student is 20% of the total required class hours. An absent student
must present an excuse letter from the Infirmary. More than 20% of absence means an
incomplete grade. The student will have to make arrangements with the preceptor for
completion.
NOTE:
The highest grade that can be given to a student is 94 and the lowest is 75.
4. In cases where the preceptor will be late for class, students should not leave the classroom
until the first third fraction of the scheduled class has passed.
62 | P a g e
University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY I Preceptorials
School Year 2018-2019
Date
Grading System
1. Attendance (15%)
2. Return Demonstration (65%)
- Complete Pertinent Neurological
Examination
3. Participation in Preceptorials (20%)
TOTAL GRADE
With my knowledge:
____________________________ ________________________________
Student’s Signature/Date Preceptor’s Signature/Date
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY I Preceptorials
School Year 2018-2019
Criteria 4 3 2 1 Total
Student is punctual Student is present Student is present Student is absent for
and present for but less than 15 but more than 15 preceptorial class
Attendance
preceptorial class minutes late for minutes late for
preceptorial class preceptorial class
Student always has Student usually Student rarely has Student never
something RELEVANT has something something contributes any
to contribute to the RELEVANT to RELEVANT to relevant and
Level Of Engagement
group discussion by contribute to the contribute to the substantial data to the
In Small Group
sharing ideas, asking group discussion group discussion by group discussion by
Discussions
questions, or making by sharing ideas, sharing ideas, asking sharing ideas, asking
plans. asking questions, questions, or questions, or making
or making plans. making plans. plans.
Student listens when Student listens Student does not Student does not
others talk and when others talk. listen when others listen when others
Listening Skills incorporates or talk. talk and often
builds off of the ideas interrupts when
of others. others speak.
Student is very fluent Student shows Average fluency – Student has poor
– speaks in a clear, good command of speaks in a verbal fluency --
concise, well- the English reasonably generally finds
Verbal Communication
organized manner. language -- better organized manner; difficulty in expressing
Skills
than average sometimes fails to his/her thoughts.
ability to get his get points across
ideas across. well.
Student ALWAYS Student MOST OF Student Student NEVER shows
shows respect and THE TIME shows OCCASIONALLY respect and
professionalism in respect and shows respect and professionalism in
Behavior dealing with peers, professionalism in professionalism in dealing with peers,
preceptors and dealing with dealing with peers, preceptors and
patients peers, preceptors preceptors and patients
and patients patients
Student is almost Student is usually Student is rarely Student is never
Preparation for always prepared for prepared for prepared for prepared for
Preceptorial Class preceptorial case preceptorial case preceptorial case preceptorial case
discussions discussions discussions discussions
Total
64 | P a g e
University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY II Preceptorials
School Year 2018-2019
Date
Grading System
4. Attendance (15%)
5. Case Presentation (65%)
- Complete Neurologic History
- Complete Pertinent PE and NE
- Temporal Profile
- Neurologic Localization
- Case Discussion (Etiologic diagnosis
and differential diagnosis)
6. Participation in Preceptorials (20%)
TOTAL GRADE
With my knowledge:
____________________________ ________________________________
Student’s Signature/Date Preceptor’s Signature/Date
65 | P a g e
University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Criteria 4 3 2 1
Total
Written patient Written patient Written patient Written patient
history is history is adequate history shows history is incomplete
History Taking
comprehensive and but shows some numerous and inaccurate
accurate inconsistent data inconsistent data
Written clinical Written clinical Written clinical Written clinical
examination is examination is examination is examination is
Clinical
comprehensive and Comprehensive numerous incomplete and
Examination
accurate but shos some inaccurate data inaccurate
inaccurate data
Case analysis is Case analysis Case analysis Case analysis is
adequate, shows shows numerous inadequate and
Analysis of Case comprehensive and inadequacies inadequacies reflects poor critical
(Case Discussion) reflects critical thinking of the
thinking of the student
student
Writes exceedingly Writes very well, Writes reasonably Poor written
well; thoughts clear rarely requiring well, requiring communication skills;
Written and well-organized; rework in syntax or rework both in manifests difficulty in
Communication no grammar and grammar, work grammar and organizing thoughts,
Skills syntax (sentence organized and syntax; some as well as syntax and
construction) lapses clear thoughts are not gramma problems
expressed clearly
Total
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY II Preceptorials
School Year 2018-2019
Criteria 4 3 2 1 Total
Student is punctual Student is present Student is present Student is absent for
and present for but less than 15 but more than 15 preceptorial class
Attendance
preceptorial class minutes late for minutes late for
preceptorial class preceptorial class
Student always has Student usually Student rarely has Student never
something RELEVANT has something something contributes any
to contribute to the RELEVANT to RELEVANT to relevant and
Level Of Engagement
group discussion by contribute to the contribute to the substantial data to the
In Small Group
sharing ideas, asking group discussion group discussion by group discussion by
Discussions
questions, or making by sharing ideas, sharing ideas, asking sharing ideas, asking
plans. asking questions, questions, or questions, or making
or making plans. making plans. plans.
Student listens when Student listens Student does not Student does not
others talk and when others talk. listen when others listen when others
Listening Skills incorporates or talk. talk and often
builds off of the ideas interrupts when
of others. others speak.
Student is very fluent Student shows Average fluency – Student has poor
– speaks in a clear, good command of speaks in a verbal fluency --
concise, well- the English reasonably generally finds
Verbal Communication
organized manner. language -- better organized manner; difficulty in expressing
Skills
than average sometimes fails to his/her thoughts.
ability to get his get points across
ideas across. well.
Student ALWAYS Student MOST OF Student Student NEVER shows
shows respect and THE TIME shows OCCASIONALLY respect and
professionalism in respect and shows respect and professionalism in
Behavior dealing with peers, professionalism in professionalism in dealing with peers,
preceptors and dealing with dealing with peers, preceptors and
patients peers, preceptors preceptors and patients
and patients patients
Student is almost Student is usually Student is rarely Student is never
Preparation for always prepared for prepared for prepared for prepared for
Preceptorial Class preceptorial case preceptorial case preceptorial case preceptorial case
discussions discussions discussions discussions
Total
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY I OSCE
School Year 2018-2019
PARAMETERS SCORE
TASK 3 2 1 0
Speed, style and Speed, style and Examination done Examination was
technique are technique are is appropriate, but not done OR is
CLINICAL TASK adequate adequate with is clumsy and inappropriate for
(3 points) minor deficiencies confused; slow, what the task
unsure and with required
major deficiencies
TOTAL SCORE
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
NEUROLOGY II OSCE
School Year 2018-2019
PARAMETERS SCORE
TASK 3 2 1 0
Speed, style and Speed, style and Examination done Examination was
technique are technique are is appropriate, but not done OR is
CLINICAL TASK adequate adequate with is clumsy and inappropriate for
(3 points) minor deficiencies confused; slow, what the task
unsure and with required
major deficiencies
TOTAL SCORE
PARAMETERS SCORE
TASK 3 2 1 0
Laterality and Laterality given is Laterality given in No answer given
Localization given Correct but CORRECT but OR Laterality and
are both Localization is Localization given Localization given
NEUROLOGIC
CORRECT INCOMPLETE or in INCORRECT OR are INCORRECT
LOCALIZATION
PARTIALLY Laterality is
(3 points) CORRECT INCORRECT but
Localization is
CORRECT
TASK 2 1 0
Etiologic diagnosis Etiologic diagnosis No Answer is
given is CORRECT given is CORRECT given or Answer is
ETIOLOGIC DIAGNOSIS
and COMPLETE but INCOMPLETE COMPLETELY
(2 points) or PARTIALLY INCORRECT
CORRECT
TOTAL SCORE
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
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IX, X Observing the uvula and palate
Gag reflex
Taste over the posterior 1/3 of the tongue
XI Testing the sternocleidomastoid
Shoulder shrug
XII Examination of the tongue atrophy, fasciculation, deviation, strength against cheek
Articulation
MOTOR
Shoulder Flexion, Extension, Adduction, Abduction, Internal Rotation, External Rotation
Elbow Flexion, Extension
Wrist Flexion, Extension, Pronation, Supination
Thumb Radial abduction, palmar abduction, opposition
Hip Flexion, Extension, Adduction, Abduction, Internal Rotation, External Rotation
Knee Flexion, Extension
Ankle Flexion, Extension, Inversion, Eversion
Big toe Toe (Flexion, Extension )
Walking on heels and toes
MUSCLE TONE
SENSORY
Spino- Touch
thalamic Pain
Temperature
Posterior Position sense
Column Vibratory sense
Graphesthesia
Stereognosis ( coin, key, R and L )
Two-point discrimination
Romberg’s
Double simultaneous stimulation
CEREBELLAR
Coordination (finger to nose, alternating pronation supination, check reflex, , heel to shin, tibial tapping)
Gait ( natural, tandem walk along a straight line )
Nystagmus
Hypotonia
REFLEXES
DTRs
Biceps, Triceps, Brachioradialis, Knee (Patellar), Ankle
OTHER REFLEXES ( glabellar, suck, snout, palmomental superficial abdominal, cremasteric, grasp)
Babinski
Clonus
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University of the East
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, Inc.
(UERMMMCI)
Aurora Boulevard, Quezon City
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VII Observe for the symmetry of movements or the presence of weakness for the ff. facial movements:
1. Wrinkle your forehead
2. Look up at the ceiling
3. Close your eyes and don’t let me open them
4. Show me your smile/show me your teeth
5. Puff out your cheeks
6. Pucker your lips
7. Pull down hard on the corners of your mouth
Taste over the anterior 2/3 of the tongue
VIII Gross hearing –rubbing hair with fingers
Weber test
Rinne test
IX, X Observing the uvula and palate
Gag reflex
Taste over the posterior 1/3 of the tongue
XI Testing the sternocleidomastoid
Shoulder shrug
XII Examination of the tongue atrophy, fasciculation, deviation, strength against cheek
Articulation
MOTOR
Shoulder Flexion, Extension, Adduction, Abduction, Internal Rotation, External Rotation
Elbow Flexion, Extension
Wrist Flexion, Extension, Pronation, Supination
Thumb Radial abduction, palmar abduction, opposition
Hip Flexion, Extension, Adduction, Abduction, Internal Rotation, External Rotation
Knee Flexion, Extension
Ankle Flexion, Extension, Inversion, Eversion
Big toe Toe (Flexion, Extension )
Walking on heels and toes
MUSCLE TONE
SENSORY
Spino- Touch
thalamic Pain
Temperature
Posterior Position sense
Column Vibratory sense
Graphesthesia
Stereognosis ( coin, key, R and L )
Two-point discrimination
Romberg’s
Double simultaneous stimulation
CEREBELLAR
Coordination (finger to nose, alternating pronation supination, check reflex, , heel to shin, tibial tapping)
Gait ( natural, tandem walk along a straight line )
Nystagmus
Hypotonia
REFLEXES
DTRs
Biceps, Triceps, Brachioradialis, Knee (Patellar), Ankle
OTHER REFLEXES ( glabellar, suck, snout, palmomental superficial abdominal, cremasteric, grasp)
Babinski
Clonus
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APPENDIX
MINI-MENTAL STATUS EXAMINATION – screening tool for memory loss
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Montreal Cognitive Assessment (MoCA) - screening tool for memory loss
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MOCA (FILIPINO VERSION)
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Glasgow Coma Score
References
Teasdale G, Jennett B. Assessment of coma and impaired consciousness. Lancet 1974; 81-84.
Teasdale G, Jennett B. Assessment and prognosis of coma after head injury. Acta Neurochir 1976; 34:45-
55.
www.neuroexam.com/neuroexam
Adam’s Principles of Neurology
DeMyer
Clinical Neurology through Clinical Cases
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CLINICAL CASES FOR LOCALIZATION
Neurology I
CASE 1
A 70-year-old man woke up one morning and could not move his right arm or hand. He had trouble
trying to speak to his wife, but could understand her questions and follow her directions. At the hospital,
neurological exam revealed the following abnormalities:
• paralysis of right lower face muscles (but he could wrinkle his forehead on both sides)
• 3/5 motor paralysis and hyperreflexia of right hand and arm
• mild sensory loss (both modalities) in right hand, arm and face
• decreased verbal output, intact comprehension, impaired naming and impaired repetition
• Preferential gaze to the left
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CASE 2
A 65-year-old womman with a history of poorly controlled hypertension woke up and fell on the floor
as she tried to stand up from the bed. She was immediately brought to the emergency room where
neurological examination revealed the following:
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CASE 3
A 39-year-old woman went to see her family physician complaining of weakness in her legs. She
said her legs felt tired when she stood up too long. She first noticed the weakness three months earlier, a
few weeks after she slipped in the bathroom and fell on her buttocks. Since then, there was noted
intermittent, shock-like pain when she drove through traffic or when she sat too long. Examination
revealed increased reflexes in both legs and bilateral Babinski signs. There was marked weakness of foot,
ankle and calf muscles, but thigh muscles did not show definitive weakness. Sensory examination revealed
mild deficits in all modalities in both lower legs.
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CASE 4
A 65-year-old man presented with loss of all sensation in the left thumb, adjacent hand and strip
along the lateral forearm. There were no other abnormal findings on neurological exam.
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CASE 5
A 57-year-old man complained of sudden onset doubling of vision after a traffic altercation. At
the emergency room, the blood pressure was 220/100mmHg. Neurological examination revealed inability
to close his left eye, inability to wrinkle the left side of his forehead, and no movement on the left side of
his face when he tried to smile. He also noted decreased taste sensation on the left side of the tongue.
His right showed unremarkable movement. His left eye was noted to be deviated towards the nose and
he was unable to abduct the left eye. His right upper and motor extremities had motor strength of 4/5.
CASE 6
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A 47-year-old man complained of facial asymmetry on the right for the past two days. History
started 5 days ago when he had sore throat, nasal congestion and low-grade fever. Three days ago, he
complained of 5/10 pain over the right temporal area relieved by Paracetamol. Two days ago, he woke up
and his daughter noted that his right eyelid was not closing and he drooled on the right side of his mouth
when he drank water. Neurological examination revealed inability to close his left eye, inability to wrinkle
the left side of his forehead, and no movement on the left side of his face when he tried to smile. Taste
was also impaired on the left side of the tongue. Examination of hearing was normal. The rest of the
neurological examination was unremarkable.
CASE 7
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A 42-year-old woman with known history of rheumatic heart disease and paroxysmal atrial
fibrillation had sudden onset, severe dizziness described as a sensation of spinning which did not resolve
upon closing the eyes and episodes of vomiting. Upon examination, there was difficulty evaluating the
eyes as she preferred them closed but was noted to have bilateral nystagmus on primary gaze. Motor
strength and sensory examination were unremarkable although there was slight hypotonia on the left
upper and lower extremities. There was dysmetria and dysdiadochokinesia on the left. Speech was
dysarthric and she was talking “as if she was drunk”.
CASE 8
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Refer to the patient in Case 7. On further neurological examination, the patient had additional
findings of: loss of pain and temperature sensation on the left side of her face and left side of her body,
hoarseness, and difficulty swallowing liquids.
CASE 9
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A 55-year-old man complained of weakness of the right arm and leg and diplopia. . Examination
revealed hyperreflexia and Babinski sign on the right, and weakness of the right lower face. The left eye
showed ptosis, dilated pupil, and inability to adduct.
CASE 10
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A 54 year old man was referred for progressive weakness over the past 8 months. Weakness
began as a foot drop in the left lower extremity, and similar symptoms developed 2 months later in the
right leg. The mental status was unremarkable. There were noted fasciculations on the right and left sides
of the tongue. There is slight atrophy in the intrinsic hand muscles bilaterally, but motor strength was 5/5.
In the lower extremities, there was spasticity with prominent wasting and fasciculations in all muscles
below the knees. There is mild weakness at 4+/5 in hip flexion, extension, abduction and adduction. Exam
of the more distal muscles shows marked bilateral foot drop as well as weakness of plantar flexion, ankle
inversion and eversion. The reflexes were normal in the upper extremities but the lower extremities
showed clonus and bilateral Babinski. Sensory exam: normal to light touch, temperature and vibration.
Coordination: No tremor, or dysmetria in the upper extermities. No ataxia. Gait: slow, spastic, and
slapping.
CASE 11
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Differentiate the types of dysconjugate eye movements (walleyed syndrome; vertical one and a
half syndrome; internuclear ophthalmoplegia; parinaud syndrome; one and a half syndrome) by:
CASE 12
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Differentiate the types of pupillary abnormalities: Horner Syndrome; Argyll-Robertson Pupil; Adie
Tonic Pupil; Marcus Gunn Pupil) by:
CLINICAL CASES
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Neurology II
CASE 1
A 70-year-old man woke up one morning and could not move his right arm or hand. He had trouble
trying to speak to his wife, and could not understand her questions and follow her directions. At the
hospital, neurological exam revealed the following abnormalities:
• paralysis of right lower face muscles (but he could wrinkle his forehead on both sides)
• 3/5 motor paralysis and hyperreflexia of right hand and arm
• mild sensory loss (both modalities) in right hand, arm and face
• absent verbal output, absent comprehension, absent naming and absent repetition
• Preferential gaze to the left
• Absent visual threat on the right
CASE 2
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A 55-year-old man, ship captain was in good health until 8 months ago when he noted the
development of a tremor involving the right hand. He noted the tremors to be more prominent when he
was stressed and would disappear spontaneously. Sometimes, he would notice the tremor when his hand
was on the table while he was doing paperwork. He consulted a neurologist because he was disturbed by
these symptoms. He has no other complaints. On examination, there is a tremor in the right arm at rest
and while he walks. He has a sustained tremor in both arms, and a fine tremor during finger-nose
examination. His gait is fairly unremarkable. Tone is increased in the right arm and leg. The physical
examination is otherwise unremarkable. He and his wife deny his use of alcohol or any other medications.
CASE 3
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A 22-year-old medical student was studying late at night for an examination, talking to his friends.
All of a sudden, his friends noted that he began smacking his lips, stared into space, seemed confused,
and kept mumbling the same word repeatedly. During this time, his fingers were moving “as if they were
fidgeting”. This episode lasted approximately 30 seconds. During the episode, his friends tried to talk to
him, but he was unresponsive. Within a few more seconds, he suddenly became asymptomatic although
he seemed slightly confused for 5 to 10 more seconds. He was brought to the emergency room where the
symptoms recurred. However, instead of resolving, he was noted to have progression towards generalized
tonic-clonic jerking of the upper and lower extremities which persisted for the next 5 minutes.
CASE 4
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A 27-year-old female consults due to headaches of increasing frequency. Upon interview, she has
a 10-year history of headaches which started in College. She would experience headaches anywhere from
2 – 4 times a month especially during the time of her menstruation and when she lacked sleep. The
headache starts behind the right eye, throbbing in character and is usually preceded by flashing lights and
zigzag lines. Once the headache occurs, it progresses in intensity. There is extreme nausea and vomiting,
and the patient goes into a dark room to minimize her head pain. She claims that vomiting relieves her
and she needs to “sleep it off” to relieve her headaches as she did not like taking pain relievers. Generally,
the headache lasts 4 to 6 hours, but the patient feels tired and listless for the next 24 hours. The patient
feels that the headache worsens with her menstrual cycle, and certain foods especially red wine can
exacerbate her headache. Six months ago, she started taking combination low-dose oral contraceptive
pills. Since then, she noted increased frequency of headache to almost daily episodes. She discontinued
the pills but the headaches remain frequent.
Her general and neurologic examinations are normal.
CASE 5
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A 28-year-old male, construction worker was brought to the emergency room due to 1 week
complaint of headache. The headache is primarily in the frontal and occipital regions and associated with
mild nausea and lightheadedness. The mother also noted low-grade, undocumented fever and dry cough.
He has taken various paracetamol 500mg every 4 hours without any improvement in the headache. The
intensity of the headache has gradually increased since it began prompting evaluation as he was no longer
able to tolerate it. He also noted neck pain and stiffness about 3 days ago.
On examination, he has a temperature of 38.4°C; blood pressure, 110/70 mmHg; and pulse, of
102 beats/min. He is awake and alert and fully oriented. His Mental Status Examination is normal. Cranial
nerves are normal except for bilateral papilledema. The deep tendon reflexes are 3+ throughout without
evidence of a Babinski sign. His motor, sensory, and cerebellar examinations are normal. Brudzinski and
Kernig signs were present.
CASE 6
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A 36-year-old woman consulted at the Neurology OPD clinic complaining of severe headache of 1
month duration. She has been experiencing headaches almost 1 month prior to consult. Her headaches
were described as generalized and dull, involving the entire head. Initially, the pain scale was 3-4/10 but
over the past 2 weeks, she noted increasing severity of the headache, now at 8-10/10. She has not been
able to report to work as a saleslady. She has tried taking paracetamol, then celecoxib for the headache
but these afforded very little relief. For the past week, she noticed transient blurring of vision described
as “graying-out” of vision when she defecates or when she lifts pails of water. On review of history, she
started taking oral contraceptive pills for birth control about 6 months prior to the onset of symptoms
On examination, vital signs were unremarkable. There are no cranial bruits, and her cardiovascular
examination is normal. Her neurologic examination is notable for bilateral papilledema with intact visual
acuity and intact extra-ocular muscles. Her visual fields are normal. She has normal color perception. The
rest of the neurological examination was unremarkable.
CASE 7
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A 28-year-old male, known HIV-positive and currently on antiretroviral treatment, consults at the
emergency room with right facial paralysis of 1 day duration. Three days ago, he began to experience right
ear pain, throbbing and tender to the touch, around 4/10 in pain score. He did not take any pain
medication and has not had any fever. Yesterday, he was able to feel and see small, reddish blisters on
his right earlobe. This morning, he woke up and noted that the right side of his face was not moving and
that sounds seemed to be muffled on his right ear. Water and saliva drooled over the right side of his
mouth and he noted impairment of taste over the right side of his tongue as he was eating breakfast.
He does have a past history of chicken pox as a child.
His physical examination shows small blisters on an erythematous base in the right external ear.
The examination of the ear canal is painful to her, but the tympanic membrane is intact. No pus is seen in
the ear canal. The left ear canal is normal.
His neurological examination shows right peripheral facial palsy, decreased taste on the right and
decreased hearing on gross testing over the right ear. The Weber tuning fork test lateralizes to the left
ear. The Rinne test is normal in both ears. Taste is impaired on the right side of the tongue. The rest of
the neurological examination is normal.
CASE 8
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A 65-year-old male consulted at the Neurology OPD clinic due to progressive weakness of 10
months. He first noticed weakness of his right hand with difficulty and clumsiness holding on to mugs and
kitchen utensils. After about 2 months, the symptoms progressed and the patient began to experience
difficulty raising his arm above his head or carrying things. In the past 4 months, he noted that, sometimes,
he would choke when drinking water but still had good appetite.
On neurological examination, mental status was intact. Examination of the tongue showed
atrophy of the right side of the tongue as well as fasciculations on the surface of the tongue. There were
findings of muscle atrophy and wasting of the intrinsic and small muscles of his right hand, right triceps,
and muscles of his right shoulder. There was visible muscle twitching of both arm muscles and paraspinal
muscles of his back. The neurologic examination showed 3/5 motor strength of the right upper extremity
and 4/5 motor strength on his left proximal upper extremity. Reflexes were 3+ on all extremities. His
sensory and cerebellar examinations were normal. MRI of the brain and spine were normal. Laboratory
studies were normal. Electrodiagnostic studies (EMG/NCV) reveal diffuse muscle denervation in his arms,
legs, and paraspinal muscles. There was no evidence of neuropathy or myopathy.
CASE 9
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A 48-year-old female, left-handed office secretary consults due to numbness and pain of both
hands. 1 year prior to consult, she began to experience intermittent numbness and pain of her left index
and middle fingers, described as pins-and-needles sensation as well as a feeling of cold. These were
experienced typing on her keyboard and when she performed household chores like chopping, doing the
laundry and cleaning the dishes. These were experienced intermittently until 6 months ago when she
started experiencing the same symptoms on her right hand also. The numbness and pain involved her left
index and middle fingers. At about this time, she noted that the pain and numbness over the left hand
became increasingly frequent and often awakened the patient from sleep. She has also recently noticed
decreased grip strength associated with frequent dropping of heavy objects when she used her left hand.
Her neurologic and physical examinations are significant for numbness to pinprick sensation along
the lateral sides of both her palm, thumb, index and middle fingers. The findings were more pronounced
on the left. Tinel and Phalen’s sign were present bilaterally, with the left worse than the right. The rest of
her examination, including muscle and sensory testing are normal. Her deep tendon reflexes are normal,
throughout. There are no musculoskeletal or joint abnormalities observed.
CASE 10
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A 28-year-old woman presents at your clinic with a 3-month history of muscle soreness, cramps,
and muscle fatigue with climbing stairs and carrying objects. She initially thought that this was due to
fatigue and sleep deprivation due to her work at an ad agency. Two weeks ago, she went on vacation but
the symptoms persisted. A week ago, she noted reddish rashes on her cheeks, necks, chest, and back and
swelling around her eyes.
Physical examination shows erythematous rash across her cheeks, neck, chest, and back and mild
lid edema. The cardiac exam is significant for occasional skipped beats but otherwise unremarkable. The
neurologic examination shows proximal muscle weakness of the patient’s deltoids, biceps, hip flexors, and
knee flexors at 4/5. Mental status, cranial nerves, sensory and cerebellar examination is normal.
Laboratory studies are normal except for elevated serum creatine kinase of 1770 (normal 50–200).
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