Tribendimidine

Tribendimidine is a broad-spectrum anthelmintic agent developed in

China, at the National Institute of Parasitic Diseases in Shanghai. It is Tribendimidine
a derivative of amidantel.[1]

In clinical trials, it was highly effective in treating ankylostomiasis,

ascariasis and enterobiasis.[2] It is also effective against
clonorchiasis.[3] However, animal studies suggest it is ineffective in
treating Schistosoma mansoni or Fasciola hepatica disease.[1] The Clinical data
drug has also performed well in trials against opisthorchiasis, curing ATC code
none
about 70% of cases.[4]
Identifiers
Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical
IUPAC name
Company Limited in Zibo, Shandong, China. It was approved by the
China Food and Drug Administration in 2007. N,N-bis(4-(1-dimethylamino)ethylideneaminoph
enyl)-1,4

References -phenylene dimethylidyneamine

CAS 115103-15-6 (http://w

1. Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J Number
ww.commonchemistry.
(2007). "Evaluation of the in vivo activity of tribendimidine
org/ChemicalDetail.as
against Schistosoma mansoni, Fasciola hepatica,
Clonorchis sinensis, and Opisthorchis viverrini" (https://ww px?ref=115103-15-6)
w.ncbi.nlm.nih.gov/pmc/articles/PMC1803157). Antimicrob PubChem 3086564 (https://pubc
Agents Chemother. 51 (3): 1096–8. CID
hem.ncbi.nlm.nih.gov/
doi:10.1128/AAC.01366-06 (https://doi.org/10.1128%2FAA
C.01366-06). PMC 1803157 (https://www.ncbi.nlm.nih.gov/ compound/3086564)
pmc/articles/PMC1803157). PMID 17194822 (https://pubm ChemSpider 2343161 (http://www.c
ed.ncbi.nlm.nih.gov/17194822). Free full text (http://aac.as
hemspider.com/Chemi
m.org/cgi/content/full/51/3/1096).
cal-Structure.2343161.
2. Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W
html)
(2005). "Tribendimidine: a promising, safe and broad-
spectrum anthelmintic agent from China". Acta Trop. 94 (1): UNII YO6SOD6ZTJ (https://
1–14. doi:10.1016/j.actatropica.2005.01.013 (https://doi.or fdasis.nlm.nih.gov/srs/
g/10.1016%2Fj.actatropica.2005.01.013). PMID 15777691
unii/YO6SOD6ZTJ)
(https://pubmed.ncbi.nlm.nih.gov/15777691).
3. Zhang, H; Liu, C; Zheng, Q (December 2019). ChEMBL ChEMBL427256 (http
"Development and application of anthelminthic drugs in s://www.ebi.ac.uk/che
China". Acta Tropica. 200: 105181. mbldb/index.php/comp
doi:10.1016/j.actatropica.2019.105181 (https://doi.org/10.1
ound/inspect/ChEMBL
016%2Fj.actatropica.2019.105181). PMID 31542370 (http
s://pubmed.ncbi.nlm.nih.gov/31542370). 427256)
4. "New drug shows promise against Asian liver fluke" (http CompTox DTXSID50894077 (htt
s://www.reuters.com/article/us-liver-fluke-drugs-idUSTRE6 Dashboard
(EPA) ps://comptox.epa.gov/
AO00520101125). 2010-11-24.
dashboard/DTXSID50
894077)
Chemical and physical data
Formula C28H32N6
 Molar mass 452.606 g·mol−1
3D model Interactive image (http
(JSmol)
s://chemapps.stolaf.ed
u/jmol/jmol.php?model
=N%28%3DC%2Fc2cc
c%28%5CC%3DN%5C
c1ccc%28%2FN%3D
C%28%2FN%28C%29
C%29C%29cc1%29cc
2%29%5Cc3ccc%28%
5CN%3DC%28%5C
N%28C%29C%29C%2
9cc3)

SMILES
N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)
cc2)\c3ccc(\N=C(\N(C)C)C)cc3

InChI
InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-1
1-25(12-16-27)29-19-23-7-9-24(10-8-23)2
0-30-26-13-17-28(18-14-26)32-22(2)34(5)
6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32
-22+
Key:XOIOGKHKNQYULW-HTNNXBMUSA-N

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