“Frontiers in Life Sciences.

Signalling and Metabolism”

Belarusian – Lithuanian – Polish
Andrzej Sniadecki Memorial Conference
Grodno, 8-9 November 2018

7th November 2018

16:00 – 18:00 Tour round Grodno

8th November 2018

Opening Session
Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, conference hall

No Time Activity/title Title of Presentation/Affiliation Comments

8:00-9:00 Registration
9:00-9:15 Opening Ceremony Welcome of the National Academy of
Sciences of Belarus authorities and the
Director of the Institute of Biologically Active
Compounds and the Presidents of the
Societies
1 9:15-9:35 Andrzej (Jedrzej) Sniadecki – a great Andrzej Legocki, Prof., No discussion
scientist of the Age of Enlightenment Institute of Bioorganic Chemistry, Polish
Academy of Sciences, Poznań, Poland
2 9:35-9:50 The level of chemistry studies in Vilnius Rimantas Vaitkus, Dr., Ass. Prof., No discussion
University at the beginning of the XIX th Institute of Chemistry Vilnius University,
century Vilnius, Lithuania
3 9:50-10:10 Overview of Molecular Life Science Vida Mildažiene, Prof., No discussion
Education in Lithuania Vytautas Magnus University, Kaunas,
Lithuania
Gervydas Dienys, Prof.,
Institute of Biotechnology, Vilnius University,
Lithuania

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4 10:10-10:40 Regulation of mitochondrial potassium Adam Szewczyk, Prof., 25 min + 5 min
channels Nencki Institute of Experimental Biology, discussion
Warsaw University of Life Sciences, Warsaw,
Poland
5 10:40-11:10 Structure and function of cholesterol S. A. Usanov, Prof., 25 min + 5 min
metabolic enzymes National Academy of Sciences of Belarus, discussion
Minsk, Belarus
11:10-11:30 Coffee Break

6 11:30-12:00 Bioinformatics analysis provides new Venclovas Česlovas, Dr. Sci., 25 min + 5 min
insights into the structure and Institute of Biotechnology, Vilnius University, discussion
regulation of bacterial Y-family DNA Vilnius, Lithuania
polymerases
7 12:00-12:30 Generation in yeast of recombinant Aurelija Žvirblienė, Prof., 25 min + 5 min
virus-like particles and their diagnostic Vilnius University, Life Sciences Center, discussion
applications Institute of Biotechnology, Vilnius, Lithuania
8 12:30-13:00 Diagnostic biosystems based on N. M. Litvinko, Dr., 25 min + 5 min
phosphatideacylhydrolases and National Academy of Sciences of Belarus, discussion
hemoproteins Minsk, Belarus
9 13:00-13:30 Reactive sulfur species and thiol-based Malgorzata Iciek, Ass. Prof., 25 min + 5 min
redox regulation Jagiellonian University Medical College, discussion
Chair of Medical Chemistry, Kraków, Poland
10 13:30-14:00 Intracellular Signaling and Proteolysis: A. A. Chirkin, Prof., 25 min + 5 min
Evolutionary and Oncological Aspects State University named after P. M. Masherov, discussion
Department of Chemistry, Vitebsk, Belarus
14:00-15:00 Lunch
Session 1
15:00-18:00 Selected circuits of genetic control
Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, lecture room 301
Co-chairpersons: Rimantas Vaitkus
Jolanta Jura
Natalya Litvinko

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11 15:00-15:15 Signaling in seed stress response: Vida Mildažiene, Prof., 10 min + 5 min
eustress versus distress Vytautas Magnus University, Kaunas, discussion
Lithuania
12 15:15-15:30 Stability of transcripts – role of the PIN Jolanta Jura, Prof., 10 min + 5 min
containing proteins Faculty of Biochemistry, Biophysics and discussion
Biotechnology Jagiellonian University,
Kraków, Poland
13 15:30-15:45 Cyclic oligoadenylates - novel bacterial Gintautas Tamulaitis, Dr., 10 min + 5 min
messengers Institute of Biotechnology, Vilnius University, discussion
Vilnius, Lithuania
14 15:45-16:00 Bioinformatic design of epidermal V. V. Khrustalev, Dr., 10 min + 5 min
growth factor receptor inhibitors based Belarusian State Medical University, Institute discussion
on mutational pressure theory of Physiology, Minsk, Belarus
15 16:00-16:15 Using nanotechnology to create hybrid Anna Jagusiak, Ass. Prof., 10 min + 5 min
complexes with drugs delivery Jagiellonian University Medical College, discussion
capabilities Kraków, Poland
16:15-16:45 Coffee Break
Poster Session
16 16:45-17:00 Genome-wide inference of bacterial Y. A. Nikolaichik, Dr., 10 min + 5 min
transcription factor binding sites based Belarusian State University, Minsk, Belarus discussion
on 3D structures of TF-DNA complexes
17 17:00-17:15 Fluorescent substrates and inhibitors of V. M. Shkumatov, Prof., 10 min + 5 min
steroidogenic fermentation Belarusian State University, Minsk, Belarus discussion
18 17:15-17:30 Toxic levels of NaСl induce generation S. N. Zvanarou, Ass. Prof., 10 min + 5 min
of ROS and formation of single- and Belarusian State University, Minsk, Belarus discussion
double-strand DNA breaks in
Physcomitrella patens
19 17:30-17:45 Induction of cytoplasmatic Ca2+-signals M. A. Vaitsiakhovich, Ass. Prof. 10 min + 5 min
under exogenous L-ascorbate action in V. V. Demidchik, Dr. Sci., discussion
the roots of Arabidopsis thaliana (L). Belarusian State University, Minsk, Belarus
Heynh
20 17:45-18:00 Role of ros sensor of potassium I. Yu. Novoselsky, Jun. Res., 10 min + 5 min

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 channel gork in activation of out P. V. Griusevich, discussion
-directed k+ conductivity under the A. I. Sokolik,
action of hydroxyl radical-generating V. V. Demidchik, Dr. Sci.,
mixtures Belarusian State University, Minsk, Belarus

Session 2
Signalling pathways and communication
15:00-18:05 Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, conference hall
Co-chairpersons: Adam Szewczyk
Česlovas Venclovas
Aleksander Chirkin

21 15:00-15:15 Aging-associated changes in Dariusz Rakus, Prof., 10 min + 5 min

hippocampal glycolysis and glycogen Department of Molecular Physiology and discussion
metabolism Neurobiology, University of Wroclaw,
Wroclaw, Poland
22 From pantothenate protein complexes N. P. Kanunnikova, Dr. Sci., 10 min + 5 min
15:15-15:30 to protein CoAlation and redox V. A. Gurinovich, Dr., discussion
signaling A. G. Moiseenok, Prof.,
Institute of Biochemistry of Biologically Active
Compounds, NAS of Belarus, Grodno,
Belarus
23 15:30-15:45 Post-translational modification of A. V. Yantsevich, Dr., 10 min + 5 min
cytochrome-dependent Institute of Bioorganic Chemistry, NAS of discussion
monooxygenases: mechanisms and Belarus, Minsk, Belarus
regulatory role
24 15:45-16:00 Phytosteroids as effectors of Aliaksei Sysa, Dr., 10 min + 5 min
mammalian monooxygenase systems International Sakharov Environmental discussion
Institute of the Belarusian State University,
Minsk, Belarus
25 16:00-16:15 Shall we focus on the adenosine M. N. Kurbat, Ph. D., Ass. Prof., 10 min + 5 min
pathway during drug-induced liver Grodno State Medical University, Grodno, discussion

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 disease (DILI) in HIV-infected patients? Belarus
16:15-16:45 Coffee Break
Poster Session
26 16:45-17:00 Nucleotide receptors signaling in Paweł Pomorski, Prof., 10 min + 5 min
cancer progression and cancel cell Nencki Institute of Experimental Biology, discussion
motility Warsaw, University of Life Sciences,
Warsaw, Poland
27 17:00-17:15 Chemoresistant cancer cells have more T. M. Doroshenko, Ph. D., 10 min + 5 min
aggressive invasive phenotype and A. A. Alexandrov National Cancer Centre of discussion
altered microtubules expression Belarus, Minsk, Belarus
28 17:15-17:30 Matrix metalloproteinases in cancer of Lech Romanowicz, Dr., 10 min + 5 min
urinary tract Grgegorz Mlynarczyk, Dr., discussion
Krzystof Sobolewski, Prof.,
Medical University of Bialystok, Bialystok,
Poland
29 17:30-17:45 Genome scale metabolic models and Valeryia Mikalayeva, Dr., 10 min + 5 min
transcriptional regulation in breast Lithuanian University of Health Sciences, discussion
cancer cells Institute of Cardiology, Kaunas, Lithuania
30 17:45-17:55 Differentially expressed microRNAs in Katarzyna Maria Laskowska-Kaszub, Ph. 7 min + 3 min
blood plasma as potential biomarkes at D. student, discussion
early stages of Alzheimer’s disease Nencki Institute of Experimental Biology,
Polish Academy of Sciences, Warsaw,
Poland
31 17:55-18:05 Western diet as a potent risk factor of Angelika Więckowska, Ph. D. student, 7 min + 3 min
Alzheimer's disease pathology Nencki Institute of Experimental Biology, discussion
progression: Influence of a long-term Polish Academy of Sciences, Warsaw,
Western diet feeding on brain Poland
neuroinflammation in early stage of
Alzheimer's disease development
Session 3
Molecular aspects of biomedicine
15:00-16:30 Grodno State Medical University, lecture room 100

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 Co-chairpersons: Stefan Chłopicki
Viktor Snezhitskiy
32 15:00-15:30 Experimental Pharmacology of Stefan Chłopicki, Prof., 25 min + 5 min
Endothelium Jagellonian Center for Experimental discussion
Therapeutics, Kraków, Poland
33 15:30-15:45 Molecular-genetic aspects of the V. V. Zinchuk, Prof., 10 min + 5 min
relationship of the L-arginine-NO- Grodno State Medical University, Grodno, discussion
system, redox mechanisms and the Belarus
transport of oxygen by blood
34 15:45-16:00 Advanced glycation end products and A. I. Shevtsova, Prof., 10 min + 5 min
its receptors in experimental Dnipropetrovsk Medical Academy, Dnipro, discussion
myocardial ischemia Ukraine
35 16:00-16:15 Coronary vasodilator responses on V. I. Kozlovski, Dr. Sci., 10 min + 5 min
purines in isolated hearts of mice with Grodno State Medical University, Grodno, discussion
overexpression of alpha subunit of Gq Belarus,
protein in cardiomyocytes Stefan Chłopicki, Prof.,
Jagellonian Center for Experimental
Therapeutics, Kraków, Poland
36 16:15-16:30 Participation of hemoglobin in the M. N. Khodosovsky, Dr., 10 min + 5 min
regulation of redox-state in tissues Grodno State Medical University, Grodno, discussion
during hepatic ischemia-reperfusion Belarus
16:30-16:45 Coffee Break
Session 4
Physiological role of vitamin D
16:45-18:00 Grodno State Medical University, lecture room 100
Co-chairpersons: Paweł Płudowski
Viktor Snezhitskiy
37 16:45-17:15 Vitamin D status in Poland Paweł Płudowski, Prof., 25 min + 5 min
The Children’s Memorial Health Institute, discussion
Warszaw, Poland
38 17:15-17:35 Pathogenetic relationships and L. V. Yakubova, Ph. D., Ass. Prof., 15 min + 5 min
influence of vitamin D on Grodno State Medical University, Grodno, discussion

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 cardiovascular system Belarus
39 17:35-17:45 Vitamin D L. V. Kezhun, Ph. D., 7 min + 3 min
deficiency/insufficiency and plasma Grodno State Medical University, Grodno, discussion
renin activity in arterial hypertension Belarus
40 17:45-17:55 Epigenetic factors related to the Y. Z. Maksimchik, Ph. D. student, 7 min + 3 min
metabolism and effects of vitamin D I. S. Khviasko., Ph. D. student, discussion
V. A. Gurinovich, Dr.,
A. G. Moiseenok, Prof.,
Institute of Biochemistry of Biologically Active
Compounds, NAS of Belarus, Grodno,
Belarus
18:30 Conference Dinner
9th November 2018
Session 5
Molecular physiology and patophysiology
9:30-12:10 Institute of Biochemistry of Biologically Active Compounds NAS of Belarus, conference hall
Co-chairpersons: Natalya Litvinko
Vyacheslav Buko
9:30-10:00 Sponsor presentation
41 10:00-10:15 The search for the most structurally V. V. Khrustalev, Ph. D., Ass. Prof., 10 min + 5 min
stable fragments of the epidermal V. V. Poboinev, discussion
growth factor receptor tyrosine-kinase T. A. Khrustaleva,
domain K. V. Yurchenko,
Belarusian State Medical University, Institute
of Physiology, NAS of Belarus , Minsk,
Belarus
42 10:15-10:30 Neurochemical aspects of experimental Y. M. Doroshenko, Ph. D., Ass. Prof., 10 min + 5 min
taurine deficiency: brain pool of free Grodno State Medical University, Grodno, discussion
amino acids and related compounds Belarus
43 10:30-10:45 Glycotopes of blood cells  under O. V. Netronina, Ph. D., Ass. Prof., 10 min + 5 min
oncoproliferative  processes G. S. Maslak,  Ph. D., Ass. Prof., discussion
D. M. Romanukha, 

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44 10:45-11:00 Functional state of basic
neurotransmitter systems of rat`s
midbrain in various forms of alcohol
intoxication
45 11:00-11:10 The protective role of melatonin in the
treatment of patients with
gastroesophageal reflux disease
A. G. Sirko,
Dnipropetrovsk Medical Academy,
Mechnikov Dnipropetrovsk Regional Clinical
Hospital, Dnipro, Ukraine
V. K. Gushcha, Senior Instr., 10 min + 5 min
S. V. Lelevich, Dr. Sci., discussion
V. V. Lelevich, Prof.,
Grodno State Medical University, Grodno,
Belarus
O. A. Karpovich, Ass., V. I. Shyshko, 7 min + 3 min
Grodno State Medical University, Grodno, discussion
Belarus

46 11:10-11:20 Functional activity of proteins involvedYu.S. Kanash, Jun. Res. Ass., 7 min + 3 min
in xenobiotics transport in human A. V. Tamashevski, Ph.D., discussion
erythrocytes on exposure to α- Yu. M. Harmaza,
tocopherol and ascorbic acid in vitro E. I. Slobozhanina, Prof.
Institute of Biophysics and Cell Engineering
of the National Academy of Sciences of
Belarus, Minsk, Belarus
47 11:20-11:30 Method for assessment of the change Yu. M. Harmaza, Ph. D., 7 min + 3 min
of the intracellular zinc pool in human A. V. Tamashevski, discussion
erythrocytes using fluorescent probe E. I. Slobozhanina, Prof.
FluoZin-3 Institute of Biophysics and Cell Engineering
of the National Academy of Sciences of
Belarus, Minsk, Belarus
11:30-11:50 Coffee Break
48 11:50-12:00 Search and evaluation of functional Y. S. Pustsiungha, Ph. D. student, 7 min + 3 min
quality of sorbents ligands based on Y. M. Yermola, discussion
aromatic amino acids on IGG binding V. P. Golubovich, Prof.,
from biological liquids Institute of Bioorganic Chemistry, Minsk,
Belarus

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49 12:00-12:10 Morphofunctional characteristic of E. I. Bon, Ass. Prof. 7 min + 3 min
neurons of parietal corps and rathes of N. E. Maksimovich, Prof., discussion
rats under conditions of subtotal Grodno State Medical University, Grodno,
cerebral ischemia Belarus

Session 6
12:10-13:15 Poster Session
Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, conference hall
Co-chairpersons: Alexander Chirkin
Lilya Nadolnik
12:10-12:30 Fixed poster presentations
A. V. Bakunovich, O. D. Bichan, L. M. Lаbanok, K. Ya. Bulanаva,
International Sakharov Environmental Institute of Belarusian State University, Minsk, Belarus.
С-1 Features of influence of Ap4A on thrombin-induced platelet aggregation of pregnant women with
preeclampsia

O. M. Balaeva-Tikhomirova, E. O. Danchenko, V. V. Dolmatova, E. I. Katsnelson, Т. А. Tolkacheva, A.

A. Chirkin,
С-2 State University named after P. M. Masherov, Vitebsk, Belarus
Metabolic response of tissues of pulmonary freshwater molluscs to the action of factors of physical and
chemical nature
R. M. Beridze,
Gomel State Medical University, Gomel, Belarus
С-3
Target therapy of bladder cancer by inhibiting the signaling of FGFR3

М. A. Charnysh, D. A. Przhevalskaya, I. A. Horski, L. A. Tsybulskaya, V. N. Zhabinskii, V. A.

Khripach, V. V. Demidchik,
С-4 Belarusian State University, Minsk, Belarus
Brassinosteroid-induced modifications in growth and development of Phalaenopsis protocorm in vitro
culture
С-5 Y. V. Diubo,
Belarusian State Unversity, Minsk, Belarus.

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 A self-transmissible plasmid controls signalling between plant pathogenic Pectobacterium and its host

V. V. Dolmatova,
С-6 State University named after P. M. Masherov, Department of Chemistry, Vitebsk, Belarus
Evolution of cellular enzymes unregulated proteolysis
A. I. Gritsuk, Koval A. N.,
Gomel State Medical University, Gomel, Belarus
С-7
Eventual mechanisms of stress factors influence on subcellular biochemical processes in living organisms

Anatolii Ivankov, Giedrė Paužaitė, Zita Naučienė, Rasa Žūkienė, Eglė Norkevičienė, Vilma
Olšauskaitė, Audrius Padarauskas, Irina Filatova, Veronika Lyuskevich, Vida Mildažienė,
Vytautas Magnus University, Kaunas, Lithuania
С-8
Seed Treatment with Cold Plasma and Electromagnetic Field: Effects on Germination, Plant Growth, and
Amounts of Flavonoids in the Leaves of Red Clover (Trifoliumpratense)

A. V. Kolubako, Y. A. Nikolaichik,
Belarusian State University, Minsk, Belarus
С-9 Contribution of receptor kinase RLK5 in Solanum bulbocastanumplants to the recognition of
Pectobacterium carotovorum

A. N. Kruk, E. A. Nikolaychik, N. E. Gogoleva, Yu. V Gogolev.,

Belarusian State University, Minsk, Belarus
С-10
Analysis of quorum dependent transcription factors in Pectobacterim sp

O. E. Kuznetsov.,
Grodno State Medical University, Grodno, Belarus
С-11
The indicator of acute kidney injury.

S. A. Labor, A. A. Ostrovsky, V. I. Stsiapura, V. Yu. Smirnov, I. I. Stepuro,

Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, Grodno
С-12
Thiamine (vitamin B1) formation on thiamine disulfide exposure to ultraviolet light

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 V. S. Mackievic, V. V. Samokhina, N. A. Kuzniatsova, V. V. Demidchik,
Belarusian State University, Minsk, Belarus
С-13
Analysis of nickel interaction with histidine in development of signal reactions in the roots of higher plants
at "nickel stress"
D. A. Makarevich, T. V. Ryabtseva, E. M. Yermola, V. P. Golubovich,
Institute of Bioorganic Chemistry, NAS of Belarus, Minsk, Belarus
С-14
Binding of cytokines from standardized test solution by solid phase-fixed oligopeptides

V. P. Martsinovich, O. V. Gribovskaya, V. Yu. Afonin, V. P. Golubovich,

С-15 Institute of Bioorganic Chemistry, NAS of Belarus, Minsk, Belarus
Design and synthesis of rgd analogues for obtaining compounds with a different spectrum of activity
Y. I. Novgorodskaya, M. N. Kurbat,
Grodno State Medical University, Grodno, Belarus
С-16
Levels of low-molecular sulfur-containing compounds in rat blood plasma after administration of ethionine

S. S. Osochuk, A. F. Martsinkevich,
Vitebsk State Medical University, Vitebsk, Belarus
С-17
Effect of oxidative modification on the activity of transmembrane carriers

A. A. Poddubny,
Gomel State Medical University, Gomel, Belarus
С-18
The problem of the radiosensivity myocardium in white rats

V. V. Samokhina, V. S. Mackievic, А. I. Sokolik, V. V. Demidchik,

Belarusian State University, Minsk, Belarus
С-19 Analysis of the stress-induced efflux of K + from arabidopsis thaliana roots lacking outwardly-rectifying K +
channel GORK

С-20 I. P. Sutsko, A. H Shlyahtun, O. V. Titko, N. V. Yankevich, A. V. Kolodko, P. G. Telegin, N. G.

Zverinskaya, I. V. Zverinsky, I. N. Semenenya,
Institute of Biochemistry of Biologically Active Compounds, NAS of Belarus, Grodno, Belarus.
Changes of the glutathione antioxidant system in the liver of rats with toxic hepatitis treated with silymarin

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 solubilized in self-emulsifying delivery system
S. L. Usnich, V. S. Mackievic, D. A. Przhevalskaya, M. A. Charnysh, A. Yu. Shashko, V. Yu.
Bandarenka , D. V. Kalbanov, V. V. Demidchik,
С-21 Belarusian State University, Minsk, Belarus
Synthesis of reactive oxygen species in roots of forsythia intermedia microclones during their transferring
to ex vitro conditions
12:30-12:50 Poster discussions
50 12:50-13:15 Appeal of the workshop on work with A. A. Chirkin, Prof., No discussion
young scientists at the Belarusian State University named after P. M. Masherov,
Society of Biochemists and Molecular Department of Chemistry, Vitebsk, Belarus
Biologists concerning current
approaches to molecular biologic
research
13:15 Closing ceremony
Departure of conference participants to the Oshmyany district
9:00-22:00 Visit to memorial places associated with A.Sniadecki’s life and activities
Conference in the District Executive Committee of Oshmyany
51 15:00-15:15 Tradition of memorial events related to A. G. Moiseenok, Prof., No discussion
the name of A.Sniadecki in the Grodno Institute of Biochemistry of Biologically Active
region Compounds, NAS of Belarus, Grodno,
Belarus
52 15:15-15:30 On the creative force that propels life. Jan Barciszewski, Prof., No discussion
The Jędrzej Śniadecki’s history. Institute of Bioorganic Chemistry of the Polish
Academy of Sciences, NanoBioMedical
Center of of Adam Mickiewicz University,
Poznań, Poland
53 15:30-15:55 Andrzej Sniadecki – life and work in Birute Railienė, Dr., No discussion
Vilnius University Wroblewski Library of the Lithuanian
Academy of Sciences, Vilnius, Lithuania

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