CTP PCP RAS, MOSCOW (RUSSIA)

SYSTEMS BIOLOGY AND

SYSTEMS PHYSIOLOGY:
REGULATION OF
DEC 7-9, 2020

BIOLOGICAL NETWORKS
VIRTUAL CONFERENCE 2020
SCIENTIFIC PROGRAM
 TIME ZONES

GMT-5 United States Pennsylvania, Michigan

(EST) Canada Quebec
8 hours behind schedule time

GMT United Kingdom

3 hours behind schedule time

GMT+1 France, the Netherlands, Switzerland

(CET) 2 hours behind schedule time

GMT+3 Moscow
Schedule time

GMT+5.30 India
2 h 30 min after schedule time

GMT+8 Singapore
(SST) 5 h after schedule time
 SCIENTIFIC PROGRAM
DECEMBER 7th, 2020
GMT+3

15:00-15:05 Welcome speech

Prof. Mikhail Panteleev
Director of Center for Theoretical

15:05-15:10 Welcome speech

Prof. Fazoil Ataullakhanov
Scientific Advisor of Center for
Theoretical Problems of Physico-
Chemical Pharmacology RAS
Head of the Program Committee

SECTIONS

15:10-17:20 CELL AS A COMPLEX BIOLOGICAL SYSTEM:

TOPICAL ISSUES OF REGULATION OF CELL
DIVISION, METABOLISM AND SIGNALLING
(SUBSECTION 1)

CHAIRS:
Prof.Fazoil Ataullakhanov, Russia
Dr.Nikita Gudimchuk, Russia
15:10-15:45 Role of mechanical forces in regulation
of filopodia dynamics and activation of
Ca2+-dependent signaling
Dr. Artem Efremov
Mechanobiology Institute, National
University of Singapore
Singapore

15:45-16:10 Development of the in silico approach

for investigating EB1 and microtubules
interaction
Mikhail Anisimov
Lomonosov Moscow State University
Moscow, Russia

16:10-16:45 Mechanisms of microtubule assembly,

disassembly and force generation
Dr. Nikita Gudimchuk
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Moscow, Russia

16:45-17:20 Disordered gears for the tubulin motors:

emergent properties of unstructured
protein domain ensembles
Dr. Vladimir Volkov
Delft University of Technology
Delft, Netherlands

17:20-17:35 BREAK
17:35-19:55 CELL AS A COMPLEX BIOLOGICAL SYSTEM:
TOPICAL ISSUES OF REGULATION OF CELL
DIVISION, METABOLISM AND SIGNALLING
(SUBSECTION 2)

CHAIRS:
Dr.Eugene Mosharov, United States
Dr.Svetlana Komarova, Canada

17:35-18:10 Purinergic signaling in bone adaptation

to mechanical forces
Dr. Svetlana Komarova
McGill Univeristy
Montreal, Canada

18:10-18:45 The Role of Dopamine, Calcium and

alpha-Synuclein in Selective
Vulnerability of Neurons in Parkinson’s
Disease
Dr. EugeneMosharov
Columbia University
New York, United States

18:45-19:20 Quantitative Systems Pharmacology

modeling and its use in the development
of new drugs
Kirill Zhudenkov
M&S Decisions LLC
Moscow, Russia
19:20-19:55 Permitted and restricted steps of human
kinetochore assembly in mitotic cell
extracts
Ekaterina Tarasovetc
University of Pennsylvania
Philadelphia, United States
 DECEMBER 8th, 2020
GMT+3
15:00-17:20 FUNCTIONAL REGULATION OF HUMAN BODY
SYSTEMS: FROM THEORY TO PRACTICE
(SUBSECTION 1)

CHAIRS:
Prof.Fazoil Ataullakhanov, Russia
Dr.Dmitry Nechipurenko, Russia

15:00-15:35 Regulation of, and variation in, the

mechanisms that lead to thrombus
formation
Dr. Joanne Dunster
University of Reading
Reading, United Kingdom

15:35-16:10 Dissecting complex regulation of

germinal centers by follicular regulatory
T cells
Prof. Irina Grigorova
University of Michigan Medical School
Ann Arbor, United States

16:10-16:45 In vitro thrombosis model demonstrates

several types of thrombus dynamics
Dr. Dmitry Nechipurenko
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia
 16:45-17:20 The relationship between thrombin
generation parameters and their
sensitivity to coagulation factors,
inhibitors and platelets
Dr. Leonid Parunov
U.S. Food and Drug Administration
Silver Spring, United States

17:20-17:40 BREAK

17:40-19:50 FUNDAMENTAL AND APPLIED ASPECTS OF

CELL DIAGNOSTICS AND THERAPY

CHAIRS:
Prof.Fazoil Ataullakhanov, Russia
Dr.Sofya Kuznetsova, Russia

17:40-18:15 Erythrocytes-bioreactors for removing

ammonium from the blood
Larisa Koleva
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia

18:15-18:50 Statistical description of cell

margination in blood flows and
implications in microfluidics
Dr. Gábor Závodszky
University of Amsterdam
Amsterdam, the Netherlands
18:50-19:25 Numerical modelling of Ndc80 complex
interaction with microtubules in an
ultrafast force clamp assay
Ivan Gonchar
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia

19:25-19:50 Erythrocytes-bioreactors and limitations

of their efficiency
Eugeniy Protasov
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia
 DECEMBER 9th, 2020
GMT+3
15:00-17:25 FUNCTIONAL REGULATION OF HUMAN BODY
SYSTEMS: FROM THEORY TO PRACTICE
(SUBSECTION 2)

Chairs:
Prof. Vitaly Volpert, France
Dr.Alexey Shibeko, Russia

15:00-15:35 Anomalous transport, adhesion and

aggregation properties of platelets
Prof. Bastien Chopard
University of Geneva
Geneva, Switzerland

15:35-16:00 3D modelling of Intravascular

Thrombolysis
Rémy Valentin Petkantchin
University of Geneva
Geneva, Switzerland

16:00-16:35 Developments leading to a Factor XI

enhanced model of blood coagulation
Dr. Anand Mohan
IIT Hyderabad
Sangareddy, India
16:35-17:00 The quasi-one-dimensionalmodelling of
the lymph flow in the human lymphatic
system
Anastasia Mozokhina
Peoples Friendship University of Russia
Moscow, Russia

17:00-17:25 Combining computational modelling and

machine learning to predict the specific
response of patients to anticoagulant
therapy in flow
Dr. Anass Bouchnita
Ecole Centrale Casablanca
Casablanca, Morocco

17:25-17:40 BREAK

17:40-19:30 FUNCTIONAL REGULATION OF HUMAN BODY

SYSTEMS: FROM THEORY TO PRACTICE
(SUBSECTION 3)

Chairs:
Dr. Joanne Dunster, United Kingdom
Dr. Anastasia Sveshnikova, Russia

17:40-18:15 Molecular mechanisms of "coding" and

"decoding" of information in platelet
signal transduction
Dr. Anastasia Sveshnikova
Lomonosov Moscow State University
Moscow, Russia
18:15-18:40 Spatiotemporal dynamics of platelet
GPVI signaling is tightly regulated by
structural aspects of GPVI ligands
Alexey Martyanov
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia

18:40-19:05 The computational analysis of the

substrate delivery pathways for the
enzymatic complexes of prothrombinase,
intrinsic and extrinsic tenases
Dr. Tatiana Kovalenko
Center for Theoretical Problems of
Physico-Chemical Pharmacology, Russian
Academy of Sciences
Moscow, Russia

19:05-19:30 Computational modelling of agonist-

driven thrombus formation under arterial
blood flow
Anastasia Masaltseva
Lomonosov Moscow State University
Moscow, Russia