t (min) Pt (bar) Xa K t min Pt bar

0 25 0 #DIV/0! 0 2
0.21 25.133 0.0266667 0.013333333 5 2.117387467
0.42 25.267 0.0533334 0.013333333 10 2.210110585
0.65 25.400 0.0800001 0.013333333 15 2.285203717
0.90 25.533 0.1066668 0.013333333 20 2.347258486
1.15 25.667 0.1333335 0.013333333 25 2.399399399
1.43 25.800 0.1600002 0.013333333 30 2.443826474
1.72 25.933 0.1866669 0.013333333 35 2.48213361
2.03 26.067 0.2133336 0.013333333 40 2.515503876
2.37 26.200 0.2400003 0.013333333 45 2.544833864
2.73 26.333 0.266667 0.013333333 50 2.570815451
3.11 26.467 0.2933337 0.013333333 55 2.593991068
3.53 26.600 0.3200004 0.013333333 60 2.614791988
3.98 26.733 0.3466671 0.013333333 65 2.633565409
4.47 26.867 0.3733338 0.013333333 70 2.65059399
5.00 27.000 0.4000005 0.013333333 75 2.666110184
5.58 27.133 0.4266672 0.013333333 80 2.680306905
6.22 27.267 0.4533339 0.013333333 85 2.6933456
6.92 27.400 0.4800006 0.013333333 90 2.705362404
7.70 27.533 0.5066673 0.013333333 95 2.716472923
8.57 27.667 0.533334 0.013333333 100 2.726775956
9.55 27.800 0.5600007 0.013333333 105 2.736356446
10.65 27.933 0.5866674 0.013333333 110 2.745287825
11.90 28.067 0.6133341 0.013333333 115 2.7536339
13.33 28.200 0.6400008 0.013333333 120 2.761450382
15.00 28.333 0.6666675 0.013333333 125 2.768786127
16.96 28.467 0.6933342 0.013333333 130 2.775684163
19.29 28.600 0.7200009 0.013333333 135 2.782182531
22.11 28.733 0.7466676 0.013333333 140 2.788314987
25.59 28.867 0.7733343 0.013333333 145 2.794111592
30.00 29.000 0.800001 0.013333333 150 2.799599198
inf 30 1 #VALUE!

Pa0 10.000
 Producto Reactivo
Pa bar Xa (1-Xa)
2 0 1 Presión total vs Tiempo Reactivo
1.764757787 0.117387466902 0.882612533098
3
1.579030475 0.210110584518 0.789889415482
f(x) = 0.004260809159682 x + 2.27086500674835
1.428673477 0.2852037169412.5
0.714796283059
1.304461258 0.34725848564 0.65274151436

Presión Total (bar)

2
1.200120012 0.399399399399 0.600600600601
1.111234582 0.443826473861.50.55617352614
1.034607625 0.482133609529 0.517866390471
1
0.967866822 0.515503875969 0.484496124031
0.909214893 0.544833864360.50.45516613564
0.857265324 0.570815450644 0.429184549356
0
0
0.810931355 0.593991067803 0.406008932197 20 40 60 80 100 120 140 160

0.769349131 0.614791987673 0.385208012327 tiempo (min)

0.731823338 0.633565408575 0.366434591425
0.697788012 0.650593990217 0.349406009783
0.666777796 0.666110183639 0.333889816361Presión vs Tiempo Reactivo
0.638406537 0.680306905371 0.319693094629
2.5
0.612351122 0.693345599509 0.306654400491
2
0.588339119 0.705362404243 0.294637595757
0.566139214 0.716472923164 0.283527076836
1.5
0.545553737 0.726775956284 0.273224043716
Pt (bar)

0.52641276 0.736356446085 0.263643553915

1
0.508569394 0.745287824758 0.254712175242
0.491896013 0.753633899975 0.246366100025
0.5
0.476281196 0.761450381679 0.238549618321
0
0.461627236 0.768786127168 0.231213872832
0 20 40 60 80 100 120 140 160
0.44784809 0.775684163302 0.224315836698 tiempo (min)
0.434867692 0.782182531039 0.217817468961
0.422618545 0.788314987299 0.211685012701
0.411040549 0.794111591517 0.205888408483
0.400080016 0.799599198397 0.200400801603
activo 30 Presión vs Tiempo
29
f(x) = 9.37474E-07 x⁵ − 8.46739E-05 x⁴ + 0.00299863 x³ − 0.0548686 x² + 0.6068181 x
28 + 25.023644
R² = 0.999919647344428
27
p (bar)

26

25

24

23

120 140 160 22

0 5 10 15 20 25 30 35
tiempo (min)

120 140 160

Tiempo (min) [Acetaminosalol] (ppm) Ca (En el parche)
0 0 1000
1 28 972
2 57 943
3 85 915
5 113 887
6 142 858
7 170 830
9 198 802
10 227 773
12 255 745
14 283 717
16 312 688
18 340 660
20 368 632
22 397 603
24 425 575
27 453 547
30 482 518
33 510 490
36 538 462
39 567 433
43 595 405
48 623 377
53 652 348
58 680 320
65 708 292
72 737 263
81 765 235
91 793 207
104 822 178
120 850 150
inf 1000 0

Columna1 Columna2 Columna3 Columna4

Orden 0 0.5 1
Xa
0.1 -0.105360515657826 0.3130167725 0.834032445247956
0.15 -0.162518929497775 0.2032700394 0.640336938760748
0.2 -0.22314355131421 0.1003635798 0.475884995327111
0.25 -0.287682072451781 0 0.326634259978281
0.3 -0.356674943938732 -0.100312296 0.185626758862366
0.35 -0.430782916092454 -0.202380548 0.048620744579389
0.4 -0.510825623765991 -0.307763786 -0.087421571790755
0.45 -0.59783700075562 -0.418004579 -0.225010673029409
0.5 -0.693147180559945 -0.534799997 -0.366512920581664
0.55 -0.798507696217772 -0.660176143 -0.514437136173803
0.6 -0.916290731874155 -0.79671672 -0.671726992092122
0.65 -1.04982212449868 -0.947914405 -0.842150990724733
0.7 -1.20397280432594 -1.118774343 -1.03093043315872
0.75 -1.38629436111989 -1.316957897 -1.24589932370724
0.8 -1.6094379124341 -1.555207251 -1.49993998675952
0.85 -1.89711998488588 -1.857315413 -1.81696079477961
0.9 -2.30258509299405 -2.276591825 -2.25036732731245
0.95 -2.99573227355399 -2.982991167 -2.97019524904216
1 #NUM! #NUM! #NUM!
α= CA/CA0

α Ln t % de acetaminosalol disuelto
1 Err:502 0
0.9716666667 0.093476439 2.833333333
0.9433333333 0.8087379258 5.666666666
0.915 1.2369345297 8.499999999
0.8866666667 1.5480023086 11.333333332
0.8583333334 1.7952262949 14.166666665
0.83 2.002367489 16.999999998
0.8016666667 2.1821259753 19.833333331
0.7733333334 2.3421074364 22.666666664
0.745 2.4872427697 25.499999997
0.7166666667 2.6209245457 28.33333333
0.6883333334 2.7455995156 31.166666663
0.66 2.8631029032 33.999999996
0.6316666667 2.9748592231 36.833333329
0.6033333334 3.0820094019 39.666666662
0.5750000001 3.1854950552 42.499999995
0.5466666667 3.2861168684 45.333333328
0.5183333334 3.3845769266 48.166666661
0.4900000001 3.481511035 50.999999994
0.4616666667 3.5775149851 53.833333327
0.4333333334 3.6731675943 56.66666666
0.4050000001 3.7690528022 59.499999993
0.3766666667 3.8657830085 62.333333326
0.3483333334 3.9640261492 65.166666659
0.3200000001 4.0645398567 67.999999992
0.2916666668 4.1682177529 70.833333325
0.2633333334 4.2761561587 73.666666658
0.2350000001 4.389755811 76.499999991
0.2066666668 4.5108860265 79.333333324
0.1783333334 4.6421668385 82.166666657
0.1500000001 4.7874917463 84.99999999
0 #VALUE!

Columna5 Columna6 Columna7 Columna1

1.5 2 2.5 3

1.464309319 2.1972245773 3.0162789574 3.90197266957464

1.1518300318 1.7346010554 2.3803642757 3.0783358020892
0.9050825361 1.3862943611 1.9149932902 2.484906649788
0.6931471806 1.0986122887 1.5404450409 2.01490302054226
0.5016741061 0.8472978604 1.2209884525 1.62048774862069
0.3225305144 0.6190392084 0.9372568348 1.27581874479529
0.1503815801 0.4054651081 0.6773047071 0.965080896043587
-0.018750731 0.2006706955 0.432947668 0.67759476755246
-0.188226406 0 0.1979909945 0.405465108108164
-0.361257643 -0.200670695 -0.032774006 0.142274055664679
-0.541303908 -0.405465108 -0.264262973 -0.117783035656384
-0.732522947 -0.619039208 -0.501726385 -0.380628184961225
-0.940436871 -0.84729786 -0.75152595 -0.653141845946246
-1.173116861 -1.098612289 -1.022390932 -0.944461608840852
-1.443635475 -1.386294361 -1.327918576 -1.26851132546351
-1.776055948 -1.734601055 -1.69259666 -1.65004366736004
-2.223911567 -2.197224577 -2.170306454 -2.14315735606594
-2.957344519 -2.944438979 -2.931478634 -2.91846349276318
#NUM! #NUM! #NUM! #NUM!
% de acetaminosalol remanente
100 Porcentaje de farmaco disuelto en fu
97.166666667 140
94.333333334
120
91.500000001
88.666666668 100
85.833333335

Tiempo (min)
80
83.000000002
80.166666669 60
77.333333336
40
74.500000003
71.66666667 20
68.833333337 0
66.000000004 0 10 20 30 40 50
63.166666671 % de farmaco disuelto
60.333333338
57.500000005
54.666666672 Porcentaje de acetaminosalol remanente e
51.833333339
140
49.000000006
46.166666673 120
43.33333334
40.500000007 100
37.666666674
34.833333341 80
32.000000008
60
29.166666675
26.333333342 40
23.500000009
20.666666676 20
17.833333343
15.00000001 0
10 20 30 40 50 60 70
0

1.2
f(x) = − 0.205812765832312 x + 1.19068334379361
R² = 0.943524993855515
1

0.8

0.6
Xa

0.4
 0.8

0.6

Xa
0.4

0.2

0
-4 -3 -2 -1 0 1 2 3 4 5
Ln Φ
maco disuelto en funcion del tiempo

30 40 50 60 70 80 90
% de farmaco disuelto

inosalol remanente en función del tiempo

50 60 70 80 90 100 110

19068334379361
3 4 5 6
Tiempo (min) pH pOH [OH]
0.000 12.0000 2.0000 0.01000 Ca t 1/2
0.274 11.9883 2.0117 0.00973 0.01000 10.25
0.563 11.9762 2.0238 0.00947 0.008 15
0.870 11.9638 2.0362 0.00920 0.006 23
1.194 11.9510 2.0490 0.00893 0.004 40
1.538 11.9379 2.0621 0.00867
1.905 11.9243 2.0757 0.00840
2.295 11.9103 2.0897 0.00813
2.712 11.8958 2.1042 0.00787
3.158 11.8808 2.1192 0.00760
3.636 11.8653 2.1347 0.00733
4.151 11.8492 2.1508 0.00707
4.706 11.8325 2.1675 0.00680
5.306 11.8151 2.1849 0.00653
5.957 11.7970 2.2030 0.00627
6.667 11.7782 2.2218 0.00600
7.442 11.7584 2.2416 0.00573
8.293 11.7377 2.2623 0.00547
9.231 11.7160 2.2840 0.00520
10.270 11.6931 2.3069 0.00493
11.429 11.6690 2.3310 0.00467
12.727 11.6435 2.3565 0.00440
14.194 11.6163 2.3837 0.00413
15.862 11.5873 2.4127 0.00387
17.778 11.5563 2.4437 0.00360
20.000 11.5229 2.4771 0.00333
22.609 11.4867 2.5133 0.00307
25.714 11.4472 2.5528 0.00280
29.474 11.4037 2.5963 0.00253
34.118 11.3554 2.6446 0.00227
40.000 11.3010 2.6990 0.00200
f(x) = − 1.476
R² = 0.99768
Ln t 1/2

-5.6 -5.4
-5.6 -5.4
 y x
Ln t 1/2 Ln Ca
2.32727771 -4.60517019
2.7080502 -4.82831374
3.13549422 -5.11599581
3.68887945 -5.52146092

Ln Ca vs Ln t 1/2
4

f(x) = − 1.47643287642124 x − 4.44342376524213 3.5

R² = 0.997686067276829
3

2.5
Ln t 1/2

1.5

0.5

0
-5.6 -5.4 -5.2 -5 -4.8 -4.6 -4.4
Ln Ca
 1

0.5

0
-5.6 -5.4 -5.2 -5 -4.8 -4.6 -4.4
Ln Ca
Tiempo (min) A
0.000 0.0000
0.281 0.0319
0.572 0.0639
0.873 0.0958
1.185 0.1277
1.509 0.1596
1.845 0.1916
2.195 0.2235
2.561 0.2554
2.942 0.2874
3.342 0.3193
3.760 0.3512
4.201 0.3831
4.665 0.4151
5.156 0.4470
5.677 0.4789
6.232 0.5109
6.825 0.5428
7.463 0.5747
8.151 0.6067
8.901 0.6386
9.722 0.6705
10.630 0.7024
11.646 0.7344
12.800 0.7663
14.134 0.7982
15.714 0.8302
17.655 0.8621
20.168 0.8940
23.743 0.9259
30.000 0.9579
inf 0.9875
ln t Tiempo (min) A A (reactivo) α (dCa/dt) Ra
0 1.4 -0.25231915 0.25231915
-1.80138771 3 0.1964 1.2036 0.85970792 -0.05597673 0.05597673
-1.10824053 6 0.3359 1.0641 0.76009973 -0.04074496 0.04074496
-0.70277542 9 0.4409 0.9591 0.68508665 -0.03124284 0.03124284
-0.41509335 12 0.5233 0.8767 0.62620185 -0.02486339 0.02486339
-0.1919498 15 0.5901 0.8099 0.57852926 -0.02034655 0.02034655
-0.00962824 18 0.6454 0.7546 0.53900236 -0.01701664 0.01701664
0.14452244 21 0.6922 0.7078 0.50560082 -0.01448243 0.01448243
0.27805383 24 0.7323 0.6677 0.47693479 -0.01250356 0.01250356
0.39583687 27 0.7672 0.6328 0.45201413 -0.01092516 0.01092516
0.50119738 30 0.7978 0.6022 0.43011267 -0.00964352 0.00964352
0.59650756 33 0.8250 0.5750 0.41068475 -0.00858689 0.00858689
0.68351894 36 0.8494 0.5506 0.39331172 -0.00770425 0.00770425
0.76356165 39 0.8713 0.5287 0.37766654 -0.00695847 0.00695847
0.83766962 42 0.8911 0.5089 0.36348973 -0.00632194 0.00632194
0.90666249 45 0.9092 0.4908 0.35057251 -0.0057738 0.0057738
0.97120101 48 0.9258 0.4742 0.33874488 -0.00529798 0.00529798
1.03182563 51 0.9410 0.4590 0.32786686 -0.00488199 0.00488199
1.08898405 54 0.9550 0.4450 0.31782207 -0.00451593 0.00451593
1.14305127 57 0.9681 0.4319 0.30851286 -0.00419192 0.00419192
1.19434456 60 0.9802 0.4198 0.29985668 -0.00390359 0.00390359
1.24313473 63 0.9915 0.4085 0.29178318 -0.00364575 0.00364575
1.28965474 66 1.0021 0.3979 0.28423205 -0.00341412 0.00341412
1.3341065 69 1.0120 0.3880 0.27715122 -0.00320519 0.00320519
1.37666612 72 1.0213 0.3787 0.27049552 -0.003016 0.003016
1.41748811 75 1.0301 0.3699 0.26422553 -0.00284406 0.00284406
1.45670883 78 1.0384 0.3616 0.25830668 -0.0026873 0.0026873
1.49444915 81 1.0462 0.3538 0.25270853 -0.00254392 0.00254392
1.5308168 84 1.0536 0.3464 0.24740415 -0.00241241 0.00241241
1.56590812 87 1.0607 0.3393 0.24236963 -0.00229145 0.00229145
1.59980967 90 1.0674 0.3326 0.23758365 -0.00217991 0.00217991
1.63259949 93 1.0738 0.3262 0.23302715 -0.00207682 0.00207682
1.66434819 96 1.0798 0.3202 0.22868302 -0.00198131 0.00198131
1.69511985 99 1.0856 0.3144 0.22453584 -0.00189264 0.00189264
1.72497281 102 1.0912 0.3088 0.2205717 -0.00181016 0.00181016
1.75396035 105 1.0965 0.3035 0.21677802 -0.00173328 0.00173328
1.78213123 108 1.1016 0.2984 0.21314337 -0.0016615 0.0016615
1.8095302 111 1.1065 0.2935 0.20965733 -0.00159435 0.00159435
1.83619845 114 1.1112 0.2888 0.20631042 -0.00153145 0.00153145
1.86217393 117 1.1157 0.2843 0.20309396 -0.00147243 0.00147243
1.88749174 120 1.1200 0.2800 0.2 -0.00141526 0.00141526
inf 1.4000
y Ln ra x ln A
Ln Ra Ln A
-1.37706053 0.33647224
-2.88281923 0.18530966
-3.20042305 0.06216661
-3.4659651 -0.04173771
-3.69435875 -0.13161027
-3.89484395 -0.21079393
-4.07356382 -0.2815631
-4.23481898 -0.34553559
-4.38174181 -0.40390326
-4.51668666 -0.45756961
-4.64146901 -0.50723585
-4.75751892 -0.55345715
-4.8659833 -0.59668056 1
-4.9677963 -0.6372714
-5.06372901 -0.67553201 0.9
-5.1544254 -0.71171548
-5.24042893 -0.74603578 0.8
-5.3222024 -0.77867542
-5.40014326 -0.80979135 0.7
-5.47459534 -0.83951951
-5.54585813 -0.86797842 0.6
-5.61419405 -0.89527204
-5.6798344 -0.92149206 0.5
α

-5.74298405 -0.94671975
-5.80382534 -0.9710275 0.4
-5.86252127 -0.99448003
-5.91921815 -1.01713549 0.3
-5.9740478 -1.03904629
-6.0271294 -1.06025981 0.2
-6.07857108 -1.08081908
-6.12847121 -1.10076325 0.1
-6.17691956 -1.12012805
-6.22399829 -1.13894621 0
-4 -3 -2 -1 0 1 2 3
-6.26978276 -1.15724772
-6.31434227 -1.17506021 Ln Φ
-6.35774071 -1.19240914
-6.40003709 -1.20931801
-6.44128602 -1.22580861
-6.48153816 -1.24190112
-6.52084057 -1.25761432
-6.56043959 -1.27296568
 Orden 0
Orden 0.5
Orden 1
Orden 1.5
Orden 2
Orden 2.5
Orden 3
Problema

1 2 3 4 5
 x1 x2 y
Ca Cb Ra Ln Ca Ln Cb Ln Ra x1^2
0.01 0.005 0.0005 -4.605170186 -5.29831737 -7.60090246 21.2075924
0.02 0.01 0.002 -3.912023005 -4.60517019 -6.2146081 15.303924
0.03 0.02 0.006 -3.506557897 -3.91202301 -5.11599581 12.2959483
0.04 0.03 0.012 -3.218875825 -3.5065579 -4.42284863 10.3611616
0.05 0.05 0.025 -2.995732274 -2.99573227 -3.68887945 8.97441185
0.06 0.05 0.03 -2.813410717 -2.99573227 -3.5065579 7.91527986
Sumatorias -21.0517699 -23.313533 -30.5497923 76.058318

Minimos Cuadrados linealizados

Matrriz
na0 + a1Σx1 + a2Σx2… 6 -21.0517699 -23.313533
a0Σx1 + a1Σx1^2 + a2Σx2x1… -21.0517699 76.058318 84.8227316
a0Σx2 + a1Σx1x2 + Σx2^2… -23.313533 84.8227316 94.8284554

a0 lnk= #NAME?
a1 ɒ= #NAME?
a2 β= #NAME?
x2^2 x1x2 x1y x2y
28.0721669 24.3996532 35.0034494 40.2719935
21.2075924 18.0155317 24.3116899 28.6193279
15.303924 13.7177352 17.9395355 20.0138933
12.2959483 11.2871744 14.2366005 15.5089748
8.97441185 8.97441185 11.0508952 11.0508952
8.97441185 8.42822528 9.86538757 10.5047087
94.8284554 84.8227316 112.407558 125.969793

Matriz Inversa
Σy= -30.5497923 17.6012224 18.793764 -12.4835073
Σx1y= 112.407558 18.793764 25.4559992 -18.1495981
Σx2y= 125.969793 -12.4835073 -18.1495981 13.1760433

K= 10
Resumen

Estadísticas de la regresión
Coeficiente d 1
Coeficiente d 1
R^2 ajustado 1
Error típico 1.58282E-16
Observacione 6

ANÁLISIS DE VARIANZA
Grados de libertad
Suma de cuadrados
Promedio de los cuadradosF Valor crítico de F
Regresión 2 12.485553 6.24277648 2.4918E+32 4.6705E-49
Residuos 3 7.51594E-32 2.50531E-32
Total 5 12.485553

Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%
Intercepción 2.30258509 6.64053E-16 3.4675E+15 5.2897E-47 2.30258509 2.30258509 2.30258509
Variable X 1 1 7.98594E-16 1.2522E+15 1.12318E-45 1 1 1
Variable X 2 1 5.74544E-16 1.7405E+15 4.18255E-46 1 1 1
Superior 95.0% LnK= 2.30258509 K= 10
2.30258509 α= 1
1 β= 1
1