IFMBE Proceedings

Volume 65

Series editor
James Goh

Deputy Editors
Fatimah Ibrahim
Igor Lacković
Piotr Ładyżyński
Emilio Sacristan Rock
The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational
organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a
non-profit organization fostering the creation, dissemination and application of medical and biological engineering knowledge
and the management of technology for improved health and quality of life. Its activities include participation in the formulation
of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical,
and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate
information and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational.

The IFMBE is a WHO accredited NGO covering the full range of biomedical and clinical engineering, healthcare, healthcare
technology and management. It is representing through its 60 member societies some 120.000 professionals involved in the
various issues of improved health and health care delivery.

IFMBE Officers
President: James Goh, Vice-President: Shankhar M. Krishnan
Past President: Ratko Magjarevic
Treasurer: Marc Nyssen, Secretary-General: Kang Ping LIN
http://www.ifmbe.org

More information about this series at http://www.springer.com/series/7403

Hannu Eskola Outi Väisänen
•

Jari Viik Jari Hyttinen (Eds.)

•

EMBEC & NBC 2017

Joint Conference of the European Medical and Biological
Engineering Conference (EMBEC) and the Nordic-Baltic
Conference on Biomedical Engineering and Medical
Physics (NBC), Tampere, Finland, June 2017

123
Editors
Hannu Eskola Jari Viik
BioMediTech Institute and Faculty BioMediTech Institute and Faculty
of Biomedical Sciences and Engineering of Biomedical Sciences and Engineering
Tampere University of Technology Tampere University of Technology
Tampere Tampere
Finland Finland
Outi Väisänen Jari Hyttinen
BioMediTech Institute and Faculty BioMediTech Institute and Faculty
of Biomedical Sciences and Engineering of Biomedical Sciences and Engineering
Tampere University of Technology Tampere University of Technology
Tampere Tampere
Finland Finland

ISSN 1680-0737 ISSN 1433-9277 (electronic)

IFMBE Proceedings
ISBN 978-981-10-5121-0 ISBN 978-981-10-5122-7 (eBook)
DOI 10.1007/978-981-10-5122-7

Library of Congress Control Number: 2017943085

© Springer Nature Singapore Pte Ltd. 2018, corrected publication 2018

This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of
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The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of
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Printed on acid-free paper

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 Preface

We warmly welcome you to the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic
Conference on Biomedical Engineering and Medical Physics (NBC) held in Tampere, Finland, in June 2017! These two long
running conferences are now combined for the first time with aim to build a truly cross-discipline conference. With close to
500 accepted papers we believe that this task has been achieved. We aimed to present all traditional fields of biomedical
engineering, but also to highlight new emerging fields, such as tissue engineering, bioinformatics, biosensing, neurotech-
nology, additive manufacturing technologies for medicine and biology, and bioimaging, to name a few. Biomedical engi-
neering is developing and - similarly as medicine - the science of biomedical engineering is transferring from organs and body
towards cells, genes and proteins and on the other hand towards healthcare delivery with important aspect of health technology
assessment and clinical engineering and physics. Our selection of plenary and keynote speakers, as well as the topics of almost
50 special sessions and all the contributed papers also indicate this transition towards even more multi–disciplinary science.
Moreover, we also emphasized the role of education, translational research, and commercialization. With special pithing event
for the Finnish start-ups and broad commercial exhibition, we hope to achieve these goals as well.
The conference is endorsed by EMBEC society, EAMBES and IFMBE. We would like to give our sincere thanks for all
of them for the support on organizing the meeting and hope that same kind of collaboration will be available in coming
EMBEC meetings as well.
This proceedings published by Springer at IFMBE conference series contains the 4 page papers submitted to the conference.
The one-page abstracts are covered in separate proceedings that is available during the conference.
To achieve this proceedings book about 2000 colleagues have been active on writing and reviewing the papers, as well as
co-chairing the review process. Each paper has been evaluated by minimum of three specialists, who have spent enormous
efforts on the evaluation process. We would like to express our gratitude to all the organizers of the special sessions, authors
and especially the associate editors and reviewers who – despite the challenges of the online system - were able to ensure the
quality of the meeting and this proceedings.
We do hope that you as a participant of the scientific and social program of EMBEC & NBC 2017 find the event as
excellent platform for meet colleagues in this multidisciplinary area and to enhance knowledge and scientific achievements.
Welcome to Tampere in 2017!

Jari Hyttinen
Chair of the EMBEC and NBC 2017 Conference
Hannu Eskola
Editor in Chief of the EMBEC and NBC 2017 Conference Proceedings
The original version of the book was revised:
For detailed information please see Erratum.
The erratum to the book is available at
https://doi.org/10.1007/978-981-10-5122-7_283
 Organization

Local Organizing Committee

Jari Hyttinen (Chair) Tampere University of Technology
Francois Christophe Tampere University of Technology
Hannu Eskola Tampere University of Technology
Pasi Kallio Tampere University of Technology
Minna Kellomäki Tampere University of Technology
Juha Laiho University of Tampere
Johanna Lehto University of Tampere
Jonathan Massera Tampere University of Technology
Jarno Mikkonen University of Jyväskylä
Pia Mäenpää University of Tampere
Hannu Nieminen Tampere University of Technology
Matti Nykter University of Tampere
Tapio Seppänen University of Oulu
Heli Skottman University of Tampere
Kaisa Valtee University of Tampere
Jari Viik Tampere University of Technology
Outi Väisänen Tampere University of Technology
Juho Väisänen University of Tampere

Scientific Committee
Jari Hyttinen (Chair) Tampere University of Technology, Finland
Kari Antila VTT Technical Research Centre of Finland Ltd, Finland
Joseph Barbenel University of Strathclyde, UK
Regis Beuscart University of Lille, France
Toni Björninen Tampere University of Technology, Finland
Patrik Celka Polar Electro Oy, Switzerland
Paulo de Carvalho University of Coimbra, Portugal
Sergio Cerutti Polytechnic University of Milan, Italy
Francois Christophe Tampere University of Technology, Finland
Cristiana Corsi University of Bologna, Italy
Kathleen Curran University College Dublin, Ireland
Kim Dremstrup University of Aalborg, Denmark
Olaf Dössel Karlsruhe Institute of Technology, Germany
Hannu Eskola Tampere University of Technology, Finland
Dimitris Fotiadis University of Ioannina, Greece
Birgit Glasmacher Leibniz University of Hanover, Germany
James Goh Cho Hong National University of Singapore, Singapore
Bin He University of Minnesota, USA
Thordur Helgason Reykjavik University, Iceland
Hiie Hinrikus Tallinn University of Technology, Estonia
Pekka Hänninen University of Turku, Finland
Ernesto Iadanza University of Florence, Italy
Risto Ilmoniemi Aalto University, Finland
Ákos Jobbágy Budapest University of Technology and Economics, Hungary
X Organization

Petro Julkunen Kuopio University Hospital, Finland

Timo Jämsä University of Oulu, Finland
Eleni Kaldoudi Democritus University of Thrace, Greece
Pasi Kallio Tampere University of Technology, Finland
Pasi Karjalainen University of Eastern Finland, Finland
Aleksejs Kataševs Riga Technical University, Latvia
Minna Kellomäki Tampere University of Technology, Finland
Tuomas Kenttä University of Oulu, Finland
Charles James Kirkpatrick University Medical Center Mainz, Germany
Ilkka Korhonen Tampere University of Technology, Finland
Rami Korhonen University of Eastern Finland, Finland
Jukka Kortelainen University of Oulu, Finland
Shankhar M. Krishnan Wentworth Institute of Technology, USA
Panayiotis Kyriacou City University London, UK
Jaanus Lass Tallin University of Technology, Estonia
Piotr Ladyzynski Polish Academy of Sciences, Poland
Pablo Laguna University of Zaragoza, Spain
Lenka Lhotská Czech Technical University in Prague, Czech Republic
Dayou Li University of Bedfordshire, UK
Kang-Ping Lin Chung-Yan Christian University, Taiwan
Tarmo Lipping Tampere University of Technology, Finland
Ratko Magjarevic University of Zagreb, Croatia
Andrzej Materka Lodz University of Technology, Poland
Mario Medvedec University Hospital Centre Zagreb, Croatia
Kalju Meigas Tallin University of Technology, Estonia
Andreas Meltzer University of Dundee, UK
Mart Min Tallinn University of Technology, Estonia
Marcel Mlynczak Warsaw University of Technology, Poland
Ralph Müller ETH Zurich, Switzerland
Hannu Nieminen University of Oulu, Finland
Miika Nieminen University of Oulu, Finland
Jaakko Nieminen Aalto University, Finland
Matti Nykter University of Tampere, Finland
Tapio Ollonqvist Turku University Hospital, Finland
Nicolas Pallikarakis University of Patras, Greece
Jan-Erik Palmgren Kuopio University Hospital, Finland
Lauri Parkkonen Aalto University, Finland
Constantinos S. Pattichis University of Cyprus, Cyprus
Leandro Pecchia University of Warwick, UK
Mikael Persson Chalmers University of Technology, Sweden
Kristjan Pilt Tallinn University of Technology, Estonia
Sampsa Pursiainen Tampere University of Technology, Finland
Blanca Rodriguez University of Oxford, UK
Richard Reilly Trinity College Dublin, Ireland
Katja Schenke-Layland University of Tübingen, Germany
Heinrich Schima Medical University of Vienna, Austria
Erik Schkommadau University of Applied Sciences and Arts Northwestern Switzerland, Switzerland
Tapio Seppänen University of Oulu, Finland
Stefano Severi University of Bologna, Italy
Maria Siebes Academic Medical Center, The Netherlands
Heli Skottman University of Tampere, Finland
Josep Sola Centre Suisse d’Electronique et de Microtechnique (CSEM), Switzerland
Organization XI

Jos Spaan Academic Medical Center, The Netherlands

Leif Sörnmo Lund University, Sweden
Liz Tanner University of Glasgow, UK
Mika Tarvainen University of Eastern Finland, Finland
Mirja Tenhunen Tampere University Hospital, Finland
Heikki Teriö Karolinska Institutet, Sweden
Lenarz Thomas Hannover Medical School, Germany
Leena Ukkonen Tampere University of Technology, Finland
Jos Vander Sloten University of Leuven, Belgium
Jari Viik Tampere University of Technology, Finland
Johanna Virkki Tampere University of Technology, Finland
Juho Väisänen University of Tampere, Finland
May Wang Georgia Institute of Technology, USA
Karin Wårdell Linköping University, Sweden
Marcy Zenobi-Wong ETH Zurich, Switzerland
Martha Zequera University of Javeriana, Colombia

Organised by

BioMediTech Institute, joint institute of University of Tampere and Tampere University of Technology, Tampere, Finland
Tampere University of Technology, Tampere, Finland
University of Tampere, Tampere, Finland
Finnish Society for Medical Physics and Medical Engineering, Finland

Co-Organized and Supported by

International Organization for Medical and Biological Engineering

European Alliance for Medical and Biological Engineering & Sciences
EMBEC Society, Austria

Supported by

City of Tampere, Tampere, Finland

Tampere Convention Bureau, Tampere, Finland
 Contents

A Novel Composite and Suspended Nanofibrous Scaffold for Skin Tissue Engineering . . . . . . . . . . . . . . . . . . . . . 1
Caihong Zhu, Chengwei Wang, Ruihua Chen, and Changhai Ru

Temperature effect on the baseline noise in MEA measurements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

Tomi Ryynänen and Jukka Lekkala

The Effect of Occlusion with the Cuff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Ákos Jobbágy and P. Nagy

Functional connectivity of hand-arm muscles during a repetitive dynamic task . . . . . . . . . . . . . . . . . . . . . . . . . . . 13

Afshin Samani

EEG Spectral Asymmetry Index Detects DifferencesBetween Leaders and Non-leaders . . . . . . . . . . . . . . . . . . . . . 17

Toomas Põld, Maie Bachman, Laura Orgo, Kaia Kalev, Jaanus Lass, and Hiie Hinrikus

Prediction of meditation experience using fMRI functional connectivity and multivariate pattern analysis. . . . . . . . . 21
R. Guidotti, Cosimo Del Gratta, M.G. Perrucci, G.L. Romani, and A. Raffone

Evaluation of WAMP protocol in real-time remote ECG monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

Muhammad Awais Aslam, Aleksei Tiulpin, Kai Noponen, and Tapio Seppänen

Current trends in Electronic Family Resilience Tools: Implementing a tool for the cancer domain . . . . . . . . . . . . . . 29
Eleni Kazantzaki, Lefteris Koumakis, Haridimos Kondylakis, Chiara Renzi, Chiara Fioretti, Ketti Mazzocco,
Kostas Marias, Manolis Tsiknakis, and Gabriella Pravettoni

Prior Variances and Depth Un-Biased Estimators in EEG Focal Source Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . 33
A. Koulouri, V. Rimpiläinen, M. Brookes, and J.P. Kaipio

Using quantitative parameters of ocular blood filling with transpalpebral rheoophthalmography. . . . . . . . . . . . . . . . 37

Petr V. Luzhnov, Dmitry M. Shamaev, Elena N. Iomdina, Gayane A. Markosyan, Elena P. Tarutta,
and Alisa A. Sianosyan

Pre-processing to Enhance the Quantitative Analysis of Glucose from NIR and MIR Spectra . . . . . . . . . . . . . . . . . 41
Osamah A. Alrezj, Krishna Patchava, Mohammed Benaissa, and Salih A. Alshebeili

Motion artifact detection in respiratory signals based on Teager energy operator and accelerometer signals . . . . . . . 45
Marcel Młyńczak and Gerard Cybulski

Integrating human factors and health economics to inform the design of medical device: a conceptual framework . . . 49
Simone Borsci, Peter Buckle, Ijeoma Uchegbu, Melody Ni, Simon Walne, and George B. Hanna

UV Intensity of Pre-irradiation in Gafchromic XR-RV3 and XR-SP2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53

Tadao Kuwano, Yoshihiro Takeda, Toshizo Katsuda, Rumi Gotanda, Tatsuhiro Gotanda, Takuya Akagawa,
Nobuyoshi Tanki, Atsushi Noguchi, Yasuyuki Kawaji, Kenyu Yamamoto, and Koichi Yabunaka

The level of mental load during a functional task is reflected in oculometrics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57

Ramtin Zargari Marandi, Afshin Samani, and Pascal Madeleine

Quantitative pigment extraction analysis for human pluripotent stem cell derived retinal pigment epithelial cells . . . . 61
Jochen Rieck, Kati Juuti-Uusitalo, Reija Autio, Vesa Hytönen, and Heli Skottman
XIV Contents

Enhanced Wiener Filter for Ultrasound image denoising . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65

Fabio Baselice, Giampaolo Ferraioli, Vito Pascazio, and Gilda Schirinzi

Heart Rate Variability Analysis and Performance during a Repeated Mental Workload Task . . . . . . . . . . . . . . . . . 69
Rossana Castaldo, Luis Montesinos, Tim S. Wan, Andra Serban, Sebastiano Massaro, and Leandro Pecchia

Importance of HTA in modern Clinical Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73

Guillermo Avendaño, Antonio Rienzo, and Luis Danyau

Non-Contact Estimation of Sleep Staging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77

Alberto Zaffaroni, Emer P. Doheny, Luke Gahan, Yuri Ivanov, Hannah Kilroy, Niall O’Mahony,
and Damien O’Rourke

Automatic real time derivation of breathing rate from thermal video sequences . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Dragos Daniel Țarălungă, Bogdan Mocanu, and Ruxandra Țapu

Simulation of the Vectorcardiogram using a simple Volume Conductor Model . . . . . . . . . . . . . . . . . . . . . . . . . . . 85

Leonie Korn, Daniel Rüschen, Steffen Leonhardt, and Marian Walter

Data Flow and Collection for Remote Patients Monitoring: From Wireless Sensors through a Relational
Database to a Web interface in Real Time . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89
Ivan Tomasic, Nikola Petrović, Hossein Fotouhi, Maria Lindén, and Mats Björkman

Application for pre-processing and visualization of electrodermal activity wearable data. . . . . . . . . . . . . . . . . . . . . 93

Kari Suoja, Jari Liukkonen, Jari Jussila, Henna Salonius, Niina Venho, Virpi Sillanpää, Vilma Vuori,
and Nina Helander

Connectivity Analysis of Full Montage EEG in Traumatic Brain Injury Patients in the ICU . . . . . . . . . . . . . . . . . . 97
Tarmo Lipping, Niko Erkintalo, Mika Särkelä, Riikka S.K. Takala, Ari Katila, Janek Frantzén, Jussi P. Posti,
Markus Müller, and Olli Tenovuo

Cuff-induced changes of pulse arrival time: models and experimental results . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101
Erik Bresch, Jens Muehlsteff, and Lars Schmitt

Biomedical Engineering Education in Context of New Legislation in the Czech Republic . . . . . . . . . . . . . . . . . . . 105
Lenka Lhotska and Jirí Hozman

Ultrasound despeckling based on Non Local Means . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

Michele Ambrosanio, Fabio Baselice, Giampaolo Ferraioli, and Vito Pascazio

Photoacoustic image reconstruction with uncertainty quantification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113

Jenni Tick, Aki Pulkkinen, and Tanja Tarvainen

Determination of the Effect of SiO2 Nanoparticles on Spontaneous Activity of Rat Uterus Smooth Muscles
using Wavelet Scalogram Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Selma Yaman, Ülkü Çömelekoğlu, and Evren Değirmenci

Effect of Nitrocellulose Membrane on the Electrochemical Behavior of Hydroquinone. . . . . . . . . . . . . . . . . . . . . . 121

Adriana Ferancova, Maarit Hattuniemi, Satu Kämäräinen, Pirkko Tervo, Elisa Tikkanen, Jarkko Räty,
and Vesa Virtanen

Nocturnal Use of Light Compression Garments and Recovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125

Viivi I. Jokinen, Janika Korpela, Eeva Lehtinen, Jarmo Perttunen, and Jari Viik

Tensor Regularized Total Variation for Third Harmonic Generation Brain Images . . . . . . . . . . . . . . . . . . . . . . . . . 129
Zhiqing Zhang, Marie Louise Groot, and Jan C. de Munck
Contents XV

Knowledge and Data Driven Approaches Applied to Clinical Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133

Diana Mendes, Simão Paredes, Teresa Rocha, Jorge Henriques, Paulo Carvalho, and João Morais

Improvement in Quantitative Analysis of RBCs Velocity in Microcirculation Based on Block-matching

Motion Estimation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Wen-Chen Lin, Kuan-Chou Chen, Sheng-Cheng Huang, Cheng-Lun Tsai, and Kang-Ping Lin

Multiresolution MAPEM Method for 3D Reconstruction of Symmetrical Particles with Electron Microscopy . . . . . . 141
Erman Acar, Mo A. Baikoghli, Marie Stark, Sari Peltonen, Ulla Ruotsalainen, and R. Holland Cheng

Evaluation of the accuracy and reliability for photoplethysmography based heart rate and beat-to-beat
detection during daily activities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
Julia Pietilä, Saeed Mehrang, Johanna Tolonen, Elina Helander, Holly Jimison, Misha Pavel,
and Ilkka Korhonen

Association of Drivers’ sleepiness with heart rate variability: A Pilot Study with Drivers on Real Roads . . . . . . . . . 149
Farhad Abtahi, Anna Anund, Carina Fors, Fernando Seoane, and Kaj Lindecrantz

Comparison of linear and non-linear heart rate variability indices between preterm infants at their theoretical
term age and full term newborns. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Elina Helander, Nadine Khodor, Antti Kallonen, Alpo Värri, Hugues Patural, Guy Carrault, and Patrick Pladys

Geometry-based Computational Modeling of Calcium Signaling in an Astrocyte . . . . . . . . . . . . . . . . . . . . . . . . . . 157

Muhammad Uzair Khalid, Aapo Tervonen, Iina Korkka, Jari Hyttinen, and Kerstin Lenk

Inter-observer variation in segmenting glioma on MRI before and after resection . . . . . . . . . . . . . . . . . . . . . . . . . 161
Martin Visser, Domenique Müller, Niels Verburg, Roelant Eijgelaar, Marnix Witte, Frederik Barkhof,
Philip de Witt Hamer, and Jan de Munck

The Quality of Automatic Artifact Identification in Ambulatory Impedance Cardiography Monitoring . . . . . . . . . . . 165
Gerard Cybulski, Gerard Młyńczak, Marcel Żyliński, Anna Strasz, Anna Gąsiorowska,
and Wiktor Niewiadomski

Automatic Classification of Forum Posts: A Finnish Online Health Discussion Forum Case . . . . . . . . . . . . . . . . . . 169
Oguzhan Gencoglu

Detection and Assessment of Sleep-Disordered Breathing with Emfit Mattress . . . . . . . . . . . . . . . . . . . . . . . . . . . 173

Mirja Tenhunen, Jari Hyttinen, Jari Viik, Jose Maria Perez-Macias, and Sari-Leena Himanen

Chronic Disease Management via Mobile Apps: The Diabetes Case . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Sotirios Zaires, Georgios Perrakis, Eleni Bekri, Panagiotis Katrakazas, George Lambrou,
and Dimitris Koutsouris

Heart Rate Variability During Cardiorespiratory Exercise Test in Type 1 Diabetes . . . . . . . . . . . . . . . . . . . . . . . . 181
Mika P. Tarvainen, Sami Nikkonen, Juha E. Peltonen, Jyrki M. Aho, Anne S. Koponen, Jukka A. Lipponen,
Antti-Pekka E. Rissanen, and Heikki O. Tikkanen

Bots in messaging platforms, a new paradigm in healthcare delivery: application to custom

prescription in dermatology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Álvaro Alesanco, Jorge Sancho, Yolanda Gilaberte, Edgar Abarca, and Jose García

Texture-property relations of bioamine crosslinked gellan gum hydrogels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189

Janne T. Koivisto, Olli Koskela, Toni Montonen, Jenny E. Parraga, Tiina Joki, Laura Ylä-Outinen,
Susanna Narkilahti, Edite Figueiras, Jari Hyttinen, and Minna Kellomäki
XVI Contents

Prostate cancer detection ex vivo combining Raman spectroscopy and tactile resonance technology. . . . . . . . . . . . . 193
Olof A. Lindahl, Kerstin Ramser, Tomas Bäcklund, Börje Ljungberg, and Anders Bergh

Markerless Motion Analysis for Early Detection of Infantile Movement Disorders. . . . . . . . . . . . . . . . . . . . . . . . . 197
Nikolas Hesse, A. Sebastian Schroeder, Wolfgang Müller-Felber, Christoph Bodensteiner, Michael Arens,
and Ulrich G. Hofmann

Predictive Modeling of Exercise Response in CVD Patients under Rehabilitation . . . . . . . . . . . . . . . . . . . . . . . . . 201

Dimitris Filos, Andreas Triantafyllidis, Vasilis Manolios, Kristina Livitckaia, Jommw Claes, Roselien Buys,
Veronique Cornelissen, Evelyn Kouidi, Nicos Maglaveras, and Ioanna Chouvarda

Application of photocatalytic nanolayers SmartCoat in health care facility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205

Vit Prindis, Jan Michalek, and Ivana Kubatova

An Evolution Equation of Blood Flow in a Dilated Artery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209

Elena V. Nikolova, Vladimir K. Kotev, and Gergana S. Nikolova

Enhanced Sensing of Interleukin 8 by Stripping Voltammetry: Carbon Nanotubes versus Fullerene . . . . . . . . . . . . . 213
Sarah Tonello, Mariagrazia Marziano, Giulia Abate, Tugba Kilic, Maurizio Memo, Daniela Uberti,
Sandro Carrara, Nicola F. Lopomo, Mauro Serpelloni, and Emilio Sardini

A Neural Network Model of Peripersonal Space Representation Around Different Body Parts . . . . . . . . . . . . . . . . 217
Matteo Vissani, Andrea Serino, and Elisa Magosso

Artifact detection in neonatal EEG using Gaussian mixture models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221

Minna Kauppila, Sampsa Vanhatalo, and Nathan J. Stevenson

Health Technology Assessment of Medical Devices in Low and Middle Income Countries: study design
and preliminary results. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Leandro Pecchia

Research and development of methods and means, based on the analysis of processes of human brain activity,
for creating the control systems of the anthropomorphic technical devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
Roman V. Olejnik, Sergey V. Krivosheev, and Stanislav S. Reznikov

Performance Analysis of Novel Flexible Electrodes for Wearable ECG/Heart Rate Monitoring . . . . . . . . . . . . . . . . 237
Emma S. Kaappa, Atte S. Joutsen, and Jukka Vanhala

Calling Homopolymer Stretches from Raw Nanopore Reads by Analyzing k-mer Dwell Times. . . . . . . . . . . . . . . . 241
Peter Sarkozy, Ákos Jobbágy, and Peter Antal
99m 123
Physical characteristics of collimators for dual-isotope imaging with Tc and I ....................... 245
Virpi Tunninen, Tomi Kauppinen, and Hannu Eskola

Detection of sleep stages in neonatal EEG records . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250

Vladimir Krajca, Vaclava Piorecka, Hana Schaabova, Jan Strobl, Marek Piorecky, Lenka Lhotska,
and Karel Paul

A Framework for Technology Enhanced Education in Orthopaedics: Knee Surgery Case Study . . . . . . . . . . . . . . . 254
Goran Devedzic, Suzana Petrovic, Aleksandar Matic, Branko Ristic, Vladan Devedzic, Zahra Asgharpour,
and Sasa Cukovic

Evidence-based approach to medical equipment maintenance monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 258

Valentina Gonnelli, Francesca Satta, Francesco Frosini, and Prof. Ernesto Iadanza
Contents XVII

Center of Pressure based Assessment of Balance Responses to Repeated Perturbations of Upright Stance . . . . . . . . 262
Alessandro Mengarelli, Stefano Cardarelli, Sandro Fioretti, Laura Burattini, Francesco Di Nardo,
and Federica Verdini
18
Effect of sinus attenuation in MR-based attenuation correction in F-FDG brain PET/MR. . . . . . . . . . . . . . . . . . . 266
Jarmo Teuho, Jouni Tuisku, Jani Linden, and Mika Teräs

Coronary artery disease diagnosis by means of heart rate variability analysis using respiratory information. . . . . . . . 270
David Hernando, M. Kähönen, J. Lázaro, R. Lehtinen, T. Nieminen, K. Nikus, T. Lehtimäki, R. Bailón,
and J. Viik

Managing heterogeneous data in the HEALS project . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 274

Luc J.M. Cluitmans

Numerical modeling of cardiovascular physiology Study of dynamic changes during autonomic reflexes . . . . . . . . . 278
João Apura, Jorge Tiago, A. Sequeira, and L.B. Rosário

Computational model for multifocal imaging in optical projection tomography and numerical analysis
of all-in-focus fusion in tomographic image reconstruction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282
Olli Koskela, Sampsa Pursiainen, Birhanu Belay, Toni Montonen, Edite Figueiras, and Jari Hyttinen

Overview of Health Behavior Change Interventions to Promote Physical-activity-related Adherence

in Patients with Heart Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 286
Kristina Livitckaia, Vassilis Koutkias, Nicos Maglaveras, Evelyn Kouidi, Mark van Gils, and Ioanna Chouvarda

Quantization of the response signal differences for the electrical bioimpedance measurement . . . . . . . . . . . . . . . . . 290
Paul Annus, Raul Land, Eiko Priidel, Margus Metshein, Mart Min, and Olev Märtens

Robust Assistance Control of Left Ventricular Assist Devices. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294

Daniel Rüschen, Sebastian Opitz, Leonie Korn, Steffen Leonhardt, and Marian Walter

Impacts of laminin and polyethyleneimine surface coatings on morphology of differentiating human

SH-SY5Y cells and networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 298
Heidi Teppola, Jertta-Rinna Sarkanen, Tuula Orvokki Jalonen, and Marja-Leena Linne

Electrode Comparison for Textile-Integrated Electrocardiogram and Impedance Pneumography Measurement . . . . . . 302
Katariina Tuohimäki, Shadi Mahdiani, Vala Jeyhani, Antti Vehkaoja, Pekka Iso-Ketola, Jukka Vanhala,
Jari Viik, and Matti Mäntysalo

Nonlinear Local Projection Filter for Impedance Pneumography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 306

Javier Gracia, Ville-Pekka Seppä, Anna Pelkonen, Anne Kotaniemi-Syrjänen, Mika Mäkelä, Pekka Malmberg,
and Jari Viik

A Technique for Quantifying the Relative Angular Movement of the Head and Shoulders . . . . . . . . . . . . . . . . . . . 310
Patrik Kutilek, Petr Volf, Jan Hejda, Jirí Hozman, Slavka Viteckova, Vaclav Krivanek, Radek Doskocil,
and Rudolf Cerny

Clinical Engineering Online Courses for Africa. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 314

Ernesto Iadanza and Anna Worm

Magnetic Resonance Imaging Restoration based on Kolmogorov-Smirnov Non Local Mean. . . . . . . . . . . . . . . . . . 318
Fabio Baselice, Giampaolo Ferraioli, and Antonietta Sorriso

Incorporating spike correlations into an SVM-based neonatal seizure detector . . . . . . . . . . . . . . . . . . . . . . . . . . . . 322

Karoliina T. Tapani, Sampsa Vanhatalo, and Nathan J. Stevenson
XVIII Contents

Development and Testing of a XYZ Scanner for Atomic Force Microscope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 326
Kunhai Cai, Xianbin He, Yanling Tian, Xianping Liu, and Liangyu Cui

Optically Induced Semiconductor Gas Sensor: Acetone Detection Range using Continuous and Cyclic
Optical Irradiation Types . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330
Yuri Dekhtyar, Maksims Komars, Filips Morozovs, and Maksims Sneiders

K-Band Doppler Radar is feasible and accurate to record and assess overnight respiratory rate . . . . . . . . . . . . . . . . 334
Rakesh Vasireddy, Corinne Roth, Josef Goette, Marcel Jacomet, and Andreas Vogt

Determination of Drug Activity on Pulmonary Arterial Hypertension using Time Domain Parameters of ECG . . . . . 338
Hüseyin Yanık, Evren Değirmenci, Belgin Büyükakıllı, Derya Çıtırık, and Olgu Hallıoğlu

Short-term stability of combined finger and toe photoplethysmogram analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . 342

Mikko Peltokangas, Matti Huotari, Jarmo Verho, Ville M. Mattila, Juha Röning, Pekka Romsi, Jukka Lekkala,
Antti Vehkaoja, and Niku Oksala

Impact assessment and risk analysis in the redevelopment of a healthcare structure . . . . . . . . . . . . . . . . . . . . . . . . 346
Elena Ciagli, Marcantonio Catelani, Lorenzo Ciani, Fabrizio Dori, Cristiana Degl’Innocenti, Marco Geddes,
Silvia Briani, Francesco Frosini, Piero Tortoli, Andrea Belardinelli, and Ernesto Iadanza

The Study of Needle Electrode Characteristics for Venipuncture Electrical impedance Controlling System . . . . . . . . 350
Ivan A. Kudashov, S.I. Shchukin, and M.B. Al-harosh

Electric field of EEG during anesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354

Ville Jäntti, Narayan Puthanmadam Subramaniyam, Kotoe Kamata, Tuomo Ylinen, Arvi Yli-Hankala,
Pasi Kauppinen, and Outi Väisänen

Removal Estimation of Uremic CVD Marker Phosphate in Dialysis Using Spectrophoto-and

Fluorimetrical Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 358
Jana Holmar, Jürgen Arund, Sigrid Kalle, Kai Lauri, Merike Luman, Risto Tanner, Ruth Tomson,
and Ivo Fridolin

A Developed Magnetic Force Microscope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 362

Jinyun Y. Liu, Zuobin B. Wang, and Dayou Y. Li

Assessment of Instantaneous Heartbeat Dynamics in amnestic Mild Cognitive Impairment . . . . . . . . . . . . . . . . . . . 366

NIcola Toschi, Gaetano Valenza, Luca Citi, Maria Guerrisi, Stefano Orsolini, Carlo Tessa, Stefano Diciotti,
and Riccardo Barbieri

Design and Development of a Low-Budget Infrasonic Detector. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 370

Marios Pitsaris, Panagiotis Katrakazas, and Dimitrios-Dionysios Koutsouris

An automatic deep learning approach for coronary artery calcium segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . 374
Gianmarco Santini, Daniele Della Latta, Nicola Martini, Gabriele Valvano, Andrea Gori, Andrea Ripoli,
Carla L. Susini, Luigi Landini, and Dante Chiappino

Simple and convenient remote photoplethysmography system for monitoring regional anesthesia effectiveness . . . . . 378
Uldis Rubins, Aleksejs Miscuks, and Marta Lange

Low Invasive Technology of Sclera Crosslinking: an Experimental Implementation. . . . . . . . . . . . . . . . . . . . . . . . 382

Elena N. Iomdina, Elena P. Tarutta, Vladimir A. Semchishen, Natalia Yu. Ignatyeva, Tatiana N. Kiseleva,
Alisa A. Sianosyan, and Sergey V. Milash
Contents XIX

Ultraviolet Ray Strength for Pre-irradiation in Gafchromic EBT2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 386

Toshizo Katsuda, Rumi Gotanda, Tatsuhiro Gotanda, Takuya Akagawa, Nobuyoshi Tanki, Atsushi Noguchi,
Tadao Kuwano, and Kouichi Yabunaka

Testing of infusion pumps in healthcare institutions in Bosnia and Herzegovina . . . . . . . . . . . . . . . . . . . . . . . . . . 390

Lejla Gurbeta, Berina Alic, Z. Dzemic, and Almir Badnjevic

Determination of Stimulation Timing Pattern based on EMG Signals for FES Cycling with Pedaling Wheelchair . . . . 394
Takashi Watanabe and Takumi Tadano

Stroke volume assessment by impedance cardiography: Comparative analysis with transthoracic echocardiography . . . . 398
Sandra Silluta, Kristjan Pilt, Elja Bischler, Kristina Kööts, Kalju Meigas, and Margus Viigimaa

IFMBE/Clinical Engineering Division projects for the advancement of the profession of Clinical Engineering . . . . . 402
Ernesto Iadanza

2D-EEG Topography and fMRI Brain Images for Relaxation and Letter Writing . . . . . . . . . . . . . . . . . . . . . . . . . 406
N.B. Mohamad, Khuan Y. Lee, Wahidah Mansor, Z. Mahmoodin, and S. Amirin

Three-dimensional Magnetic Camera for the Characterization of Magnetic Manipulation Instrumentation Systems
for Electrophysiology Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 410
Joris Pascal, Dorian Vogel, Sven Knecht, Marco Vescovo, and Luc Hébrard

Automatic Segmentation of Computed Tomography Images of Liver Using Watershed

and Thresholding Algorithms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 414
Tugce Sena Avşar and Sami Arıca

Contactless 3D detection of respiratory effort . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 418

Heinrich Garn, Bernhard Kohn, Fabian Schmid, Christoph Wiesmeyr, Klaus Dittrich, Gerhard Kloesch,
Marion Boeck, Andrijana Stefanic, Magdalena Mandl, Markus Wimmer, and Stefan Seidel

Stimulation Waveform Selection to Suppress Functional Electrical Stimulation Artifact from Surface
EMG Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 422
Ville Rantanen, Antti Vehkaoja, and Jarmo Verho

Ankle Muscles Co-Activation Patterns During Normal Gait: An Amplitude Evaluation . . . . . . . . . . . . . . . . . . . . . 426
Stefano Cardarelli, Andrea Gentili, Alessandro Mengarelli, Federica Verdini, Sandro Fioretti, Laura Burattini,
and Francesco Di Nardo

Interpretation of the pinched point position in human skin memristor measurements . . . . . . . . . . . . . . . . . . . . . . . 430
Oliver Pabst and Ørjan Grøttem Martinsen

The use of the TLD-100 for quality assurance in Total Body Irradiation (TBI) . . . . . . . . . . . . . . . . . . . . . . . . . . . 434
Arnie Verde Nolasco and Luiz O. Faria

Evaluation of a Deep Convolutional Neural Network method for the segmentation of breast microcalcifications
in Mammography Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 438
Gabriele Valvano, Daniele Della Latta, Nicola Martini, Gianmarco Santini, Andrea Gori, Chiara Iacconi,
Andrea Ripoli, Luigi Landini, and Dante Chiappino

Changes in network activity in a neuro-robotic environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 442

Daisuke Ito, Jacopo Tessadori, Stefano Buccelli, and Michela Chiappalone

Method for Evaluation of Surgical Wound Healing: A Case Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 446

Atte Kekonen, Mikael Bergelin, Jan-Erik Eriksson, Ilkka Kaartinen, and Jari Viik
XX Contents

Treatment planning of microbrachytherapy with 3D NSGA-II. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 450

Richard Brown, Manuel Bardiès, and Xavier Franceries

Characterization of Chloride Channels in Human Embryonic Stem Cell Derived Retinal Pigment Epithelium . . . . . . 454
Iina Korkka, Julia K. Johansson, Heli Skottman, Jari Hyttinen, and Soile Nymark

Clinical Engineering Revisited: the Grip of Leadership - Part 2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 458

Mario Medvedec and Mladen Poluta

The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability . . . . . . 462
faezeh Marzbanrad, Chandan K. Karmakar, Ahsan H. Khandoker, Marimuthu Palaniswami, Toshio Moritani,
and Herbert F. Jelinek

Laser Interference Lithography for Applications in Biomedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 466

Wenjun Li, Xiaofeng Wei, Qi Liu, Dayou Li, and Zuobin Wang

Testing of dialysis machines in healthcare institutions in Bosnia and Herzegovina. . . . . . . . . . . . . . . . . . . . . . . . . 470

Lejla Gurbeta, Berina Alic, Zijad Dzemic, and Almir Badnjevic

Development of radiofrequency ultrasound based method for elasticity characterization using low frequency
endogenous motion: phantom study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 474
Andrius Sakalauskas, Rytis Jurkonis, Sigita Gelman, Ar̄unas Lukoševičius, and Limas Kupčinskas

Quantification of T-wave Morphological Variability Using Time-warping Methods . . . . . . . . . . . . . . . . . . . . . . . . 478

Julia Ramírez, Michele Orini, Esther Pueyo, and Pablo Laguna

Optimized Raman Setting of Objective Lens, Laser Power and Integration Time for High and Low Concentration
of Nonstructural Protein 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 482
Nur Hainani Othman, Khuan Y. Lee, Afaf Rozan Mohd Radzol, and Wahidah Mansor

Blood flow analysis for prediction of pressure ulcer development using diffuse correlation spectroscopy . . . . . . . . . 486
Alec Lafontant, David Diaz, Michael Neidrauer, Michael S. Weingarten, Rose Ann DiMaria-Ghalili,
Ericka Scruggs, Julianne Rece, Guy W. Fried, Vladimir L. Kuzmin, Peter Lewin, and Leonid Zubkov

A comparison between the commercially available gamma criteria evolution software and new modified
algorithm for field-in-field technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 490
Alvis Bernans, Ritvars Meziels, and Alexei Katashev

Time-frequency analysis of surface EMG signals for maximum energy localization during walking . . . . . . . . . . . . . 494
Annachiara Strazza, Federica Verdini, Laura Burattini, Sandro Fioretti, and Francesco Di Nardo

Magnetic fields and childhood leukemia; science and policy in the Netherlands . . . . . . . . . . . . . . . . . . . . . . . . . . 498
Gert Kelfkens and Mathieu Pruppers

To improve patient care & safety of rural patients empowering the village doctors . . . . . . . . . . . . . . . . . . . . . . . . 502
Dr. Mannan Mridha and Dr. Muhammad Islam

Deep Learning for outcome prediction of postanoxic coma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 506

Michel J.A.M. van Putten, Jeannette Hofmeijer, Barry J. Ruijter, and Marleen C. Tjepkema-Cloostermans

Estimation of kinematic parameters in a model of artificial aortic valve leaflets. . . . . . . . . . . . . . . . . . . . . . . . . . . 510

Mariusz Pawlak, Wojciech Klein, Arkadiusz Mężyk, Wojciech Danek, Michał Sobota, and Jakub Włodarczyk

Graphene electrodes for long-term impedance pneumography - a feasibility study . . . . . . . . . . . . . . . . . . . . . . . . . 514

Marcel Młyńczak, Marek Zyliński, Daniel Janczak, Małgorzata Jakubowska, Wiktor Niewiadomski,
and Gerard Cybulski
Contents XXI

Separation of Superimposed Electrocardiographic and Electromyographic Signals . . . . . . . . . . . . . . . . . . . . . . . . . 518

Agnese Sbrollini, Angela Agostinelli, Micaela Morettini, Federica Verdini, Francesco Di Nardo,
Sandro Fioretti, and Laura Burattini

Artificial Eye Blink Pacemaker - A First Investigation into the Blink Production Using Constant-Interval
Electrical Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 522
Jani Lylykangas, Mirja Ilves, Hanna Venesvirta, Ville Rantanen, Eeva Mäkelä, Antti Vehkaoja, Jarmo Verho,
Jukka Lekkala, Markus Rautiainen, and Veikko Surakka

Academia Industry Partnerships in the Biomedical Engineering Domain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 526

Shankar M. Krishnan

MEDICIS-Promed: an Innovative Training Network for a new generation of professionals in nuclear medicine . . . . 530
Thomas Elias Cocolios, Cristina Ferrari, Fiona Reid, and Thierry Stora

Day-to-day repeatability of the results of the finger-toe-plot analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 534

Mikko Peltokangas, Anca A. Telembeci, Jarmo Verho, Jukka Lekkala, Antti Vehkaoja, and Niku Oksala

The Venous Occlusion Effect To Increase The Accuracy Of Electrical Impedance Peripheral Veins Detection . . . . . 538
Mugeb B. Al-harosh and S.I. Shchukin

Enhanced Patient Queue Management: Development of Slot-Back Model Equation Using University of Maiduguri
Medical Centre as Experimental Site . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 542
Aboaba A. Abdulfattah, Abideen A. Ismail, and Peter Dibal

Setup of a white light selective plane microscope to investigate microprobe insertion in a brain model . . . . . . . . . . 547
Mohamed Fadi Yassine, Kevin Joseph, and Ulrich G. Hofmann

Learned vs. Hand-Designed Features for ECG Beat Classification: A Comprehensive Study . . . . . . . . . . . . . . . . . . 551
Turker Ince, Morteza Zabihi, Serkan Kiranyaz, and Moncef Gabbouj

Predicting Gene Expression Levels from Histone Modification Signals with Convolutional Recurrent
Neural Networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 555
Lingyu Zhu, Juha Kesseli, Matti Nykter, and Heikki Huttunen

The Role of Simulation for Preoperative Planning in Patients Requiring Mechanical Circulatory Support . . . . . . . . . 559
Massimo Capoccia, Sanjeet Avtaar Singh, and Claudio De Lazzari

Topics and Trends Analysis in eHealth Literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 563

George Drosatos, Spiros E. Kavvadias, and Eleni Kaldoudi

Contactless Respiration Monitoring in Real-Time via a Video Camera . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 567

Fabian Braun, Alia Lemkaddem, Virginie Moser, Stephan Dasen, Olivier Grossenbacher, and Mattia Bertschi

Designing a mobile system for safety reporting of arthroplasty adverse events . . . . . . . . . . . . . . . . . . . . . . . . . . . 571
Hanne ÅserødB. Sc and Ankica BabicPhD

Augmented virtuality platform for usability evaluation of a novel endoscope concept . . . . . . . . . . . . . . . . . . . . . . 575
Tuukka Karvonen, Goshiro Yamamoto, Yusuke Muranishi, Toshihiko Sato, and Tomohiro Kuroda

Determination of Mass-Inertial Characteristics of the Human Body in Basic Body Positions: Computer
and Mathematical Modelling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579
Vladimir Konstantinov Kotev, Gergana S. Nikolova, and Daniel M. Dantchev

PathWalue: Pathways with Value . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583

Pauli Losoi and Tommi Aho
XXII Contents

Human Activity Recognition Using A Single Optical Heart Rate Monitoring Wristband Equipped
with Triaxial Accelerometer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 587
Saeed Mehrang, Julia Pietila, Johanna Tolonen, Elina Helander, Holly Jimison, Misha Pavel,
and Ilkka Korhonen

Line Contrast Figure of Merit for Dual Energy X-ray Image Quality Assessment: Initial Results. . . . . . . . . . . . . . . 591
Aris Dermitzakis and Nicolas Pallikarakis

Development of a pneumo-tactile vibrissae stimulator for freely behaving rodents . . . . . . . . . . . . . . . . . . . . . . . . . 595

Olaf ChristDipl. Inf, Dipl. Inf., Benedikt Hofmeier, and Ulrich G. Hofmann

Development of a pneumo-tactile vibrissae stimulator for freely behaving rodents . . . . . . . . . . . . . . . . . . . . . . . . . 599

Olaf Christ, Benedikt Hofmeier, and Ulrich G. Hofmann

Insulin Bolus Calculator with Automatic Speech Recognition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 603

Piotr Foltynski, Piotr Ladyzynski, Ewa Pankowska, Karolina Mazurczak, Monika Rachuta, Barbara Bonalska,
and Janusz Krzymien

Broadband dielectric characterization of zebrafish embryo suspensions using the impedance

spectroscopy technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 607
Sagrario Muñoz, José Luis Sebastián, Maria Carmen Pérez, Jesús Pablo García, Pedro Antoranz,
and Aránzazu Sanchis

Day-to-day variation in sleep quality and static balance: results from an exploratory study . . . . . . . . . . . . . . . . . . . 611
Luis Montesinos, Rossana Castaldo, Davide Piaggio, and Leandro Pecchia

Optical wrist-worn device for sleep monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 615

Philippe Renevey, Ricard Delgado-Gonzalo, Alia Lemkaddem, Martin Proença, Mathieu Lemay, Josep Solà,
Adrian Tarniceriu, and Mattia Bertschi

Peculiarities of Spectral and Multifractal Estimates of the Brain Microwave Radiation . . . . . . . . . . . . . . . . . . . . . . 619
Vladimir S. Kublanov, Vasilii I. Borisov, and Taisiya G. Kopytova

Sensitivity Distribution of Electrical Impedance Epithelial Measurement Systems . . . . . . . . . . . . . . . . . . . . . . . . . 623

Aapo Tervonen and Jari Hyttinen

Syncope Prediction using Photoplethysmography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 627

Nuno Pinheiro, Ricardo Couceiro, Jens Muehlsteff, Christian Eickholt, Jorge Henriques, and Paulo Carvalho

Evidence-gathering across industry and academia on early Health Technology Assessment (HTA) of medical
devices: survey design and piloting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 631
Stefania Manetti, Richeal M. Burns, and Giuseppe Turchetti

Automated Pipeline for Brain ROI Analysis with Results Comparable to Previous Freehand Measures
in Clinical Settings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 635
Tero Ilvesmäki, Ullamari Hakulinen, and Hannu Eskola

Extents, Locations and Geometrical Configurations of Calcification in Abdominal Aortic Aneurysm . . . . . . . . . . . . 639
Zinan He, Rosaire Mongrain, Simon Lessard, and Gilles Soulez

To What Extent Can We Shorten HRV Analysis in Wearable Sensing? A Case Study on Mental Stress Detection. . . . 643
Rossana Castaldo, Luis Montesinos, Paolo Melillo, Sebastiano Massaro, and Leandro Pecchia

Mechanism of Low-level Microwave Radiation Effect on Brain: Frequency Limits . . . . . . . . . . . . . . . . . . . . . . . . 647

Hiie Hinrikus, Maie Bachmann, and Jaanus Lass
Contents XXIII

Inter-regional Dynamics in Hippocampal Sub-Networks Co-cultured on Microelectrode Arrays and Connected

via Micro-Tunnels. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 651
Daniele Poli, Thomas B. DeMarse, Gregory J. Brewer, and Prof Bruce C. Wheeler

Simple Assessment of Insulin Sensitivity in the Zucker Rat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 655

Micaela Morettini, Emanuela Faelli, Luisa Perasso, Sandro Fioretti, Laura Burattini, Piero Ruggeri,
and Francesco Di Nardo

Conduction velocity effects due to ephaptic interactions between myelinated axons . . . . . . . . . . . . . . . . . . . . . . . . 659
M. Capllonch-Juan and F. Sepulveda

The importance of VERIFI (“Vasomotoric Elimination and Reconstructed Identification of the Initial set-point”)
for the performance of the CNAP technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 663
Jürgen Fortin, Christian Fellner, Nina Mocnik, Julian Grond, Thomas Brunner, and Doris Flotzinger

Identification of feasible pathway information for c-di-GMP binding proteins in cellulose production . . . . . . . . . . . 667
Syeda Sakira Hassan, Rahul Mangayil, Tommi Aho, Olli Yli-Harja, and Matti Karp

Variation of Cardiac and Respiratory Waveform on Human Thoraxin the Case of Inductive Coupling . . . . . . . . . . . 671
Margus Metshein, Paul Annus, Raul Land, Andrei Krivošei, Jaan Ojarand, Alvo Aabloo, and Mart Min

Basic research on countermeasures against barium sulfate aggregation using a gastric phantom. . . . . . . . . . . . . . . . 675
Kenyu Yamamoto, Naoko Fujiwara, Yoshihiro Takeda, Rena Takakura, Tetsushi Ishida, Toshizo Katsuda,
Tadao Kuwano, Misao Yoneda, Tatsuhiro Gotanda, Shuji Abe, Makoto Shimada, Masami Azuma,
and Sachiko Tanaka

Altered synaptic signaling due to b-amyloid interference in astrocytes: A modeling study . . . . . . . . . . . . . . . . . . . 679
R. Havela, T. Manninen, and M.-L. Linne

Life Science innovation ecosystem in Poland – case study of BioTechMed Cluster Mazovia . . . . . . . . . . . . . . . . . 683
Paweł Nowicki

Wearable multi-antenna multi-band measurement system for personal radio-frequency exposure assessment . . . . . . . 687
Patrick Van Torre, Sam Agneessens, Reza Aminzadeh, Arno Thielens, Matthias Van den Bossche, Wout Joseph,
and Hendrik Rogier

Entropy-based Axon-to-Axon Mutual Interaction Characterization via Iterative Learning Identification. . . . . . . . . . . 691
Qichun Zhang and Francisco Sepulveda

Fast skull conductivity estimation using Boundary Element Method . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 695

Jan C. de Munck and Joost Hulshof

Motor control strategies in gastrocnemins mnscles are affected differently in yonnger than in older adnlts
after 14-day bed rest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 699
Matjaž Divjak, Boštjan Šimunič, Rado Pišot, Mitja Gerževič, Katja Koren, and Aleš Holobar

A wearable 12-lead ECG T-shirt with textile electrodes for unobtrusive long-term monitoring – Evaluation
of an ongoing clinical trial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 703
Xinchi Yu, Anna Boehm, Wilko Neu, Boudewijn Venema, Nikolaus Marx, Steffen Leonhardt,
and Daniel Teichmann

Effects of small and rapid temperature oscillations on adherent cell cultures: Exposure system, experimental
method and a pilot study on human cancer cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 707
Lucas A. Portelli, Aditya Kausik, and Frank S. Barnes
XXIV Contents

Impact of High-Frequency Electromagnetic Fields on Secretion and Structure of Pancreas in Rats. . . . . . . . . . . . . . 711
Smiljana D. Paraš, Radoslav B. Gajanin, Maja Lj. Manojlović, and Zoran Nj. Ružić

Analysis and optimization of clinical pathway of a cancer patient in a University Hospital . . . . . . . . . . . . . . . . . . . 715
Elena Ciagli, Lorenzo Antonuzzo, Francesco Frosini, Duccio Cocchi, Jacopo Regolini, Alessandro Benassi,
Piero Tortoli, Andrea Belardinelli, Francesco Di Costanzo, and Ernesto Iadanza

Assessment of Health Risks of Intermediate Frequency Magnetic Fields . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 719

Mikko Herrala, Kajal Kumari, Amélie Blomme, Muhamma Waseem Khan, Henna Koivisto, Jonne Naarala,
Päivi Roivainen, Heikk Tanila, Matti Viluksela, and Jukka Juutilainen

Atrial Signals – Modeling Meets Biosignal Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 723

Olaf Dössel, Gustavo Lenis, Axel Loewe, Stefan Pollnow, Markus Rottmann, Bhawna Verma, Claus Schmitt,
Armin Luik, and Tobias Oesterlein

Early stage Health Technology Assessment of Electrochemotherapy of skin-directed therapy for skin melanoma
and Basal Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 727
Eva Pirc, Leandro Pecchia, Gregor Serša, Marko Snoj, Aleš Grošelj, Matej Reberšek, and Damian Miklavčič

General Data Format Security Extensions for Biomedical Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 731

Saulius Daukantas, Vaidotas Marozas, George Drosatos, Eleni Kaldoudi, and Arunas Lukosevicius

Dry electrode sizes in recording ECG and heart rate in wearable applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . 735
Atte S. Joutsen, Emma S. Kaappa, Tapio J. Karinsalo, and Jukka Vanhala

Clinical Engineering and the Changing Face of Patient Safety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 739

Monique Frize

Shielding static magnetic fields from Magnetic Resonance Imaging units by ferromagnetic material . . . . . . . . . . . . 743
Tarmo Koppel, Peeter Ross, and Inese Vilcane

Evaluating Different Shapes of Cranial Fixation Mini-plates Using Finite Element Method. . . . . . . . . . . . . . . . . . . 747
Jakub Chamrad, Petr Marcián, Nathaniel Narra, and Libor Borák

Actively Breathing Mechanical Lung Simulator Development and Preliminary Measurements. . . . . . . . . . . . . . . . . 751
Richard Paštěka and Mathias Forjan

Rényi and permutation entropy analysis for assessment of cardiac autonomic neuropathy . . . . . . . . . . . . . . . . . . . . 755
Claudia Carricarte-Naranjo, David J. Cornforth, Lazaro M. Sanchez-Rodriguez, Marta Brown, Mario Estévez,
Andres Machado, and Herbert F. Jelinek

The Precordial Electrical Impedance Methods Possibilities in the Evaluation of Local Heart Chambers Contractility . . . . . 759
Artem I. Malakhov, Aleksey N. Tikhomirov, Sergey I. Shchookin, and Vera Y. Kaplunova

Expectation–maximization algorithm with a nonlinear Kalman smoother for MEG/EEG connectivity estimation . . . . 763
Narayan Puthanmadam Subramaniyam, Filip Tronarp, Simo Särkkä, and Lauri Parkkonen

DataBrain: a web-accessible database for three-dimensional reconstructions and quantitative

morphometrics of neurons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 767
C. Magliaro, A.L. Callara, N. Arami, C. De Maria, V. Ferrari, N. Vanello, A. Tognetti, M. Mangione,
M.C. Viaggi, F. Vaglini, M. Castagna, D. De Rossi, L. Landini, and A. Ahluwalia

Predicting Blood Glucose Levels for a Type I Diabetes Patient by Combination of Autoregressive
with One Compartment Open Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 771
Kyriaki Saiti, Martin Macaš, Kateřina Štechová, Pavlína Pit’hová, and Lenka Lhotská
Contents XXV

Time characteristics of prolonged partial obstruction periods using an Emfit mattress . . . . . . . . . . . . . . . . . . . . . . 775
Jose Maria Perez-Macias, Jari Viik, Alpo Värri, Sari-Leena Himanen, and Mirja Tenhunen

Functional Brain Connectivity analysis using Coherent Measures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 779

V. Santhosh Kumar and T.V.K. Hanumantha Rao

Carbon on poly(-caprolactone) (PCL) Ink-jet Printed Sensor for Monitoring Cell Cultures of Myoblasts . . . . . . . . . 783
Mariagrazia Marziano, Sarah Tonello, Marialaura Serzanti, Michela Borghetti, Nicola F. Lopomo, Mauro Serpelloni,
Stefano Pandini, Andrea Merlettini, Chiara Gualandi, Maria Letizia Focarete, Massimo Messori, Maurizio Toselli,
Daniela Uberti, Maurizio Memo, Patrizia Dell’Era, and Emilio Sardini

A Hybrid Machine Learning Method for Detecting Cardiac Ejection Murmurs . . . . . . . . . . . . . . . . . . . . . . . . . . . 787
Arash Gharehbaghi, Amir A. Sepehri, Maria Lindén, and Ankica Babic

Cardio-respiratory phase locking in newborn and one month infants as a function of sleep state . . . . . . . . . . . . . . . 791
Maristella Lucchini, Nicolò Pini, William P. Fifer, Nina Burtchen, and Maria G. Signorini

Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795
Rainer Körber

Dependence of the EEG Nonlinear Coupling on the Frequency Bands and the Segment Lengths . . . . . . . . . . . . . . 799
Laura Orgo, Maie Bachmann, Kaia Kalev, Mari Järvelaid, Jaan Raik, and Hiie Hinrikus

Clinical Engineering Revisited: the Grip of Leadership - Part 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 803

Mario Medvedec and Mladen Poluta

Prediction of Bone Mineral Density in Menopaused Women by Using Bioimpedance Parameters . . . . . . . . . . . . . . 807
Fırat Matur, Nermin Ozturk, and Yekta Ulgen

Reproducible preparation method of hydrogels for cell culture applications – case study with spermidine
crosslinked gellan gum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 811
Christine Gering, Janne T. Koivisto, Jenny E. Parraga, and Minna Kellomäki

Nonlinear Dynamics of Heart Rate Variability in Children with Asthmatic Symptoms . . . . . . . . . . . . . . . . . . . . . . 815
Javier Milagro, Eduardo Gil, Juan Bolea, Ville-Pekka Seppä, L. Pekka Malmberg, Anna S. Pelkonen,
Anne Kotaniemi-Syrjänen, Mika J. Mäkelä, Jari Viik, and Raquel Bailón

Investigation of photoplethysmographic signal augmentation index estimation differences between fingers . . . . . . . . 819
Kristjan Pilt, Sandra Silluta, Kristina Kööts, Deniss Karai, Kalju Meigas, and Margus Viigimaa

Portal and Hepatic Vein Segmentation with Leak Restriction: A Pilot Study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 823
R.P. Kumar, L. Barkhatov, B. Edwin, F. Albregtsen, and O.J. Elle

MRI imaging texture features in prostate lesions classification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 827

Piotr Sobecki, Dominika Życka-Malesa, Ihor Mykhalevych, Katarzyna Sklinda, and Artur Przelaskowski

The Use of Multichannel Photoplethysmography for the Analysis of Heart Rate Variability . . . . . . . . . . . . . . . . . . 831
Lukas Peter, M. Ladrova, M. Cerny, and Iveta Bryjova

Electrodermal activity asymmetry in sleep - a case study for migraine detection . . . . . . . . . . . . . . . . . . . . . . . . . . 835
H. Mönttinen, H. Koskimäki, P. Siirtola, and J. Röning

High Resolution E-Jet Printed Temperature Sensor on Artificial Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 839

Tiina Vuorinen, Mika-Matti Laurila, Rahul Mangayil, Matti Karp, and Matti Mäntysalo
XXVI Contents

Bayesian multi–dipole localization and uncertainty quantification from simultaneous EEG and MEG recordings . . . . 843
Filippo Rossi, Gianvittorio Luria, Sara Sommariva, and Alberto Sorrentino

Optimization of 99mTc-sestamibi/123I subtraction SPECT/CT protocol for parathyroid scintigraphy . . . . . . . . . . . . . 847

Virpi Tunninen, Tomi Kauppinen, and Hannu Eskola

HMM Based Cough Sound Analysis for Classifying Pneumonia and Asthma in Pediatric Population . . . . . . . . . . . 852
Yusuf A. Amrulloh, Udantha R. Abeyratne, Vinayak Swarnkar, Duliph Herath, Rina Triasih, and Amalia Setyati

Some Problems and Supports in the Colorectal Cancer Screening Behavior in Japan . . . . . . . . . . . . . . . . . . . . . . . 856
Naoko Fujiwara, Kenyu Yamamoto, Miki Inagaki, Misao Yoneda, and Masami Azuma

Efficient techniques for gait-analysis: comparing marker-less and IMU-based tracking systems for monitoring
rehabilitation processes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 860
Heinz-Josef Eikerling, Michael Uelschen, and Benedikt Stuntebeck

Performance of Systolic Blood Pressure estimation from radial Pulse Arrival Time (PAT) in anesthetized patients . . . . 864
Josep Solà, Anna Vybornova, Fabian Braun, Martin Proença, Ricard Delgado-Gonzalo, Damien Ferrario,
Christophe Verjus, Mattia Bertschi, Nicolas Pierrel, and Nicolas Schoettker

Design and Implementation of a Web Portal for Non-Medical Prescribing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 868

Gerard Boyle, Christopher Soraghan, and D. Robinson

Classification of physical activities and sedentary behavior using raw data of 3D hip acceleration . . . . . . . . . . . . . . 872
Petra Tjurin, Maisa Niemelä, Mari Huusko, Riikka Ahola, Maarit Kangas, and Timo Jämsä

Multiregional Fuzzy Thresholding Segmentation Completed by Spatial Median Aggregation: Modeling

and Segmentation of Early Pathological Findings of Articular Cartilage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 876
Jan Kubicek, Martin Augustynek, Marek Penhaker, Iveta Bryjova, and Lukas Peter

Non-Thermal Effects of Electromagnetic Fields in Biology and Medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 880

Wlodzimierz Klonowski

Crosswalk – a time-ordered metric . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 884

Tomas Koutny

Biomedical Engineering Education: Need for Harmonisation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 888

Nicolas Pallikarakis, Ratko Magjarevic, Leandro Pecchia, and Aris Dermitzakis

Bayesian Modelling of Skull Conductivity Uncertainties in EEG Source Imaging . . . . . . . . . . . . . . . . . . . . . . . . . 892

Ville Rimpiläinen, Alexandra Koulouri, Felix Lucka, Jari P. Kaipio, and Carsten H. Wolters

Heartbeat Detection Using Multidimensional Cardiac Motion Signals and Dynamic Balancing . . . . . . . . . . . . . . . . 896
Tero Hurnanen, Matti Kaisti, Mojtaba Jafari Tadi, Matti Vähä-Heikkilä, Sami Nieminen, Zuhair Iftikhar,
Mikko Paukkunen, Mikko Pänkäälä, and Tero Koivisto

Volumetric Assessment of Bone Microstructures by a 3D Local Binary Patterns –Based Method: Bone
Changes with Osteoarthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 900
Jérôme Thevenot, Jukka Hirvasniemi, Mikko Finnilä, Petri Lehenkari, and Simo Saarakkala

High radio frequency biosensor for a nano-concentration detection of the label free Prostate Specific
Antigen cancerous cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 904
Hayder Ashelaish, John Hedley, and Neil Keegan

Stochastic Modelling and Optimal Spectral Estimation of EEG signals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 908

Rachele Anderson and Maria Sandsten
Contents XXVII

Artificial Astrocytic Modulation of Neuron’s Output . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 912

Lucas Anton Pastur-Romay, Francisco Cedrón, and Ana B. Porto-Pazos

The evaluation of medical devices: are we getting closer to solve the puzzle? A review of recent trends . . . . . . . . . 916
Oriana Ciani, Carlo Federici, and Leandro Pecchia

Controllable Limiter of Signal Amplitudes for Bioimpedance Measurements. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 920

Jaan Ojarand and Mart Min

Pattern recognition techniques and classification sets supporting behavioural tagging when using a limited
number of body sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 924
Wilhelm Daniel Scherz, Juan Antonio Ortega, Ralf Seepold, and Massimo Conti

Optimizing the detection of characteristic waves in ECG based on exploration of processing steps combinations . . . 928
Krešimir Friganovic, Alan Jovic, Davor Kukolja, Mario Cifrek, and Goran Krstacic

Assessing representativeness of a rural Australian clinical database using a spatial modelling approach . . . . . . . . . . 932
Rachel Whitsed, Ana Horta, and Herbert F. Jelinek

Clinical Decision Support Systems for COPD: a general overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 936

Vlad Antoniu Mudura, Francesco Frosini, and Ernesto Iadanza

Analysis of Instantaneous Cardiac EBI Signal Variability over the Heart Cycle(s): Non-Linear
Time-Scale Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 940
Andrei Krivoshei, Mart Min, Paul Annus, Hip Kõiv, Alvo Aabloo, and Tiina Uuetoa

Health Technology Assessment of Medical Devices: The Canadian Experience. . . . . . . . . . . . . . . . . . . . . . . . . . . 944

Julie PolisenaPhD

Split Ring Resonator Inspired Passive UHF RFID Antenna System For Wireless Intra-Abdominal Pressure Sensor . . . 948
Shubin Ma, Lauri Sydänheimo, Leena Ukkonen, and Toni Björninen

Low-Field NMR Relaxation Times Distributions and Their Magnetic Field Dependence
as a Possible Biomarker in Cartilage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 952
Oleg V. Petrov, Erik Rössler, Carlos Mattea, Miika T. Nieminen, Petri Lehenkari, Sakari Karhula,
Simo Saarakkala, and Siegfried Stapf

Semi-automatic hippocampus delineation algorithm using surface fairing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 956

Fabian Bartel, H. Vrenken, Marcel van Herk, Michiel B. de Ruiter, Jose Belderbos, Joost Hulshof,
and Jan C. de Munck

A piezoelectric organic surface to control bacterial adhesion and growth . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 960

Rosalia Moreddu, Nicholas Boechler, Anne Marie Krachler, and Paula M. Mendes

Embedded Sensor Systems for Health – collaboration between industry, academia and healthcare . . . . . . . . . . . . . . 964
Maria Lindén, Mats Björkman, Christer Gerdtman, and Bertil Hök

A camera-based multispectral setup for remote vital signs assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 968

Michael Paul, Boudewijn Venema, Vladimir Blazek, Jens Mühlsteff, and Steffen Leonhardt

Correlation of Depth of Anesthesia Indexes with MAC in Volatile Anesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . 972

Elzbieta Olejarczyk, Tarmo Lipping, and Radoslaw Marciniak

Gait asymmetry in Winters’ group I hemiplegic children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 976

Francesco Di Nardo, Valentina Agostini, Annachiara Strazza, Alberto Nascimbeni, Marco Knaflitz,
Laura Burattini, and Sandro Fioretti
XXVIII Contents

Novel adaptive approach for correcting baseline wander from ECG signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 980
Aleksandr A. Fedotov, Sergei A. Akulov, and Anna S. Akulova

A scale with ECG measurements capability for home cardiac monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 984
Mariusz Kaczmarek, Adam Bujnowski, Kamil Osiński, and Jerzy Wtorek

The Thermodynamic Cost of Intelligence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 988

George I. Lambrou, Panagiotis Katrakazas, Dimitra Iliopoulou, Tzortzia Koutsouri, Ioanna Iliopoulou,
and Dimitris D. Koutsouris

Early Stage Health Technology Assessment of eHealth solution for DiabetesExperience on the usage
of the MAFEIP tool: data collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 992
Giuseppe Fico, Miguel Lopez-Valverde, and Maria T. Arredondo

Optical Projection Tomography Imaging of Single Cells in 3D Gellan Gum Hydrogel . . . . . . . . . . . . . . . . . . . . . . 996
Birhanu Belay, Janne T. Koivisto, Kaisa Vuornos, Toni Montonen, Olli Koskela, Mari Lehti-Polojärvi,
Susanna Miettinen, Minna Kellomäki, Edite Figueiras, and Jari Hyttinen

Modeling of ocular and eyelid pulse blood filling in diagnosing using transpalpebral rheoophthalmography . . . . . . . 1000
Dmitry M. Shamaev, Petr V. Luzhnov, and Elena N. Iomdina

Circadian blood pressure pattern in positive drug responsive hypertensives, hypertensives and normotensives,
and gender influences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1004
Federica De Dea, Lorenzo Pascazio, Monica Guerra, Gastone Sabbadini, and Agostino Accardo

An evaluation of the direct electromagnetic influence on the safety of users of wearable insulin pumps caused
by low frequency magnetic field . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1008
Patryk Zradziński, Jolanta Karpowicz, Krzysztof Gryz, and Wiesław Leszko

Wearable RFID perspiration sensor tags for well-being applications – from laboratory to field use . . . . . . . . . . . . . 1012
Kyle Mulholland, Johanna Virkki, Pasi Raumonen, and Sari Merilampi

Low-latency EMG Onset and Termination Detection for Facial Pacing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1016
Anton Kontunen, Ville Rantanen, Antti Vehkaoja, Mirja Ilves, Jani Lylykangas, Eeva Mäkelä,
Markus Rautiainen, Veikko Surakka, and Jukka Lekkala

Auto-regression-driven, reallocative particle filtering approaches in PPG-based respiration rate estimation . . . . . . . . 1020
Mikko Pirhonen, Olli Suominen, and Antti Vehkaoja

IBM Watson Analytics for Managing Congestive Heart Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1025

Vlad Antoniu Mudura, Francesco Frosini, and Ernesto Iadanza

Fabrication and characterization of nanocellulose aerogel structures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1029

Juhani Virtanen, Marika Janka, and Sampo Tuukkanen

Does asthma-like increased breathing load influence impedance pneumography signal? . . . . . . . . . . . . . . . . . . . . . 1033
Marek Żyliński, Wiktor Niewiadomski, Marcel Młyńczak, and Gerard Cybulski

Influence of scattered radiation on Gafchromic EBT3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1037

Tatsuhiro Gotanda, Toshizo Katsuda, Ayano Kawasaki, Rumi Gotanda, Takuya Akagawa, Tadao Kuwano,
Nobuyoshi Tanki, Yasuyuki Kawaji, Tetsunori Shimono, Kenyu Yamamoto, and Koichi Yabunaka

Clinical Trial of Wireless Epidermal Temperature Sensors: preliminary results . . . . . . . . . . . . . . . . . . . . . . . . . . . 1041

Carolina Miozzi, Sara Amendola, Alberto Bergamini, and Gaetano Marrocco
Contents XXIX

Biophysical Evaluation of Microwave Radiation for Functional Research of the Human Brain . . . . . . . . . . . . . . . . 1045
Vladimir S. Kublanov and Vasilii I. Borisov

Sleep-wake detection and computation of sleep continuity from a wrist unit in children, adolescents and adults . . . . 1049
Patrick Celka, Kaisu Martinmaki, Topi Korhonen, Nuutti Santaniemi, and Jussi Virkkala

Application of digital imaging for quantitative assessment of wheal formation . . . . . . . . . . . . . . . . . . . . . . . . . . . 1053

Eugeniusz Rokita, Tomasz Rok, and G. Tatoń

No Changes in Glucose Effectiveness in Condition of Reduced Insulin Action but Preserved Glucose Tolerance
as Assessed by Minimal Model Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1057
Micaela Morettini, Francesco Di Nardo, Sandro Fioretti, Giovanni Pacini, Andrea Tura, and Laura Burattini

Automatic identification for surgical instruments using UHF band passive RFID. . . . . . . . . . . . . . . . . . . . . . . . . . 1061
Ryosuke Hosaka and Ryosuke Noji

A Case Study of Focal Bayesian EEG Inversion for Whitney Element Source Spaces:
Mesh-Based vs. Cartesian Orientations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1065
Tuuli Miinalainen and Sampsa Pursiainen

Computational modeling of radiofrequency ablation with an internally cooled wet electrode . . . . . . . . . . . . . . . . . . 1069
Elzbieta Ewertowska, Rita Quesada-Diez, Aleksandar Radosevic, Anna Andaluz, Xavier Moll, Enrique Berjano,
Fernando Burdio, and Macarena Trujillo

Investigation of LVAD Sputnik electrical parameters for modified geometry of the rotor . . . . . . . . . . . . . . . . . . . . 1073
Dmitry V. Telyshev, Eduard A. Mindubaev, Igor V. Nesterenko, and Sergey V. Selishchev

Linearity of Simultaneously Recorded Impedance Pneumography and Direct Pneumotachography

in Thoracic Surgery Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1077
Milla Jauhiainen, Javier Gracia, Ville-Pekka Seppä, Heidi Mahrberg, Lassi Tuomisto, Jari Laurikka,
and Jari Viik

Predictive Health Technology and Policy Assessment of Socioeconomic Impacts . . . . . . . . . . . . . . . . . . . . . . . . . 1081

Jukka Ranta, Tero Jokinen, and Peter Ylén

Photoplethysmographic authentication in long-term scenarios: a preliminary assessment . . . . . . . . . . . . . . . . . . . . . 1085

Jorge Sancho, Alvaro Alesanco, and Jose Garca

Co-creating with consumers and stakeholders to understand the benefit of Internet of Things in Smart Living
Environments for Ageing Well: the approach adopted in the Madrid Deployment Site of the ACTIVAGE
Large Scale Pilot . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1089
Giuseppe Fico, Juan-Bautista Montalva, Alejandro Medrano, Nikos Liappas, Angeles Mata-Díaz,
Gloria Cea, and Maria Teresa Arredondo

A Preliminary Study in Neonatal Cardiorespiratory Monitoring through Diaphragmatic Electromyography . . . . . . . . 1093

Marcela Tobón-Cardona, Tapio Seppänen, and Róbinson Torres

A strategy for dissecting the kinetics of transcription repression mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1097

Cristina S.D. Palma, Sofia Startceva, Ramakanth Neeli-Venkata, Marzieh Zare, Nadia S.M. Goncalves,
Jose M. Fonseca, Samuel M.D. Oliveira, and Andre S. Ribeiro

A Simple Approach to Detect Alcoholics using Electroencephalographic Signals . . . . . . . . . . . . . . . . . . . . . . . . . 1101

Nahit Gökşen and Sami Arıca
XXX Contents

Evaluation of the effective and functional connectivity estimators for microelectrode array recordings
during in vitro neuronal network maturation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1105
Fikret Emre Kapucu, Jarno M.A. Tanskanen, Francois Christophe, Tommi Mikkonen, and Jari A.K. Hyttinen

Capacitively coupled ECG measurements - a CMRR circuit improvement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1109

Adam Bujnowski, Mariusz Kaczmarek, Kamil Osiński, Marta Gońka, and Jerzy Wtorek

Cohort Description for MADDEC – Mass Data in Detection and Prevention of Serious Adverse Events
in Cardiovascular Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1113
Jussi A. Hernesniemi, Shadi Mahdiani, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Markku Eskola, Kjell Nikus,
Kari Antila, and Niku Oksala

Twelve Years Follow-up of Ballistocardiography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1117

Jarmo Alametsä and Jari Viik

Motion artifacts reduction in wearable respiratory monitoring device . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1121

A.A. Fedotov, S.A. Akulov, and A.S. Akulova

Association between Accelerations and Decelerations of Fetal Heart Rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1125

A. Agostinelli, G. Belgiovine, M.C. Fiorentino, G. Turri, A. Sbrollini, L. Burattini, M. Morettini, F. Di Nardo,
S. Fioretti, and L. Burattini

Electrocardiographic QRS Onset and Offset Time Estimation Using Bandpass Filtered Hilbert Transform:
A Simulation Result . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1129
Noriyuki Takano

Erratum to: EMBEC & NBC 2017 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . E1

Hannu Eskola, Outi Väisänen, Jari Viik, and Jari Hyttinen

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1133