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  • Desipramine (RX) : Pharmacology

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    William Omar
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    Desipramine is an antidepressant of the tricyclic class that works by inhibiting the reuptake of neurotransmitters like norepinephrine and serotonin. It has a half-life of 15-24 hours, with an onset of initial effects within 2-5 days and full effects within 2-3 weeks after reaching peak plasma levels around 4-6 hours. Desipramine is metabolized in the liver by the CYP2D6 enzyme and excreted primarily through urine.

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    Desipramine is an antidepressant of the tricyclic class that works by inhibiting the reuptake of neurotransmitters like norepinephrine and serotonin. It has a half-life of 15-24 hours, with an onset of initial effects within 2-5 days and full effects within 2-3 weeks after reaching peak plasma levels around 4-6 hours. Desipramine is metabolized in the liver by the CYP2D6 enzyme and excreted primarily through urine.

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    5 views1 page

    Desipramine (RX) : Pharmacology

    Uploaded by

    William Omar
    Desipramine is an antidepressant of the tricyclic class that works by inhibiting the reuptake of neurotransmitters like norepinephrine and serotonin. It has a half-life of 15-24 hours, with an onset of initial effects within 2-5 days and full effects within 2-3 weeks after reaching peak plasma levels around 4-6 hours. Desipramine is metabolized in the liver by the CYP2D6 enzyme and excreted primarily through urine.

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    1/10/2019 Norpramin (desipramine) dosing, indications, interactions, adverse effects, and more

    This site is intended for healthcare professionals

    desipramine (Rx)
    Brand and Other Names: Norpramin
    Classes: Antidepressants, TCAs

    Pharmacology
    Mechanism of Action
    Neurotransmitter (esp NE & serotonin) reuptake inhibitor; inhibits reuptake by neuronal membrane;
    may also downregulate beta-adrenergic receptors and serotonin receptors

    Pharmacokinetics

    Half-Life elimination: 15-24hr

    Onset: 2-5 days (initial therapeutic effect); 2-3 wk (full effect)

    Peak Plasma Time: 4-6 hr

    Excretion: Urine (70%)

    Metabolism: Hepatic CYP2D6

    Metabolites: 2-hydroxydesipramine

    https://reference.medscape.com/drug/norpramin-desipramine-342939#10 1/1

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