We ea amar MICROBIOLOGIE GENERALA Prof. univ. dr, Roxana Moldavan Prof. univ. dr. Monica Licker Sef lucr. dr. Elena Hogea Asist. dr, Luminifa Béditoiusajmuspeeiiic grvacoue i MRACDISEL fSINBDOLVE 9 i sumnauationed dep sopomsetoncs wooed +S iy ap soyohneanae 293004 é usa 7 sayeeg ey suse THIN rasengutedig 27° + EeHpasa 7 weisajeus pO V5 yNWINzEOVE YOMANES ino 9p apOWH O'S ozs ehuaDyus SP eaank3i VF yRUSHOGEIH £5 e290 OLA (3 ettezodian {> ova vIDTOr2 > soygsappee 8 85%: news, esdase BipaUs op 19 220m FEMS & “suasapeg jeinja9 EAMPANE 7S sgyveg e¥dojO}IOW YE yosqa“Uansnaty £°2 DroneDoid ZZ bee 94SN0Sd TE 1 A TAWSINYDHOOUDIA WOU MALSIS NI SOLLIASNE HOTLINES WIDOT = e3aNGOULNE SNIwda2-2 Factori de patrundere si adereni Factori de invazie microbiand Ea ine bacteriene ‘ ae g 4 Pactorii genetici . 2.2 Barierete anatomice peo ecanisme de recunoastere molecular a agentiles inledic s ‘it cadrul rezistentei antiinfectioase innascute 104 5 RESISTENTA ANTLINFECTIOASA NATURAL... as OF 3 REESTENTA ANTIINFECTIOASA DOBANDITA ne 23 AMUIgEN ELE we rntennetnrensenieen eno, 128 O4 Sistemul cohitar immunocompetent 169 a infectiiter ae tapele evolutive ale infecyiet ectele nocive ale infectie! "+ Manifestarile clinice ate infectic! #5 Notiuni de epidemiologie a infectitlor 6 Profitaxia bolilor infectioase ...... 18.7 infectia nosocomiala .. HOUNIZAREA ARTIFICIALA ACTIVA SUPA: 179 Lnunoprofilaxia active a9 snoprofilaxia prin seruri terapeutice 185 jasificare ' a «. Barmacocinetica ea ‘fecte nedorite ale administrarii agentiiac jcrablent : resneaes EYL i2.4, Rezistenta bacteriilor la antibiotice 194 reiesbalele clase de agonti terapeutici antigacterical , 16 lizarea chimleterapicelor antilntectioase nS 2.9. terapla empiric’... RAPIE SSLECTIVA # INTRODUCERE permis conservarea Rok sioar in a doua jumaiate precedaie de mu Phucidide (465-395 Ze.n contagiu viu - can respira. Ac aeruitid ot Girolamo Fracastor et curatione”. Teo recerea. de. imate, “semninaria morbi”. Descoperirea micrabilor. MS Antoni van LvenwenhoeeI~ CEBU) amapsingdescoperi Fine a at efectnat i une! exotoxine, ion si Theobald Smith des administrarea deera, tarmac: importame si e att in ps : 5 lapesta si Vien: ‘asteur, Vine ca profesor de hacteriologie si anatomic ndurse de cele mai variate probleme derompau s9 nny ) fic wsdese SuBMSa2 PSM) Rung *a|are0z0}0.Ki URE UN-IUE aindss MOTWSINYDNOCUOIN OLLVIWTISIS NT SOMLOSANI BOTLLNEDV INDO Z01 0h ~ —— at SIA a ~ risuove : eh carer — 19Nnd = Ob BuvOzZ0LONd = a Lio loidoscuoiy SOLL9a4Ni LINBOV | a 1b - 0 RVINTSORIN Td ‘uinman | | — 0 oulozaniLinaoy _ © (uu) aWNeyh Sp a}9 ates auyup auaiony ad Huiang Wu ~aneinoF 1S prenixase © joe osaddet> umm wgzoid S$ o® RaIOZOqu siuszaid | axyetusejdlopu | 21 16 upuos01 NeipRapy Rajonexioyoss0%y TOAUOH ire rE id my aay nanl aaveunonl ieaLoweanfoys arsree yin | (pueyes:p28 aysis wind soosea hyreYMVINSIOVE VIDTOIZISeucu9 en EHRndwies aysasvjo} DD poneusedons ea olurisyns P98 varEpiKey soe tod oe sie ap planes ty = sat WD 8 wore ns op aseHOsCWo ANA ajins op puns ranadupe doos n> a¢eoyoap ap exes p qieuonene exeg = 9 ‘ailueuoda eze4 = fey an exeg =e son 2818 aigeup ea JUS OU: ad wjnoipusdiad ure tay opvauaned f99nja9 wou ISo9Y pup “BuauALeG 1 8 OUT 1 uae eT sp ‘sunaaip 0 ‘ae2ay) > UN Wag! RS “ASW gueN) aS3 JOHUAIING T aIe> auauaIoey s0]sueZue ‘piaqsane powi}yruu 18 2a1oqSoa32p Pqmna pus iwio ut tomeie 904 vasa FES org 2 {Boj sugar soteiyco ynseweNws Pay UE ANOLE NOY LATHE juin auvosde asangs, 9309 “1 yoraus ap augaseop JP 005 PL ne “parmaadliar ase. sojaaneg dayipeuny eadnse nypeur ap z9y,10;9¢1 viuangey sb sunOLEwoquea ay DP: oi ap mip. quadtt sutg UO} rayaegpuryou sana y oipee und auaya iudt0R MMLISHEIA}N suns ap vlunisip snsonatt | asus aul pugDse od 18 mutanyjoqer z sy >| ‘uy yeasasqo * yrtansed 1 out 22 nWS [UN ap SHMpe GM AIpoUL 1 mpmad 9s 21H sounpd ea ede “yinzyas aueo) o182 jowuseyd ap ov parid 108 34are erED/pen eundossyy 292 pugs ad 3 inns) y dn ep nun ” an 2 istteaont psp 98 & Nav fp ap Eyal + ws NAV ap HO} veuepuadapsen evorcouaro. unnezong jneozoutEs) £7" yoaiue 9p ajaluasos zs6 Lago ainfion 9p Inpuise D+op pay A wi May eosspunares F i t jendv9 puspuesep aajsuen es ‘use 8Zo1 WL soneuel 8209 NG ap Bu} “y. suueinus sowunoud aqoad ap 23 yey6 1 BISIOAUOS A> 30 ints org ny Pa Suna ip wAup \daoar wun a gnop aja ‘auoyo: sonoud a 2peasyatuaavas ea teugagay jguue op anu OMI 36ISoH rE #8 j casa gop ugzowars sreaden pepe eizodsuen pou youd sep/NPIBONOTE: wiNADOLYE 9pgnuisyuRdse © epee, rae 2p pouruaBored 9p npeAs aise whuaynsy., estutond utes YOTINSLO¥E TV SLVLINSDOLYd HG NNOLOYE &ss (sysad 1 shogeaodap aues ¢) -poHsep> ose ruporoancet oy ais valapon avout =p autesoud nynsios szaywouoduios 2 MIXEONE LEEa ye}UOs 19 “pean VURLYN WS¥OLMLOaaRTLLY VENGLSIZ9a ‘ezoyaomey S-npue Ms ajseiajou woeas Cacao66 sopuieineg cidase ne 18 ay 98 poss egeUnAdendf feuuiod rilda: 2s ayapunga ap sdnoude pzeoio. apisy “Hloayuy run y Myoruuan jaudsorday una 198 Hivoupe4-200 pluarsycox 970) fern We 5 “wyeana afoazUy op eersaoe al 2p azide tay aumuode nt e| aj puggep oer 8angfesaelsarci somo SareeVLIINYEOG YsvOLoggNILLNY ¥ apiafog eueSpuy LSIZaU rireapunymziqed opoutyy ayaa panna!9280 auMUU, sopLnUas very ad aaauwoap 1 az an yuuses 1h jy dtwn Sej30 sy “oneoyoeds op Repay "H alpladey sojou Bue ezey od ac tinasouna roytaods. sdi0o4 use manip absouna93 sesso y dna ronosepsiqdiy ap) atu osnue eel nuct sundses vn a9 e2eq 9f IS HoIoNy S29" ofmaotioan 8 uoyedsas 5 eseotioa ajuanue easenede 8 oyeugisas “2yeun 3] xp YoULsOY o1S CLT EN) sopesvoznT pw rH aise 18 pend veto aroInyeUE As ajo 40) varwzoée edn aorgumuiose oneust) {Eup uN ap ouNdsi ve no ad wuljds asasuayd 18 BAUE ajariggjMr “eonupUaP 2p uuie# soja © yjourreu muCZ 189 noquadique erbmaojut [9p id Ur oT BaLOJsUR 40 as opun (oxPUIEUD “240; Fup nes (9}2 Suny *[erTazosn as BSgf myonso fen top JJ nabpun op asoopemuzead ajoqngey yeudns ad 9) onuept aIsel 29 plnjexins ap joyous ssiaatp i punangd “elena nurzaudn pomuaa \ vopuapr arajofeny - pprosusy amSpsa no apyag jaiose wisveDe Uy poop. yowes wyuazesd aysa 1S 4 Ese] uu ue wposr ¥9 elnyeadas yuadns vy pUsEKINe 22m "yao 9P uaa mu falustU¥I0 area no auahuE ‘29 nue wurzard afoTeporeUH “oy a9 aouuspuap 2j 4’NuL ered98 iny IMpugE e] 2109 “yy 21005. a]aBeJOIDHIY ad ainejas dnp vorayzorut-nye >| yeu Ya) UE WEISER 28 | dng] “Goudaoas ayy 102) LAT —aptoyoias anpuep 2} ssanupuap anja 2p ieap "G9 gpa yaynyca etaywsdns (OL) eapsmieg? 2721 ud sop ayes0uism 31 it jqpsundsar ais jou & Beiosynytop pus1 stl PLjaue HneUOFAL isd sede speuoyouour schoosnue peamwu pour idoyids wud ouafinue ajoque oop ap HaIEULIE soMpur Jos “fuNED lug] oJ vane tod attairue ynop poep “pusy mache a st Ferpsca. ium) ZA uae ap ofatuoutos go wleundasaud 1 atiotuas “auucuHA ap ams enaiEs stsa anes «8 ayes nuitied sonauad ‘ojouingo|foune op we auedsip 1 eu 9p agofounant 9] Pu towed 9) -uyjouazaudas y pa dowand areooy “Huai name "udioon ap aynsajow! ap ,,ot # 84 | ap anf ul asasuwueD axa 01 20 WUT yUADISIS YD ErEdzToaNd 9g “mNJOUDdIA fnndovids somgzundsais wleyerdns od hay 9 2pqMIDA suede nawad x jo0x9 axinouno 2sari rewazaxt uoipur SeaoR ap SEN na eaa1pose 1 TEES AP po EHO gompsnes yanagadd a son2ipsep 1oppp> OF fnadis vp Bunge poy Jaq wamnatiod 9p.ome es SABA 8BBEY) ec aininsun: wise ufers ee “pqnjannns aAgrayncet7 RAS HLOTRRETGO pdo wy np psvoriaaji uape S16 ena tay qe, ND yrapuadapodinaym v2iDis >pseH0H5Sst Fe | ad anzea es win why “seu soatiad 9s yup eyes,, BUULIOSI & ap ehuszaudBA 28 nusdiayy NOU 0 ap IeSue[s9p jyourzoo compar ra ¢ eaLyNo| sonpord va ams woouseid ag “|nuuswEeBI0 var wareinsiysap uy s wad) atusutenypau “a: ) ye aja Hap qwods RSL ssuasiedyy ap itor. Siuny> JoMVE;pew BaLeLEqHE Jojsyqseus camnuesB9C wSniy (erexpout atloeas) arnurat vaane9 soop uy oxede yoe 9je sonutja ajourowduns ap aqrqneuodsas juns vaisooe o7e0,,phnpaucin: Pp eavamsqenosiodtyy “a y¢ enh qUsisjdulos ap BrEIpaLi ezy ghee | idiooque ap esonjen suafique ‘pAganstt02 pamf pmnyoa. op poyeaquayyue 1 vaysaoe Bop ido uaxendea sofesea jnusun um 20jexsidauos, pessundapabejfoceyy —snea op a¥tpour fap Suet JUNE UT ru peg n> VU 1) ooguU | earmppgssuasiadiyy P HieBsa, veate u ary “2deyos0out ku ap BasEZOQHP > vam] y AOA MNYRUEDE) PaLEIBUDZA aywioLASp au SF sysouOL “SNDOAU ydngy “ereuouad yzojmoseqna save grep eunlad naued dtu op yiegesp “orto ap maeutop “yseoreWto | oyonas juns weyzapre yayjoo ap amasaus 122—¥d mn ap rranfuoaur apse yeas eee rou | 219959 18 alasqo jod as tun ary (gzojna13qn 200 26 wtinjoaa "enOHUOD © suoreuUoSipoH HECORKOIOHS wIUOIEP IMpexd 3s yun aynja0 pregusioy waoHZzY 10a aLseC amyeo wy wuuoysies: JON 28 Dyed O suey aaUIp ayePeaswIa ap agumu aie ynun wawanoe 1S 499) UL vasE|MUUNDe yoEOACR! ans fos wiagHo JOA aIeZH ENSUES J 2[>31904 Siissiadly BP ST}ovoLD POOADMT 1On UATSIW ope =I FRYALISTEDTIOOIAG LAITY OseSTIST wu SRTTTETET 2 ajaxaqdiao.) SNPURSI; ‘ajajusuniar azanauod ws sfiqudes 9 tnpaonionen 1wiaz09) sore ap mBAapeVELOSEME OFIngnluste vouopunned 9 aiuede a Wi 2s 9[alustueBLOMoN ‘BIouD Uy “pMiLHES tjuazaid vo natued soyzeundsauoo [ant un aunayds op ajowistamootu guy sonporc 8 wanvod oyun void anus ued ase auutsises00201 voep asleayuy anpast bivyeudns od op owned etumeues rod 1% Imuuade no myorsel Hoara-gonpoud ion owed uo eingeidns ad ap asedsip 30% ann Ir yMuusyuRI o1e92 pueanp amorous jogiotu yz ojpitiaGin ayosorsp appuoyiouny ts 3: prone B10 WpeNe DE DE §DOU 31919039 €-01 1 eng aap mis wisaytant 98 2p yorfoopes ape aarynons afaerd OF291 ap ymadaouto.y “CpL nef adyjonsw 8 IN roomy ey Sel a ane oe | 1m ororyewosdurs 2 et 9p as MD esBOLoesty Og ‘qoun Ran1 | | H Ieee 20 ) junue o-RULd L0[9S999p [M | S-AUL yep UAWIONT UP Bh 1 | 1 5 : v Larapuyoqmr sp youn 1 sss 1a op arvitay oy es ’ saquansayy ALi vamen Bf gugd umumdss sp ‘gluon paso mt EOMCAISWUFWIPE Bj SOURS RAQjor 25. paseUIZOUA NUE Y alsonpul ap ado. un auasap vaswzt aoe 18 GAoR aseziUnH! ap nt 2p89 ad snpoxd Joa 29 onuaprunsa 8 a ¥emsonpontl muizesdas expo 1uLiaTap 99 9 aM joeruy yyoq. no erdny n 18 eanriadonsec 2G YAISWdIS YALLOV YIVIOULYY VaUVZINAIT EL sad whut soayjor sone son pour Iw sor0p v9 408m aysoy 2 uauua® no m29ju! dq ‘oa Rimsise eilnugdsar “eppeusuaie? tuna “AAIZEAM 2]8O4pOtll azAMURUE 40% soot od vaysany ezey ‘snaunn's “vsoutiinsan swuowopras,) “12/2040 ‘oyjatsqay yo] WES SWUyPIUL waxoaay ww aynoads ~wluajnsLs A UjAap “yeILUS Ut Sasw> DLOEY eww op ‘yhéunpodo ouued,, Hrunuap pum “puatored, 288 fansyuu 215908 Wy 219-10‘a 24 vinpmeurosas ese, o_O | S10z PrUgwoy ~ LELIODES ap eUEHiEN pUEpUA!ES +1 nRA sojopusvde sd rad ap eyequszascas wed noi > Ul pups od ows appre Pa ag “ound wevadsar aingai5 axeus tout 529 us ogesuodsar sft you paueaUSDUCS 1S easLersEand UUM sMped 1 joear aL aud y ood 8 nuro9ea a}uapIp nd apse p “jeo) stewie od urigo 9s atoyosoaay ‘ey yaddar pour : and as 8 (quguneides 25 au Huode un gre saytpads 10do]auisjupBioosopt PINISOL8IF0G NDS DpPLeDoY MUAY + SSVOLLOSANNINY SOi4VUaLOMNIHD 21fara) wy ayespransviayy ay sella 218 Qn f ayoue 29011 10d 39 onus 9 t93p “DH, ipuRqop 1 dars-ouo) yleyni uEHOIIPG BINI29 ¢ jour ape afa9 U8 nUsMUIopy el ssanmsolsarong 20/99! ap inyeur yoodls 3 wumap “spsals > aanougnum no a9ns: aideamtorgnueysod saait0ap va) “area io} D8ID8IP ersat piuaysyza4 9 nya. OM “ESLE ddvaey Nuafe ap asepaayedouiid sZt epequuE ppt seat uo ‘ozene3t 9p yoousd uy nT poo 16 sojeuromad ye aim 2yszmiR} e124 apn 9 soun waisonposd omsnaeg ap aay fa8aep Pe aMIBANDLY ZnNND WB S}sIapISYD AY 9p aweasyonynur india = zai usouadiyina sav ee °p YSHDsop) — vovTHEIqOU serauofiur » i aAVA aeadia by royppioeqoseue eiuasizer touredns xno un gznezslva1 39 ap apor xnyo un 1S ates. aoyoqerout muse 0 saured ony aodomno wseAoR uoaap ne aro atieauenuos eazapeos 9jouq fediounad 2s eueMerang BIN}ED ML NMI Y7AANNU NUTRI yrdodo1 04.99 ayuaistzas candjns ie jeewu anna run oq nuAd ange na nu ES FO|HONOIGMUE Fused TOU Ds aia ap giao isaoy “ananstzau 9} oF fnyeUOsiad a1 josoiae ap yzeaUNOS 98 40) yes ypapuiidns iaysizes sooswoap “PUN 8 aorseow vareysidecyylooxr no aa jose uno oye a eu 28 219 RUONTE 9p apaunsodsoynfa:y aanng ma9ioosw Botpur 96) idejeats prasepid>speosn pnt waisored “ouuteost! “yyotaiue “aruadoyogmon id pay \gAS no eounyfoesoyu (prided vaio PHO) OEE e HENS ASIOApe OqELIARI nomiay ung ap sin m0 av roapuys vpyouaa 18 oq) “aumUap (ih up 1S ase0 Uy maimyoazop pape & pinosaup gee saiuaysiza1 mene © 8 az ysl soayn n> od A smawyortpa]y 99 §soaNn09} eBeay as suey ap auiuosaap ‘atdwuerouot i eagatiay yo Un O18 "BAM pus . sels suounppgopy “els suntan umuaronyrs) ‘Saeia santsoronguordoay “ds seopwouss| * us naydsonboy te} yl yy ovessanaad ogi “ds suza0a0ndeu nds -eu1suuena, “ap0i440U0% nyzod s1ue ap xaya wiajuy rousesic lum fog “lagedow RIA "VSUIN Artist jmunsfou ppyow ound any ap apundisp exmat8-NCW gzBeH90Ig 29 yZeIMS 9p 201d(a1ey3y uid BEAR Joa as RAOdMEp nu zo 380ole AP AOIKEL S814 DO jountnay 3 ABojo1gos04) 5 gjeaypayy eA sanzejes eyes)sex 9480,01 Sv ni uopidsy INS {yoRMAOeULAE oFBOJOIGOIOUN, oureien ap py" URED Hg Zilog pauuyy dome yoUpAL ] Mee “AN BUND POW. 12 002 Ax UBB pe -ofunypounay ApsnoqnoIpAL ope foyo 1p 001 uvetren wee wi ove ‘say soIseAoAN ipnow peur Asoimoge Jo stsngy aiFo1ou) sapoiguur d Srapimng “wonIpsy Sf “aseasicy swe FOOT “oreo purmsougnue nf 2q°O TeaeHOg “Y pen “A. SS0}OIGOINY “DN 1 24 $C00e “SPUN rar aang tole ¥ Z 7 ssate Austa Aderapowaly mqoronunuy °C pooaraaity 107 ‘aH IA “aeueNN|d “HOU oytiayg Sisno{noIpAy PMA, PORTE $8007 “WoNRY LOK drouy sToUELY 7p 10/40 fy soupisisau fpUayonG] ur snOINe WOW AC UES Boy