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Gen Med 1 Final Study Guide
Gen Med 1 Final Study Guide
Epidermis
Stratum Corneum Dead Keratinocytes Tough outer layer that protects deeper layers of epidermis
Stratum Lucidum Melanocytes Produces melanin to prevent UV absorption
Mature Keratinocytes Produces Keratin to make the skin waterproof
Stratum Granulosum
Langerhan's Cells Interacts with immune cells
Undergoes mitosis to continue skin cell development but to a
Stratum Spinosum Keratinocytes
lesser degree than basal
New Keratinocytes The origin of skin skills, which undergoes mitosis, then moves ↑
Stratum Basale
Merkel's Cells Detects Touch
Dermis
Areolar connective tissue Binds epidermis and dermis together
Meissner's Corpuscles Detects light touch
Papillary Layer
Blood and lymph vessels Provides circulation and drainage
Free nerve endings Detects heat and pain
Collagen, elastin, reticular
Reticular Layer Provides strength and resilience
fibers
Hypodermis
Subcutaneous fat Provides insulation and shock absorption
Subcutaneous Pacinian Cells Detects pressure
Free nerve endings Detects cold
2. Bed mobility- push patient to opposite side of bed and always roll TOWARD you
a. Reposition patient in:
Supine/sideling- every 2 hours
Sitting- every 10 to 20 minutes side lean, forward lean, sitting push up
b. Move in 3 sections: head and shoulders/ pelvis/ legs (when moving to side)
c. Cross opposite ankle on top to the side you are rolling to
d. When side lying sit, put hand on patients iliac crest for cue
e. Log roll prevent trunk rotation /side bending
Put hands from top to down under to support knees
Move UE and LE at same time
f. Supine long sit short sit is common in orthopedic/total joint replacements b/c patients
CANNOT roll
g. Pump ankles and take deep breaths to avoid orthostatic hypotension
3. Mobility/gait
a. For bariatric patient only time you DO NOT use supinated grip (use handshake position) for
sit to stand
b. Bobath dependent transfer PRONATED grip & patients head in OPPOSITE direction of way
you are going/moving them
c. Axillar crutches: 2 inches lateral and 4-6 inches anterior to foot
d. Sit stand with NO crutches: position stronger foot in the back (should be 4-6 inches from
chair) and affected foot in the front
e. Assistive device stays with affected side and it is up with the good down with the bad
ONE EXCEPTION: using a walker up the curb/stairs with a partial weight bearing
status up with bad, down with good
f. Walker does NOT stay with affected side when going up curb 5” or less for Full Weight
Bearing face curb forward place walker up on curb, then step up with unaffected
g. Walker going up curb backwards (6” or more) up with good, then move affected and walker
together
h. NO RAIL with walker make the heights of walker legs different, and go UP BACKWARD and
DOWN FORWARD
Best method!!!!
i. WITH rail with walker fold walker, and use walker as a moveable rail LEAST STABLE
Possible viral/autoimmune,
Etiologic Factors Obesity-associated insulin resistance
resulting in destruction of islet cells
Type Indication
Gauze May be used for any type of wound if properly applied and removed
Transparent Film Autolytic debridement, to reduce friction, superficial wounds with minimal drainage, secondary
dressing over foam or gauze
Hydrocolloids Partial - or full-thickness wounds with low to moderate drainage, including partially necrotic
wounds. Provide a moist environment and promote autolysis
Amorphous Dry eschar wounds, clean granulating wounds, exposed tendon and bone
Hydrogels Partial-thickness wounds with minimal drainage, or a secondary dressing on full-thickness wounds
Foams Partial - or full-thickness wounds with minimal to moderate drainage
Calcium Partial - and full-thickness wounds with large amounts of drainage, infected or noninfectred
Alginates wounds. Provide a moist wound environment to facilitate autolysis
Collagen Matrix Any recalcitrant wound to facilitate migration of collage
Topical Dressings Wounds requiring topical medications
OA RA
Initially develops between ages 25-50 yr
Usually begins at age 40 yr
Onset Sudden onset over several weeks to months;
Gradual onset over many years; > 65 yr
intermittent exacerbations and remissions
Incidence 12% of US adults; 21 million 1-2% adults; 600,000 men/1.5 million women
Most common in men before age 45; after Women 3:1; but more disabling and severe when in
Gender
women men
Multifactorial; local biomechanical factors,
Etiology Unknown biochemistry, previous injury, inherited
predisposition
Begins in joints on one side of the body
Primarily: hips, knees, spine, hands, feet Symmetric simultaneous Joint Disturbance
Inflammation w redness, warmth, edema Can affect any joint; predilection for UE
Manifestations
(10% of cases) Inflammation almost always present
Brief morning stiffness that is decreased by Prolong morning stiffness lasting 1 hour or more
physical activity and movement
No systemic symptoms; possible associated System presentation with constitutional symptoms
S&S
trigger points (e.g. fatigue, malaise, weight loss, fever
Synovial fluid ↑ WBC and ↓ viscosity
Effusions rare, synovial fluid has ↓ WBC & ↑
ESR markedly increased
viscosity
Lab Values Rheumatoid factor usually present
ESR may be mildly to moderately increased
C-reactive protein, a true predictor of inflammation
Rheumatoid factor absent
present
10.Hip precautions: maintain hip in abduction when sitting and sleeping abduction pillows
Approach Precautions
No hip flexion beyond 90°
Posterolateral No excessive IR
No hip adduction past neutral
Lateral No combined hip flexion beyond 90° with ADD, IR, or both
Anterolateral (more Hip extension and ER past 45° are to be avoided
common due to less
dislocations than
posterior)
15.Osteoporosis vs Osteopenia
17.Gait Cycle
Lab Values
Kidney GFR Rates
o Normal: 90 mL/min or more
o End stage Renal Disease (ERSD): less than 15 mL/ min
Stage 5
Arterial pH
o Normal: 7.35 to 7.45
DKA occurs with pH <7.3
Creatine
o Normal: 0.6 to 1.2 mg/dl
Increased level indicates kidney disease
Ketones
o Normal: <0.6 mmol/L
>3.0 mmol indicates DKA
o
Glucose Fasting (60 to 100)
o Normal Adult: 70 to 100 mg/dl
o Normal Adult over 60: 80 to 110 mg/dl
>300 indicates DKA
>200 indicates DM
Urine ACR
o Normal:<30 mg/gm
A1C
o Normal: <5.7 %
o Prediabetes: 5.7-6.4%
o Diabetics: >6.5 % indicates DM
1- Intact skin with nonblancahable redness of localized area usually over bony prominence
2- Partial thickness loss of fermis presenting as a shallow open ulcer with a red pink wound bed without slough;
may also show intact or open/ruptured blister; shiny or dry
3- Full thickness tissue loss; subcutaneous fat may be visible but NOT bone, tendon or muscle; may include
tunneling
4- Full thickness tissue loss with exposed bone, tendon, or muscle; slough or eschar present with undermining and
tunneling
Unstageable: full thickness tissue loss in which base of ulcer is covered by slough (yellow, tan, gray, green, brown)
and/or eschar (tan, brown, or black) in wound bed; at least a stage 3 or 4
Suspected Deep Tissue Injury: purple or maroon localized area of discolored intact skin or blood-filled blister
6 subscales:
- Mobility
- Activity
- Sensory perception
- Moisture
- Nutrition
- Friction/shear
Score (1-4) each subscale if score is 18 (out of 23) and under, initiate pressure ulcer prevention and treatment
1- Completely limited
2- Very limited
3- Slightly limited
4- No impairment
Dressings
Calcium Alginates
Amniotic membrane
Collagen derivatives
Alginates
layer
K Levels
K 0: no potential for use of prosthesis (wheelchair bound)
K 1: potential for use of prosthesis for transfer or limited ambulation at fixed speed on level surfaces
K 4: prosthetic needs that exceed basic ambulation, exhibiting high impact, stress, or high energy levels
Harris Hip Scale
10 domains with 4 items: max score = 100 points
Pain
o 1 item
Function- (ADLs)
o 7 items
Absence of deformity
o 1 item
ROM
o 2 items
Scoring:
FIM
Complete independence Pt ambulate >150 ft without an 7 Points
assistive device
Transfers
Sliding boards:
Hardwood basic: 250 lb weight limit
Hardwood special notch wood: 250 lb weight limit
Black plastic: 400 lb weight limit
Beasy Board: 350 lb weight limit
S shaped board with a disk/tract
7-ply birch board: 400 lb weight limit
Exam 2
1. Ventilator Rehabilitation Contraindications
a. Do NOT exercise if:
i. FiO2 is > or equal to 60 %
ii. PEEP > or equal to 10-15
iii. Tidal Volume < 325 mL
1. Normal: 500 mL
2. High levels indicate decreased venous return
iv. ICP > 15
v. BP instability despite vasopressors
vi. Uncontrolled arrythmias
2. ICU Lines & Purposes
Description Placement
ART Line Continuous monitoring of HR & BP, site to Radial or Femoral artery; contain
draw ABGs pressurized IV bag
Central Venous Pressure Pressure of circulating fluid volume as Subclavian/jugular vein SVC sits
Line entering R atrium; vascular access for TPN, outside R atrium
repeated blood samples, admin blood/fluids
& chemo
Pulse Oximetry % of HGB saturated with O2 in arterial blood Finger, toe, nose, earlobe
Chest Tube Remove fluid (hemothorax) or air Placed in pleural space between 4th and
(pneumothorax) 5th intercostal
External Ventricular Device Control & monitor ICP by allowing for Placed in ventricle in brain
therapeutic CSF drainage
Intraortic Balloon Pump Increase myocardial oxygen perfusion & Balloon sits in aorta
increase cardiac output (deflates in systole &
inflates in diastole)
Ventricular Assist Device Take over function of heart while waiting for
transplant
Nasogastric Tube Keep stomach empty after surgery to rest Nostril esophagus sit in stomach
bowel & can be used for delivering tube
feeding/meds (put in and take out materials)
PEG/PEJ Long term access for nutrition Abdominal wall sit in jejunum or
stomach
Peripherally Inserted Central Long term admin of TPN, meds, fluid Basilic/cephalic vein SVC Sit outside
Venous Catheter (PICC) R atrium
Mechanical Ventilation Positive Pressure breathing (normally we do Nose/mouth/trachea sit in main stem
negative pressure breathing) volume bronchus
controlled, pressure controlled,
spontaneously controlled
Chloride indicates 95 to 105 mEq/L *Levels fluctuate with fluid *Levels fluctuate with fluid
hydration & acid/base status status status
*controlled by kidneys
Calcium 9 to 11 mg/dl
6. Coagulation Profile
Define Normal Therapeutic Range Critical levels
Range
Prothrombin Time (PT) - Time required for a 12 to 15 For anticoagulant -3 times control
fibrin clot to form when seconds therapy may be value
extrinsic pathway is 1.5 to 2 times the
stimulated reference range - Risk for
hemorrhage
- Blood comes into
contact with tissue
thromboplastin
-Measure effectiveness
of oral anticoagulant
therapy
(coumadin/warfarin)
- Monitors effectiveness
of Heparin therapy
(more immediate effect)
International - Ratio of prothrombin 0.9 to 1.1 Usually 2 to 3 times INR >3.5 is at an
Normalized Ratio (INR) time to the reference the normal range increased risk for
range of prothrombin (blood things due to bleeding
time heart valve or DVT)
- Rubella - SARS
- Invasive H. influenza
10.ABG’s
a. Compensated (fully): pH is normal, and BOTH PaCO2 and HCO3 are out of range
b. Partial compensated: pH is out of range (but moving toward normal range), and BOTH PaCO2
and HCO3 are out of range
c. Uncompensated: pH is out of range, and EITHER PaCO2 OR HCO3 are out of range
i. Increased PaCO2 makes plasma more acidic
ii. Increased HCO3- makes plasma less acidic (or more basic)
1. For every 10 point change in PaCO2 there should be a 0.08 change in pH in
opposite direction (inverse)
2. For every 10 point change in HCO3- there should be a 0.15 change in pH in the
same direction (direct)
d. Two systems CANNOT overcompensate (kidneys take longer to compensate 12 to 24 hrs.)
e. Whatever pH is match HCO3 & PaCO2 to determine metabolic versus respiratory
f. Usually reported as PaO2/PaCO2/pH/HCO3- followed by + or - which indicates BE
pH PaCo2 S/S Causes
Metabolic acidosis ↓ pH ↓ HCO3 - Pulmonary (Kussmaul - Renal failure, DM, DKA, anaerobic metabolism
respirations- deep, desperate (lactic acidosis), starvation, alcoholism, diarrhea,
breathing in attempt to ↑pH by ostomy drainage, parental nutrition (extended
removing CO2) need), salicylate intoxication (aspirin)
- CV (Dysrhythmia)
Metabolic ↑ pH ↑ HCO3 - Neurological (dizziness, - Excess base (excess ingestion of antacids, excess
alkalosis lethargy, disorientation, use of bicarb, use of lactate in dialysis)
seizures, coma)
- Loss of acids (Vomiting, NG suction,
- Pulmonary (respiratory hypochloremia, hypokalemia, excess diuretics, high
depression- attempt to retain levels of aldosterone)
PaCO2 by ↓ pH)
- Banked blood transfusions
- Musculoskeletal (weakness,
muscle twitching, muscle - Cushing’s Syndrome (overactive adrenal gland)
cramps, tetany)
- GI (Nausea, vomiting)
11.Emotion/Spirituality
a. Spirituality: ultimate or immaterial reality
i. Association with transcending entity or dimension
ii. Deepest values and meanings by which people live (purpose of life)
iii. Great diversity
b. Religion: collection of cultural systems, belief systems, and worldwide views that establish
symbols that relate to humanity and spirituality and sometimes moral values
i. Emphasize community development and institutionalization of shared beliefs/practices
ii. Overlaps with spirituality more organized
iii. Gives meaning to illness, pain and suffering
iv. Most apparent in critically ill patients
v. Unmet needs in psychosocial aspect more than physically
c. JCAHO requires spiritual assessment
i. Hospital must determine the patients denomination, beliefs, and what spiritual practice
is important to them
d. Gestures
i. Thumbs up
1. US good
2. Germany mean #1
3. Japan Means #5
4. Afghanistan insult
ii. Thumb & finger circle
1. US means ok
2. Japan means pay me
3. France means you’re worthless
4. Russia vulgar insult
12. Cultures
a. 5 Guidelines for Respectful Care
i. Understand spiritual needs, resources & preferences
ii. Follow expressed wishes
iii. Do not prescribe (prevent) new spiritual practices
iv. Understand ones spirituality
v. Integrity
b. Paradigms
i. Western guilt or innocence
ii. Muslim shame or honor
iii. Tribal fear or power
c. Christian
i. Values eternal life & life
ii. Struggle against death doesn’t always make sense
d. Jewish (E. European countries) Orthodox (most strict), Conservative, Reform (least strict)
i. Sanctity of life
ii. Israel is holy land
iii. English, Hebrew, Yiddish
iv. Sabbath is from sundown on Friday to sundown Saturday
1. Invite other families in for Friday evening Sabbath dinner
v. Kosher diet
1. Prepared according to Jewish law under Rabbinical supervision
2. Eating unclean animals is forbidden
3. Blood and animal fats are taboo blood is synonymous with life
4. Do not mix meat with dairy
vi. Saving life overrides all religious obligations
vii. Men do not touch women, unless its their wife
1. Touch is only for hands-on care
viii. Very talkative and friendly
ix. Stoic and authoritative
x. Respect health care workers who show self confidence
xi. Appreciate family accommodation
xii. Jewish law must seek complete medical care
xiii. Donor transplants not acceptable but are to conserve and reform
xiv. Discourage cremation at death
1. Autopsy is permitted in less strict groups
xv. At death, soul returns to heaven and body returns to dust of earth
xvi. Patient is NOT touched by care provider of opposite sex
xvii. All body parts buried together including amputated
1. Entire body, tissue, organs, and blood need to be available for burial
xviii. Do not cross hands in postmortem care
xix. Unnecessary procedures are avoided during the Sabbath or other holy days
e. Muslim
i. Judgment day and life after death
ii. Encourages submission to will of God (Allah)
1. Believe in Allah, Mohammed and his prophet
iii. 5 daily prayers
iv. Zakat giving of alms to poor
v. Pilgrimage to Mecca is the goal of the faithful
vi. No pork or alcohol
1. Eat only Halal meat (type of Kosher)
vii. Limit eye contact, do not touch when talking
viii. Women cover entire body expect face and hands
ix. Do not force food when religiously forbidden
x. Abortion before 130 days
1. Fetus treated as discarded tissue
2. After 130 days treated as human being
xi. Fatalistic worldview to ‘inshallah’ (God willing)
xii. Some prohibit handshakes or any contact between genders
xiii. Confession of sins and begging forgiveness in presence of family before death
1. After death only relatives or priest may touch body
2. Body is bathed and clothed in white and buried within 24 hours
xiv. Recite Islamic Creed (Koran) at death holy book
xv. Ramadan month of fasting from dawn to dusk
f. Hindu
i. Cyclic birth and reincarnation
ii. Everything determined by behavior in last life (status, condition, caste)
iii. Cow is sacred (no beef)
iv. Limit eye contact & do not touch while talking
v. Priest may tie thread around neck/wrist to signify blessing at death do NOT remove
1. Priest will pour water into mouth of body
2. Family will request to wash body
3. Eldest son responsible for funeral rites
vi. Do not force foods when religiously forbidden
g. Buddhist
i. Budhi means “to awaken”
ii. Buddha was born in 563 BC
iii. Principles of Buddhism Dhamma or Truth
iv. Balance between self-indulgence and self-modification
v. Moral life
vi. Mindful and aware of thought and actions
vii. Wisdom and understanding
viii. Calm and collected
ix. Tolerant and not concerned with labels
x. Elimination of suffering by reaching “Nirvana” or “Enlightenment”
xi. If eliminate all desire can eliminate suffering
1. Great # of reincarnations
xii. Animalistic approach in Far East to increase luck instead of involving in time-consuming
& demanding practices
xiii. 9 is a lucky number
xiv. Karma deeds good or bad, will be rewarded in kind
xv. ½ are vegetarian/near vegetarian
1. Nonviolence to animals
13. Emotional Status (need to meet emotional needs of patients)
a. Dysthymic disorder: low grade depression but lasts longer than depression
b. Major depression= most common mood disorder
i. Affects 1/3 internal medicine patients
ii. Risk increases over time (most episodes occur at age 25)
1. 2-3 more times likely in women
iii. Increased depression= decreased PT/ adherence
iv. Most commonly associated with suicide (50% associated with suicide)
v. Caffeine, alcohol and Marijuana can worsen this
c. Major Depression Symptoms
i. Major depression: 5 or more of the following symptoms present during the same two-
week period and shows change from previous function (1 out of the 5 must be deep
sadness/emptiness OR apathy)
ii. Symptoms:
1. Deep sadness/emptiness
2. Apathy
3. Agitation or restlessness
4. Sleep disturbance
5. Weight/appetite disturbance
a. Loss/gain > or equal to 5 % in a month without trying
6. Lack of concentration
7. Feelings of excessive guilt or worthlessness
8. Morbid thoughts
9. Fatigue
iii. NMDA receptor agonist new antidepressant for treatment resistance depression
(TRD)
1. Resistant to at least 2 different antidepressants
2. Nasal spray at MD office and monitored for 2 hours after rapid effect
iv. Treatment
1. Exercise takes 1 week daily for symptoms to decrease
2. Deep breathing
3. Bright light therapy
4. Regular, restful sleep
5. Avoid negative thinking
6. Classical musical therapy
7. Daily spiritual exercises
v. Diets increasing depression= omega 3 fats, folic acid, vitamin B12, homocysteine, animal
protein intake/puberty
d. Frontal lobe (Prefrontal cortex) aka the control center/planning area of the brain for
decisions, behaviors, emotions & “crown” of the brain
i. Depression decreased frontal lobe blood flow and activity
ii. Alcohol reduce frontal lobe activity
1. Loss of abstract thinking can present up to 24 hours after last drink
2. Drinking less than legal limit weakens judgement 9x higher fatal accidents
iii. Nicotine affects frontal lobe
1. Decreases sleep, mental tasks, stress control, brain function depression
iv. Hypnosis short circuited frontal lobe
1. Loses thought activity (weak beta brain waves)
v. TV frequent switching of camera angles causes frontal lobe suppression
1. If angle is linear for 30 to 60 secs allow full frontal lobe involvement
2. Train yourself not to react
e. Smoking Cessation
i. 5 A’s
1. Ask about use
2. Advise to quit
3. Assess willingness to make a quit
4. Assist in quit attempt
5. Arrange follow up
ii. 5 R’s for unwilling to quit
1. Relevance of quitting
2. Risks of use
3. Rewards of quitting
4. Roadblocks possible to quitting
5. Repetition of discussion
f. Exercising the Brain
i. # of neurons and # of connections can increase by stimulation
ii. Reading
iii. Learn foreign language
iv. Use imagination
v. Spiritual exercises (memorizing scripture)
Response Score
No response: no vocalization 1
I Unresponsive
II Generalized Response
IV Confused; agitated
VI Confused; appropriate
Speech and language impairments (dominant Visual-perceptual impairments: L-sided unilateral neglect,
hemisphere/r-handed individuals): non-fluent (Broca’s) agnosia, visuospatial impairments, disturbances of body
aphasia, fluent (Wernicke’s) aphasia, global aphasia image and body scheme
Often very aware of impairments, anxious about poor Often unaware of impairments, poor judgment, inability to
performance self-correct; increased safety risk
Difficulty with processing delays; highly distractible Rigidity of thought, difficulty with abstract reasoning
Difficulty with expression of positive emotions Difficulty with perception of emotions, expression or
negative emotions
Difficulty processing verbal cues, verbal commands Difficulty processing visual cues
Memory impairments, typically related to language Memory impairments, typically related to spatial-
perceptual information
Good spontaneous
No Spontaneous Some Spontaneous Independent with
breathing: RR > 10
Breathing - Total Breathing: RR < 10 Weak Spontaneous Breathing: (RR < ventilation and able
but inspiratory
Ventilator Inspiratory efforts: VT < 6 10) Good effort: VT > 10 ml/kg to physiologically
effort still weak: VT
Dependence mL/kg support self
< 10 mL/kg
Continuous
Synchronous
Assist Pressure
Assisted Intermittent
Control Mode Control Support Positive Extubated
Ventilation Mandatory
Mode Ventilation Airway
Ventilation
Pressure