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ORIGINAL ARTICLE

Predicting Attention-Shaping Response in People


With Schizophrenia
Danielle M. Beaudette, MS,* James M. Gold, PhD,† James Waltz, PhD,† Judy L. Thompson, PhD,‡
Lindsay Cherneski, MA,‡ Victoria Martin, MA,‡ Brian Monteiro, MA,‡
Lisa N. Cruz, MA,‡ and Steven M. Silverstein, PhD‡

mental illness. Multiple studies (Silverstein et al. 2009, 2014) have in-
Abstract: People with schizophrenia often experience attentional impairments vestigated the effects of adding attention shaping to the University of
that hinder learning during psychological interventions. Attention shaping is a California, Los Angeles (UCLA) Basic Conversations Skills Module
behavioral technique that improves attentiveness in this population. Because rein- (BCSM; Liberman and Wallace, 1990). Silverstein et al. (2009) found
forcement learning (RL) is thought to be the mechanism by which attention shap- that patients who received the BCSM augmented with attention shaping
ing operates, we investigated if preshaping RL performance predicted level of demonstrated higher levels of skills acquisition than patients who
response to attention shaping in people with schizophrenia. Contrary to hypoth- underwent the standard BCSM without attention shaping. Moreover,
eses, a steeper attentiveness growth curve was predicted by less intact pretreat- change in attentiveness was associated with amount of skills acquired.
ment RL ability and lower baseline attentiveness, accounting for 59% of the Silverstein et al. (2014) replicated these results and further demon-
variance. Moreover, baseline attentiveness accounted for over 13 times more var- strated that greater improvements in attention during the social skills
iance in response to attention shaping than did RL ability. Results suggest atten- training intervention increased patients' abilities to generalize skills to
tion shaping is most effective for lower-functioning patients, and those high in RL novel social situations.
ability may already be close to ceiling in terms of their response to reinforcers. Although attention shaping has been successful in increasing at-
Attention shaping may not be a primarily RL-driven intervention, and other tention and learning for those with schizophrenia, it is resource inten-
mechanisms of its effects should be considered. sive (i.e., it requires a second staff member to deliver in-group
Key Words: Schizophrenia, reinforcement learning, attention shaping, behavioral reinforcement) and time-consuming (i.e., it can increase the number
intervention of group sessions required to complete all exercises in a treatment man-
ual). It would be beneficial to establish a screening tool to determine
(J Nerv Ment Dis 2021;209: 203–207)
which patients would benefit most from this intervention. Given atten-
tion shaping's foundation in operant conditioning, reinforcement learn-
S evere attentional impairments in people with schizophrenia have
been noted since the first descriptions of the disorder. These deficits
usually begin before the onset of the illness (Fusar-Poli et al., 2012),
ing (RL)—or the extent to which learning rate is modulated by the
positive and negative consequences of behaviors/choices—is thought
to be the mechanism through which attention shaping works. Therefore,
worsen as the illness progresses, and continue even after a psychotic ep-
the current study sought to determine if response to attention shaping
isode has remitted (Medalia and Choi, 2009). Research shows that de-
can be predicted by a computerized measure of RL. There were two
gree of attentional impairment in this population is inversely related to
study hypotheses: a) those with more intact RL ability at baseline would
social and vocational functioning and quality of life (Addington and
improve their attention more throughout the intervention (i.e., would be
Addington, 2000; Oie et al., 2011). Because sustained attention is es-
more responsive to the intervention), and b) baseline RL ability would
sential for learning, this deficit also severely limits one's ability to ben-
predict attention shaping outcome over and above a person's general
efit from psychosocial treatments (e.g., skills training, supported
cognitive ability and his or her ability to pay attention at baseline.
employment; Green, 1996; Green et al., 2000). Thus, treating attentional
deficits in schizophrenia is critical to enhancing treatment outcomes.
For patients with the most severe attentional deficits, the technique METHODS
of attention shaping has demonstrated success in improving attentiveness
and learning of material taught in psychiatric rehabilitation groups Study Design and Participants
(Silverstein et al., 2001, 2005, 2009, 2014). Attention shaping was devel-
This research was carried out in accordance with the latest ver-
oped as a form of operant conditioning, with attentiveness as the target
sion of the Declaration of Helsinki. It was approved by the Institutional
behavior. It involves systematic and differential reinforcement of suc-
Review Board at Rutgers University, and all participants underwent a
cessive approximations toward socially appropriate levels of attentive
thorough informed consent process before being enrolled in the study.
behavior. Attention shaping has been incorporated into group therapy
Our sample was recruited from a partial hospitalization treatment pro-
programs to accelerate acquisition of posthospital community reentry
gram. Participants were between 18 and 55 years old and had a diagno-
skills (Silverstein et al. 2005), social skills (Silverstein et al. 2009,
sis of schizophrenia or schizoaffective disorder according to the
2014), and social cognition (Combs et al. 2008) for those with serious
Structured Clinical Interview for the DSM-IV (First et al., 2007). Exclu-
sion criteria included a) substance use disorder in the past 6 months, b)
history of medical illness that influences the function of the central nervous
*Indiana University–Purdue University Indianapolis, Indianapolis, Indiana; †Maryland
Psychiatric Research Center, University of Maryland, Catonsville, Maryland; and
system (e.g., uncontrolled diabetes, untreated hypertension), c) diagnosis of
‡Rutgers University, Behavioral Health Care, Piscataway Township, New Jersey. autism spectrum or pervasive developmental disorder, and d) history of
Send reprint requests to Danielle M. Beaudette, MS, Indiana University–Purdue a neurological disorder or head injury with loss of consciousness.
University at Indianapolis, 402 N Blackford Street, LD 126X, Indianapolis, IN Subjects participated in the UCLA BCSM (Liberman and
46202. E‐mail: dbeaudet@iu.edu.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Wallace, 1990) augmented with an attention shaping intervention.
ISSN: 0022-3018/21/20903–0203 The BCSM (Liberman and Wallace, 1990) is a manualized, social skills
DOI: 10.1097/NMD.0000000000001286 training program that teaches five major skills using a structured,

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Beaudette et al. The Journal of Nervous and Mental Disease • Volume 209, Number 3, March 2021

repetitive format. Attention shaping involves the application of differ- picture received the feedback “Keep your money!,” whereas selection
ential reinforcement to sequentially reward closer and closer approxi- of the incorrect picture resulted in the feedback “Lose!” Again, better
mations to a target behavior while decreasing reinforcement for responses to the loss-avoiding pairs were reinforced on 90% of trials
versions of the behavior that are farther from this target. The desired be- in one pair and on 80% of trials in the other pair. Thus, success in the
havior is undivided attention throughout group therapy sessions, and task requires two types of learning: gain driven and loss avoidance. This
participants begin with an attention goal they can already achieve task yields four subscale RL scores, one for each stimulus pair. A com-
(e.g., 2 minutes of continuous attention), set based on a baseline assess- posite learning score denoting one's overall ability to learn from predic-
ment during the first two sessions (see below). As part of the attention- tion errors is also calculated from the four stimulus pairs. The task took
shaping intervention, monetary reinforcement is given as participants about 30 minutes to complete and was administered at baseline.
reach their attentional goals. Once a participant meets his or her goal
for two consecutive sessions, the goal is raised to the next step on the Intelligence and Cognition
prespecified hierarchy (e.g., 3 minutes of continuous attention), and The Wechsler Abbreviated Scale of Intelligence, Second Edition
the previous goal is no longer reinforced. (WASI-II; Wechsler, 2011), is a measure of intelligence designed for in-
Eight rounds of the program were completed with approximately dividuals 6 to 90 years of age. It consists of four subtests: vocabulary,
six participants per group. The groups met twice weekly for 1 hour over similarities, block design, and matrix reasoning. Subtest scores can be
4 months. Before beginning the intervention, participants were assessed combined to create a Full-Scale IQ-4 Subtests composite score. The
using selected measures of intelligence, cognition, and RL (see below WASI-II was standardized using a large, representative sample from
for description of measures). Participant attentiveness during each ther- the United States, and psychometric data suggest excellent internal con-
apy session was also rated using an observational assessment measure sistency and test-retest reliability, as well as high convergent validity
(described below). with the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV;
Wechsler, 2008, 2011). In this study, IQ scores were collected at base-
line to better understand the cognitive functioning of our sample and
Measures to determine if this variable impacted how much participants gained
Attention from the attention shaping intervention.
During each session, a noninteractive observer rated each partic- The MATRICS Consensus Cognitive Battery (MCCB; Nuechterlein
ipant on operationalized attentiveness criteria (see Silverstein et al., et al., 2008) is a neuropsychological assessment that measures working
2009 for details). These criteria included behaviors that showed the par- memory, attention/vigilance, verbal learning and memory, visual learn-
ticipant was paying attention (e.g., head up, eyes open, looking at the ing and memory, speed of processing, reasoning and problem solving,
focus of the group such as the leader) and/or participating (responding and social cognition. To summarize a person's overall cognitive ability,
to questions within 5 seconds, responses are relevant, and participates the MCCB produces an age- and sex-corrected global cognition T-
in role-plays). Behaviors that indicated lack of attention included mak- score. The assessments making up the battery have excellent psycho-
ing irrelevant comments or interrupting others, arguing, staring off (into metric properties, small practice effects, no ceiling effects, and strong
space, at the floor, etc.), getting out of one's chair, or leaving the group. relationships with social functioning (Nuechterlein et al., 2008). In
The rater observed each participant for 10 consecutive seconds during the current study, the MCCB was completed at baseline. Composite
each minute and then coded each minute (interval sampled) for each scores and the attention/vigilance subscale scores were used to under-
participant as “meeting attentiveness criteria” or not. In this way, each stand baseline cognitive functioning of our sample and determine if
subject was measured on how many minutes he or she paid attention these variables affected one's ability to benefit from the attention shap-
during every group session. Reliability of attention ratings was initially ing intervention.
established using a set of “gold standard” video recordings requiring all
potential attention raters to achieve a 95% level of agreement. Rerating Analytic Plan
of at least two full session recordings occurred every 6 months to guard Analyses were run using IBM SPSS Statistics for Windows, Ver-
against rater drift. From these ratings, two attention measures were sion 25.0. First, we computed descriptive statistics including demo-
computed: a) the mean of the total minutes of attention over the first graphic information and average level of education, IQ, and cognitive
two sessions (before the use of attention shaping procedures) was com- functioning to assess the representativeness of our sample. Next, we
puted as a baseline measure of attention, and b) the slope or change in ran correlation and regression analyses to test the main hypotheses.
total minutes of attention over all group sessions corrected for the These analyses were conducted in two parts. First, participants who
first-order autoregressive component was computed as an outcome attended at least 50% of all group session were included in the analyses
measure for attention shaping. (n = 40). Next, analyses were repeated to include participants who
attended at least 25% of sessions (n = 47). This procedure was imple-
Reinforcement Learning mented to determine if results vary based on how many attention shap-
The Gains vs. Loss Avoidance Test (Gold et al., 2012) is a com- ing sessions participants had.
puterized measure of RL. In each trial, participants are presented pairs
of pictures and are asked to choose the “better” picture. After making RESULTS
a choice, participants are given one of four types of feedback: “Win Forty-nine people diagnosed with schizophrenia or schizoaffective
$0.05!,” “Not a winner. Try again!,” “Keep your money!,” or “Lose disorder completed the study. Table 1 outlines descriptive statistics of the fi-
$0.05!” The “better” picture is explained as the one most likely to earn nal sample, including demographic information and cognitive functioning.
$0.05 or allow them to keep the money they already have. In this way, To test our first hypothesis, we performed correlation analyses to
participants learn which is the “better” picture through trial and error. determine associations between RL scores and slope of attentiveness
Four different stimulus pairs are presented. Two pairs involved potential over the course of the intervention. We also tested correlations between
gain; if the correct item was selected, participants received the “Win slope of attentiveness and measures of baseline cognitive functioning
$0.05!” feedback; if the incorrect item was selected, they saw “Not a (IQ and MCCB scores). Because the corrected slope of attentiveness
winner, Try again!” The correct response was reinforced on 90% of tri- yielded nonnormally distributed data, Spearman's Rho correlations
als in one pair and on 80% of trials in the other pair. Two other pairs in- were used. Results of these analyses are outlined in Table 2. For the first
volved learning to avoid losses; in these pairs, choosing the correct set of analyses (n = 40), only one stimulus pair yielded an RL subscore

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The Journal of Nervous and Mental Disease • Volume 209, Number 3, March 2021 Attention Shaping in Schizophrenia

Results were not in line with our initial hypotheses. First, most of the
TABLE 1. Descriptive Statistics of the Sample (N = 49) baseline measures of RL were not statistically related to attention shap-
ing outcome, even without controlling for multiple statistical tests. Pre-
Age, mean (SD) 41.3 (10.9) vious research testing associations between RL task scores and
Sex, % male 81.6% real-world variables have yielded mixed results (e.g., McCarthy et al.,
Race 2016; Treadway et al., 2015), suggesting that many real-world behav-
Caucasian 42.9% iors, even if occurring in the context of delivery of reinforcement, are
Black/African-American 42.9% determined by multiple factors, some or all of which may be more pre-
Asian 12.2% dictive than reward processing ability. In the current study, RL scores
Multiracial 2.0% from one stimulus pair were significantly correlated with change in at-
Ethnicity, % non-Hispanic 81.6% tention over time, but the direction of this relationship was in the oppo-
site direction of what was predicted: Poorer pretreatment performance
Years of education, mean (SD) 12.4 (1.8)
on the laboratory RL task was related to larger improvements in atten-
WASI FSIQ-4, mean (SD) 81.6 (18.0)
tiveness during the attention shaping intervention. This apparently par-
MCCB adoxical finding suggests that even patients who seem to have RL
Composite, mean (SD) 23.6 (16.0) deficits are sensitive to reward under conditions where rewards are
AttnVig, mean (SD) 32.0 (13.0) made salient and are consistently delivered for specific behaviors. This
Baseline Attn, mean (SD) 75.2 (23.5) conclusion fits with much data on strong treatment effects for social
learning–based milieu interventions for “treatment-refractory” patients
AttnVig indicates attention vigilance; Baseline Attn, average percentage of
with schizophrenia (Glynn and Mueser, 1986; Paul and Lentz, 1977;
session each participant paid attention to for over the first two group sessions;
MCCB, MATRICS Consensus Cognitive Battery; WASI FSIQ-4, Wechsler Ab- Silverstein et al., 2006). Moreover, people with intact baseline RL
breviated Scale of Intelligence Full Scale IQ-4 Subtest. may already be sensitive enough to social reinforcement that they do
not need additional external reinforcers to increase their attention spans
(i.e., they are close to their ceiling at baseline in terms of attentiveness in
that was significantly related to slope of attention (the gain/miss with group situations). Second, RL ability weakly accounted for additional
80% probability of best outcome pair). In the second set of analyses variance in attentiveness change over time over and above baseline at-
(n = 47), a second stimulus pair was significantly related to slope of atten- tention. Thus, results indicate that attention shaping should not be
tion (the loss/avoid with 90% probability of best outcome pair). For both viewed as a primarily RL-driven intervention.
sets of analyses, the direction of the association between the RL compos- In our sample, participant's IQ and baseline measures of cognitive
ite score and slope of attentiveness change over time was the opposite of functioning were unrelated to attention shaping response. Importantly,
the predicted direction and did not reach significance. Moreover, baseline
measures of cognitive functioning (IQ and MCCB scores) were unrelated
to slope of attention in both sets of analyses (Table 2).
To test our second hypothesis, we ran hierarchical linear regres- TABLE 2. Spearman's Rho Correlation Analyses
sion models to see if RL predicted slope of attention over and above the
Slope of Attention Slope of Attention
predictive ability of baseline attentiveness. Because IQ and MCCB
(n = 40) (n = 47)
scores were unrelated to slope of attention, these measures were ex-
cluded from regression models. For each regression model, the depen- RL stimulus pair
dent variable was the corrected slope of attention over the course of the Gain/miss pair (90%) 0.18 0.07
intervention, and baseline attentiveness (i.e., attentiveness during the p = 0.26 p = 0.64
first two group sessions, before the initiation of attention shaping proce- Gain/miss pair (80%) −0.35* −0.34*
dures) was included as a predictor in the first step of the model. We in-
p = 0.03 p = 0.02
cluded the RL subscore that was significantly associated with slope of
attention as a predictor in the second step of each model. In our first Loss/avoid pair (90%) −0.27 −0.30*
analysis (model 1, n = 40), the gain/miss with 80% probability of best p = 0.10 p = 0.04
outcome pair was included in the second step. The resulting model sig- Loss/avoid pair (80%) −0.07 −0.10
nificantly predicted slope of attention, accounting for 59% of the vari- p = 0.69 p = 0.51
ance, R2 = 0.59, F(2,37) = 26.40, p < 0.001 (Table 3). Results Composite RL Score −0.14 −0.22
revealed that at step 1, baseline attention significantly contributed to p = 38 p = 0.13
the model and accounted for 55% of the variance, R2 = 0.55, Measures of cognition
F(1,38) = 45.88, p < 0.001. Introducing the RL variable added an addi- WASI FSIQ-4 −0.19 −0.13
tional 4% of variance in slope of attention; however, this change in R2 p = 0.23 p = 0.38
only approached significance, F(1,37) = 3.68, p = 0.063. We ran two
MCCB composite −0.21 −0.14
subsequent regression analyses including the larger sample (n = 47):
one with the gain/miss with 80% probability of best outcome pair in- p = 0.21 p = 0.35
cluded in the second step (model 2), and one with the loss-avoid with MCCB AttnVig 0.03 0.73
90% probability of best outcome included (model 3). These analyses p = 0.86 p = 0.62
yielded similar results to those of model 1. Regression models were sig- Percentage for each stimulus pair refers to probability of best outcome. Sam-
nificant, but adding each RL subscore at step 2 did not add significant ple size differences refer to participants who attended at least 50% and 25% of
predictive value to either model (Table 3). sessions, respectively.
AttnVig indicates attention vigilance; MCCB, MATRICS Consensus Cogni-
tive Battery; WASI FSIQ-4, Wechsler Abbreviated Scale of Intelligence Full
DISCUSSION Scale IQ-4 Subtest.
The purpose of this study was to examine if RL ability can pre- *p < 0.05.
dict one's ability to benefit from an attention shaping intervention.

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Beaudette et al. The Journal of Nervous and Mental Disease • Volume 209, Number 3, March 2021

Next, the attention shaping intervention in this study took place only twice
TABLE 3. Summary of Hierarchical Regression Analyses for Variables a week. In other published studies of attention shaping (e.g., Silverstein
Predicting Slope of Attention
et al., 1998), sessions were held three to five times per week. Therefore,
it is unclear if our results would generalize to predicting treatment re-
Variable b t R R2 ΔR2
sponse under those more intensive reinforcement delivery conditions.
Model 1 (n = 40) Lastly, researchers have questioned the reliability of probabilistic
Step 1 0.74 0.55 0.55*** RL tasks (Baker et al., 2013), and the reliability of the specific task used
Baseline attention −0.01 −6.77*** in this study is not yet known. Therefore, this research is limited in that
Step 2 0.77 0.59 0.04+ the robustness of our findings cannot be currently estimated. However,
Baseline attention −0.01 −6.17*** test-retest reliability may not be a meaningful metric for tests involving
learning, as prior experience with the test may lead to insights about
RL gain/miss 80% score −0.24 −1.92+
how to approach the test that can affect subsequent scores. It may also
Model 2 (n = 47) be the case that even if low test-retest reliability is obtained, the test
Step 1 0.76 0.57 0.57*** could still be valid. That is, it may accurately measure the construct of
Baseline attention −0.01 −7.79*** interest, and variability in scores over time could be accounted for by spe-
Step 2 0.77 0.60 0.03 cific factors that are expected to affect learning (e.g., drug use, amount of
Baseline attention −0.01 −7.29*** sleep, fluctuations in attention, symptoms). This point has been noted in
RL gain/miss 80% score −0.21 −1.57 prior discussions of psychometric issues in interpreting data from patients
Model 3 (n = 47) with schizophrenia (Mathalon et al., 1993; Silverstein, 2008). In such
Step 1 0.76 0.57 0.57*** cases, reduced test-retest reliability can actually be associated with in-
Baseline attention −0.01 −7.79*** creases in validity (Mathalon et al., 1993; Silverstein, 2008; Willett, 1989).
Future research should consider other mechanisms involved in
Step 2 0.78 0.60 0.03+
attention shaping. A recent meta-analysis found that stronger therapeu-
Baseline attention −0.01 −7.46*** tic alliance in treatment for serious mental illness predicted greater
RL loss/avoid 90% score −0.26 −1.71+ treatment adherence and improvements in functioning across interven-
Percentage indicates the probability of best outcome. tions (Browne et al., 2019). Moreover, Beaudette et al. (2020) found
+
p < 0.10.
that clinician-rated alliance was associated with average attention dur-
ing a similar attention shaping intervention; alliance mediated the rela-
***p < 0.001.
tionship between negative symptoms and attention shaping outcome.
Thus, it seems that one's ability to form a strong alliance with treatment
staff may determine attention shaping success. Relatedly, one's level of
engagement with treatment (i.e., participation in services) greatly influ-
ences therapeutic and functional outcomes (Dixon et al., 2016) and
baseline attention/vigilance as measured by the MCCB did not influ- should also be considered as a potential predictor of attention shaping
ence one's ability to benefit from attention shaping during the group in- response. Research suggests client factors such as better insight, less
tervention. Although these results may seem counterintuitive, they perceived stigma, and a higher sense of mastery are associated with
align with our conclusion that attention shaping benefits even the ability to form a strong therapeutic alliance (Beaudette et al., 2020;
lowest-functioning patients. That is, our participants exhibited below Browne et al., 2019). Sense of mastery itself may be a particularly im-
average IQ and MCCB scores compared with other schizophrenia sam- portant mechanism through which attention shaping operates. Errorless
ples (August et al., 2012) yet still exhibited attentional gains. In a pre- learning, as seen in attention shaping, is thought to lead to recovery by
vious investigation of attention shaping (Silverstein et al., 2014), continuously promoting goal setting, control, and mastery, thereby
patients who showed the greatest shaping response did not differ from strengthening positive self-beliefs in the individual (Grant et al., 2018).
nonresponders on any demographic or clinical variables. Silverstein Similarly, goal attainment leads to improved sense of self (Clarke et al.,
et al. (2014) concluded that patients should not be excluded from atten- 2009) and better therapeutic outcomes for people with serious mental ill-
tion shaping interventions based on clinical or demographic character- ness (Michalak and Holtforth, 2006). In this way, patients high in
istics. Our results extend these findings, as IQ and baseline cognitive self-esteem and mastery may be at an advantage when it comes to
functioning did not affect one's ability to benefit from attention shap- goal-based interventions like attention shaping. Alternatively, attention
ing. Thus, patients should not be excluded from this intervention based shaping may be best suited for those low in mastery because its error-
on low cognitive functioning. less learning design directly targets and improves this domain. Either
Key limitations of this study should be considered. First, because way, future research exploring these constructs may elucidate the pri-
of a relatively small sample (N = 49), lack of power to detect true rela- mary processes through which attention shaping works. Assessing fac-
tionships is a concern. Relatedly, our sample was mostly male and ex- tors such as working alliance, self-esteem, and sense of mastery at
hibited below average cognitive functioning compared with other baseline may help better identify patients best suited for an attention
schizophrenia samples (August et al., 2012). Thus, restrictions in the shaping intervention.
representativeness of our sample should be considered when interpret-
ing results. Our procedure of only analyzing data from participants who
attended a minimum percentage of group sessions is also potentially CONCLUSIONS
problematic. Missing many sessions or discontinuing treatment pre- Although attention shaping has been shown to successfully in-
maturely may be indicative of, or related to having, extreme atten- crease learning during psychological interventions for people with
tional impairments relevant for the success of this intervention. schizophrenia (Silverstein et al., 2001, 2014), it is a resource- and
Excluding these participants may inadvertently exclude a subset of time-intensive process. Thus, establishing a screening tool to determine
the lowest-functioning people with schizophrenia and therefore con- which patients would benefit most from attention shaping is crucial for
found results. However, given that findings were consistent across anal- efficiently and practically delivering this intervention in treatment pro-
yses of data from those who attended at least 50% (n = 40) and at least grams. The current study tested baseline RL ability as a predictor of at-
25% (n = 47) of group sessions, this limitation is likely not a concern. tention shaping response in those with schizophrenia. Contrary to

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The Journal of Nervous and Mental Disease • Volume 209, Number 3, March 2021 Attention Shaping in Schizophrenia

hypotheses, we found that less intact pretreatment RL ability and lower Green MF, Kern RS, Braff DL, Mintz J (2000) Neurocognitive deficits and functional
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DISCLOSURE Medalia A, Choi J (2009) Cognitive remediation in schizophrenia. Neuropsychol Rev.
This work was supported by the National Institutes of Mental 19:353–364.
Health, Clinical and Computational Studies of Dopamine Function in
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Schizophrenia (grant number 2R01 MH080066-06A1). Principal inves-
psychotherapy. Clin Psychol (New York). 13:346–365.
tigator: James M. Gold; site principal investigator at Rutgers: Steven
M. Silverstein. Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Essock S,
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