PMID- 17479604

OWN - NLM
STAT- MEDLINE
DCOM- 20070717
LR - 20190608
IS - 1088-5412 (Print)
IS - 1088-5412 (Linking)
VI - 28
IP - 2
DP - 2007 Mar-Apr
TI - Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway
inflammation in asthmatic children: a preliminary report.
PG - 194-8
AB - Macrolide antibiotics have immunomodulatory effects that may be beneficial to

patients with chronic inflammatory pulmonary conditions. The aim of this

study was
to evaluate the effects of azithromycin on lung function, bronchial
hyperresponsiveness (BHR), and airway inflammation in asthmatic children.
Sixteen
asthmatic children were treated with either azithromycin or placebo for 8
weeks.
Lung function, BHR expressed as the dose-response slope (DRS) of forced
expiratory
volume in 1 second (FEV1) fall after hypertonic saline inhalation (DRS), and
induced
sputum were evaluated at baseline and after treatment. No significant change
was
observed in lung function before and after treatment. DRS (percent fall of
FEV1/mL)
decreased from (X +/- SD) 2.75 +/- 2.12 to 1.42 +/- 1.54 (p = 0.02) in
azithromycin-treated children but not in the placebo group, which was 1.48
+/- 1.75
at baseline and 1.01 +/- 1.38 at the end of the study period. Neutrophil
leukocytes
decreased significantly in the azithromycin-treated group from 10 +/- 5.3% to
2.2
+/- 2.4% (p < 0.01) but not in the placebo group, with 7.2 +/- 4.2% at
baseline and
3.3 +/- 3.6% at the end of the study. A short course of azithromycin is
associated
with amelioration of BHR and reduction in airway neutrophil infiltration in
some
children with asthma.
FAU - Piacentini, Giorgio L
AU - Piacentini GL
AD - Department of Pediatrics, University of Verona, Verona, Italy.
FAU - Peroni, Diego G
AU - Peroni DG
FAU - Bodini, Alessandro
AU - Bodini A
FAU - Pigozzi, Roberta
AU - Pigozzi R
FAU - Costella, Silvia
AU - Costella S
FAU - Loiacono, Attilio
AU - Loiacono A
FAU - Boner, Attilio L
AU - Boner AL
LA - eng
PT - Journal Article
PT - Randomized Controlled Trial
PL - United States
TA - Allergy Asthma Proc
JT - Allergy and asthma proceedings
JID - 9603640
RN - 0 (Anti-Asthmatic Agents)
RN - 0 (Immunologic Factors)
RN - 83905-01-5 (Azithromycin)
SB - IM
MH - Adolescent
MH - Anti-Asthmatic Agents/pharmacology/*therapeutic use
MH - Asthma/*drug therapy/immunology/physiopathology
MH - Azithromycin/pharmacology/*therapeutic use
MH - Bronchial Hyperreactivity/*drug therapy/immunology/physiopathology
MH - Child
MH - Double-Blind Method
MH - Female
MH - Forced Expiratory Volume
MH - Humans
MH - Immunologic Factors/pharmacology/*therapeutic use
MH - Inflammation/*drug therapy/immunology/physiopathology
MH - Male
MH - Neutrophil Infiltration/*drug effects
MH - Sputum/cytology
MH - Treatment Outcome
EDAT- 2007/05/08 09:00
MHDA- 2007/07/18 09:00
CRDT- 2007/05/08 09:00
PHST- 2007/05/08 09:00 [pubmed]
PHST- 2007/07/18 09:00 [medline]
PHST- 2007/05/08 09:00 [entrez]
AID - 10.2500/aap.2007.28.2958 [doi]
PST - ppublish
SO - Allergy Asthma Proc. 2007 Mar-Apr;28(2):194-8. doi: 10.2500/aap.2007.28.2958.